| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
our results characterize the temporal evolutions and relative orderings of alzheimer disease biomarkers across the adult lifespan and the modification effect of apoe ɛ4. |
2022-08-04 |
2023-08-14 |
human |
| Guojun B. APOE targeting strategy in Alzheimer's disease: lessons learned from protective variants. Molecular neurodegeneration. vol 17. issue 1. 2022-08-03. PMID:35922805. |
apoe targeting strategy in alzheimer's disease: lessons learned from protective variants. |
2022-08-03 |
2023-08-14 |
Not clear |
| Catherine Schramm, Camille Charbonnier, Aline Zaréa, Morgane Lacour, David Wallon, Anne Boland, Jean-François Deleuze, Robert Olaso, Flora Alarcon, Dominique Campion, Grégory Nuel, Gaël Nicola. Publisher Correction: Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes. Genome medicine. vol 14. issue 1. 2022-08-03. PMID:35922859. |
publisher correction: penetrance estimation of alzheimer disease in sorl1 loss-of-function variant carriers using a family-based strategy and stratification by apoe genotypes. |
2022-08-03 |
2023-08-14 |
Not clear |
| Hongsheng Zhang, Lin Shao, Zhihao Lin, Quan-Xin Long, Huilong Yuan, Lujian Cai, Guangtong Jiang, Xiaoyi Guo, Renzhi Yang, Zepeng Zhang, Bingchang Zhang, Fan Liu, Zhiyong Li, Qilin Ma, Yun-Wu Zhang, Ai-Long Huang, Zhanxiang Wang, Yingjun Zhao, Huaxi X. APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients. Signal transduction and targeted therapy. vol 7. issue 1. 2022-08-01. PMID:35915083. |
the apoe ε4 (apoe4) allele is a major genetic risk factor for alzheimer's and cardiovascular diseases. |
2022-08-01 |
2023-08-14 |
Not clear |
| Chia-Chen Liu, Jing Zhao, Yuan Fu, Yasuteru Inoue, Yingxue Ren, Yuanxin Chen, Sydney V Doss, Francis Shue, Suren Jeevaratnam, Ligia Bastea, Na Wang, Yuka A Martens, Wenhui Qiao, Minghui Wang, Na Zhao, Lin Jia, Yu Yamazaki, Akari Yamazaki, Cassandra L Rosenberg, Zhen Wang, Dehui Kong, Zonghua Li, Lindsey A Kuchenbecker, Zachary A Trottier, Lindsey Felton, Justin Rogers, Zachary S Quicksall, Cynthia Linares, Joshua Knight, Yixing Chen, Aishe Kurti, Takahisa Kanekiyo, John D Fryer, Yan W Asmann, Peter Storz, Xusheng Wang, Junmin Peng, Bin Zhang, Betty Y S Kim, Guojun B. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nature neuroscience. vol 25. issue 8. 2022-08-01. PMID:35915180. |
the ε4 allele of the apolipoprotein e (apoe) gene, a genetic risk factor for alzheimer's disease, is abundantly expressed in both the brain and periphery. |
2022-08-01 |
2023-08-14 |
mouse |
| Chia-Chen Liu, Jing Zhao, Yuan Fu, Yasuteru Inoue, Yingxue Ren, Yuanxin Chen, Sydney V Doss, Francis Shue, Suren Jeevaratnam, Ligia Bastea, Na Wang, Yuka A Martens, Wenhui Qiao, Minghui Wang, Na Zhao, Lin Jia, Yu Yamazaki, Akari Yamazaki, Cassandra L Rosenberg, Zhen Wang, Dehui Kong, Zonghua Li, Lindsey A Kuchenbecker, Zachary A Trottier, Lindsey Felton, Justin Rogers, Zachary S Quicksall, Cynthia Linares, Joshua Knight, Yixing Chen, Aishe Kurti, Takahisa Kanekiyo, John D Fryer, Yan W Asmann, Peter Storz, Xusheng Wang, Junmin Peng, Bin Zhang, Betty Y S Kim, Guojun B. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nature neuroscience. vol 25. issue 8. 2022-08-01. PMID:35915180. |
here, we present evidence that peripheral apoe isoforms, separated from those in the brain by the blood-brain barrier, differentially impact alzheimer's disease pathogenesis and cognition. |
2022-08-01 |
2023-08-14 |
mouse |
