| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyi Xu, Jiseon Kwon, Ruiqi Yan, Catherine Apio, Soomin Song, Gyujin Heo, Qijun Yang, Jigyasha Timsina, Menghan Liu, John Budde, Kaj Blennow, Henrik Zetterberg, Alberto Lleó, Agustin Ruiz, José Luis Molinuevo, Virginia Man-Yee Lee, Yuetiva Deming, Amanda J Heslegrave, Tim J Hohman, Pau Pastor, Elaine R Peskind, Marilyn S Albert, John C Morris, Taesung Park, Carlos Cruchaga, Yun Ju Sun. Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries. JAMA network open. vol 8. issue 3. 2025-03-11. PMID:40067298. |
age, sex, and apolipoprotein e (apoe) are the strongest risk factors for late-onset alzheimer disease (ad). |
2025-03-11 |
2025-03-14 |
Not clear |
| Kaue O Frassao, Sandro M S Filho, Renata Valle Pedroso, Carla Manuela Crispim Nascimento, Henrique Pott, Marcia Regina Cominetti, Francisco J Frag. Event-Related Potentials and Event-Related Spectral Perturbation for Classification of Apolipoprotein E ϵ4 Allele Carriers in Alzheimer Disease Patients and Healthy Controls. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2024. 2025-03-05. PMID:40039594. |
in this paper we used event-related potentials and event-related spectral perturbation as features for classification of apolipoprotein e ϵ4 allele (apoe ε4) carriers in alzheimer disease (ad) patients and healthy controls. |
2025-03-05 |
2025-03-07 |
human |
| Julie E Oomens, Veerle van Gils, Stephanie J B Vos, Whitney M Freeze, Nancy N Maserejian, Gioacchino Curiale, Cai Gillis, Mercè Boada, Wiesje M van der Flier, Jakub Hort, Sterling C Johnson, Alberto Lleó, Inez H Ramakers, Karen M Rodrigue, Pascual Sánchez-Juan, Marie Sarazin, Nikolaos Scarmeas, Henrik Zetterberg, Daniel Alcolea, Frederik Barkhof, Kaj Blennow, Michel Bottlaender, Anouk den Braber, Jirí Cerman, Marta Drake-Perez, Juan Fortea, Ron Handels, Silvia Ingala, Julio F Jiménez-Bonilla, Stratos Karavasilis, Julien Lagarde, Nienke Legdeur, Luigi Lorenzini, Marta Marquié, Justine E F Moonen, Pauline Olivieri, Adelina Orellana, Rik Ossenkoppele, Leonardo A Rivera-Rivera, Eloy Rodríguez-Rodriguez, Agustín Ruiz Laza, Charlotte E Teunissen, Betty M Tijms, Giorgos Velonakis, Frans R J Verhey, Pieter Jelle Visser, Willemijn J Janse. Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study. JAMA network open. vol 8. issue 1. 2025-01-22. PMID:39841474. |
baseline cerebral microbleeds (cmbs) and apoe ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with alzheimer disease (ad) receiving therapies to lower amyloid-β plaque levels. |
2025-01-22 |
2025-01-24 |
Not clear |
| Daniela Diaz Caro, Sophia Rodriguez, John Brandon Wetmore, Jonathan D Godinez, Itzel A Camarillo, Jill Goldman, Wendy R Uhlmann, Sarah McCain, Maria Caban, Cheng-Shiun Leu, Ana F Abraido-Lanza, Rafael A Lantigua, Wendy K Chung, J Scott Roberts, Karolynn Siegel, Ruth Ottma. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750995. |
this study addresses this gap by investigating the immediate impact of disclosing an apoe ε4/ε4 genotype in the información de la enfermedad de alzheimer para latinos (ideal) study, a latino community-based study. |
2025-01-03 |
2025-01-05 |
Not clear |
| Derek M Dykxhoorn, Oded Oron, Jack Trittipo, Larry D Adams, Takiyah D Starks, Heriberto Acosta, Briseida E Feliciano-Astacio, Goldie S Byrd, Margaret A Pericak-Vance, Anthony J Griswold, Jeffery M Vance, Juan I Youn. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751256. |
the apoliproprotein e (apoe) e4 allele is the most significant genetic risk factor for late-onset alzheimer disease (ad). |
2025-01-03 |
2025-01-05 |
Not clear |
| Ruichen Han, Xue Zhang, Ya Chen, Xinle Hou, Feng Ba. Associations between differential connectivity patterns of executive control networks and APOE ɛ4 in the Alzheimer continuum. Brain research. 2024-09-10. PMID:39255904. |
associations between differential connectivity patterns of executive control networks and apoe ɛ4 in the alzheimer continuum. |
2024-09-10 |
2024-09-13 |
human |
| Steven Lehrer, Peter Rheinstei. The paired immunoglobulin-like type 2 receptor alpha (PILRA) gene polymorphism rs1859788 reduces risk of Alzheimer's Disease in men homozygous for the ApoE ε4 allele. Research square. 2024-08-16. PMID:39149451. |
background the apoe gene has long been associated with alzheimer disease (ad) risk. |
2024-08-16 |
2024-08-18 |
human |
| Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Poz. Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology. 2024-06-21. PMID:38906999. |
multifaceted roles of apoe in alzheimer disease. |
2024-06-21 |
2024-06-24 |
mouse |
| Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Poz. Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology. 2024-06-21. PMID:38906999. |
for the past three decades, apolipoprotein e (apoe) has been known as the single greatest genetic modulator of sporadic alzheimer disease (ad) risk, influencing both the average age of onset and the lifetime risk of developing ad. |
2024-06-21 |
2024-06-24 |
mouse |
