| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathleen M Hayden, Peter P Zandi, Nancy A West, Joann T Tschanz, Maria C Norton, Chris Corcoran, John C S Breitner, Kathleen A Welsh-Bohme. Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study. Archives of neurology. vol 66. issue 11. 2009-12-16. PMID:19901170. |
to evaluate the influences of a family history of alzheimer dementia (fhxad) and the apolipoprotein e epsilon4 genotype (apoe epsilon4) on cognitive decline. |
2009-12-16 |
2023-08-12 |
Not clear |
| Robert C Green, Sally E McNagny, Parimala Jayakumar, L Adrienne Cupples, Kelly Benke, Lindsay A Farre. Statin use and the risk of Alzheimer's disease: the MIRAGE study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 2. issue 2. 2009-12-14. PMID:19595865. |
the aim of this study was to examine the association between statin use before the onset of alzheimer's disease (ad) symptoms and risk of having ad, and to explore the potential impact of apoe genotype and race on this association. |
2009-12-14 |
2023-08-12 |
Not clear |
| Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Angeles Gómez Beldarraín, Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta, Marian M de Pancorb. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC neuroscience. vol 10. 2009-12-09. PMID:19793392. |
the comt val158 met polymorphism as an associated risk factor for alzheimer disease and mild cognitive impairment in apoe 4 carriers. |
2009-12-09 |
2023-08-12 |
Not clear |
| Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Angeles Gómez Beldarraín, Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta, Marian M de Pancorb. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers. BMC neuroscience. vol 10. 2009-12-09. PMID:19793392. |
the aim of this study is to examine the influence of the catechol-o-methyltranferase (comt) gene (polymorphism val158 met) as a risk factor for alzheimer's disease (ad) and mild cognitive impairment of amnesic type (mci), and its synergistic effect with the apolipoprotein e gene (apoe).a total of 223 mci patients, 345 ad and 253 healthy controls were analyzed. |
2009-12-09 |
2023-08-12 |
Not clear |
| Lars Bertram, Rudolph E Tanz. Genome-wide association studies in Alzheimer's disease. Human molecular genetics. vol 18. issue R2. 2009-12-09. PMID:19808789. |
in the field of alzheimer's disease (ad), there are currently eight published and two provisionally reported gwas, highlighting over two dozen novel potential susceptibility loci beyond the well-established apoe association. |
2009-12-09 |
2023-08-12 |
Not clear |
| Olga Calero, Rafael Hortigüela, María J Bullido, Miguel Caler. Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays. Journal of neuroscience methods. vol 183. issue 2. 2009-12-04. PMID:19583979. |
the apolipoprotein e gene (apoe) polymorphism genotyping has an allegedly important predictive value for coronary heart disorders and alzheimer's disease. |
2009-12-04 |
2023-08-12 |
Not clear |
| Marina Del Prete, Simona Spaccavento, Angela Craca, Pietro Fiore, Paola Angelell. Neuropsychiatric symptoms and the APOE genotype in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 30. issue 5. 2009-12-04. PMID:19590821. |
neuropsychiatric symptoms and the apoe genotype in alzheimer's disease. |
2009-12-04 |
2023-08-12 |
Not clear |
| Marina Del Prete, Simona Spaccavento, Angela Craca, Pietro Fiore, Paola Angelell. Neuropsychiatric symptoms and the APOE genotype in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 30. issue 5. 2009-12-04. PMID:19590821. |
the study aimed to characterize neuropsychiatric symptomatology in alzheimer's disease (ad) and investigate the role of apoe genotype and other clinical variables in the onset of neuropsychiatric disorders. |
2009-12-04 |
2023-08-12 |
Not clear |
