| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leticia Gutiérrez-Galve, Manja Lehmann, Nicola Z Hobbs, Matthew J Clarkson, Gerard R Ridgway, Sebastian Crutch, Sebastien Ourselin, Jonathan M Schott, Nick C Fox, Josephine Barne. Patterns of cortical thickness according to APOE genotype in Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 28. issue 5. 2010-03-01. PMID:19940480. |
we aimed to assess the influence of apoe genotype on cortical thickness and regional brain volumes in ad (alzheimer's disease). |
2010-03-01 |
2023-08-12 |
Not clear |
| Friederike Flachsbart, Amke Caliebe, Michael Nothnagel, Rabea Kleindorp, Susanna Nikolaus, Stefan Schreiber, Almut Nebe. Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals. European journal of human genetics : EJHG. vol 18. issue 1. 2010-02-22. PMID:19639019. |
consistent with this hypothesis, earlier studies showed a depletion of the alzheimer's disease risk factor apoe*epsilon4 in long-lived individuals (llis). |
2010-02-22 |
2023-08-12 |
Not clear |
| A E van der Vlies, E L G E Koedam, Y A L Pijnenburg, J W R Twisk, P Scheltens, W M van der Flie. Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19335933. |
most rapid cognitive decline in apoe epsilon4 negative alzheimer's disease with early onset. |
2010-02-17 |
2023-08-12 |
Not clear |
| A E van der Vlies, E L G E Koedam, Y A L Pijnenburg, J W R Twisk, P Scheltens, W M van der Flie. Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. Psychological medicine. vol 39. issue 11. 2010-02-17. PMID:19335933. |
we aimed to compare the rate of cognitive decline in patients with early and late onset alzheimer's disease (ad) and to investigate the potentially modifying influence of the apolipoprotein e (apoe) genotype. |
2010-02-17 |
2023-08-12 |
Not clear |
| Huriletemuer, Binbin Wang, Jing Wang, Guan Wang, Chunyu Zhang, Shigang Zhao, Sirui Zhou, Xu Ma, De Sheng Wan. APOE epsilon4 is a high-risk factor for Alzheimer's disease in the Mongolian population. Journal of the neurological sciences. vol 288. issue 1-2. 2010-02-17. PMID:19819468. |
apoe epsilon4 is a high-risk factor for alzheimer's disease in the mongolian population. |
2010-02-17 |
2023-08-12 |
human |
| Huriletemuer, Binbin Wang, Jing Wang, Guan Wang, Chunyu Zhang, Shigang Zhao, Sirui Zhou, Xu Ma, De Sheng Wan. APOE epsilon4 is a high-risk factor for Alzheimer's disease in the Mongolian population. Journal of the neurological sciences. vol 288. issue 1-2. 2010-02-17. PMID:19819468. |
to determine the relationship between apolipoprotein e (apoe) epsilon4 and sporadic alzheimer's disease (sad) in the mongolian population in china, we examined 106 mongolian sad patients in china and 100 mongolian healthy controls. |
2010-02-17 |
2023-08-12 |
human |
| Susanne Jungwirth, Sonja Zehetmayer, Peter Bauer, Silvia Weissgram, Karl Heinz Tragl, Peter Fische. Prediction of Alzheimer dementia with short neuropsychological instruments. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 11. 2010-02-12. PMID:19784754. |
a combination of reduced verbal memory, reduced visual motor speed, subjective memory complaints and the apoe epsilon4 carriage was best in predicting incident probable alzheimer dementia (r(2) = 0.42, roc curve = 0.91). |
2010-02-12 |
2023-08-12 |
human |
| Madhav Thambisetty, Lori Beason-Held, Yang An, Michael A Kraut, Susan M Resnic. APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. Archives of neurology. vol 67. issue 1. 2010-02-12. PMID:20065135. |
to study differences in longitudinal changes in regional cerebral blood flow (rcbf) between apolipoprotein e (apoe) epsilon4 carriers and noncarriers in nondemented older adults from the baltimore longitudinal study of aging using positron emission tomography in order to determine whether there are regionally specific longitudinal changes in rcbf in apoe epsilon4 carriers that might be related to its well-established role as a genetic risk factor for alzheimer disease. |
2010-02-12 |
2023-08-12 |
Not clear |
| K A Crutcher, H N Lilley, S R Anthony, W Zhou, V Narayanaswam. Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide. Brain research. vol 1306. 2010-02-03. PMID:19836363. |
these results might bear on the question of the role of apoe in neuronal degeneration, such as occurs in alzheimer's disease where apoe4 confers a significantly greater risk of pathology. |
2010-02-03 |
2023-08-12 |
cattle |
| J Chapuis, D Hot, F Hansmannel, O Kerdraon, S Ferreira, C Hubans, C A Maurage, L Huot, F Bensemain, G Laumet, A M Ayral, N Fievet, J J Hauw, S T DeKosky, Y Lemoine, T Iwatsubo, F Wavrant-Devrièze, J F Dartigues, C Tzourio, L Buée, F Pasquier, C Berr, D Mann, C Lendon, A Alpérovitch, M I Kamboh, P Amouyel, J C Lamber. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Molecular psychiatry. vol 14. issue 11. 2010-01-25. PMID:19204726. |
