| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cellular and molecular life sciences : CMLS. vol 80. issue 12. 2023-11-27. PMID:38010414. |
molecular modeling of apoe in complexes with alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. |
2023-11-27 |
2023-11-29 |
human |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. Cellular and molecular life sciences : CMLS. vol 80. issue 12. 2023-11-27. PMID:38010414. |
to understand how apoe interacts with alzheimer's amyloid-β (aβ) peptide in fibrillary deposits, the nmr structure of full-length human apoe was docked to four structures of patient-derived aβ |
2023-11-27 |
2023-11-29 |
human |
| Dongbing Lai, Michael Zhang, Rudong Li, Chi Zhang, Pengyue Zhang, Yunlong Liu, Sujuan Gao, Tatiana Forou. Identifying Genes Associated with Alzheimer's Disease Using Gene-Based Polygenic Risk Score. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007651. |
except apoe, alzheimer's disease (ad) associated genes identified in recent large-scale genome-wide association studies (gwas) had small effects and explained a small portion of heritability. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yan-Bing Liu, Xue-Jie Wang, Lan Tan, Chen-Chen Tan, Wei X. PICALM Variation Moderates the Relationships of APOE ɛ4 with Alzheimer's Disease Cerebrospinal Biomarkers and Memory Function Among Non-Demented Population. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007652. |
picalm variation moderates the relationships of apoe ɛ4 with alzheimer's disease cerebrospinal biomarkers and memory function among non-demented population. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yan-Bing Liu, Xue-Jie Wang, Lan Tan, Chen-Chen Tan, Wei X. PICALM Variation Moderates the Relationships of APOE ɛ4 with Alzheimer's Disease Cerebrospinal Biomarkers and Memory Function Among Non-Demented Population. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007652. |
apoe ɛ4 and picalm are established genes associated with risk of late-onset alzheimer's disease (ad). |
2023-11-26 |
2023-11-28 |
Not clear |
| Sheng-Min Wang, Dong Woo Kang, Yoo Hyun Um, Sunghwan Kim, Chang Uk Lee, Hyun Kook Li. Functional Connectivity Change Associated With Apolipoprotein E Allotypes Precedes Structural Connectivity and Neurodegeneration in Cognitive Normal Older Adults Without Cerebral Aβ Deposition. Psychiatry investigation. vol 20. issue 11. 2023-11-24. PMID:37997333. |
apolipoprotein e (apoe) gene is known to influence cerebral functional connectivity (fc) in alzheimer's disease continuum. |
2023-11-24 |
2023-11-29 |
Not clear |
| Alexandra Litvinchuk, Jung H Suh, Jing L Guo, Karin Lin, Sonnet S Davis, Nga Bien-Ly, Eric Tycksen, G Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J Perez, Carla M Yuede, Anil G Cashikar, Jason D Ulrich, Gilbert Di Paolo, David M Holtzma. Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron. 2023-11-23. PMID:37995685. |
apolipoprotein e (apoe) is a strong genetic risk factor for late-onset alzheimer's disease (load). |
2023-11-23 |
2023-11-29 |
mouse |
| Do-Hoon Kim, Minyoung Oh, Jae Seung Ki. Prediction of Conversion from Mild Cognitive Impairment to Alzheimer's Disease Using Amyloid PET and Brain MR Imaging Data: A 48-Month Follow-Up Analysis of the Alzheimer's Disease Neuroimaging Initiative Cohort. Diagnostics (Basel, Switzerland). vol 13. issue 21. 2023-11-14. PMID:37958271. |
age, mini-mental state examination (mmse), cognitive subscale of the alzheimer's disease assessment scale (adas-cog), apolipoprotein e (apoe), standardized uptake value ratio (suvr), av45_bass, mr_bai, and shape feature were significantly different between converters and non-converters. |
2023-11-14 |
2023-11-20 |
Not clear |
| Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, Lingyan Su, Pan P Li, Bao Zhang, Erzsebet Kokovay, James D Lechleiter, Harald H Göring, Philip L De Jager, Joel E Kleinman, Thomas M Hyde, Agustín Ruiz, Daniel R Weinberger, Sudha Seshadri, Liang M. Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961425. |
identification of a specific apoe transcript and functional elements associated with alzheimer's disease. |
2023-11-14 |
2023-11-20 |
Not clear |
| Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, Lingyan Su, Pan P Li, Bao Zhang, Erzsebet Kokovay, James D Lechleiter, Harald H Göring, Philip L De Jager, Joel E Kleinman, Thomas M Hyde, Agustín Ruiz, Daniel R Weinberger, Sudha Seshadri, Liang M. Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease. medRxiv : the preprint server for health sciences. 2023-11-14. PMID:37961425. |
the apoe gene is the strongest genetic risk factor for late-onset alzheimer's disease (load). |
2023-11-14 |
2023-11-20 |
Not clear |
| Kevin Kirchner, Linda Garvert, Luise Kühn, Sarah Bonk, Hans Jörgen Grabe, Sandra Van der Auwer. Detrimental Effects of ApoE ε4 on Blood-Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer's Disease. Cells. vol 12. issue 21. 2023-11-10. PMID:37947590. |
detrimental effects of apoe ε4 on blood-brain barrier integrity and their potential implications on the pathogenesis of alzheimer's disease. |
2023-11-10 |
2023-11-20 |
Not clear |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
the apolipoprotein (apoe) ɛ4 allele is a risk factor for alzheimer's disease (ad), while the ɛ2 allele is thought to be protective against ad. |
2023-11-07 |
2023-11-20 |
human |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
alzheimer's disease neuroimaging participants were divided into one of four apoe allele profiles (e4= ɛ4ɛ4 or ɛ3 ɛ4; e2= ɛ2ɛ2 or ɛ2ɛ3; e3= ɛ3ɛ3; or e24= ɛ2ɛ4). |
2023-11-07 |
2023-11-20 |
human |
| Michael E Belloy, Shea J Andrews, Yann Le Guen, Michael Cuccaro, Lindsay A Farrer, Valerio Napolioni, Michael D Greiciu. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA neurology. 2023-11-06. PMID:37930705. |
apoe genotype and alzheimer disease risk across age, sex, and population ancestry. |
2023-11-06 |
2023-11-08 |
Not clear |
| Michael E Belloy, Shea J Andrews, Yann Le Guen, Michael Cuccaro, Lindsay A Farrer, Valerio Napolioni, Michael D Greiciu. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA neurology. 2023-11-06. PMID:37930705. |
apolipoprotein e (apoe)*2 and apoe*4 are, respectively, the strongest protective and risk-increasing, common genetic variants for late-onset alzheimer disease (ad), making apoe status highly relevant toward clinical trial design and ad research broadly. |
2023-11-06 |
2023-11-08 |
Not clear |
| Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Li. Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE. Progress in lipid research. vol 93. 2023-11-03. PMID:37890592. |
effects of dha on cognitive dysfunction in aging and alzheimer's disease: the mediating roles of apoe. |
2023-11-03 |
2023-11-08 |
Not clear |
| Deebika Balu, Ana C Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu, Leon M Ta. A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice. Alzheimer's research & therapy. vol 15. issue 1. 2023-10-20. PMID:37858252. |
apoe genotype is the greatest genetic risk factor for sporadic alzheimer's disease (ad). |
2023-10-20 |
2023-11-08 |
mouse |
| Yuexuan Xu, Zhongxuan Sun, Erin Jonaitis, Yuetiva Deming, Qiongshi Lu, Sterling C Johnson, Corinne D Engelma. Apolipoprotein E moderates the association between non-APOE polygenic risk score for Alzheimer's disease and aging on preclinical cognitive function. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-20. PMID:37858606. |
variation in preclinical cognitive decline suggests additional genetic factors related to alzheimer's disease (eg, a non-apoe polygenic risk score [prs]) may interact with the apoe ε4 allele to influence cognitive decline. |
2023-10-20 |
2023-11-08 |
Not clear |
| Anqi Li, Jing Du, Yue Cai, Xuhui Chen, Kun Sun, Tengfei Gu. Body Mass Index Decrease Has a Distinct Association with Alzheimer's Disease Pathophysiology in APOE ɛ4 Carriers and Non-Carriers. Journal of Alzheimer's disease : JAD. 2023-10-16. PMID:37840490. |
body mass index decrease has a distinct association with alzheimer's disease pathophysiology in apoe ɛ4 carriers and non-carriers. |
2023-10-16 |
2023-11-08 |
Not clear |
| Anqi Li, Jing Du, Yue Cai, Xuhui Chen, Kun Sun, Tengfei Gu. Body Mass Index Decrease Has a Distinct Association with Alzheimer's Disease Pathophysiology in APOE ɛ4 Carriers and Non-Carriers. Journal of Alzheimer's disease : JAD. 2023-10-16. PMID:37840490. |
body mass index (bmi) changes may be related to alzheimer's disease (ad) alterations, but it is unclear how the apolipoprotein e ɛ4 (apoe ɛ4) allele affects their association. |
2023-10-16 |
2023-11-08 |
Not clear |