| Marina Del Prete, Simona Spaccavento, Angela Craca, Pietro Fiore, Paola Angelell. Neuropsychiatric symptoms and the APOE genotype in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 30. issue 5. 2009-12-04. PMID:19590821. |
apoe epsilon(4) allele is associated to a peculiar neuropsychiatric profile characterizing the onset and evolution of alzheimer's disease. |
2009-12-04 |
2023-08-12 |
Not clear |
| Lee E Moore, Paul Brennan, Sara Karami, Idan Menashe, Sonja I Berndt, Linda M Dong, Allison Meisner, Meredith Yeager, Stephen Chanock, Joanne Colt, Kendra Schwartz, Faith Davis, David Zaridze, Vsevolod Mattveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Ivana Holcatova, Paolo Boffetta, Wong-Ho Chow, Philip S Rosenberg, Nathaniel Rothma. Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer research. vol 69. issue 20. 2009-11-24. PMID:19808960. |
this association is biologically plausible as snp rs405509 was shown to modify protein binding and transcriptional activity of the apoe protein in vitro and is in linkage disequilibrium with key known variants defining the e2, e3, and e4 alleles that modify risk of atherosclerosis, alzheimer's disease risk, and progression to aids. |
2009-11-24 |
2023-08-12 |
Not clear |
| Cynthia M Stonnington, Peter J Snyder, Joseph G Hentz, Eric M Reiman, Richard J Casell. Double-blind crossover study of the cognitive effects of lorazepam in healthy apolipoprotein E (APOE)-epsilon4 carriers. The Journal of clinical psychiatry. vol 70. issue 10. 2009-11-23. PMID:19573495. |
to examine cognitive effects of pharmacologically induced somnolence in cognitively normal carriers and noncarriers of the apolipoprotein e (apoe)-epsilon4 allele, a common alzheimer's disease susceptibility gene. |
2009-11-23 |
2023-08-12 |
Not clear |
| Jing Du, Junlei Chang, Songxi Guo, Qing Zhang, Zhao Wan. ApoE 4 reduces the expression of Abeta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons. Neuroscience letters. vol 464. issue 2. 2009-11-23. PMID:19616072. |
apolipoprotein e (apoe) 4 is a potent risk factor for alzheimer's disease (ad). |
2009-11-23 |
2023-08-12 |
Not clear |
| Agnes Fehér, Anna Juhász, Agnes Rimanóczy, Eva Csibri, János Kálmán, Zoltán Jank. Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia. Dementia and geriatric cognitive disorders. vol 28. issue 1. 2009-11-16. PMID:19641318. |
we tested the hypothesis whether the partially duplicated variant of alpha7 nicotinic acetylcholine receptor subunit gene (chrfam7a) 2-bp deletion (-2 bp) polymorphism and apolipoprotein e (apoe) epsilon4 allele confer susceptibility to alzheimer's disease (ad), dementia with lewy bodies (dlb), pick's disease (pid) and vascular dementia (vd). |
2009-11-16 |
2023-08-12 |
Not clear |
| Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panz. Dietary fatty acids and predementia syndromes. TheScientificWorldJournal. vol 9. 2009-11-09. PMID:19705039. |
however, recent findings from clinical trials with n-3 pufa supplementation showed efficacy on depressive symptoms in non-apolipoprotein e (apoe) epsilon4 carriers, and on cognitive symptoms only in very mild alzheimer's disease (ad) subgroups, mci patients, and cognitively unimpaired non-apoe epsilon4 carriers. |
2009-11-09 |
2023-08-12 |
Not clear |
| R Ramirez-Lorca, M Boada, M E Saez, I Hernandez, A Mauleon, M Rosende-Roca, P Martinez-Lage, M Gutierrez, L M Real, J Lopez-Arrieta, J Gayan, C Antunez, A Gonzalez-Perez, L Tarraga, A Rui. GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers. The journal of nutrition, health & aging. vol 13. issue 3. 2009-11-03. PMID:19262956. |
gab2 gene does not modify the risk of alzheimer's disease in spanish apoe 4 carriers. |
2009-11-03 |
2023-08-12 |
Not clear |