| Ian Fyf. APOE α4 homozygosity - a genetic form of Alzheimer disease? Nature reviews. Neurology. 2024-06-03. PMID:38831096. |
apoe α4 homozygosity - a genetic form of alzheimer disease? |
2024-06-03 |
2024-06-06 |
Not clear |
| Renhao Luo, Dena Zeraatkar, Maria Glymour, Randall J Ellis, Hossein Estiri, Chirag J Pate. Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank. BMC medicine. vol 22. issue 1. 2024-05-29. PMID:38807092. |
in 2020, the lancet commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified apoe e4/e4 genotype and family history of alzheimer's disease strongly associated with dementia outcomes; however, it is unclear how robust these relationships are across dementia subtypes and analytic scenarios. |
2024-05-29 |
2024-06-02 |
Not clear |
| b' Kinga Igloi, Blanca Marin Bosch, No\xe9mie Kuenzi, Aur\xe9lien Thomas, Estelle Lauer, Aur\xe9lien Bringard, Sophie Schwart. Interactions between physical exercise, associative memory, and genetic risk for Alzheimer\'s disease. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 5. 2024-05-27. PMID:38802684.' |
the ε4 allele of the apoe gene heightens the risk of late onset alzheimer's disease. |
2024-05-27 |
2024-06-03 |
human |
| Rohan Nadkarni, Zay Yar Han, Robert J Anderson, Alex J Allphin, Darin P Clark, Alexandra Badea, Cristian T Bade. High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry. PloS one. vol 19. issue 5. 2024-05-23. PMID:38781243. |
brain region segmentation and morphometry in humanized apolipoprotein e (apoe) mouse models with a human nos2 background (hn) contribute to alzheimer's disease (ad) research by demonstrating how various risk factors affect the brain. |
2024-05-23 |
2024-05-27 |
mouse |
| Katherine Y Peng, Braison Liemisa, Jonathan Pasato, Pasquale D'Acunzo, Monika Pawlik, Adriana Heguy, Sai C Penikalapati, Amanda Labuza, Harshitha Pidikiti, Melissa J Alldred, Stephen D Ginsberg, Efrat Levy, Paul M Mathew. Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging. Traffic (Copenhagen, Denmark). vol 25. issue 5. 2024-05-22. PMID:38777335. |
the polymorphic apoe gene is the greatest genetic determinant of sporadic alzheimer's disease risk: the apoe4 allele increases risk, while the apoe2 allele is neuroprotective compared with the risk-neutral apoe3 allele. |
2024-05-22 |
2024-05-27 |
mouse |
| Bonnie H Lee, Melike Cevizci, Stephanie E Lieblich, Muna Ibrahim, Yanhua Wen, Rand S Eid, Yvonne Lamers, Paula Duarte-Guterman, Liisa A M Gale. Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age. Brain, behavior, and immunity. 2024-05-21. PMID:38772427. |
female sex and apolipoprotein e (apoe) ε4 genotype are top non-modifiable risk factors for alzheimer's disease (ad). |
2024-05-21 |
2024-05-27 |
rat |
| Madison Bailey, Zlatomira Georgieva Ilchovska, Akram A Hosseini, JeYoung Jun. The impact of APOE ε4 in Alzheimer's disease: a meta-analysis of voxel-based morphometry studies. medRxiv : the preprint server for health sciences. 2024-05-20. PMID:38766196. |
the impact of apoe ε4 in alzheimer's disease: a meta-analysis of voxel-based morphometry studies. |
2024-05-20 |
2024-05-27 |
Not clear |
| Kate E Foley, Donna M Wilcoc. Three major effects of APOE Frontiers in aging neuroscience. vol 16. 2024-05-18. PMID:38756535. |
three major effects of apoe the targeting of amyloid-beta (aβ) plaques therapeutically as one of the primary causes of alzheimer's disease (ad) dementia has been an ongoing effort spanning decades. |
2024-05-18 |
2024-05-27 |
Not clear |
| Jillian Belgrad, Qi Tang, Sam Hildebrand, Ashley Summers, Ellen Sapp, Dimas Echeverria, Dan O'Reilly, Eric Luu, Brianna Bramato, Sarah Allen, David Cooper, Julia Alterman, Ken Yamada, Neil Aronin, Marian DiFiglia, Anastasia Khvorov. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic acids research. 2024-05-13. PMID:38726879. |
huntington's disease: msh3 and htt; alzheimer's disease: apoe and jak1) with similar potency to a mixture of single-targeting divalent sirnas against each gene. |
2024-05-13 |
2024-05-27 |
mouse |
| Gulafsha Kausar, Shashi B Chauhan, Ritirupa Roy, Shashi Kumar, Christian Engwerda, Susanne Nylen, Rajiv Kumar, Mary E Wilson, Shyam Sunda. Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis. Parasite immunology. vol 46. issue 5. 2024-05-09. PMID:38720445. |
apolipoprotein e (apoe) has been associated with several diseases including parkinson's disease, alzheimer's and multiple sclerosis. |
2024-05-09 |
2024-05-27 |
human |
| Ilenia Libri, Chiara Silvestri, Salvatore Caratozzolo, Antonella Alberici, Andrea Pilotto, Silvana Archetti, Laura Trainini, Barbara Borroni, Alessandro Padovani, Alberto Benuss. Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders. Neurobiology of aging. vol 140. 2024-05-08. PMID:38718740. |
this study explores the impact of apoe genotypes on bbb integrity among 230 participants experiencing cognitive impairment, encompassing cases of alzheimer's disease (ad) as well as various non-ad neurodegenerative conditions. |
2024-05-08 |
2024-05-27 |
human |