| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas J Schork, Jeremy A Elma. Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers. Journal of Alzheimer's disease : JAD. 2023-09-04. PMID:37661888. |
apoe is the largest genetic risk factor for alzheimer's disease (ad), but there is a substantial polygenic component. |
2023-09-04 |
2023-09-07 |
Not clear |
| M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk. Molecular psychiatry. 2023-09-04. PMID:37666928. |
the apoe 2/3/4 polymorphism is the greatest genetic risk factor for alzheimer's disease (ad). |
2023-09-04 |
2023-09-07 |
human |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, David M Holtzman, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645718. |
epidemiological studies show that individuals who carry the relatively uncommon apoe ε2 allele rarely develop alzheimer disease, and if they do they have a later age of onset, milder clinical course, and less severe neuropathological findings than others with alzheimer disease. |
2023-08-30 |
2023-09-07 |
mouse |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, David M Holtzman, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. bioRxiv : the preprint server for biology. 2023-08-30. PMID:37645718. |
the contrast is especially stark in comparison to the phenotype associated with the major genetic risk factor for alzheimer disease, apoe ε4, which has an age of onset several decades earlier, as well as a more aggressive clinical course and notably more severe neuropathological findings, especially in terms of the amount of amyloid deposition. |
2023-08-30 |
2023-09-07 |
mouse |
| Tamar Sofer, Nuzulul Kurniansyah, Einat Granot-Hershkovitz, Matthew O Goodman, Wassim Tarraf, Iris Broce, Richard B Lipton, Martha Daviglus, Melissa Lamar, Sylvia Wassertheil-Smoller, Jianwen Cai, Charles S DeCarli, Hector M Gonzalez, Myriam Fornag. A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S. Alzheimer's research & therapy. vol 15. issue 1. 2023-08-30. PMID:37649099. |
a polygenic risk score for alzheimer's disease constructed using apoe-region variants has stronger association than apoe alleles with mild cognitive impairment in hispanic/latino adults in the u.s. polygenic risk scores (prss) are summaries of genetic risk alleles for an outcome. |
2023-08-30 |
2023-09-07 |
Not clear |
| Hyo Lee, Aimee J Aylward, Richard V Pearse, Alexandra M Lish, Yi-Chen Hsieh, Zachary M Augur, Courtney R Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M Duong, Nicholas T Seyfried, David A Bennett, Mariko F Taga, Kevin Huynh, Matthias Arnold, Peter J Meikle, Philip L De Jager, Vilas Menon, Jessica E Young, Tracy L Young-Pears. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1. Cell reports. 2023-08-23. PMID:37611586. |
cell-type-specific regulation of apoe and clu levels in human neurons by the alzheimer's disease risk gene sorl1. |
2023-08-23 |
2023-09-07 |
human |
| Jing Zhao, Tadafumi C Ikezu, Wenyan Lu, Jesse R Macyczko, Yonghe Li, Laura J Lewis-Tuffin, Yuka A Martens, Yingxue Ren, Yiyang Zhu, Yan W Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun B. APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids. Stem cell research & therapy. vol 14. issue 1. 2023-08-22. PMID:37605285. |
the apolipoprotein e (apoe) gene is the strongest genetic risk factor for alzheimer's disease (ad); however, how it modulates brain homeostasis is not clear. |
2023-08-22 |
2023-09-07 |
human |
| Shuixin Lv, Yusi Zhang, Yingbin Lin, Wenting Fang, Yu Wang, Zihang Li, Anlan Lin, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Che. ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl-CoA level. Aging cell. 2023-08-18. PMID:37594184. |
although aging and apolipoprotein e (apoe) ε4 allele have been documented as two major risk factors for late-onset alzheimer's disease (load), their interaction and potential underlying mechanisms remain unelucidated. |
2023-08-18 |
2023-09-07 |
mouse |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577501. |
molecular modeling of apoe in complexes with alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. |
2023-08-14 |
2023-08-16 |
human |
| Emily Lewkowicz, Mari N Nakamura, Michael J Rynkiewicz, Olga Gursk. Molecular modeling of apoE in complexes with Alzheimer's amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577501. |
to understand how apoe interacts with alzheimer's amyloid- |
2023-08-14 |
2023-08-16 |
human |
| Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. |
the relationship between apoe genotype, csf tau and cognition across the alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. |
2023-08-14 |
2023-08-16 |
Not clear |
| Yao Zhu, Yan Wu, Xinyi Lv, Jiaonan Wu, Chunzi Shen, Qiqiang Tang, Guoping Wan. The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. CNS neuroscience & therapeutics. 2023-08-14. PMID:37577852. |
to investigate whether insula network connectivity modulates the relationship between apolipoprotein e (apoe) ε4 genotype, cerebrospinal fluid (csf) biomarkers (aβ, tau, and ptau) and cognition across alzheimer's disease (ad) spectrum. |
2023-08-14 |
2023-08-16 |
Not clear |
| Mark Monane, Kim G Johnson, B Joy Snider, Raymond S Turner, Jonathan D Drake, Demetrius M Maraganore, James L Bicksel, Daniel H Jacobs, Julia L Ortega, Joni Henderson, Yan Jiang, Shuguang Huang, Justine Coppinger, Ilana Fogelman, Tim West, Joel B Braunstei. A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment. Annals of clinical and translational neurology. 2023-08-08. PMID:37550958. |
the objective of this study was to examine clinicians' patient selection and result interpretation of a clinically validated mass spectrometry test measuring amyloid beta and apoe blood biomarkers combined with patient age (precivityad® blood test) in symptomatic patients evaluated for alzheimer's disease (ad) or other causes of cognitive decline. |
2023-08-08 |
2023-08-14 |
Not clear |
| Yu-Kai Chang, Jennifer L Etnier, Ruei-Hong Li, Fei-Fei Ren, Jing-Yi Ai, Chien-Heng Ch. Acute Exercise Effect on Neurocognitive Function among Cognitively Normal Late-Middle-Aged Adults with/without Genetic Risk of AD: The Moderating Role of Exercise Volume and APOE Genotype. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-08-01. PMID:37526237. |
acute exercise is a behavior that benefits cognitive function; however, its effect on populations with different risks for alzheimer's disease (ad) and the role of exercise variance and apolipoprotein e (apoe) genotype on this effect remains unknown. |
2023-08-01 |
2023-08-14 |
Not clear |
| Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenne. Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years. Alzheimer's research & therapy. vol 15. issue 1. 2023-07-29. PMID:37516890. |
alzheimer's polygenic risk scores, apoe, alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years. |
2023-07-29 |
2023-08-14 |
Not clear |
| Sára Nemes, Paige E Logan, Mohit K Manchella, Nidhi S Mundada, Renaud La Joie, Angelina J Polsinelli, Dustin B Hammers, Robert A Koeppe, Tatiana M Foroud, Kelly N Nudelman, Ani Eloyan, Leonardo Iaccarino, Valérie Dorsant-Ardón, Alexander Taurone, Maryanne Thangarajah, Jeffery L Dage, Paul Aisen, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, Kyle B Womack, David A Wolk, Gil D Rabinovici, Maria C Carrillo, Bradford C Dickerson, Liana G Apostolov. Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-27. PMID:37496307. |
sex and apoe ε4 carrier effects on atrophy, amyloid pet, and tau pet burden in early-onset alzheimer's disease. |
2023-07-27 |
2023-08-14 |
Not clear |
| Sára Nemes, Paige E Logan, Mohit K Manchella, Nidhi S Mundada, Renaud La Joie, Angelina J Polsinelli, Dustin B Hammers, Robert A Koeppe, Tatiana M Foroud, Kelly N Nudelman, Ani Eloyan, Leonardo Iaccarino, Valérie Dorsant-Ardón, Alexander Taurone, Maryanne Thangarajah, Jeffery L Dage, Paul Aisen, Lea T Grinberg, Clifford R Jack, Joel Kramer, Walter A Kukull, Melissa E Murray, Malia Rumbaugh, David N Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Lawrence S Honig, David T Jones, Joseph Masdeu, Mario F Mendez, Erik Musiek, Chiadi U Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J Sha, Raymond S Turner, Thomas S Wingo, Kyle B Womack, David A Wolk, Gil D Rabinovici, Maria C Carrillo, Bradford C Dickerson, Liana G Apostolov. Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-07-27. PMID:37496307. |
we used sex and apolipoprotein e ε4 (apoe ε4) carrier status as predictors of pathologic burden in early-onset alzheimer's disease (eoad). |
2023-07-27 |
2023-08-14 |
Not clear |
| Elizabeth R Paitel, Kristy A Nielso. Cerebellar EEG source localization reveals age-related compensatory activity moderated by genetic risk for Alzheimer's disease. Psychophysiology. 2023-07-26. PMID:37493042. |
the apolipoprotein-e (apoe) ε4 allele is the greatest genetic risk factor for late-onset alzheimer's disease (ad), but alone it is not sufficiently predictive. |
2023-07-26 |
2023-08-14 |
Not clear |
| Patrycja Dzianok, Ewa Kubli. Altered granulocyte count and erythrocyte measures in middle-aged, healthy carriers of APOE and PICALM risk genes for Alzheimer's disease. Acta neurobiologiae experimentalis. vol 83. issue 2. 2023-07-26. PMID:37493530. |
altered granulocyte count and erythrocyte measures in middle-aged, healthy carriers of apoe and picalm risk genes for alzheimer's disease. |
2023-07-26 |
2023-08-14 |
human |