| Antoinette E Zehnder, Stefan Bläsi, Manfred Berres, Andreas U Monsch, Hannes B Stähelin, René Spiege. Impact of APOE status on cognitive maintenance in healthy elderly persons. International journal of geriatric psychiatry. vol 24. issue 2. 2009-11-02. PMID:18615849. |
the epsilon4 allele, a variant of the apolipoprotein e (apoe) gene, is the most prominent genetic risk factor for sporadic, non-familial alzheimer's disease (ad) currently known. |
2009-11-02 |
2023-08-12 |
Not clear |
| Lina Rosvall, Debora Rizzuto, Hui-Xin Wang, Bengt Winblad, Caroline Graff, Laura Fratiglion. APOE-related mortality: effect of dementia, cardiovascular disease and gender. Neurobiology of aging. vol 30. issue 10. 2009-10-30. PMID:18237822. |
our aim was to assess the effect of apoe on survival taking into account the possible contribution of alzheimer's disease, other dementias, ischemic heart- and cerebrovascular disease (ihcd). |
2009-10-30 |
2023-08-12 |
Not clear |
| J L Woodard, M Seidenberg, K A Nielson, P Antuono, L Guidotti, S Durgerian, Q Zhang, M Lancaster, N Hantke, A Butts, S M Ra. Semantic memory activation in amnestic mild cognitive impairment. Brain : a journal of neurology. vol 132. issue Pt 8. 2009-10-29. PMID:19515831. |
fifty-seven participants, aged 65-85 years, comprised three groups (n = 19 each): amnestic mci patients; cognitively intact older participants at risk for developing alzheimer's disease based on having at least one apoe epsilon4 allele and a positive family history of alzheimer's disease (at risk); and cognitively intact participants without alzheimer's disease risk factors (control). |
2009-10-29 |
2023-08-12 |
human |
| Jean-Charles Lambert, Simon Heath, Gael Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Diana Zelenika, Maria J Bullido, Béatrice Tavernier, Luc Letenneur, Karolien Bettens, Claudine Berr, Florence Pasquier, Nathalie Fiévet, Pascale Barberger-Gateau, Sebastiaan Engelborghs, Peter De Deyn, Ignacio Mateo, Ana Franck, Seppo Helisalmi, Elisa Porcellini, Olivier Hanon, Marian M de Pancorbo, Corinne Lendon, Carole Dufouil, Céline Jaillard, Thierry Leveillard, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Paola Piccardi, Giorgio Annoni, Davide Seripa, Daniela Galimberti, Didier Hannequin, Federico Licastro, Hilkka Soininen, Karen Ritchie, Hélène Blanché, Jean-François Dartigues, Christophe Tzourio, Ivo Gut, Christine Van Broeckhoven, Annick Alpérovitch, Mark Lathrop, Philippe Amouye. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature genetics. vol 41. issue 10. 2009-10-14. PMID:19734903. |
the gene encoding apolipoprotein e (apoe) on chromosome 19 is the only confirmed susceptibility locus for late-onset alzheimer's disease. |
2009-10-14 |
2023-08-12 |
Not clear |
| Jean-Charles Lambert, Simon Heath, Gael Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros, Diana Zelenika, Maria J Bullido, Béatrice Tavernier, Luc Letenneur, Karolien Bettens, Claudine Berr, Florence Pasquier, Nathalie Fiévet, Pascale Barberger-Gateau, Sebastiaan Engelborghs, Peter De Deyn, Ignacio Mateo, Ana Franck, Seppo Helisalmi, Elisa Porcellini, Olivier Hanon, Marian M de Pancorbo, Corinne Lendon, Carole Dufouil, Céline Jaillard, Thierry Leveillard, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Paola Piccardi, Giorgio Annoni, Davide Seripa, Daniela Galimberti, Didier Hannequin, Federico Licastro, Hilkka Soininen, Karen Ritchie, Hélène Blanché, Jean-François Dartigues, Christophe Tzourio, Ivo Gut, Christine Van Broeckhoven, Annick Alpérovitch, Mark Lathrop, Philippe Amouye. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature genetics. vol 41. issue 10. 2009-10-14. PMID:19734903. |
markers outside apoe with suggestive evidence of association (p < 10(-5)) were examined in collections from belgium, finland, italy and spain totaling 3,978 alzheimer's disease cases and 3,297 controls. |
2009-10-14 |
2023-08-12 |
Not clear |