| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianwen Lou, Borui Tao, Ming Che. Relationship of APOE with Alzheimer's Disease and Other Neurological Disorders: An Updated Review. Neuroscience. 2023-02-03. PMID:36736614. |
relationship of apoe with alzheimer's disease and other neurological disorders: an updated review. |
2023-02-03 |
2023-08-14 |
Not clear |
| Angelina J Polsinelli, Kathleen A Lane, Mohit K Manchella, Paige E Logan, Sujuan Gao, Liana G Apostolov. APOE ε4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-01. PMID:36722399. |
we studied the effect of apolipoprotein e (apoe) ε4 status and sex on age of symptom onset (ao) in early- (eo) and late- (lo) onset alzheimer's disease (ad). |
2023-02-01 |
2023-08-14 |
Not clear |
| Eva Vasiljevic, Rebecca Langhough Koscik, Erin Jonaitis, Tobey Betthauser, Sterling C Johnson, Corinne D Engelma. Cognitive trajectories diverge by genetic risk in a preclinical longitudinal cohort. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-02-01. PMID:36723444. |
we sought to characterize the timing of changes in cognitive trajectories related to genetic risk using the apolipoprotein e (apoe) score, a continuous measure of alzheimer's disease (ad) risk. |
2023-02-01 |
2023-08-14 |
Not clear |
| Hyunah Lee, Jack Price, Deepak P Srivastava, Sandrine Thure. In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis. Hippocampus. 2023-01-29. PMID:36709412. |
apoe polymorphism is the most common genetic risk factor for late-onset alzheimer's disease where the ε4 genotype is associated with a significantly earlier disease onset compared to the neutral ε3 allele. |
2023-01-29 |
2023-08-14 |
human |
| Rui Sun, Tao Wu, Shu Xing, Sheng Wei, John K Bielicki, Xuefang Pan, Mingyang Zhou, Jianbin Che. Caffeic acid protects against atherosclerotic lesions and cognitive decline in ApoE Journal of pharmacological sciences. vol 151. issue 2. 2023-01-27. PMID:36707176. |
given that atherosclerosis and alzheimer's disease share common features including distracted lipid balance and chronic inflammation, the concurrent effects of caffeic acid on atherosclerotic lesions and cognitive decline were explored here by using the apoe |
2023-01-27 |
2023-08-14 |
Not clear |
| Chelsea C Hays Weeks, Zvinka Z Zlatar, M J Meloy, David D Shin, Liu Thomas, Christina E Wiereng. APOE Genotype Modifies the Association of Fusiform Gyrus Cerebral Metabolic Rate of Oxygen Consumption and Object Naming Performance. Journal of Alzheimer's disease : JAD. 2023-01-15. PMID:36641668. |
the apolipoprotein e (apoe) ɛ4 allele confers risk for age and alzheimer's disease related cognitive decline but the mechanistic link remains poorly understood. |
2023-01-15 |
2023-08-14 |
Not clear |
| Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuk. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. vol 123. 2023-01-13. PMID:36638682. |
accumulation of amyloid-β in the brain of mouse models of alzheimer's disease is modified by altered gene expression in the presence of human apoe isoforms during aging. |
2023-01-13 |
2023-08-14 |
mouse |
| Alexander M Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskay. Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers. Aging. vol 14. issue 24. 2023-01-11. PMID:36399096. |
associations of the apoe ε2 and ε4 alleles and polygenic profiles comprising apoe-tomm40-apoc1 variants with alzheimer's disease biomarkers. |
2023-01-11 |
2023-08-16 |
Not clear |
| Isha Mhatre-Winters, Aseel Eid, Yoonhee Han, Kim Tieu, Jason R Richardso. Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice. ASN neuro. vol 15. 2023-01-06. PMID:36604975. |
apolipoprotein e4 (apoe4) genotype and sex are significant risk factors for alzheimer's disease (ad), with females demonstrating increased risk modulated by apoe genotype. |
2023-01-06 |
2023-08-14 |
mouse |
| Christina B Young, Emily Johns, Gabriel Kennedy, Michael E Belloy, Philip S Insel, Michael D Greicius, Reisa A Sperling, Keith A Johnson, Kathleen L Poston, Elizabeth C Mormin. APOE effects on regional tau in preclinical Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-01-03. PMID:36597122. |
apoe effects on regional tau in preclinical alzheimer's disease. |
2023-01-03 |
2023-08-14 |
human |
| Rebecca M Fleeman, Amanda M Snyder, Madison K Kuhn, Dennis C Chan, Grace C Smith, Nicole A Crowley, Amy C Arnold, Elizabeth A Procto. Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice. Neurobiology of aging. 2022-12-26. PMID:36572594. |
the ε4 variant of apolipoprotein e (apoe) is the strongest and most common genetic risk factor for alzheimer's disease (ad). |
2022-12-26 |
2023-08-14 |
mouse |
| Axel D Meneses, Shunsuke Koga, Zonghua Li, Justin O'Leary, Fuyao Li, Kai Chen, Aya Murakami, Wenhui Qiao, Aishe Kurti, Michael G Heckman, Launia White, Manling Xie, Yixing Chen, NiCole A Finch, Melina J Lim, Marion Delenclos, Michael A DeTure, Cynthia Linares, Nicholas B Martin, Tadafumi C Ikezu, Marka M van Blitterswijk, Long-Jun Wu, Pamela J McLean, Rosa Rademakers, Owen A Ross, Dennis W Dickson, Guojun Bu, Na Zha. APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology. Annals of neurology. 2022-12-22. PMID:36546684. |
recent evidence supports a link between increased tdp-43 burden and the presence of an apoe4 gene allele in alzheimer's disease (ad); however, it is difficult to conclude the direct effect of apoe on tdp-43 pathology due to the presence of mixed ad pathologies. |
2022-12-22 |
2023-08-14 |
Not clear |
| Kingston King-Shi Mok, Sunny Hoi-Sang Yeung, Gerald Wai-Yeung Cheng, Iris Wai-Ting Ma, Ralph Hon-Sun Lee, Karl Herrup, Kai-Hei Ts. Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport. Journal of neurochemistry. 2022-12-22. PMID:36549843. |
carriers of the apoe4 (apolipoprotein e ε4) variant of the apoe gene are subject to several age-related health risks, including alzheimer's disease (ad). |
2022-12-22 |
2023-08-14 |
mouse |
| Jinghan Huang, Qiushan Tao, Ting Fang Alvin Ang, John Farrell, Congcong Zhu, Yixuan Wang, Thor D Stein, Kathryn L Lunetta, Joseph Massaro, Jesse Mez, Rhoda Au, Lindsay A Farrer, Wei Qiao Qiu, Xiaoling Zhan. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease. Translational psychiatry. vol 12. issue 1. 2022-12-22. PMID:36550123. |
apolipoprotein ε4 (apoe ε4) is the most significant genetic risk factor for late-onset alzheimer's disease (ad). |
2022-12-22 |
2023-08-14 |
human |
| KangHsien Fan, Lily Francis, M Muaaz Aslam, Margret A Bedison, Elizabeth Lawrence, Vibha Acharya, Beth E Snitz, Mary Ganguli, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease. Neurobiology of aging. vol 122. 2022-12-18. PMID:36528961. |
investigation of the independent role of a rare apoe variant (l28p; apoe*4pittsburgh) in late-onset alzheimer disease. |
2022-12-18 |
2023-08-14 |
human |
| KangHsien Fan, Lily Francis, M Muaaz Aslam, Margret A Bedison, Elizabeth Lawrence, Vibha Acharya, Beth E Snitz, Mary Ganguli, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kambo. Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease. Neurobiology of aging. vol 122. 2022-12-18. PMID:36528961. |
a rare missense apoe variant (l28p; apoe*4pittsburgh), which is present only in populations with european ancestry, has been reported to be a risk factor for late-onset alzheimer's disease (load). |
2022-12-18 |
2023-08-14 |
human |
| Jori Tomassen, Anouk den Braber, Sven J van der Lee, Lianne M Reus, Elles Konijnenberg, Stephen F Carter, Maqsood Yaqub, Bart N M van Berckel, Lyduine E Collij, Dorret I Boomsma, Eco J C de Geus, Philip Scheltens, Karl Herholz, Betty M Tijms, Pieter Jelle Visse. Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score. BMC neurology. vol 22. issue 1. 2022-12-15. PMID:36522743. |
amyloid-β and apoe genotype predict memory decline in cognitively unimpaired older individuals independently of alzheimer's disease polygenic risk score. |
2022-12-15 |
2023-08-14 |
Not clear |
| Emma Nichols, Adam M Brickman, Kaitlin B Casaletto, Kristen Dams-O'Connor, Kristen M George, Raj G Kumar, Priya Palta, Jennifer S Rabin, Claudia L Satizabal, Julie Schneider, Judy Pa, Renaud La Joi. AD and non-AD mediators of the pathway between the APOE genotype and cognition. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-12-14. PMID:36516004. |
we used causal mediation methods to characterize pathways linking the apoe genotype to late-life cognition through alzheimer's disease (ad) and non-ad neuropathologies. |
2022-12-14 |
2023-08-14 |
Not clear |
| Ganggang Miao, Danping Zhuo, Xue Han, Wentao Yao, Chuan Liu, Hanyuan Liu, Hongyong Cao, Yangbai Sun, Zhiqiang Chen, Tingting Fen. From degenerative disease to malignant tumors: Insight to the function of ApoE. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-14. PMID:36516696. |
due to genetic polymorphisms of apoe (ε2, ε3, and ε4), its three common structural isoforms (apoe2, apoe3, apoe4) are also associated with the risk of many diseases, especially degenerative diseases, such as vascular degenerative diseases including atherosclerosis (as), coronary heart disease (chd), and neurodegenerative disease like alzheimer's disease (ad). |
2022-12-14 |
2023-08-14 |
Not clear |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
apoe alleles are associated with sex-specific structural differences in brain regions affected in alzheimer's disease and related dementia. |
2022-12-13 |
2023-08-14 |
human |