| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ursula S Sandau, Trevor J McFarland, Sierra J Smith, Douglas R Galasko, Joseph F Quinn, Julie A Saugsta. Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer's Disease Compared to Males. Frontiers in cell and developmental biology. vol 10. 2022-05-16. PMID:35573689. |
differential effects of apoe genotype on microrna cargo of cerebrospinal fluid extracellular vesicles in females with alzheimer's disease compared to males. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yang Yu, M Yang, X Zhuang, J Pan, J Feng, J Yu, Yonghao Y. Neurotoxic 18-kDa apolipoprotein E fragment production contributes to anesthetic sevoflurane-induced tau phosphorylation and neuroinflammation in vitro. Human & experimental toxicology. vol 41. 2022-05-16. PMID:35575159. |
apolipoprotein e (apoe) may play a protective role in neuronal activity and injury repair, whereas its 18-kda fragments are reported to induce neurodegeneration and neuroinflammation in alzheimer's disease patients. |
2022-05-16 |
2023-08-13 |
mouse |
| Katherine L Wagner, Jazmin N Dunlap, Brikena Gusek, Carleton Jones, Delrae M Eckma. Mesenteric Artery Reactivity in Young APOE3 and APOE4 Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555173. |
variant isoforms of apolipoprotein e (apoe) are risk factors for both alzheimer's disease (ad) and cardiovascular disease (cvd), with the apoe4 isoform increasing risk compared to the most common isoform, apoe3. |
2022-05-13 |
2023-08-13 |
mouse |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
thus, apoe expression may be involved in the activation of microglia in alzheimer's disease, eliciting an overactive immune response that accelerates disease progression. |
2022-05-13 |
2023-08-13 |
mouse |
| Botong Shen, Dena G Hernandez, Kumaraswamy Naidu Chitrala, Marie T Fanelli-Kuczmarski, Nicole Noren Hooten, Natasha L Pacheco, Nicolle A Mode, Alan B Zonderman, Ngozi Ezike, Michele K Evan. APOE gene region methylation is associated with cognitive performance in middle-aged urban adults. Neurobiology of aging. vol 116. 2022-05-13. PMID:35561457. |
apolipoprotein (apoe) ε4 allele is a strong risk factor for alzheimer's disease (ad) and cognitive decline. |
2022-05-13 |
2023-08-13 |
Not clear |
| Sopak Supakul, Nicolas Leventoux, Hajime Tabuchi, Masaru Mimura, Daisuke Ito, Sumihiro Maeda, Hideyuki Okan. Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD). Stem cell research. vol 62. 2022-05-10. PMID:35537244. |
herein, we generated the keioi005-a-induced pluripotent stem cell (ipsc) line from urine-derived cells (udcs) of a mild alzheimer's disease (ad) patient with multiple sad risk snps comprising t > c heterozygous apoe ε3/ε4 (rs429358), a > g heterozygous bin1 (rs744373), and t > g homozygous ms4a6a (rs610932). |
2022-05-10 |
2023-08-13 |
Not clear |
| O G Steele, A C Stuart, L Minkley, K Shaw, O Bonnar, S Anderle, A C Penn, J Rusted, L Serpell, C Hall, S Kin. A multi-hit hypothesis for an APOE4-dependent pathophysiological state. The European journal of neuroscience. 2022-05-05. PMID:35510513. |
the apoe gene encoding the apolipoprotein e protein is the single most significant genetic risk factor for late-onset alzheimer's disease. |
2022-05-05 |
2023-08-13 |
Not clear |
| Hyun Kim, Alina Levine, Daniel Cohen, Philip Gehrman, Xi Zhu, Davangere P Devanand, Seonjoo Lee, Terry E Goldber. The Role of Amyloid, Tau, and APOE Genotype on the Relationship Between Informant-Reported Sleep Disturbance and Alzheimer's Disease Risks. Journal of Alzheimer's disease : JAD. 2022-05-02. PMID:35491776. |
the role of amyloid, tau, and apoe genotype on the relationship between informant-reported sleep disturbance and alzheimer's disease risks. |
2022-05-02 |
2023-08-13 |
Not clear |
| Rui Chang, Eugenia Trushina, Kuixi Zhu, Syed Shujaat Ali Zaidi, Branden M Lau, Alexandra Kueider-Paisley, Sara Moein, Qianying He, Melissa L Alamprese, Barbora Vagnerova, Andrew Tang, Ramachandran Vijayan, Yanyun Liu, Andrew J Saykin, Roberta D Brinton, Rima Kaddurah-Daou. Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-04-28. PMID:35481667. |
predictive metabolic networks reveal sex- and apoe genotype-specific metabolic signatures and drivers for precision medicine in alzheimer's disease. |
2022-04-28 |
2023-08-13 |
Not clear |
| Abdel Ali Belaidi, Shashank Masaldan, Adam Southon, Pawel Kalinowski, Karla Acevedo, Ambili T Appukuttan, Stuart Portbury, Peng Lei, Puja Agarwal, Sue E Leurgans, Julie Schneider, Marcus Conrad, Ashley I Bush, Scott Ayto. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Molecular psychiatry. 2022-04-28. PMID:35484240. |
allelic variation to the apoe gene confers the greatest genetic risk for sporadic alzheimer's disease (ad). |
2022-04-28 |
2023-08-13 |
Not clear |
