| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, Jeffery M Vanc. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS genetics. vol 18. issue 7. 2022-07-05. PMID:35788729. |
the presence of the rs10423769_a allele reduces the odds ratio for alzheimer disease risk from 7.2 for apoe ε4/ε4 carriers lacking the a allele to 2.1 for apoe ε4/ε4 carriers with at least one a allele. |
2022-07-05 |
2023-08-14 |
Not clear |
| Farid Rajabli, Gary W Beecham, Hugh C Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A Kushch, Marina Lipkin-Vasquez, Kara L Hamilton-Nelson, Juan I Young, Derek M Dykxhoorn, Karen Nuytemans, Brian W Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E Feliciano-Astacio, Gerard D Schellenberg, Clifton L Dalgard, Anthony J Griswold, Goldie S Byrd, Christiane Reitz, Michael L Cuccaro, Jonathan L Haines, Margaret A Pericak-Vance, Jeffery M Vanc. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS genetics. vol 18. issue 7. 2022-07-05. PMID:35788729. |
this study identified a new african-ancestry specific locus that reduces the risk effect of apoe ε4 for developing alzheimer disease. |
2022-07-05 |
2023-08-14 |
Not clear |
| Noah R Johnson, Athena C-J Wang, Christina Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil Markham, Cody Allen, A Ranjitha Dhanasekaran, Heidi J Chial, Huntington Potte. Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer's disease cognition. Alzheimer's research & therapy. vol 14. issue 1. 2022-06-29. PMID:35768831. |
the apolipoprotein e (apoe) ε4 allele confers the strongest risk for late-onset alzheimer's disease (ad) besides age itself, but the mechanisms underlying this risk are debated. |
2022-06-29 |
2023-08-14 |
Not clear |
| Jaya Bagaria, Yeonsil Moon, Eva Bagyinszky, Kyu Hwan Shim, Seong Soo A An, SangYun Kim, Seol Heui Ha. Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease. Frontiers in neurology. vol 13. 2022-06-27. PMID:35756922. |
whole exome sequencing reveals a novel apoe mutation in a patient with sporadic early-onset alzheimer's disease. |
2022-06-27 |
2023-08-14 |
Not clear |
| Jaya Bagaria, Yeonsil Moon, Eva Bagyinszky, Kyu Hwan Shim, Seong Soo A An, SangYun Kim, Seol Heui Ha. Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease. Frontiers in neurology. vol 13. 2022-06-27. PMID:35756922. |
apolipoprotein (apoe) is implicated and verified as the main risk factor for early-onset alzheimer's disease (ad). |
2022-06-27 |
2023-08-14 |
Not clear |
| Catherine Schramm, Camille Charbonnier, Aline Zaréa, Morgane Lacour, David Wallon, Anne Boland, Jean-François Deleuze, Robert Olaso, Flora Alarcon, Dominique Campion, Grégory Nuel, Gaël Nicola. Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes. Genome medicine. vol 14. issue 1. 2022-06-27. PMID:35761418. |
penetrance estimation of alzheimer disease in sorl1 loss-of-function variant carriers using a family-based strategy and stratification by apoe genotypes. |
2022-06-27 |
2023-08-14 |
Not clear |
| Garam Kim, Aaron D Gitle. APOE told me put my fat in the bag and nobody gets hurt. Cell. vol 185. issue 13. 2022-06-24. PMID:35750028. |
the ε4 variant in the apoe gene is the strongest genetic risk factor for alzheimer's disease. |
2022-06-24 |
2023-08-14 |
Not clear |
| Neha Atulkumar Singh, Nirubol Tosakulwong, Jonathan Graff-Radford, Mary M Machulda, Nha Trang Thu Pham, Irene Sintini, Stephen D Weigand, Christopher G Schwarz, Matthew L Senjem, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. APOE ε4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-06-12. PMID:35691047. |
apoe ε4 influences medial temporal atrophy and tau deposition in atypical alzheimer's disease. |
2022-06-12 |
2023-08-14 |
Not clear |
| Neha Atulkumar Singh, Nirubol Tosakulwong, Jonathan Graff-Radford, Mary M Machulda, Nha Trang Thu Pham, Irene Sintini, Stephen D Weigand, Christopher G Schwarz, Matthew L Senjem, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. APOE ε4 influences medial temporal atrophy and tau deposition in atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-06-12. PMID:35691047. |
apolipoprotein e (apoe) ε4 is an important genetic risk factor for typical alzheimer's disease (ad), influencing brain volume and tau burden. |
