| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie T Odenkirk, Xueyun Zheng, Jennifer E Kyle, Kelly G Stratton, Carrie D Nicora, Kent J Bloodsworth, Catriona A Mclean, Colin L Masters, Matthew E Monroe, James D Doecke, Richard D Smith, Kristin E Burnum-Johnson, Blaine R Roberts, Erin S Bake. Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions. Journal of proteome research. 2024-01-18. PMID:38236019. |
deciphering apoe genotype-driven proteomic and lipidomic alterations in alzheimer's disease across distinct brain regions. |
2024-01-18 |
2024-01-20 |
Not clear |
| L I Thompson, M Cummings, S Emrani, D J Libon, A Ang, C Karjadi, R Au, C Li. Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults. The journal of prevention of Alzheimer's disease. vol 11. issue 1. 2024-01-17. PMID:38230720. |
digital clock drawing as an alzheimer's disease susceptibility biomarker: associations with genetic risk score and apoe in older adults. |
2024-01-17 |
2024-01-19 |
Not clear |
| S M Pruntel, B C van Munster, J J de Vries, A Vissink, A Visse. Oral Health as a Risk Factor for Alzheimer Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 1. 2024-01-17. PMID:38230738. |
4 theories could be distinguished that describe the possible links between oral health and the development or onset of alzheimer's disease; 1) role of pathogens, 2) role of inflammatory mediators, 3) role of apoe alleles and 4) role of aβ peptide. |
2024-01-17 |
2024-01-19 |
Not clear |
| Francisco C Almeida, Kalicharan Patra, Andreas Giannisis, Anezka Niesnerova, Renu Nandakumar, Ewa Ellis, Tiago Gil Oliveira, Henrietta M Nielse. APOE genotype dictates lipidomic signatures in primary human hepatocytes. Journal of lipid research. 2024-01-12. PMID:38216055. |
apolipoprotein e (apoe) genetic variants are most notably known for their divergent impact on the risk of developing alzheimer's disease. |
2024-01-12 |
2024-01-15 |
human |
| Meenakshisundaram Balasubramaniam, Jagadeesh Narasimhappagari, Ling Liu, Akshatha Ganne, Srinivas Ayyadevara, Ramani Atluri, Haarika Ayyadevara, Guy Caldwell, Robert J Shmookler Reis, Steven W Barger, W Sue T Griffi. Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules. Communications biology. vol 7. issue 1. 2024-01-08. PMID:38191671. |
homozygosity for the ε4 allele of apoe increases the odds of developing alzheimer's by 12 to 15 times relative to the most common ε3;ε3 genotype, and its association with higher plaque loads comports with evidence that apoeε4 compromises autophagy. |
2024-01-08 |
2024-01-10 |
mouse |
| Jessica Blumenfeld, Oscar Yip, Min Joo Kim, Yadong Huan. Cell type-specific roles of APOE4 in Alzheimer disease. Nature reviews. Neuroscience. 2024-01-08. PMID:38191720. |
the ɛ4 allele of the apolipoprotein e gene (apoe), which translates to the apoe4 isoform, is the strongest genetic risk factor for late-onset alzheimer disease (ad). |
2024-01-08 |
2024-01-10 |
Not clear |
| Lisa Waterink, Larissa A Masselink, Sven J van der Lee, Leonie N C Visser, Solange Cleutjens, Jetske van der Schaar, Argonde C van Harten, Philip Scheltens, Sietske A M Sikkes, Wiesje M van der Flier, Marissa D Zwa. Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study. Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167083. |
apolipoprotein-e (apoe) genetic testing for alzheimer's disease is becoming more important as clinical trials are increasingly targeting individuals carrying apoe-ε4 alleles. |
2024-01-03 |
