| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae Myeong Kang, Jeong-Hyeon Shin, Woo-Ram Kim, Seongho Seo, Haeun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Nobuyuki Okamura, Joon-Kyoung Seong, Young No. Effects of the APOEɛ4 Allele on the Relationship Between Tau and Amyloid-β in Early- and Late-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-07-02. PMID:37393505. |
little is known regarding the differential effects of the apolipoprotein e (apoe) ɛ4 on the regional topography of amyloid and tau in patients with both early-onset (eoad) and late-onset alzheimer's disease (load). |
2023-07-02 |
2023-08-14 |
Not clear |
| Lilian Calderón-Garcidueñas, Jacqueline Hernández-Luna, Mario Aiello-Mora, Rafael Brito-Aguilar, Pablo A Evelson, Rodolfo Villarreal-Ríos, Ricardo Torres-Jardón, Alberto Ayala, Partha S Mukherje. APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371506. |
apoe peripheral and brain impact: apoe4 carriers accelerate their alzheimer continuum and have a high risk of suicide in pm this review emphasizes the impact of apoe4-the most significant genetic risk factor for alzheimer's disease (ad)-on peripheral and neural effects starting in childhood. |
2023-06-28 |
2023-08-14 |
Not clear |
| Linda G Yang, Zachary M March, Roxan A Stephenson, Priyanka S Naraya. Apolipoprotein E in lipid metabolism and neurodegenerative disease. Trends in endocrinology and metabolism: TEM. 2023-06-25. PMID:37357100. |
variants of the lipid transport protein, apolipoprotein e (apoe), modulate risk and resilience in several neurodegenerative diseases including late-onset alzheimer's disease (load). |
2023-06-25 |
2023-08-14 |
Not clear |
| Kamran Nissar, Parveena Firdous, Arshad Hussain, Samirul Bashir, Zubair Ahmad, Bashir Ahmad Gana. Transcriptomic Downregulation of APOE, Polymorphic Variations of APOE, Diet, Social Isolation, and Co-morbidities as Contributing Factors to Alzheimer's Disease: a Case-Control Study of Kashmiri Population. Molecular neurobiology. 2023-06-25. PMID:37357229. |
transcriptomic downregulation of apoe, polymorphic variations of apoe, diet, social isolation, and co-morbidities as contributing factors to alzheimer's disease: a case-control study of kashmiri population. |
2023-06-25 |
2023-08-14 |
Not clear |
| T Walsh, L Duff, M-E Riviere, P N Tariot, K Doak, M Smith, B Borowsky, C Lopez Lopez, P C Arratia, F Liu, I Scholten, D Gordon, J Arbuckle, A Graf, M Quinn, J Ricart, J B Langbau. Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer's Prevention Trial: A global Perspective from the API Generation Program. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357285. |
outreach, screening, and randomization of apoe ε4 carriers into an alzheimer's prevention trial: a global perspective from the api generation program. |
2023-06-25 |
2023-08-14 |
Not clear |
| L Fan, X Zhu, A R Borenstein, X Huang, M J Shrubsole, L L Dugan, Q Da. Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort. The journal of prevention of Alzheimer's disease. vol 10. issue 3. 2023-06-25. PMID:37357292. |
this study aims to determine 1) whether plasma caprylic acid (c8:0) is associated with risk of incident mild cognitive impairment (mci) among baseline cognitively normal (cn) participants, and incident alzheimer's disease (ad) among baseline mci participants; and 2) whether these associations differ by sex, comorbidity of cardiometabolic diseases, apolipoprotein e (apoe) ε4 alleles, and adas-cog 13. |
2023-06-25 |
2023-08-14 |
human |
| Orla Bonnar, Kira Shaw, Silvia Anderle, Dori M Grijseels, Devin Clarke, Laura Bell, Sarah L King, Catherine N Hal. APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-06-23. PMID:37350319. |
vascular factors are known to be early and important players in alzheimer's disease (ad) development, however the role of the ε4 allele of the apolipoprotein (apoe) gene (a risk factor for developing ad) remains unclear. |
2023-06-23 |
2023-08-14 |
mouse |
| Lan Zhang, Yiyuan Xia, Yuran Gu. Neuronal ApoE4 in Alzheimer's disease and potential therapeutic targets. Frontiers in aging neuroscience. vol 15. 2023-06-19. PMID:37333457. |
the most prevalent genetic risk factor for alzheimer's disease (ad) is apolipoprotein e (apoe), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that give rise to the apoe subtypes e2, e3, and e4, respectively. |
2023-06-19 |
2023-08-14 |
Not clear |
| Nneoma Adaku, Benjamin N Ostendorf, Wenbin Mei, Sohail F Tavazoi. Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression. Cancer research. 2023-06-19. PMID:37335131. |
the secreted lipid transporter apolipoprotein e (apoe) plays important roles in atherosclerosis and alzheimer's disease and has been implicated as a suppressor of melanoma progression. |
2023-06-19 |
2023-08-14 |
mouse |
