| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
the apoe locus is strongly associated with risk for developing alzheimer's disease and dementia with lewy bodies. |
2022-04-05 |
2023-08-13 |
Not clear |
| Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W Schol. Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups. Brain : a journal of neurology. 2022-04-05. PMID:35381062. |
our examination found that apoe ε4 was associated with dementia with lewy bodies + alzheimer's disease (p = 1.29 × 10-32, or = 4.25, 95% ci = 3.35-5.39) and dementia with lewy bodies + intermediate alzheimer's disease (p = 0.0011, or = 2.31, 95% ci = 1.40-3.83), but not with pure dementia with lewy bodies (p = 0.31, or = 0.75, 95% ci = 0.43-1.30). |
2022-04-05 |
2023-08-13 |
Not clear |
| Matthew D Cykowski, Anithachristy S Arumanayagam, Suzanne Z Powell, Andreana L Rivera, Erin L Abner, Gustavo C Roman, Joseph C Masdeu, Peter T Nelso. Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies. Acta neuropathologica. 2022-04-02. PMID:35366087. |
the most common patterns were: pattern 1, with lamina ii tdp-43 + processes and preinclusion pathology in cortices of the amygdala region, and frequent late-nc stage 3 with hs; pattern 2, previously described as type-β, with neurofibrillary tangle-like tdp-43 neuronal cytoplasmic inclusions (ncis), high alzheimer's disease neuropathologic change (adnc), frequent apoe ε4, and usually late-nc stage 2; pattern 3, with round ncis and thick neurites in amygdala, younger age at death, and often comorbid lewy body disease; and pattern 4 (the most common pattern), with tortuous tdp-43 processes in subpial and wm regions, low adnc, rare hs, and lower dementia probability. |
2022-04-02 |
2023-08-13 |
human |
| Jonathan Blackman, Seth Love, Lindsey Sinclair, Richard Cain, Elizabeth Coulthar. APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia. Alzheimer's research & therapy. vol 14. issue 1. 2022-03-31. PMID:35354468. |
apoe ε4, alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia. |
2022-03-31 |
2023-08-13 |
Not clear |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Yuka A Martens, Na Zhao, Chia-Chen Liu, Takahisa Kanekiyo, Austin J Yang, Alison M Goate, David M Holtzman, Guojun B. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias. Neuron. 2022-03-17. PMID:35298921. |
apoe cascade hypothesis in the pathogenesis of alzheimer's disease and related dementias. |
2022-03-17 |
2023-08-13 |
Not clear |
| Maud Gratuze, Hong Jiang, Chanung Wang, Monica Xiong, Xin Bao, David M Holtzma. APOE antibody inhibits Aβ-associated tau seeding and spreading in a mouse model. Annals of neurology. 2022-03-14. PMID:35285073. |
apoe is the strongest genetic factor for late-onset alzheimer's disease (ad). |
2022-03-14 |
2023-08-13 |
mouse |
| Fabricio Ferreira de Oliveira, Sandro Soares de Almeida, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. APOE ε4 Carrier Status as Mediator of Effects of Psychotropic Drugs on Clinical Changes in Patients With Alzheimer's Disease. The Journal of neuropsychiatry and clinical neurosciences. 2022-03-11. PMID:35272493. |
apoe ε4 carrier status as mediator of effects of psychotropic drugs on clinical changes in patients with alzheimer's disease. |
2022-03-11 |
2023-08-13 |
Not clear |
| Fabricio Ferreira de Oliveira, Sandro Soares de Almeida, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. APOE ε4 Carrier Status as Mediator of Effects of Psychotropic Drugs on Clinical Changes in Patients With Alzheimer's Disease. The Journal of neuropsychiatry and clinical neurosciences. 2022-03-11. PMID:35272493. |
this study aimed to assess the prospective effects of psychotropic drugs on cognitive and functional changes in alzheimer's disease according to apoe ε4 carrier status. |
2022-03-11 |
2023-08-13 |
Not clear |
| Tyler C Hammond, Xin Xing, Lucy M Yanckello, Arnold Stromberg, Ya-Hsuan Chang, Peter T Nelson, Ai-Ling Li. Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer's Disease. Journal of cellular immunology. vol 3. issue 6. 2022-03-10. PMID:35265943. |
human gray and white matter metabolomics to differentiate apoe and stage dependent changes in alzheimer's disease. |
2022-03-10 |
2023-08-13 |
human |