2022-06-12 |
2023-08-14 |
Not clear |
| Inés López-Cuenca, Elena Salobrar-García, Lidia Sánchez-Puebla, Eva Espejel, Lucía García Del Arco, Pilar Rojas, Lorena Elvira-Hurtado, José A Fernández-Albarral, Federico Ramírez-Toraño, Ana Barabash, Juan J Salazar, José M Ramírez, Rosa de Hoz, Ana I Ramíre. Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer's Disease and Cardiovascular Risk Factors. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683633. |
in 103 subjects with a high genetic risk of developing alzheimer's disease (ad), family history (fh) of ad and apoe ɛ4 characterization (apoe ɛ4) were analyzed for changes in the retinal vascular network by octa (optical coherence tomography angiography), and angiotool and erlangen-angio-tool (ea-tool) as imaging analysis software. |
2022-06-10 |
2023-08-14 |
human |
| Jorge J Llibre-Guerra, Jing Li, Yuting Qian, Juan de Jesús Llibre-Rodriguez, Ivonne Z Jiménez-Velázquez, Daisy Acosta, Aquiles Salas, Juan Carlos Llibre-Guerra, Adolfo Valvuerdi, Amal Harrati, Jordan Weiss, Mao-Mei Liu, William H Do. Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-06-06. PMID:35661582. |
apolipoprotein e (apoe) is considered the major susceptibility gene for developing alzheimer's disease. |
2022-06-06 |
2023-08-14 |
Not clear |
| Joost M Riphagen, Roy W E van Hooren, Gunter Kenis, Frans R J Verhey, Heidi I L Jacob. Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology. Journal of Alzheimer's disease : JAD. 2022-06-06. PMID:35662115. |
we used cerebrospinal fluid (csf) amyloid-β (aβ)42 and phosphorylated tau (p-tau) to investigate associations with bdnf polymorphisms and modifications by apoe ɛ4 or inflammation in a memory clinic population (n = 114; subjective cognitive decline, mild cognitive impairment, alzheimer's disease). |
2022-06-06 |
2023-08-14 |
Not clear |
| Joost M Riphagen, Roy W E van Hooren, Gunter Kenis, Frans R J Verhey, Heidi I L Jacob. Distinct Patterns Link the BDNF Val66Met Polymorphism to Alzheimer's Disease Pathology. Journal of Alzheimer's disease : JAD. 2022-06-06. PMID:35662115. |
we found distinct pathways to alzheimer's disease pathology: val-met displayed lower csf-aβ 42 in apoe ɛ4+ carriers, independent of p-tau, while val-val displayed greater p-tau at higher il-6 and sub-threshold aβ 42. |
2022-06-06 |
2023-08-14 |
Not clear |
| Javier de la Fuente, Andrew D Grotzinger, Riccardo E Marioni, Michel G Nivard, Elliot M Tucker-Dro. Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region. PLoS genetics. vol 18. issue 6. 2022-06-03. PMID:35658006. |
integrated analysis of direct and proxy genome wide association studies highlights polygenicity of alzheimer's disease outside of the apoe region. |
2022-06-03 |
2023-08-14 |
Not clear |
| Yann Le Guen, Michael E Belloy, Benjamin Grenier-Boley, Itziar de Rojas, Atahualpa Castillo-Morales, Iris Jansen, Aude Nicolas, Céline Bellenguez, Carolina Dalmasso, Fahri Küçükali, Sarah J Eger, Katrine Laura Rasmussen, Jesper Qvist Thomassen, Jean-François Deleuze, Zihuai He, Valerio Napolioni, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Cornelia van Duijn, Magda Tsolaki, Pascual Sánchez-Juan, Kristel Sleegers, Martin Ingelsson, Giacomina Rossi, Mikko Hiltunen, Rebecca Sims, Wiesje M van der Flier, Alfredo Ramirez, Ole A Andreassen, Ruth Frikke-Schmidt, Julie Williams, Agustín Ruiz, Jean-Charles Lambert, Michael D Greicius, Beatrice Arosio, Luisa Benussi, Anne Boland, Barbara Borroni, Paolo Caffarra, Delphine Daian, Antonio Daniele, Stéphanie Debette, Carole Dufouil, Emrah Düzel, Daniela Galimberti, Vilmantas Giedraitis, Timo Grimmer, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Deckert Jürgen, Teemu Kuulasmaa, Aad van der Lugt, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Susanne Moebus, Benedetta Nacmias, Gael Nicolas, Robert Olaso, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Oliver Peters, Yolande A L Pijnenburg, Julius Popp, Innocenzo Rainero, Inez Ramakers, Steffi Riedel-Heller, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Hilkka Soininen, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Thomas J Tegos, Lucio Tremolizzo, Frans Verhey, Martin Vyhnalek, Jens Wiltfang, Mercè Boada, Pablo García-González, Raquel Puerta, Luis M Real, Victoria Álvarez, María J Bullido, Jordi Clarimon, José María García-Alberca, Pablo Mir, Fermin Moreno, Pau Pastor, Gerard Piñol-Ripoll, Laura Molina-Porcel, Jordi Pérez-Tur, Eloy Rodríguez-Rodríguez, Jose Luís Royo, Raquel Sánchez-Valle, Martin Dichgans, Dan Rujesc. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA neurology. 2022-05-31. PMID:35639372. |
