| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angelika Caputo, Amy Racine, Ines Paule, Pierre N Tariot, Jessica B Langbaum, Neva Coello, Marie-Emmanuelle Riviere, J Michael Ryan, Cristina Lopez Lopez, Ana Gra. Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-03-06. PMID:36879340. |
the alzheimer's prevention initiative (api) generation program, conducted in cognitively unimpaired individuals at risk of developing ad (e.g., enriched by the apolipoprotein e (apoe) genotype), used a novel dual primary endpoints approach, whereby demonstration of treatment effect in one of the two endpoints is sufficient for trial success. |
2023-03-06 |
2023-08-14 |
Not clear |
| Mohammad S E Sendi, Elaheh Zendehrouh, Charles A Ellis, Zening Fu, Jiayu Chen, Robyn L Miller, Elizabeth C Mormino, David H Salat, Vince D Calhou. The link between static and dynamic brain functional network connectivity and genetic risk of Alzheimer's disease. NeuroImage. Clinical. vol 37. 2023-03-05. PMID:36871405. |
apolipoprotein e (apoe) polymorphic alleles are genetic factors associated with alzheimer's disease (ad) risk. |
2023-03-05 |
2023-08-14 |
human |
| Hyo Lee, Aimee J Aylward, Richard V Pearse, Yi-Chen Hsieh, Zachary M Augur, Courtney R Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M Duong, Nicholas T Seyfried, David A Bennett, Hans-Ulrich Klein, Philip L De Jager, Vilas Menon, Jessica E Young, Tracy L Young-Pears. Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1. bioRxiv : the preprint server for biology. 2023-03-03. PMID:36865313. |
cell-type-specific regulation of apoe levels in human neurons by the alzheimer's disease risk gene sorl1. |
2023-03-03 |
2023-08-14 |
human |
| Zachary J D'Alonzo, Virginie Lam, Ryu Takechi, Michael Nesbit, Mauro Vaccarezza, John C L Mam. Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats. Genes & nutrition. vol 18. issue 1. 2023-02-25. PMID:36841786. |
peripheral metabolism of lipoprotein-amyloid beta as a risk factor for alzheimer's disease: potential interactive effects of apoe genotype with dietary fats. |
2023-02-25 |
2023-08-14 |
Not clear |
| Yann Le Guen, Ana-Caroline Raulin, Mark W Logue, Richard Sherva, Michael E Belloy, Sarah J Eger, Annabel Chen, Gabriel Kennedy, Lindsey Kuchenbecker, Justin P O'Leary, Rui Zhang, Victoria C Merritt, Matthew S Panizzon, Richard L Hauger, J Michael Gaziano, Guojun Bu, Timothy A Thornton, Lindsay A Farrer, Valerio Napolioni, Zihuai He, Michael D Greiciu. Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. JAMA. vol 329. issue 7. 2023-02-22. PMID:36809323. |
association of african ancestry-specific apoe missense variant r145c with risk of alzheimer disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Yann Le Guen, Ana-Caroline Raulin, Mark W Logue, Richard Sherva, Michael E Belloy, Sarah J Eger, Annabel Chen, Gabriel Kennedy, Lindsey Kuchenbecker, Justin P O'Leary, Rui Zhang, Victoria C Merritt, Matthew S Panizzon, Richard L Hauger, J Michael Gaziano, Guojun Bu, Timothy A Thornton, Lindsay A Farrer, Valerio Napolioni, Zihuai He, Michael D Greiciu. Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease. JAMA. vol 329. issue 7. 2023-02-22. PMID:36809323. |
numerous studies have established the association of the common apoe ε2 and apoe ε4 alleles with alzheimer disease (ad) risk across ancestries. |
2023-02-22 |
2023-08-14 |
Not clear |
| Ina Caesar, K Peter R Nilsson, Per Hammarstrom, Mikael Lindgren, Stefan Prokop, Frank L Heppner, James Schmeidler, Vahram Haroutunian, David M Holtzman, Patrick R Hof, Sam Gand. ApoE Alzheimer's Disease Aβ-amyloid plaque morphology varies according to APOE isotype. Research square. 2023-02-17. PMID:36798327. |
apoe alzheimer's disease aβ-amyloid plaque morphology varies according to apoe isotype. |
2023-02-17 |
2023-08-14 |
Not clear |
| Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M Shaw, Sanjay Asthana, Cynthia M Carlsson, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B Bendlin, Qiongshi Lu, Corinne D Engelma. Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-16. PMID:36795776. |
neuropathology-based apoe genetic risk score better quantifies alzheimer's risk. |
2023-02-16 |
2023-08-14 |
Not clear |
| Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M Shaw, Sanjay Asthana, Cynthia M Carlsson, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B Bendlin, Qiongshi Lu, Corinne D Engelma. Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-16. PMID:36795776. |
apolipoprotein e (apoe) ε4-carrier status or ε4 allele count are included in analyses to account for the apoe genetic effect on alzheimer's disease (ad); however, this does not account for protective effects of apoe ε2 or heterogeneous effect of ε2, ε3, and ε4 haplotypes. |
2023-02-16 |
2023-08-14 |
Not clear |