| Chia-Chen Liu, Jing Zhao, Yuan Fu, Yasuteru Inoue, Yingxue Ren, Yuanxin Chen, Sydney V Doss, Francis Shue, Suren Jeevaratnam, Ligia Bastea, Na Wang, Yuka A Martens, Wenhui Qiao, Minghui Wang, Na Zhao, Lin Jia, Yu Yamazaki, Akari Yamazaki, Cassandra L Rosenberg, Zhen Wang, Dehui Kong, Zonghua Li, Lindsey A Kuchenbecker, Zachary A Trottier, Lindsey Felton, Justin Rogers, Zachary S Quicksall, Cynthia Linares, Joshua Knight, Yixing Chen, Aishe Kurti, Takahisa Kanekiyo, John D Fryer, Yan W Asmann, Peter Storz, Xusheng Wang, Junmin Peng, Bin Zhang, Betty Y S Kim, Guojun B. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nature neuroscience. vol 25. issue 8. 2022-08-01. PMID:35915180. |
our findings demonstrate pathogenic effects of peripheral apoe4, providing a strong rationale for targeting peripheral apoe to treat alzheimer's disease. |
2022-08-01 |
2023-08-14 |
mouse |
| Madia Lozupone, Bruno Pietro Imbimbo, Claudia Balducci, Filomena Lo Vecchio, Paola Bisceglia, Raffaela Rita Latino, Maurizio Leone, Vittorio Dibello, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Mark Watling, Davide Seripa, Francesco Panz. Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease? Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-07-28. PMID:35900209. |
the exact mechanism by which apoe gene variants increase/decrease alzheimer's disease (ad) risk is not fully understood, but apoe isoforms differently affect brain homeostasis and neuroinflammation, blood-brain barrier (bbb) permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta (aβ) deposition, and tau-mediated neurodegeneration. |
2022-07-28 |
2023-08-14 |
mouse |
| Jiahui Hou, Jonathan L Hess, Nicola Armstrong, Joshua C Bis, Benjamin Grenier-Boley, Ida K Karlsson, Ganna Leonenko, Katya Numbers, Eleanor K O'Brien, Alexey Shadrin, Anbupalam Thalamuthu, Qiong Yang, Ole A Andreassen, Henry Brodaty, Margaret Gatz, Nicole A Kochan, Jean-Charles Lambert, Simon M Laws, Colin L Masters, Karen A Mather, Nancy L Pedersen, Danielle Posthuma, Perminder S Sachdev, Julie Williams, Chun Chieh Fan, Stephen V Faraone, Christine Fennema-Notestine, Shu-Ju Lin, Valentina Escott-Price, Peter Holmans, Sudha Seshadri, Ming T Tsuang, William S Kremen, Stephen J Glat. Polygenic resilience scores capture protective genetic effects for Alzheimer's disease. Translational psychiatry. vol 12. issue 1. 2022-07-25. PMID:35879306. |
polygenic risk scores (prss) can boost risk prediction in late-onset alzheimer's disease (load) beyond apolipoprotein e (apoe) but have not been leveraged to identify genetic resilience factors. |
2022-07-25 |
2023-08-14 |
Not clear |
| Justin M Long, Dean W Coble, Chengjie Xiong, Suzanne E Schindler, Richard J Perrin, Brian A Gordon, Tammie L S Benzinger, Elizabeth Grant, Anne M Fagan, Oscar Harari, Carlos Cruchaga, David M Holtzman, John C Morri. Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes. Brain : a journal of neurology. 2022-07-22. PMID:35867858. |
cox proportional hazards modeling indicated that preclinical alzheimer disease biomarker status, apoe ɛ4 carrier status, polygenic risk score, and centered age influenced risk of developing cognitive impairment. |
2022-07-22 |
2023-08-14 |
human |
| Senthil Selvaraj, Brian Claggett, Michelle C Johansen, Jonathan W Cunningham, Rebecca F Gottesman, Bing Yu, Eric Boerwinkle, Thomas H Mosley, Amil M Shah, Scott D Solomo. Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study. Journal of cardiac failure. vol 28. issue 7. 2022-07-16. PMID:34965472. |
whether genetic variation in apolipoprotein e (apoe) ɛ4, a common variant associated with alzheimer's disease, is associated with incident heart failure (hf), n-terminal pro-b-type natriuretic peptide (nt-probnp), and cardiac structure and function is unknown. |
2022-07-16 |
2023-08-16 |
Not clear |
