| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Sebastian, S Sylvestre, N Sundaraganesan, B Karthikeyan, S Silva. Conformational analysis, molecular structure, spectroscopic, NBO, reactivity descriptors, wavefunction and molecular docking investigations of 5,6-dimethoxy-1-indanone: A potential anti Alzheimer's agent. Heliyon. vol 8. issue 1. 2022-02-07. PMID:35128106. |
molecular docking results suggest that 5,6-dmi may exhibit inhibitory activity against apoe protein and may act as potential against alzheimer's disease. |
2022-02-07 |
2023-08-13 |
Not clear |
| Valéria Sutti Nunes, Guilherme da Silva Ferreira, Eder Carlos Rocha Quintã. Cholesterol metabolism in aging simultaneously altered in liver and nervous system. Aging. vol 14. issue undefined. 2022-02-07. PMID:35130181. |
apolipoprotein e (apoe) is important in transporting cholesterol from astrocytes to neurons in the etiology of sporadic alzheimer's disease, an aging-related dementia. |
2022-02-07 |
2023-08-13 |
mouse |
| Michael E Belloy, Sarah J Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M Arfan Ikram, Alfredo Ramirez, Anthoula C Tsolaki, Giacomina Rossi, Iris E Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M van der Flier, Jean-Charles Lambert, Zihuai He, Summer S Han, Valerio Napolioni, Michael D Greiciu. Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping. Alzheimer's research & therapy. vol 14. issue 1. 2022-02-05. PMID:35120553. |
genetic variants within the apoe locus may modulate alzheimer's disease (ad) risk independently or in conjunction with apoe*2/3/4 genotypes. |
2022-02-05 |
2023-08-13 |
Not clear |
| Javier Oltra-Cucarella, Miriam Sánchez-SanSegundo, Rosario Ferrer-Cascale. Predicting Alzheimer's disease with practice effects, APOE genotype and brain metabolism. Neurobiology of aging. vol 112. 2022-02-05. PMID:35121484. |
predicting alzheimer's disease with practice effects, apoe genotype and brain metabolism. |
2022-02-05 |
2023-08-13 |
Not clear |
| Javier Oltra-Cucarella, Miriam Sánchez-SanSegundo, Rosario Ferrer-Cascale. Predicting Alzheimer's disease with practice effects, APOE genotype and brain metabolism. Neurobiology of aging. vol 112. 2022-02-05. PMID:35121484. |
predicting progression to alzheimer's disease with practice effects, apoe genotype and brain metabolism [neurobiol aging, 2018; 71:234-240] was published, we identified a coding error of one of the variables analyzed. |
2022-02-05 |
2023-08-13 |
Not clear |
| Hunter B Dean, Thomas Brett, Erik D Roberson, Yuhua Son. Developing a functionally valid model of the TREM2-APOE complex to better understand its role in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108854. |
triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are the most potent genetic risk factors for late-onset alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Gillian Coughlan, Ryan Larsen, Min Kim, David White, Rachel Gillings, Michael Irvine, Andrew Scholey, Neal Cohen, Cristina Legido-Quigley, Michael Hornberger, Anne-Maire Minihan. APOE ε4 alters docosahexaenoic acid's influence on preclinical markers of Alzheimer disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108870. |
apoe ε4 alters docosahexaenoic acid's influence on preclinical markers of alzheimer disease. |
2022-02-03 |
2023-08-13 |
human |
| Michael E Belloy, Sarah J Eger, Yann Le Guen, Gabriel Kennedy, Zihuai He, Valerio Napolioni, Michael D Greiciu. APOE*4-stratified genome-wide association study of Alzheimer's disease in over 350,000 individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108901. |
apoe*4-stratified genome-wide association study of alzheimer's disease in over 350,000 individuals. |
2022-02-03 |
2023-08-13 |
Not clear |
| Michael E Belloy, Sarah J Eger, Yann Le Guen, Gabriel Kennedy, Zihuai He, Valerio Napolioni, Michael D Greiciu. APOE*4-stratified genome-wide association study of Alzheimer's disease in over 350,000 individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108901. |
apoe*4 is the strongest genetic risk factor for late-onset alzheimer's disease (ad) and is highly pleiotropic, such that it may be considered as a biological factor that can affect overall genetic risk for ad. |
2022-02-03 |
2023-08-13 |
Not clear |
| Jillian L King, David Anderson, Jigang Zhang, Maria Telpoukhovskaia, Niran Hadad, Amy R Dunn, Logan Dumitrescu, Timothy J Hohman, Kristen Ms O'Connell, Vivek M Philip, Catherine C Kaczorowsk. APOE variant in the receptor binding domain confers cognitive resilience to familial Alzheimer's mutations and cell-type specific gene expression changes in the hippocampus. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108927. |