2024-01-06 |
Not clear |
| Daichi Shigemizu, Koya Fukunaga, Akiko Yamakawa, Mutsumi Suganuma, Kosuke Fujita, Tetsuaki Kimura, Ken Watanabe, Taisei Mushiroda, Takashi Sakurai, Shumpei Niida, Kouichi Ozak. The HLA-DRB1*09:01-DQB1*03:03 haplotype is associated with the risk for late-onset Alzheimer's disease in APOE [Formula: see text]4-negative Japanese adults. npj aging. vol 10. issue 1. 2024-01-03. PMID:38167405. |
the hla-drb1*09:01-dqb1*03:03 haplotype is associated with the risk for late-onset alzheimer's disease in apoe [formula: see text]4-negative japanese adults. |
2024-01-03 |
2024-01-06 |
human |
| Sergio Branciamore, Grigoriy Gogoshin, Andrei S Rodin, Amanda J Myer. The Human Brainome: changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with APOE E4 to alter risk for late onset Alzheimer's disease. Research square. 2024-01-03. PMID:38168398. |
the human brainome: changes in expression of vgf, specc1l, hla-dra and ranbp3l act with apoe e4 to alter risk for late onset alzheimer's disease. |
2024-01-03 |
2024-01-06 |
human |
| Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jone. Microglial APOE4: more is less and less is more. Molecular neurodegeneration. vol 18. issue 1. 2023-12-20. PMID:38115077. |
apolipoprotein e (apoe) is the single greatest genetic risk factor for late onset alzheimer's disease (ad). |
2023-12-20 |
2023-12-23 |
Not clear |
| Mingyue He, Zhan Liu, Tenghong Lian, Peng Guo, Wenjing Zhang, Yue Huang, Yanan Zhang, Gaifen Liu, Weijiao Zhang, Jinghui Li, Huiying Guan, Weijia Zhang, Dongmei Luo, Jing Qi, Hao Yue, Xiaomin Wang, Wei Zhan. Role of nerve growth factor on cognitive impairment in patients with Alzheimer's disease carrying apolipoprotein E ε4. CNS neuroscience & therapeutics. 2023-12-19. PMID:38112032. |
to investigate the roles of neurotrophic factors on cognition in patients with alzheimer's disease (ad) carrying apolipoprotein e (apoe) ε4. |
2023-12-19 |
2023-12-21 |
Not clear |
| Darshak Gadara, Vratislav Berka, Zdenek Spaci. High-Throughput Microbore LC-MS Lipidomics to Investigate APOE Phenotypes. Analytical chemistry. 2023-12-19. PMID:38113351. |
as a proof of concept, μlc-ms/ms analysis of alzheimer's disease patient-derived ipsc cerebral organoid reveals differential lipid metabolism depending on apoe phenotype (e3/3 vs e4/4). |
2023-12-19 |
2023-12-23 |
Not clear |
| Jeffrey S Wefel, Snehal Deshmukh, Paul D Brown, David R Grosshans, Erik P Sulman, Jane H Cerhan, Minesh P Mehta, Deepak Khuntia, Wenyin Shi, Mark V Mishra, John H Suh, Nadia N Laack, Yuhchyau Chen, Amarinthia Amy Curtis, Joanna M Laba, Ahmed Elsayed, Anu Thakrar, Stephanie L Pugh, Deborah W Brune. Impact of Apolipoprotein E (APOE) Genotype on Neurocognitive Function (NCF) in Patients with Brain Metastasis (BM): An Analysis of NRG Oncology's RTOG 0614. International journal of radiation oncology, biology, physics. 2023-12-15. PMID:38101486. |
the e4 allele of the apolipoprotein e (apoe) gene is associated with increased risk of alzheimer's disease, and ncf decline associated with a variety of neurologic diseases and insults. |
2023-12-15 |
2023-12-18 |
Not clear |
| Hae Sol Moon, Ali Mahzarnia, Jacques Stout, Robert J Anderson, Madison Strain, Jessica T Tremblay, Zay Yar Han, Andrei Niculescu, Anna MacFarlane, Jasmine King, Allison Ashley-Koch, Darin Clark, Michael W Lutz, Alexandra Bade. Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics. Brain structure & function. 2023-12-13. PMID:38091051. |
apoe allelic variation is critical in brain aging and alzheimer's disease (ad). |
2023-12-13 |
2023-12-17 |
mouse |
| Braison Liemisa, Samantha F Newbury, Mariah J Novy, Jonathan A Pasato, Jose Morales-Corraliza, Katherine Y Peng, Paul M Mathew. Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner. Aging brain. vol 4. 2023-12-07. PMID:38058491. |
human apolipoprotein e (apoe) is the greatest determinant of genetic risk for memory deficits and alzheimer's disease (ad). |
2023-12-07 |
2023-12-10 |
mouse |
| Anna Rubinski, Anna Dewenter, Lukai Zheng, Nicolai Franzmeier, Henry Stephenson, Yuetiva Deming, Marco Duering, Benno Gesierich, Jannis Denecke, An-Vi Pham, Barbara Bendlin, Michael Ewer. Florbetapir PET-assessed demyelination is associated with faster tau accumulation in an APOE ε4-dependent manner. European journal of nuclear medicine and molecular imaging. 2023-12-04. PMID:38049659. |
the main objectives were to test whether (1) a decrease in myelin is associated with enhanced rate of fibrillar tau accumulation and cognitive decline in alzheimer's disease, and (2) whether apolipoprotein e (apoe) ε4 genotype is associated with worse myelin decrease and thus tau accumulation. |
2023-12-04 |
2023-12-10 |
Not clear |
| Julie Le Borgne, Philippe Amouyel, Ole Andreassen, Ruth Frikke-Schmidt, Mikko Hiltunen, Martin Ingelsson, Alfredo Ramirez, Giacomina Rossi, Agustin Ruiz, Pascual Sanchez-Juan, Rebecca Sims, Kristel Sleegers, Magda Tsolaki, Sven J van der Lee, Julie Williams, Jean-Charles Lambert, Céline Bellengue. Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-12-02. PMID:38041824. |
association of mgmt and bin1 genes with alzheimer's disease risk across sex and apoe ε4 status. |
2023-12-02 |
2023-12-10 |
Not clear |
| Matteo De Marco, Laura M Wright, Jose Manuel Valera Bermejo, Cameron E Ferguso. APOE ε4 positivity predicts centrality of episodic memory nodes in patients with mild cognitive impairment: A cohort-based, graph theory-informed study of cognitive networks. Neuropsychologia. 2023-12-01. PMID:38040087. |
as network neuroscience can capture the systemic impact of apoe variability at a neuroimaging level, this study investigated the network-based cognitive endophenotypes of ε4-carriers and non-carriers across the continuum between normal ageing and alzheimer's dementia (ad). |
2023-12-01 |
2023-12-10 |
Not clear |
| Yi Guan, Chia Hsin Cheng, Luis I Bellomo, Sriman Narain, Sherman J Bigornia, Mahdi O Garelnabi, Tammy Scott, José M Ordovás, Katherine L Tucker, Rafeeque Bhadelia, Bang-Bon Ko. APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts. Frontiers in aging neuroscience. vol 15. 2023-11-30. PMID:38035273. |
apolipoprotein e (apoe) is the strongest genetic risk factor for sporadic alzheimer's disease (ad), and the ε4 allele (apoe4) may interact with lifestyle factors that relate to brain structural changes, underlying the increased risk of ad. |
2023-11-30 |
2023-12-10 |
Not clear |
| Youssef Razouqi, Ihssane El Bouchikhi, Hassan El-Abid, Soukayna Baammi, Ayoub Nedbour, Ahmed Omar Touhami Ahami, Achraf El Allali, Laila Bouguenouc. Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication. Alzheimer disease and associated disorders. vol 37. issue 4. 2023-11-28. PMID:38015425. |
novel apoe mutation in a moroccan subject suffering from alzheimer disease: a case study and exploration of pathogenic implication. |
2023-11-28 |
2023-11-29 |
human |