| Jordy Sepulveda, Nancy Luo, Matthew Nelson, Christi Anne S Ng, G William Rebec. Independent APOE4 knock-in mouse models display reduced brain APOE protein, altered neuroinflammation, and simplification of dendritic spines. Journal of neurochemistry. 2022-07-15. PMID:35838553. |
apoe is an immunomodulator in the brain and the major genetic risk factor for late onset alzheimer's disease (ad). |
2022-07-15 |
2023-08-14 |
mouse |
| Vijay K Ramanan, Michael G Heckman, Scott A Przybelski, Timothy G Lesnick, Val J Lowe, Jonathan Graff-Radford, M Mielke, Clifford R Jack, David S Knopman, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Polygenic Scores of Alzheimer's Disease Risk Genes Add Only Modestly to APOE in Explaining Variation in Amyloid PET Burden. Journal of Alzheimer's disease : JAD. 2022-07-11. PMID:35811524. |
polygenic scores of alzheimer's disease risk genes add only modestly to apoe in explaining variation in amyloid pet burden. |
2022-07-11 |
2023-08-14 |
Not clear |
| Yang Yu, Man Yang, Xiaoli Zhuang, Jiacheng Pan, Yue Zhao, Yonghao Y. Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia. Brain and behavior. 2022-07-10. PMID:35810473. |
apolipoprotein e (apoe) may play a protective role in neuronal activity and injury repair, whereas its toxic fragments are reported to induce neurodegeneration and neurocognitive impairment in patients with alzheimer's disease (ad). |
2022-07-10 |
2023-08-14 |
mouse |
| Andrew N McCorkindale, Hamish D Mundell, Boris Guennewig, Greg T Sutherlan. Vascular Dysfunction Is Central to Alzheimer's Disease Pathogenesis in APOE e4 Carriers. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806110. |
vascular dysfunction is central to alzheimer's disease pathogenesis in apoe e4 carriers. |
2022-07-09 |
2023-08-14 |
human |
| Alireza Nazarian, Ian Philipp, Irina Culminskaya, Liang He, Alexander M Kulminsk. Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk. GeroScience. 2022-07-09. PMID:35809216. |
inter- and intra-chromosomal modulators of the apoe ɛ2 and ɛ4 effects on the alzheimer's disease risk. |
2022-07-09 |
2023-08-14 |
human |
| Alireza Nazarian, Ian Philipp, Irina Culminskaya, Liang He, Alexander M Kulminsk. Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk. GeroScience. 2022-07-09. PMID:35809216. |
the mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein e (apoe) ε2 and ε4 alleles on alzheimer's disease (ad) have not been fully understood. |
2022-07-09 |
2023-08-14 |
human |
| Amirreza Naseri, Kosar Baghernezhad, Sepideh Seyedi-Sahebari, Seyed Ardalan Alhoseini, Elnaz Gholipour-Khalili, Fatemeh Zafarani, Mahnaz Taleb. The association of apolipoprotein E (ApoE) genotype and cognitive outcomes in multiple sclerosis; a systematic review and meta-analysis. Multiple sclerosis and related disorders. vol 65. 2022-07-08. PMID:35803087. |
apolipoprotein e (apoe) genotype is one of the genetic factors which correlated significantly with cognitive status and it is a well-known risk factor for alzheimer's disease. |
2022-07-08 |
2023-08-14 |
Not clear |
| Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, Jeffery M Vanc. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS genetics. vol 18. issue 7. 2022-07-05. PMID:35788729. |
a locus at 19q13.31 significantly reduces the apoe ε4 risk for alzheimer's disease in african ancestry. |
2022-07-05 |
2023-08-14 |
Not clear |
| Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, Jeffery M Vanc. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS genetics. vol 18. issue 7. 2022-07-05. PMID:35788729. |
african descent populations have a lower alzheimer disease risk from apoe ε4 compared to other populations. |
2022-07-05 |
2023-08-14 |
Not clear |