| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristiana J Meuret, Yueming Hu, Sabrina Smadi, Mikaila Ann Bantugan, Haotian Xian, Ashley E Martinez, Ronald M Krauss, Qiu-Lan Ma, Dobrin Nedelkov, Hussein N Yassin. An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele. Alzheimer's research & therapy. vol 15. issue 1. 2023-05-23. PMID:37221560. |
carrying the apolipoprotein e (apoe) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset alzheimer's disease, but the degree to which apoe glycosylation affects its development is not clear. |
2023-05-23 |
2023-08-14 |
Not clear |
| Christopher J Wheeler. Evolutionary Selection of APOEɛ4 Encourages Increased Focus on Immunity in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-05-22. PMID:37212123. |
smith and ashford's hypothesis is intriguing in itself, but the implications for apoe ɛ4 function in alzheimer's disease are even more so and encourage greater focus on specific aspects of immunity in accounting for both ɛ4-mediated and general alzheimer's disease risk. |
2023-05-22 |
2023-08-14 |
Not clear |
| Darrell Sawmiller, Naoki Koyama, Masakazu Fujiwara, Tatsuya Segawa, Maeda Masahiro, Takashi Mor. Targeting Apolipoprotein E and N-terminal Amyloid β-protein Precursor Interaction Improves Cognition and Reduces Amyloid pathology in Alzheimer mice. The Journal of biological chemistry. 2023-05-21. PMID:37211092. |
apolipoprotein e (apoe) interaction with amyloid β-protein precursor (app) has garnered attention as the therapeutic target for alzheimer's disease (ad). |
2023-05-21 |
2023-08-14 |
mouse |
| Darrell Sawmiller, Naoki Koyama, Masakazu Fujiwara, Tatsuya Segawa, Maeda Masahiro, Takashi Mor. Targeting Apolipoprotein E and N-terminal Amyloid β-protein Precursor Interaction Improves Cognition and Reduces Amyloid pathology in Alzheimer mice. The Journal of biological chemistry. 2023-05-21. PMID:37211092. |
having discovered the apoe antagonist (6kapoep) that blocks apoe binding to n-terminal app, we tested the therapeutic potential of 6kapoep on ad-relevant phenotypes in alzheimer amyloid β-protein precursor/presenilin 1 (app/ps1) mice that express each human apoe isoform of apoe2, apoe3, or apoe4 (designated app/ps1/e2, app/ps1/e3, or app/ps1/e4 mice). |
2023-05-21 |
2023-08-14 |
mouse |
| Cynthia D Evans, JonDavid Sparks, Scott W Andersen, Dawn A Brooks, Paula M Hauck, Mark A Mintun, John R Sim. APOE ε4's impact on response to amyloid therapies in early symptomatic Alzheimer's disease: Analyses from multiple clinical trials. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-05-19. PMID:37204338. |
apoe ε4's impact on response to amyloid therapies in early symptomatic alzheimer's disease: analyses from multiple clinical trials. |
2023-05-19 |
2023-08-14 |
Not clear |
| Lidan Zheng, Ranmalee Eramudugolla, Nicolas Cherbuin, Shannon M Drouin, Roger A Dixon, Kaarin J Anste. Gender specific factors contributing to cognitive resilience in APOE ɛ4 positive older adults in a population-based sample. Scientific reports. vol 13. issue 1. 2023-05-17. PMID:37198167. |
although apoe ɛ4 has been identified as the strongest genetic risk factor for alzheimer's disease, there are some apoe ɛ4 carriers who do not go on to develop alzheimer's disease or cognitive impairment. |
2023-05-17 |
2023-08-14 |
human |
| Nikou L Damestani, John Jacoby, Shrikanth M Yadav, Allison E Lovely, Aurea Michael, Melissa Terpstra, Marziye Eshghi, Barnaly Rashid, Carlos Cruchaga, David H Salat, Meher R Juttukond. Cortical hemodynamics are dependent on age, sex and APOE genotype - A Human Connectome Project Aging study. NeuroImage. 2023-05-15. PMID:37187365. |
to better understand the mechanisms behind such variation, we studied how sex and apoe genotype, a primary genetic risk factor for alzheimer's disease (ad), influence associations between age and brain perfusion measures. |
2023-05-15 |
2023-08-14 |
human |
| Lenique K L Huggins, Se Hee Min, Samantha Kaplan, Jingkai Wei, Kathleen Welsh-Bohmer, Hanzhang X. Meta-Analysis of Variations in Association between APOE ɛ4 and Alzheimer's Disease and Related Dementias Across Hispanic Regions of Origin. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182874. |
meta-analysis of variations in association between apoe ɛ4 and alzheimer's disease and related dementias across hispanic regions of origin. |
2023-05-14 |
2023-08-14 |
Not clear |
| Lenique K L Huggins, Se Hee Min, Samantha Kaplan, Jingkai Wei, Kathleen Welsh-Bohmer, Hanzhang X. Meta-Analysis of Variations in Association between APOE ɛ4 and Alzheimer's Disease and Related Dementias Across Hispanic Regions of Origin. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182874. |
emerging research has shown racial and ethnic variations in the magnitude of association between the apolipoprotein ɛ4 (apoe ɛ4) allele and the risk of developing alzheimer's disease and related dementias (adrd). |
2023-05-14 |
2023-08-14 |
Not clear |
| Yujiao Li, Jun Chang, Xi Chen, Jianwei Liu, Lan Zha. Advances in the Study of APOE and Innate Immunity in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-05-14. PMID:37182889. |
advances in the study of apoe and innate immunity in alzheimer's disease. |
2023-05-14 |
2023-08-14 |
human |