| Song-Yi Park, Veronica Wendy Setiawan, Lon R White, Anna H Wu, Iona Cheng, Christopher A Haiman, Lynne R Wilkens, Loїc Le Marchand, Unhee Li. Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-04-27. PMID:35476309. |
modifying effects of race and ethnicity and apoe on the association of physical activity with risk of alzheimer's disease and related dementias. |
2022-04-27 |
2023-08-13 |
Not clear |
| Christopher E Ramsden, Gregory S Keyes, Elizabeth Calzada, Mark S Horowitz, Daisy Zamora, Jahandar Jahanipour, Andrea Sedlock, Fred E Indig, Ruin Moaddel, Dimitrios Kapogiannis, Dragan Mari. Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer's Disease in Humans. Journal of Alzheimer's disease : JAD. 2022-04-25. PMID:35466940. |
lipid peroxidation induced apoe receptor-ligand disruption as a unifying hypothesis underlying sporadic alzheimer's disease in humans. |
2022-04-25 |
2023-08-13 |
Not clear |
| Christopher E Ramsden, Gregory S Keyes, Elizabeth Calzada, Mark S Horowitz, Daisy Zamora, Jahandar Jahanipour, Andrea Sedlock, Fred E Indig, Ruin Moaddel, Dimitrios Kapogiannis, Dragan Mari. Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer's Disease in Humans. Journal of Alzheimer's disease : JAD. 2022-04-25. PMID:35466940. |
sporadic alzheimer's disease (sad) lacks a unifying hypothesis that can account for the lipid peroxidation observed early in the disease, enrichment of apoe in the core of neuritic plaques, hallmark plaques and tangles, and selective vulnerability of entorhinal-hippocampal structures. |
2022-04-25 |
2023-08-13 |
Not clear |
| Tristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Guilian Xu, Karen McFarland, Benoit I Giasson, Patrick Sullivan, David R Borchelt, Paramita Chakrabart. Impact of APOE genotype on prion-type propagation of tauopathy. Acta neuropathologica communications. vol 10. issue 1. 2022-04-20. PMID:35440098. |
apolipoprotein (apoe) is a major risk factor of alzheimer's disease (ad), with the e2, e3 and e4 isoforms differentially regulating the burden of ad-associated neuropathologies, such as amyloid β and tau. |
2022-04-20 |
2023-08-13 |
mouse |
| Wanrui Wei, Kairong Wang, Jiyuan Shi, Zheng L. The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer's Disease Dementia: An Integrative Review. Biological research for nursing. 2022-04-19. PMID:35439097. |
apolipoprotein e ε4 (apoe ε4) was shown to be a risk factor for mild cognitive impairment (mci) and alzheimer's disease (ad) dementia. |
2022-04-19 |
2023-08-13 |
Not clear |
| Seda Sirin, Serap Nigdelioglu Dolanbay, Belma Asli. The relationship of early- and late-onset Alzheimer's disease genes with COVID-19. Journal of neural transmission (Vienna, Austria : 1996). 2022-04-16. PMID:35429259. |
in addition, alzheimer's disease and covid-19 has a number of common risk factors and comorbid conditions including age, sex, hypertension, diabetes, and the expression of apoe ε4. |
2022-04-16 |
2023-08-13 |
Not clear |
| Isabel J Sible, Daniel A Natio. Visit-to-Visit Blood Pressure Variability and CSF Alzheimer Disease Biomarkers in Cognitively Unimpaired and Mildly Impaired Older Adults. Neurology. 2022-04-14. PMID:35418462. |
the current study examined whether visit-to-visit blood pressure variability is related to csf alzheimer's disease biomarker levels over time, and whether associations differed by apoe ϵ4 carrier status. |
2022-04-14 |
2023-08-13 |
Not clear |
| Andreas Giannisis, Kalicharan Patra, Anna K Edlund, Lur Agirrezabala Nieto, Joan Benedicto-Gras, Simon Moussaud, Andrés de la Rosa, Daniel Twohig, Tore Bengtsson, Yuan Fu, Guojun Bu, Greg Bial, Lander Foquet, Christina Hammarstedt, Stephen Strom, Kristina Kannisto, Jacob Raber, Ewa Ellis, Henrietta M Nielse. Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice. Molecular psychiatry. 2022-04-14. PMID:35418601. |
liver-generated plasma apolipoprotein e (apoe) does not enter the brain but nonetheless correlates with alzheimer's disease (ad) risk and ad biomarker levels. |
2022-04-14 |
2023-08-13 |
mouse |
| Laura E Korthauer, Robert P Giugliano, Jianping Guo, Marc S Sabatine, Peter Sever, Anthony Keech, Dan Atar, Christopher Kurtz, Christian T Ruff, Francois Mach, Brian R Ot. No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab. PloS one. vol 17. issue 4. 2022-04-11. PMID:35404972. |
apoe encodes a cholesterol transporter, and the ε4 allele is associated with higher circulating cholesterol levels, ß-amyloid burden, and risk of alzheimer's disease. |
2022-04-11 |
2023-08-13 |
human |
| Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Williams, Henrik Zetterberg, Valentina Escott-Pric. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain : a journal of neurology. 2022-04-06. PMID:35383826. |
the prediction accuracy of alzheimer's disease clinical diagnosis by the combination of all biomarkers, apoe and polygenic risk score reached auc=0.81, with the most significant contributors being ε4, aβ40 or aβ42, gfap and nfl. |
2022-04-06 |
2023-08-13 |
Not clear |