| Yingzhe Cheng, Yuanjing Li, Xiaoyan Liang, Pin Wang, Wenxin Fa, Cuicui Liu, Yongxiang Wang, Keke Liu, Nan Wang, Yifeng D. Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer's Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study. Clinical interventions in aging. vol 17. 2022-03-03. PMID:35237031. |
genetic effects of ndufaf6 rs6982393 and apoe on alzheimer's disease in chinese rural elderly: a cross-sectional population-based study. |
2022-03-03 |
2023-08-13 |
Not clear |
| Samira Parhizkar, David M Holtzma. APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease. Seminars in immunology. 2022-03-02. PMID:35232622. |
apoe mediated neuroinflammation and neurodegeneration in alzheimer's disease. |
2022-03-02 |
2023-08-13 |
Not clear |
| Jenny Ortega-Rojas, Carlos E Arboleda-Bustos, Esneyder Guerrero, Juan Neira, Humberto Arboled. Genetic Variants and Haplotypes of TOMM40, APOE, and APOC1 are Related to the Age of Onset of Late-onset Alzheimer Disease in a Colombian Population. Alzheimer disease and associated disorders. 2022-02-12. PMID:35149606. |
genetic variants and haplotypes of tomm40, apoe, and apoc1 are related to the age of onset of late-onset alzheimer disease in a colombian population. |
2022-02-12 |
2023-08-13 |
Not clear |
| Jenny Ortega-Rojas, Carlos E Arboleda-Bustos, Esneyder Guerrero, Juan Neira, Humberto Arboled. Genetic Variants and Haplotypes of TOMM40, APOE, and APOC1 are Related to the Age of Onset of Late-onset Alzheimer Disease in a Colombian Population. Alzheimer disease and associated disorders. 2022-02-12. PMID:35149606. |
the apolipoprotein e (apoe) gene is the main risk factor for late-onset alzheimer disease (load). |
2022-02-12 |
2023-08-13 |
Not clear |
| Rong Zhang, Xiaojiao Xu, Hang Yu, Xiaolan Xu, Manli Wang, Weidong L. Factors Influencing Alzheimer's Disease Risk: Whether and How They are Related to the APOE Genotype. Neuroscience bulletin. 2022-02-12. PMID:35149974. |
factors influencing alzheimer's disease risk: whether and how they are related to the apoe genotype. |
2022-02-12 |
2023-08-13 |
Not clear |
| Rebecca Panitch, Junming Hu, Weiming Xia, David A Bennett, Thor D Stein, Lindsay A Farrer, Gyungah R Ju. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-02-10. PMID:35139885. |
blood and brain transcriptome analysis reveals apoe genotype-mediated and immune-related pathways involved in alzheimer disease. |
2022-02-10 |
2023-08-13 |
Not clear |
| Gyungah R Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David A Bennett, Tatiana M Foroud, Li-San Wang, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Rhoda Au, Kathryn L Lunetta, Tsuneya Ikezu, Thor D Stein, Lindsay A Farre. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142023. |
protein phosphatase 2a and complement component 4 are linked to the protective effect of apoe ɛ2 for alzheimer's disease. |
2022-02-10 |
2023-08-13 |
Not clear |
| Gyungah R Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, David A Bennett, Tatiana M Foroud, Li-San Wang, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Rhoda Au, Kathryn L Lunetta, Tsuneya Ikezu, Thor D Stein, Lindsay A Farre. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142023. |
the apolipoprotein e (apoe) ɛ2 allele reduces risk against alzheimer's disease (ad) but mechanisms underlying this effect are largely unknown. |
2022-02-10 |
2023-08-13 |
Not clear |
| Astrid Suchy-Dicey, Barbara Howard, W T Longstreth, Eric M Reiman, Dedra Buchwal. APOE genotype, hippocampus, and cognitive markers of Alzheimer's disease in American Indians: Data from the Strong Heart Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142437. |
apoe genotype, hippocampus, and cognitive markers of alzheimer's disease in american indians: data from the strong heart study. |
2022-02-10 |
2023-08-13 |
Not clear |
| Astrid Suchy-Dicey, Barbara Howard, W T Longstreth, Eric M Reiman, Dedra Buchwal. APOE genotype, hippocampus, and cognitive markers of Alzheimer's disease in American Indians: Data from the Strong Heart Study. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-02-10. PMID:35142437. |
the apolipoprotein e (apoe) ε4 allele confers higher risk of neurodegeneration and alzheimer's disease (ad), but differs by race/ethnicity. |
2022-02-10 |
2023-08-13 |
Not clear |