the only recognized genetic determinant of the common forms of alzheimer's disease (ad) is the epsilon 4 allele of the apolipoprotein e gene (apoe). |
2010-01-25 |
2023-08-12 |
Not clear |
| Steven G Potkin, Guia Guffanti, Anita Lakatos, Jessica A Turner, Frithjof Kruggel, James H Fallon, Andrew J Saykin, Alessandro Orro, Sara Lupoli, Erika Salvi, Michael Weiner, Fabio Macciard. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668339. |
with the exception of apoe epsilon4 allele, the common genetic risk factors for sporadic alzheimer's disease (ad) are unknown. |
2010-01-19 |
2023-08-12 |
Not clear |
| Agnes Fehér, Anna Juhász, Agnes Rimanóczy, János Kálmán, Zoltán Jank. Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease. Alzheimer disease and associated disorders. vol 23. issue 3. 2010-01-08. PMID:19812463. |
apolipoprotein e (apoe) gene polymorphism is known to be associated with alzheimer disease (ad), dementia with lewy bodies (dlb), and pick disease (pid). |
2010-01-08 |
2023-08-12 |
Not clear |
| Dan Kaufer, Sam Gand. APOE {epsilon}4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics. Neurology. vol 73. issue 24. 2010-01-08. PMID:19923549. |
apoe {epsilon}4 and bapineuzumab: infusing pharmacogenomics into alzheimer disease therapeutics. |
2010-01-08 |
2023-08-12 |
Not clear |
| Ke-Feng Tang, Li Cai, Jiang-Ning Zho. Observation of the density and size of cells in hippocampus and vascular lesion in thalamus of GFAP-apoE transgenic mice. Neuroscience bulletin. vol 25. issue 4. 2010-01-06. PMID:19633698. |
apolipoprotein e (apoe) is associated with increased risk of age-related diseases, such as alzheimer's disease (ad) and cerebrovascular disease (cvd). |
2010-01-06 |
2023-08-12 |
mouse |
| Jungsu Kim, Joseph M Castellano, Hong Jiang, Jacob M Basak, Maia Parsadanian, Vi Pham, Stephanie M Mason, Steven M Paul, David M Holtzma. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. vol 64. issue 5. 2010-01-05. PMID:20005821. |
apolipoprotein e (apoe) is the strongest genetic risk factor for alzheimer's disease (ad). |
2010-01-05 |
2023-08-12 |
mouse |
| Alessandro Calabretta, Tullia Tedeschi, Gabriella Di Cola, Roberto Corradini, Stefano Sforza, Rosangela Marchell. Arginine-based PNA microarrays for APOE genotyping. Molecular bioSystems. vol 5. issue 11. 2009-12-23. PMID:19823748. |
four modified pnas containing one chiral monomer bearing two arginine-derived side chains, with the correct configuration for specific and stable dna binding, were synthesized, complementary to two dna tracts in the apoe gene containing snps related to the insurgence of alzheimer's disease. |
2009-12-23 |
2023-08-12 |
Not clear |
| Sonya B Dumanis, Joseph A Tesoriero, Lenard W Babus, Madeline T Nguyen, Justin H Trotter, Mary Jo Ladu, Edwin J Weeber, R Scott Turner, Baoji Xu, G William Rebeck, Hyang-Sook Ho. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 48. 2009-12-22. PMID:19955384. |
the three human alleles of apolipoprotein e (apoe) differentially influence outcome after cns injury and affect one's risk of developing alzheimer's disease (ad). |
2009-12-22 |
2023-08-12 |
mouse |
| Paula J Jansen, Dieter Lütjohann, Karin M Thelen, Klaus von Bergmann, Fred van Leuven, Frans C S Ramaekers, Monique Moniqu. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. Journal of Alzheimer's disease : JAD. vol 18. issue 2. 2009-12-17. PMID:19584433. |
apolipoprotein e (apoe) is a regulator of peripheral cholesterol homeostasis, and the apoe-isoform e4 is a major risk factor for the development of alzheimer's disease (ad). |
2009-12-17 |
2023-08-12 |
mouse |
| Ewa Golanska, Krystyna Hulas-Bigoszewska, Monika Sieruta, Izabela Zawlik, Monika Witusik, Sylwia M Gresner, Tomasz Sobow, Maria Styczynska, Beata Peplonska, Maria Barcikowska, Pawel P Liberski, Elizabeth H Corde. Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363267. |
earlier onset of alzheimer's disease: risk polymorphisms within prnp, prnd, cyp46, and apoe genes. |
2009-12-16 |
2023-08-12 |
Not clear |
| Ewa Golanska, Krystyna Hulas-Bigoszewska, Monika Sieruta, Izabela Zawlik, Monika Witusik, Sylwia M Gresner, Tomasz Sobow, Maria Styczynska, Beata Peplonska, Maria Barcikowska, Pawel P Liberski, Elizabeth H Corde. Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363267. |
we studied eight polymorphisms within apoe, prnp, prnd, and cyp46 genes in 213 polish late-onset patients with alzheimer's disease (ad) and 171 non-demented elderly controls. |
2009-12-16 |
2023-08-12 |
Not clear |