All Relations between Alzheimer Disease and apoe

Publication Sentence Publish Date Extraction Date Species
Mingyue He, Tenghong Lian, Peng Guo, Weijiao Zhang, Yanan Zhang, Yue Huang, Gaifen Liu, Huiying Guan, Jinghui Li, Dongmei Luo, Weijia Zhang, Wenjing Zhang, Jing Qi, Hao Yue, Xiaomin Wang, Wei Zhan. The roles of apolipoprotein E ε4 on neuropathology and neuroinflammation in patients with Alzheimer's disease. CNS neuroscience & therapeutics. 2023-09-12. PMID:37697966. to explore the roles of apolipoprotein e (apoe) ε4 on the neuropathology and neuroinflammation in alzheimer's disease (ad) patients. 2023-09-12 2023-10-07 Not clear
Ziyi Zhang, William Robert Kwapong, Le Cao, Zijuan Feng, Bo Wu, Junfeng Liu, Shuting Zhan. APOE ε4 Gene Carriers Demonstrate Reduced Retinal Capillary Densities in Asymptomatic Older Adults. Journal of clinical medicine. vol 12. issue 17. 2023-09-09. PMID:37685715. early identification of apolipoprotein e (apoe)-related microvascular pathology will help to study the microangiopathic contribution to alzheimer's disease and provide a therapeutic target for early intervention. 2023-09-09 2023-10-07 human
Tianyu Zhao, Tangsheng Zhong, Meishuang Zhang, Yang Xu, Ming Zhang, Li Che. Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686334. alzheimer's disease: causal effect between obesity and apoe gene polymorphisms. 2023-09-09 2023-10-07 Not clear
Wan-Chen Wen, Yi-Hui Lin, Tsai-Hui Duh, Chun-Hsien Chen, Chia-Hsien Feng, Yen-Ling Che. Fluorescence detection of apolipoprotein E gene polymorphisms based on oligonucleotide ligation and magnetic separation. Analytical methods : advancing methods and applications. 2023-09-08. PMID:37680175. most patients with alzheimer's disease are diagnosed with late-onset alzheimer's disease (load), with apolipoprotein e (apoe) genotypes being highly associated with the frequency of load risk. 2023-09-08 2023-10-07 Not clear
Ling-Chun Huang, Mei-Yueh Lee, Ching-Fang Chien, Yang-Pei Chang, Kuan-Ying Li, Yuan-Han Yan. Age and sex differences in the association between APOE genotype and Alzheimer's disease in a Taiwan Chinese population. Frontiers in aging neuroscience. vol 15. 2023-09-08. PMID:37680541. age and sex differences in the association between apoe genotype and alzheimer's disease in a taiwan chinese population. 2023-09-08 2023-10-07 Not clear
Xiaoqian Niu, Yuye Wang, Xiangfei Zhang, Yu Wang, Wen Shao, Leian Chen, Ziyuan Yang, Dantao Pen. Quantitative electroencephalography (qEEG), apolipoprotein A-I (APOA-I), and apolipoprotein epsilon 4 (APOE ɛ4) alleles for the diagnosis of mild cognitive impairment and Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-09-06. PMID:37673807. quantitative electroencephalography (qeeg), apolipoprotein a-i (apoa-i), and apolipoprotein epsilon 4 (apoe ɛ4) alleles for the diagnosis of mild cognitive impairment and alzheimer's disease. 2023-09-06 2023-10-07 Not clear
Nicholas J Schork, Jeremy A Elma. Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers. Journal of Alzheimer's disease : JAD. 2023-09-04. PMID:37661888. apoe is the largest genetic risk factor for alzheimer's disease (ad), but there is a substantial polygenic component. 2023-09-04 2023-09-07 Not clear
M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk. Molecular psychiatry. 2023-09-04. PMID:37666928. the apoe 2/3/4 polymorphism is the greatest genetic risk factor for alzheimer's disease (ad). 2023-09-04 2023-09-07 human
Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, David M Holtzman, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645718. epidemiological studies show that individuals who carry the relatively uncommon apoe ε2 allele rarely develop alzheimer disease, and if they do they have a later age of onset, milder clinical course, and less severe neuropathological findings than others with alzheimer disease. 2023-08-30 2023-09-07 mouse
Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, David M Holtzman, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645718. the contrast is especially stark in comparison to the phenotype associated with the major genetic risk factor for alzheimer disease, apoe ε4, which has an age of onset several decades earlier, as well as a more aggressive clinical course and notably more severe neuropathological findings, especially in terms of the amount of amyloid deposition. 2023-08-30 2023-09-07 mouse
Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, Matthew O Goodman, Wassim Tarraf, Iris Broce, Richard B Lipton, Martha Daviglus, Melissa Lamar, Sylvia Wassertheil-Smoller, Jianwen Cai, Charles S DeCarli, Hector M Gonzalez, Myriam Fornag. A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S. Alzheimer's research & therapy. vol 15. issue 1. 2023-08-30. PMID:37649099. a polygenic risk score for alzheimer's disease constructed using apoe-region variants has stronger association than apoe alleles with mild cognitive impairment in hispanic/latino adults in the u.s. polygenic risk scores (prss) are summaries of genetic risk alleles for an outcome. 2023-08-30 2023-09-07 Not clear
Hyo Lee, Aimee J Aylward, Richard V Pearse, Alexandra M Lish, Yi-Chen Hsieh, Zachary M Augur, Courtney R Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M Duong, Nicholas T Seyfried, David A Bennett, Mariko F Taga, Kevin Huynh, Matthias Arnold, Peter J Meikle, Philip L De Jager, Vilas Menon, Jessica E Young, Tracy L Young-Pears. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1. Cell reports. 2023-08-23. PMID:37611586. cell-type-specific regulation of apoe and clu levels in human neurons by the alzheimer's disease risk gene sorl1. 2023-08-23 2023-09-07 human
Jing Zhao, Tadafumi C Ikezu, Wenyan Lu, Jesse R Macyczko, Yonghe Li, Laura J Lewis-Tuffin, Yuka A Martens, Yingxue Ren, Yiyang Zhu, Yan W Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun B. APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids. Stem cell research & therapy. vol 14. issue 1. 2023-08-22. PMID:37605285. the apolipoprotein e (apoe) gene is the strongest genetic risk factor for alzheimer's disease (ad); however, how it modulates brain homeostasis is not clear. 2023-08-22 2023-09-07 human
Shuixin Lv, Yusi Zhang, Yingbin Lin, Wenting Fang, Yu Wang, Zihang Li, Anlan Lin, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Che. ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level. Aging cell. 2023-08-18. PMID:37594184. although aging and apolipoprotein e (apoe) ε4 allele have been documented as two major risk factors for late-onset alzheimer's disease (load), their interaction and potential underlying mechanisms remain unelucidated. 2023-08-18 2023-09-07 mouse
Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. 2023-08-17 2023-09-07 Not clear
Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577501. molecular modeling of apoe in complexes with alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. 2023-08-14 2023-08-16 human
Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577501. to understand how apoe interacts with alzheimer's amyloid- 2023-08-14 2023-08-16 human
Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. the relationship between apoe genotype, csf tau and cognition across the alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. 2023-08-14 2023-08-16 Not clear
Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. to investigate whether insula network connectivity modulates the relationship between apolipoprotein e (apoe) ε4 genotype, cerebrospinal fluid (csf) biomarkers (aβ, tau, and ptau) and cognition across alzheimer's disease (ad) spectrum. 2023-08-14 2023-08-16 Not clear
Mark Monane, Kim G Johnson, B Joy Snider, Raymond S Turner, Jonathan D Drake, Demetrius M Maraganore, James L Bicksel, Daniel H Jacobs, Julia L Ortega, Joni Henderson, Yan Jiang, Shuguang Huang, Justine Coppinger, Ilana Fogelman, Tim West, Joel B Braunstei. A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment. Annals of clinical and translational neurology. 2023-08-08. PMID:37550958. the objective of this study was to examine clinicians' patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and apoe blood biomarkers combined with patient age (precivityad® blood test) in symptomatic patients evaluated for alzheimer's disease (ad) or other causes of cognitive decline. 2023-08-08 2023-08-14 Not clear