| Rory A Greer, Ryan A Tuckey, Hunter B Dean, Erik D Roberson, Yuhua Son. Molecular and structural insight into the differences among common and rare Alzheimer's disease-associated apoE variants. Biophysical journal. vol 122. issue 3S1. 2023-02-14. PMID:36783682. |
molecular and structural insight into the differences among common and rare alzheimer's disease-associated apoe variants. |
2023-02-14 |
2023-08-14 |
Not clear |
| Steven Jett, Jonathan P Dyke, Camila Boneu Yepez, Camila Zarate, Caroline Carlton, Eva Schelbaum, Grace Jang, Silky Pahlajani, Schantel Williams, Roberta Diaz Brinton, Lisa Moscon. Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer's disease: A 31Phosphorus MR spectroscopy study. PloS one. vol 18. issue 2. 2023-02-14. PMID:36787293. |
effects of sex and apoe ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for alzheimer's disease: a 31phosphorus mr spectroscopy study. |
2023-02-14 |
2023-08-14 |
Not clear |
| Steven Jett, Jonathan P Dyke, Camila Boneu Yepez, Camila Zarate, Caroline Carlton, Eva Schelbaum, Grace Jang, Silky Pahlajani, Schantel Williams, Roberta Diaz Brinton, Lisa Moscon. Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer's disease: A 31Phosphorus MR spectroscopy study. PloS one. vol 18. issue 2. 2023-02-14. PMID:36787293. |
age, female sex, and apoe epsilon 4 (apoe4) genotype are the three greatest risk factors for late-onset alzheimer's disease (ad). |
2023-02-14 |
2023-08-14 |
Not clear |
| Elisabeth Black, Abbey Rasch, Tyler Wimmer, Alivia Li, Amanda Araujo, Steve Cieslak, Kevin S Steed, Rajan D Adhikari, Jonathan J Wisco, Bre Anna Hutchinso. The Effects of Age, Genotype, and Diet on Hippocampal Subfield Iron Dysregulation and Alzheimer's Disease Biomarkers in an ApoE Mouse Model. The European journal of neuroscience. 2023-02-13. PMID:36775930. |
the effects of age, genotype, and diet on hippocampal subfield iron dysregulation and alzheimer's disease biomarkers in an apoe mouse model. |
2023-02-13 |
2023-08-14 |
mouse |
| Mingyu Tang, Ning Su, Dingding Zhang, Yi Dai, Ming Yao, Lixin Zhou, Liying Cui, Shuyang Zhang, Yicheng Zhu, Jun N. The Differential Effects of Apoeɛ4 on Cerebral Volumetric Structures in Different Lifespan in Community-Dwelling Populations. Journal of Alzheimer's disease : JAD. 2023-02-13. PMID:36776052. |
apolipoprotein e (apoe) is closely related to alzheimer's disease and other age-related diseases. |
2023-02-13 |
2023-08-14 |
Not clear |
| Alexander P Gabrielli, Ian Weidling, Amol Ranjan, Xiaowan Wang, Lesya Novikova, Subir Roy Chowdhury, Blaise Menta, Alexandra Berkowicz, Heather M Wilkins, Kenneth R Peterson, Russell H Swerdlo. Mitochondria Profoundly Influence Apolipoprotein E Biology. Journal of Alzheimer's disease : JAD. 2023-02-13. PMID:36776072. |
mitochondria can trigger alzheimer's disease (ad)-associated molecular phenomena, but how mitochondria impact apolipoprotein e (apoe; apoe) is not well known. |
2023-02-13 |
2023-08-14 |
Not clear |
| Alexandra J Weigand, Gema Ortiz, Kayla S Walker, Douglas R Galasko, Mark W Bondi, Kelsey R Thoma. APOE differentially moderates cerebrospinal fluid and plasma phosphorylated tau181 associations with multi-domain cognition. Neurobiology of aging. vol 125. 2023-02-13. PMID:36780762. |
we studied 727 participants from the alzheimer's disease neuroimaging initiative with plasma and csf p-tau181 data, apolipoprotein (apoe) ε4 carrier status, amyloid positron emission tomography (pet) imaging, and neuropsychological data. |
2023-02-13 |
2023-08-14 |
human |
| Rebecca M Fleeman, Madison K Kuhn, Dennis C Chan, Elizabeth A Procto. Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid-β. Journal of neurochemistry. 2023-02-10. PMID:36762973. |
the ε4 variant of apoe (apoe4) is the strongest and most common genetic risk factor for alzheimer's disease (ad). |
2023-02-10 |
2023-08-14 |
Not clear |
| Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Gu. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-02-08. PMID:36750884. |
to better assist with the design of future clinical trials for alzheimer's disease (ad) and aid in our understanding of the disease's symptomatology, it is essential to clarify what roles β-amyloid (aβ) plaques and tau tangles play in longitudinal tau accumulation inside and outside the medial temporal lobe (mtl) as well as how age, sex, apolipoprotein e (apoe) ε4 (apoe-ε4), and klotho-vs heterozygosity (kl-vs |
2023-02-08 |
2023-08-14 |
Not clear |
| Alfonso Martín-Peña, Malú Gámez Tanse. The Alzheimer's risk gene APOE modulates the gut-brain axis. Nature. 2023-02-07. PMID:36747101. |
the alzheimer's risk gene apoe modulates the gut-brain axis. |
2023-02-07 |
2023-08-14 |
Not clear |
| Ahsas Goyal, Prashant Singh Kushwah, Neetu Agrawal, Shilpi Patha. APOE4: A Culprit for the Vulnerability of COVID-19 in Alzheimer's Patients. Current neurovascular research. 2023-02-03. PMID:36733199. |
moreover, the role of apoe in severe covid-19 in alzheimer's patients has also been reviewed. |
2023-02-03 |
2023-08-14 |
Not clear |