apoe variant in the receptor binding domain confers cognitive resilience to familial alzheimer's mutations and cell-type specific gene expression changes in the hippocampus. |
2022-02-03 |
2023-08-13 |
Not clear |
| Amir Fazlollahi, Ying Xia, Michelle K Lupton, Parnesh Raniga, Pierrick Bourgeat, Nick Martin, Vincent Dore, Stephen Rose, Olivier Salvado, Michael Breakspear, Jurgen Frip. Early effects of amyloid-β on structural and vascular brain changes in mid-life cognitively unimpaired individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108994. |
the apolipoprotein e (apoe) is the strongest genetic risk factor for late-onset alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Jianping Jia, Longfei Jia, Jie Lu, Hui Xu, Fangyu Li, Shuoqi Chen, Xiu Wang, Jianwei Yang, Wei Qin, Qiumin Qu, Lan Chu, Yan-Jiang Wang, Lu Shen, Chunkui Zhou, Honglei Li, Dantao Peng, Lan Tan, Benyan Luo, Qihao Guo, Muni Tan. The genetic risk effects of APOE ε4 and novel variants on Chinese familial and sporadic AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109005. |
the genetic risk effects of apolipoprotein e (apoe) on familial alzheimer's disease (fad) with or without gene mutations, sporadic ad (sad), and normal controls (nc) remain unclear in the chinese population. |
2022-02-03 |
2023-08-13 |
Not clear |
| Max A Thorwald, Mafalda Cacciottolo, Henry Jay Forman, Todd E Morgan, Caleb E Finc. Reductions in ApoE and GPx4 highlight the Alzheimer's disease lipid raft vulnerability. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109007. |
reductions in apoe and gpx4 highlight the alzheimer's disease lipid raft vulnerability. |
2022-02-03 |
2023-08-13 |
human |
| Tyler C Hammond, Stephanie Ham, Lucille M Yanckello, Arnold Stromberg, Peter T Nelson, Ai-Ling Li. Human gray and white matter metabolomics to differentiate APOE-dependent metabolic changes in early and late Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109115. |
here we perform a metabolomics analysis on the brain tissue of a large cohort of community-based participants in the uk-adc brain bank to characterize the biochemical profiles of brains with and without alzheimer's disease and other mixed pathologies based on apoe genotype and disease stage. |
2022-02-03 |
2023-08-13 |
human |
| Sabine C Konings, Emma Mc Nyberg, Isak Martinsson, Gunnar K Goura. Neurobiological role of Alzheimer's disease genetic risk factor ApoE on early synaptic changes in Alzheimer-like models. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109139. |
neurobiological role of alzheimer's disease genetic risk factor apoe on early synaptic changes in alzheimer-like models. |
2022-02-03 |
2023-08-13 |
mouse |
| Boyang Li, Shaowei Wang, Bilal E Kerman, David A Bennett, Zoe Arvanitakis, Hussein N Yassin. Mechanisms of endosomal dysfunction in APOE4. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109161. |
lipid poor apolipoprotein e (apoe) aggregates are central to the pathogenesis of alzheimer's disease (ad), promoting cerebral amyloid-β plaques formation, and altering endosomal recycling of apoe complexed proteins. |
2022-02-03 |
2023-08-13 |
Not clear |
| Rebecca Panitch, Junming Hu, Lindsay A Farrer, Gyungah R Ju. Multivariate analysis of blood and brain transcriptome in Alzheimer's reveals unique APOE ε4-related immune pathways. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109177. |
multivariate analysis of blood and brain transcriptome in alzheimer's reveals unique apoe ε4-related immune pathways. |
2022-02-03 |
2023-08-13 |
Not clear |
| Farid Rajabli, Brian W Kunkle, Christiane Reitz, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Kara L Hamilton-Nelson, Gary W Beecham, Margaret A Pericak-Vance, Jeffery M Vanc. African locus reduces the effect of ApoE ε4 allele in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109241. |
african locus reduces the effect of apoe ε4 allele in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Farid Rajabli, Brian W Kunkle, Christiane Reitz, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Kara L Hamilton-Nelson, Gary W Beecham, Margaret A Pericak-Vance, Jeffery M Vanc. African locus reduces the effect of ApoE ε4 allele in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109241. |
strong associations between apoe ε4 and alzheimer disease (ad) risk have been confirmed worldwide, but there is variability in the effect size across populations. |
2022-02-03 |
2023-08-13 |
Not clear |
| Jaya Bagari. Identification of a novel APOE mutation in one Korean male patient. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109268. |
a novel apoe mutation with leucine-to-proline exchange was identified in a 54-year-old korean male patient predominantly suffering with early onset alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |