| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
the impact of apolipoprotein e (apoe) isoforms on sporadic alzheimer's disease has long been studied; however, the influences of apolipoprotein e gene (apoe) on healthy and pathological human brains are not fully understood. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
apoe ε4 is the strongest genetic risk factor for sporadic alzheimer's disease, considering its role in influencing amyloid-beta metabolism. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
the exact mechanisms by which apoe gene variants may increase or decrease alzheimer's disease risk are not fully understood, but apoe was also known to affect directly and indirectly tau-mediated neurodegeneration, lipids metabolism, neurovascular unit, and microglial function. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
also, the rare protective apoe variants confirm that apoe plays an important role in alzheimer's disease pathogenesis. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
the objectives of the present mini-review were to describe classical and new roles of various apoe isoforms in alzheimer's disease pathophysiology beyond the deposition of amyloid-beta and to establish a functional link between apoe, brain function, and memory, from a molecular to a clinical level. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
apoe genotype also exerted a heterogeneous effect on clinical alzheimer's disease phenotype and its outcomes. |
2023-07-25 |
2023-08-14 |
human |
| Madia Lozupone, Francesco Panz. Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: beyond the role of amyloid beta. Neural regeneration research. vol 19. issue 1. 2023-07-25. PMID:37488848. |
also, the effects of anti-amyloid-beta drugs, recently approved for the treatment of alzheimer's disease, could be influenced by the apoe genotype. |
2023-07-25 |
2023-08-14 |
human |
| Fengfeng Pan, Yifan Wang, Ying Wang, Xiaoming Wang, Yihui Guan, Fang Xie, Qihao Gu. Sex and APOE genotype differences in amyloid deposition and cognitive performance along the Alzheimer's Continuum. Neurobiology of aging. vol 130. 2023-07-23. PMID:37481959. |
sex and apoe genotype differences in amyloid deposition and cognitive performance along the alzheimer's continuum. |
2023-07-23 |
2023-08-14 |
human |
| Fengfeng Pan, Yifan Wang, Ying Wang, Xiaoming Wang, Yihui Guan, Fang Xie, Qihao Gu. Sex and APOE genotype differences in amyloid deposition and cognitive performance along the Alzheimer's Continuum. Neurobiology of aging. vol 130. 2023-07-23. PMID:37481959. |
these findings further elucidate the impact of sex and apoe genotype on brain aβ burden and sex-related cognitive performance should be considered in the alzheimer's continuum. |
2023-07-23 |
2023-08-14 |
human |
| Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman, Joseph A Tamm, Maya E Woodbury, Robert V Talanian, Knut Biber, Eric H Karran, Bradley T Hyman, Alberto Serrano-Poz. Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-18. PMID:37461318. |
distinct transcriptomic responses to aβ plaques, neurofibrillary tangles, and apoe in alzheimer's disease. |
2023-07-18 |
2023-08-14 |
Not clear |
| Katherine R Sadleir, Robert Vassa. Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer's disease. The Journal of clinical investigation. vol 133. issue 14. 2023-07-18. PMID:37463448. |
connections between apoe, sleep, and aβ and tau pathologies in alzheimer's disease. |
2023-07-18 |
2023-08-14 |
mouse |
| Skylar Walters, Alex G Contreras, Jaclyn M Eissman, Shubhabrata Mukherjee, Michael L Lee, Seo-Eun Choi, Phoebe Scollard, Emily H Trittschuh, Jesse B Mez, William S Bush, Brian W Kunkle, Adam C Naj, Amalia Peterson, Katherine A Gifford, Michael L Cuccaro, Carlos Cruchaga, Margaret A Pericak-Vance, Lindsay A Farrer, Li-San Wang, Jonathan L Haines, Angela L Jefferson, Walter A Kukull, C Dirk Keene, Andrew J Saykin, Paul M Thompson, Eden R Martin, David A Bennett, Lisa L Barnes, Julie A Schneider, Paul K Crane, Timothy J Hohman, Logan Dumitresc. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA neurology. 2023-07-17. PMID:37459083. |
sex differences are established in associations between apolipoprotein e (apoe) ε4 and cognitive impairment in alzheimer disease (ad). |
2023-07-17 |
2023-08-14 |
Not clear |
| Justin M Palmer, Matthew Huentelman, Lee Rya. More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain. Trends in neurosciences. 2023-07-17. PMID:37460334. |
more than just risk for alzheimer's disease: apoe ε4's impact on the aging brain. |
2023-07-17 |
2023-08-14 |
Not clear |
| Justin M Palmer, Matthew Huentelman, Lee Rya. More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain. Trends in neurosciences. 2023-07-17. PMID:37460334. |
the apolipoprotein ε4 (apoe ε4) allele is most commonly associated with increased risk for late-onset alzheimer's disease (ad). |
2023-07-17 |
2023-08-14 |
Not clear |
| Michelle M Dunk, Jie Li, Simin Liu, Ramon Casanova, Jiu-Chiuan Chen, Mark A Espeland, Kathleen M Hayden, JoAnn E Manson, Stephen R Rapp, Aladdin H Shadyab, Linda G Snetselaar, Linda Van Horn, Robert Wild, Ira Driscol. Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-13. PMID:37438877. |
whether apolipoprotein e's (apoe's) involvement in lipid metabolism contributes to alzheimer's disease (ad) risk remains unknown. |
2023-07-13 |
2023-08-14 |
Not clear |
| Leon M Aksman, Neil P Oxtoby, Marzia A Scelsi, Peter A Wijeratne, Alexandra L Young, Isadora Lopes Alves, Lyduine E Collij, Jacob W Vogel, Frederik Barkhof, Daniel C Alexander, Andre Altman. A data-driven study of Alzheimer's disease related amyloid and tau pathology progression. Brain : a journal of neurology. 2023-07-11. PMID:37433038. |
within tau-first apoe ε4 carriers, we found an increased rate of amyloid-beta accumulation (via longitudinal amyloid pet), suggesting that this rare group may belong within the alzheimer's disease continuum. |
2023-07-11 |
2023-08-14 |
Not clear |
| Siyu Yang, Dong Chen, Lei Xie, Xiaoxiao Zou, Yanyuan Xiao, Lin Rao, Tianxiong Yao, Qing Zhang, Liping Cai, Fei Huang, Bin Yang, Lusheng Huan. Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus. Science China. Life sciences. 2023-07-10. PMID:37428306. |
we examined 27 alzheimer's disease-related genes in our data and found that 15 showed cell type-specific activity (trem2, rin3 and clu), and 15 genes displayed age-associated dynamic activity (bin1, rabep1 and apoe). |
2023-07-10 |
2023-08-14 |
human |
| Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihar. Comprehensive behavioral study of C57BL/6.KOR-ApoE Translational neuroscience. vol 14. issue 1. 2023-07-03. PMID:37396111. |
comprehensive behavioral study of c57bl/6.kor-apoe apolipoprotein e (apoe) is associated with alzheimer's disease (ad) and cognitive dysfunction in elderly individuals. |
2023-07-03 |
2023-08-14 |
Not clear |
| Yen Ying Lim, Nawaf Yassi, Lisa Bransby, Scott Ayton, Rachel F Buckley, Dhamidhu Eratne, Dennis Velakoulis, Qiao-Xin Li, Christopher Fowler, Colin L Masters, Paul Maruf. CSF Aβ Neurobiology of aging. vol 129. 2023-07-03. PMID:37399739. |
csf aβ this study aimed to determine the relationship between the apolipoprotein e (apoe) ε4 allele and cerebrospinal fluid (csf) and neuroimaging biomarkers of alzheimer's disease, and cognition in cognitively unimpaired (cu) middle-aged adults (n = 82; m |
2023-07-03 |
2023-08-14 |
Not clear |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
little is known regarding the differential effects of the apolipoprotein e (apoe) ɛ4 on the regional topography of amyloid and tau in patients with both early-onset (eoad) and late-onset alzheimer's disease (load). |
2023-07-02 |
2023-08-14 |
Not clear |