| Rebecca Piccarducci, Chiara Giacomelli, Maria Sofia Bertilacchi, Andrea Benito-Martinez, Nicoletta Di Giorgi, Simona Daniele, Giovanni Signore, Silvia Rocchiccioli, Marçal Vilar, Laura Marchetti, Claudia Martin. Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells. Biochimica et biophysica acta. Molecular basis of disease. 2023-06-19. PMID:37336366. |
the apoe ε4 polymorphic variant leads to impaired brain cholesterol homeostasis and amyloidogenic pathway, thus representing the major risk factor for alzheimer's disease (ad). |
2023-06-19 |
2023-08-14 |
Not clear |
| Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P Hery, Patrick Sullivan, David R Borchelt, Stefan Prokop, Paramita Chakrabart. Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta neuropathologica communications. vol 11. issue 1. 2023-06-19. PMID:37337279. |
apolipoprotein (apoe) e4 isoform is a major risk factor of alzheimer's disease and contributes to metabolic and neuropathological abnormalities during brain aging. |
2023-06-19 |
2023-08-14 |
mouse |
| Yuda Huang, Yongzhi Shan, Wen Qin, Guoguang Zha. Apolipoprotein E ε4 accelerates the longitudinal cerebral atrophy in open access series of imaging studies-3 elders without dementia at enrollment. Frontiers in aging neuroscience. vol 15. 2023-06-16. PMID:37323144. |
early studies have reported that apoe is strongly associated with brain atrophy and cognitive decline among healthy elders and alzheimer's disease (ad). |
2023-06-16 |
2023-08-14 |
Not clear |
| Megumi T Matsushita, Hao Wang, Glen M Abel, Zhengui Xi. Inducible and Conditional Activation of Adult Neurogenesis Rescues Cadmium-Induced Hippocampus-Dependent Memory Deficits in ApoE4-KI Mice. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298071. |
the apolipoprotein e (apoe) gene is a genetic risk factor for late-onset alzheimer's disease, in which ε4 allele carriers have increased risk compared to the common ε3 carriers. |
2023-06-11 |
2023-08-14 |
mouse |
| Justin O'Leary, Ana-Caroline Raulin, Zonghua Li, Yuka Martens, Yasuteru Inoue, Michael R Strickland, Xianlin Han, David M Holtzman, Guojun Bu, Na Zha. Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody. STAR protocols. vol 4. issue 2. 2023-06-08. PMID:37289593. |
the apolipoprotein e protein (apoe) confers differential risk for alzheimer's disease depending on which isoforms are expressed. |
2023-06-08 |
2023-08-14 |
human |
| Huu-Hien Huynh, Kellie Kuch, Allen Orquillas, Katrina Forrest, Lili Barahona-Carrillo, Dirk Keene, Victor W Henderson, Anthony D Wagner, Kathleen L Poston, Thomas J Montine, Amy Lin, Lu Tian, Michael J MacCoss, Michelle A Emrick, Andrew N Hoofnagl. Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid. Clinical chemistry. 2023-06-06. PMID:37279935. |
apoe genotype is associated with alzheimer disease. |
2023-06-06 |
2023-08-14 |
Not clear |
| Michal Nemergut, Sérgio M Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Mare. Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Molecular neurodegeneration. vol 18. issue 1. 2023-06-06. PMID:37280636. |
apolipoprotein e (apoe) ε4 genotype is the most prevalent risk factor for late-onset alzheimer's disease (ad). |
2023-06-06 |
2023-08-14 |
Not clear |
| Lin Hua, Fei Gao, Xiaoluan Xia, Qiwei Guo, Yonghua Zhao, Shaohui Huang, Zhen Yua. Individual-specific functional connectivity improves prediction of Alzheimer's disease's symptoms in elderly people regardless of APOE ε4 genotype. Communications biology. vol 6. issue 1. 2023-05-31. PMID:37258640. |
individual-specific functional connectivity improves prediction of alzheimer's disease's symptoms in elderly people regardless of apoe ε4 genotype. |
2023-05-31 |
2023-08-14 |
human |
| Nandakumar Nagaraja, Steven DeKosky, Ranjan Duara, Lan Kong, Wei-En Wang, David Vaillancourt, Mehmet Albayra. Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-05-28. PMID:37245492. |
in subjects with alzheimer's disease (ad), we assessed characteristic features and amounts of wmh, lacunes, and epvs in four caa categories (no, mild, moderate and severe caa) and correlated these with clinical dementia rating sum of boxes (cdrsb) score, apoe genotype, and neuropathological changes at autopsy. |
2023-05-28 |
2023-08-14 |
human |
| Yu-Ying Sun, Zhun Wang, Han-Chang Huan. Roles of ApoE4 on the Pathogenesis in Alzheimer's Disease and the Potential Therapeutic Approaches. Cellular and molecular neurobiology. 2023-05-25. PMID:37227619. |
the apolipoprotein e ε4 (apoe ε4) allele, encoding apoe4, is the strongest genetic risk factor for late-onset alzheimer's disease (load). |
2023-05-25 |
2023-08-14 |
Not clear |
| Sofia Håglin, Elise Koch, Fernanda Schäfer Hackenhaar, Lars Nyberg, Karolina Kaupp. APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals. Scientific reports. vol 13. issue 1. 2023-05-24. PMID:37225733. |
apoe ɛ4, but not polygenic alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals. |
2023-05-24 |
2023-08-14 |
Not clear |