| Meghan E Wynne, Oluwaseun Ogunbona, Alicia R Lane, Avanti Gokhale, Stephanie A Zlatic, Chongchong Xu, Zhexing Wen, Duc M Duong, Sruti Rayaprolu, Anna Ivanova, Eric A Ortlund, Eric B Dammer, Nicholas T Seyfried, Blaine R Roberts, Amanda Crocker, Vinit Shanbhag, Michael Petris, Nanami Senoo, Selvaraju Kandasamy, Steven Michael Claypool, Antoni Barrientos, Aliza Wingo, Thomas S Wingo, Srikant Rangaraju, Allan I Levey, Erica Werner, Victor Faunde. APOE expression and secretion are modulated by mitochondrial dysfunction. eLife. vol 12. 2023-05-12. PMID:37171075. |
here, we demonstrate that mitochondrial regulation of the secretome is more extensive than previously appreciated, as both genetic and pharmacological disruption of the electron transport chain caused upregulation of the alzheimer's disease risk factor apolipoprotein e (apoe) and other secretome components. |
2023-05-12 |
2023-08-14 |
mouse |
| Sarim Rashid, Raja Ram Khenhrani, Sapna Devi, Maha Veer, Maria Malik, Jahanzeb Mali. Association of Deja Vu with Cardiovascular Diseases. Current problems in cardiology. 2023-05-12. PMID:37172880. |
the apoe (apolipoprotein e) gene, in particular, has been associated with memory processing, alzheimer's disease, and an increased risk of cardiovascular disease. |
2023-05-12 |
2023-08-14 |
Not clear |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. medRxiv : the preprint server for health sciences. 2023-05-10. PMID:37162910. |
the apolipoprotein (apoe) e4 allele is a known risk factor for alzheimer's disease (ad), while the e2 allele is thought to be protective against ad. |
2023-05-10 |
2023-08-14 |
Not clear |
| Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Satoshi Fudo, Uni Rankka, Anssi Pelkonen, Paula Korhonen, Katarzyna Leskinen, Salla Keskitalo, Kari Salokas, Christina Gkolfinopoulou, Katrina E Crompton, Matti Javanainen, Lotta Happonen, Markku Varjosalo, Tarja Malm, Ville Leinonen, Angeliki Chroni, Päivi Saavalainen, Seppo Meri, Tommi Kajander, Adam Jm Wollman, Eija Nissilä, Karita Haapasal. Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation. EMBO reports. 2023-05-08. PMID:37155564. |
the apoe4 variant of apolipoprotein e (apoe) is the most prevalent genetic risk allele associated with late-onset alzheimer's disease (ad). |
2023-05-08 |
2023-08-14 |
Not clear |
| Jennifer Hua, Elvira Garcia de Paco, Nathalie Linck, Tangui Maurice, Catherine Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulman. Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-05-05. PMID:37145189. |
microglial p2x4 receptors promote apoe degradation and contribute to memory deficits in alzheimer's disease. |
2023-05-05 |
2023-08-14 |
Not clear |
| Carr J Smith, J Wesson Ashfor. Apolipoprotein ɛ4-Associated Protection Against Pediatric Enteric Infections is a Survival Advantage in Pre-Industrial Populations. Journal of Alzheimer's disease : JAD. 2023-05-01. PMID:37125551. |
until 300,000 years ago, ancestors of modern humans ubiquitously carried the apolipoprotein e (apoe) ɛ4/ɛ4 genotype, when the ɛ3 allele mutated from the ancestral ɛ4, which elevates the risk of alzheimer's disease. |
2023-05-01 |
2023-08-14 |
Not clear |
| Hongkai Zhao, Qianzhao Ji, Zeming Wu, Si Wang, Jie Ren, Kaowen Yan, Zehua Wang, Jianli Hu, Qun Chu, Huifang Hu, Yusheng Cai, Qiaoran Wang, Daoyuan Huang, Zhejun Ji, Jingyi Li, Juan Carlos Izpisua Belmonte, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Li. Destabilizing heterochromatin by APOE mediates senescence. Nature aging. vol 2. issue 4. 2023-04-28. PMID:37117743. |
although apoe is genetically associated with human longevity and alzheimer's disease, its mechanistic role in aging is largely unknown. |
2023-04-28 |
2023-08-14 |
human |
| Cally Xiao, Ioannis Pappas, Leon M Aksman, Sid E O'Bryant, Arthur W Tog. Comparison of genetic and health risk factors for mild cognitive impairment and Alzheimer's disease between Hispanic and non-Hispanic white participants. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-27. PMID:37104247. |
the influence of apolipoprotein e (apoe) genotype on mild cognitive impairment (mci) and alzheimer's disease (ad) is well studied in the non-hispanic white (nhw) population but not in the hispanic population. |
2023-04-27 |
2023-08-14 |
human |
| Courtney M Kloske, Mary D Gearon, Erica M Weekman, Colin Rogers, Ela Patel, Adam Bachstetter, Peter T Nelson, Donna M Wilcoc. Association between APOE genotype and microglial cell morphology. Journal of neuropathology and experimental neurology. 2023-04-22. PMID:37087107. |
apoe is the largest genetic risk factor for late-onset alzheimer disease (ad) with e4 conferring an increased risk for ad compared to e3. |
2023-04-22 |
2023-08-14 |
human |
| Paige E Lawler, James G Bollinger, Suzanne E Schindler, Cynthia R Hodge, Nicolas J Iglesias, Vishal Krishnan, John B Coulton, Yan Li, David M Holtzman, Randall J Batema. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype. Analytical biochemistry. 2023-04-18. PMID:37072097. |
although the apoe ε4 allele is the strongest genetic risk factor for sporadic alzheimer's disease (ad), the relationship between apolipoprotein (apoe) and ad pathophysiology is not yet fully understood. |
2023-04-18 |
2023-08-14 |
human |