association of rare apoe missense variants v236e and r251g with risk of alzheimer disease. |
2022-05-31 |
2023-08-13 |
Not clear |
| Yann Le Guen, Michael E Belloy, Benjamin Grenier-Boley, Itziar de Rojas, Atahualpa Castillo-Morales, Iris Jansen, Aude Nicolas, Céline Bellenguez, Carolina Dalmasso, Fahri Küçükali, Sarah J Eger, Katrine Laura Rasmussen, Jesper Qvist Thomassen, Jean-François Deleuze, Zihuai He, Valerio Napolioni, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Cornelia van Duijn, Magda Tsolaki, Pascual Sánchez-Juan, Kristel Sleegers, Martin Ingelsson, Giacomina Rossi, Mikko Hiltunen, Rebecca Sims, Wiesje M van der Flier, Alfredo Ramirez, Ole A Andreassen, Ruth Frikke-Schmidt, Julie Williams, Agustín Ruiz, Jean-Charles Lambert, Michael D Greicius, Beatrice Arosio, Luisa Benussi, Anne Boland, Barbara Borroni, Paolo Caffarra, Delphine Daian, Antonio Daniele, Stéphanie Debette, Carole Dufouil, Emrah Düzel, Daniela Galimberti, Vilmantas Giedraitis, Timo Grimmer, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Deckert Jürgen, Teemu Kuulasmaa, Aad van der Lugt, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Susanne Moebus, Benedetta Nacmias, Gael Nicolas, Robert Olaso, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Oliver Peters, Yolande A L Pijnenburg, Julius Popp, Innocenzo Rainero, Inez Ramakers, Steffi Riedel-Heller, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Hilkka Soininen, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Thomas J Tegos, Lucio Tremolizzo, Frans Verhey, Martin Vyhnalek, Jens Wiltfang, Mercè Boada, Pablo García-González, Raquel Puerta, Luis M Real, Victoria Álvarez, María J Bullido, Jordi Clarimon, José María García-Alberca, Pablo Mir, Fermin Moreno, Pau Pastor, Gerard Piñol-Ripoll, Laura Molina-Porcel, Jordi Pérez-Tur, Eloy Rodríguez-Rodríguez, Jose Luís Royo, Raquel Sánchez-Valle, Martin Dichgans, Dan Rujesc. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA neurology. 2022-05-31. PMID:35639372. |
the apoe ε2 and apoe ε4 alleles are the strongest protective and risk-increasing, respectively, genetic variants for late-onset alzheimer disease (ad). |
2022-05-31 |
2023-08-13 |
Not clear |
| Gil D Rabinovici, Dena B Duba. Rare APOE Missense Variants-Can We Overcome APOE ε4 and Alzheimer Disease Risk? JAMA neurology. 2022-05-31. PMID:35639398. |
rare apoe missense variants-can we overcome apoe ε4 and alzheimer disease risk? |
2022-05-31 |
2023-08-13 |
Not clear |
| Dandan Wang, Chang Xu, Wenxiao Wang, Hui Lu, Junying Zhang, Furu Liang, Xin L. The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients. Brain sciences. vol 12. issue 5. 2022-05-28. PMID:35624902. |
allele 4 of the apolipoprotein e gene (apoe ε4) and hypertension are considered risk factors for alzheimer's disease (ad). |
2022-05-28 |
2023-08-13 |
Not clear |
| Inés López-Cuenca, Elena Salobrar-García, Inés Gil-Salgado, Lidia Sánchez-Puebla, Lorena Elvira-Hurtado, José A Fernández-Albarral, Federico Ramírez-Toraño, Ana Barabash, Jaisalmer de Frutos-Lucas, Juan J Salazar, José M Ramírez, Ana I Ramírez, Rosa de Ho. Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer's Disease: An Exploratory Analysis. Journal of personalized medicine. vol 12. issue 5. 2022-05-28. PMID:35629270. |
having a family history (fh+) of alzheimer's disease (ad) and being a carrier of at least one ɛ4 allele of the apoe gene are two of the main risk factors for the development of ad. |
2022-05-28 |
2023-08-13 |
human |
| Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Carlos Cruchag. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk. PloS one. vol 17. issue 5. 2022-05-26. PMID:35617280. |
two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the klotho (kl) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with alzheimer disease (ad) risk in cognitively normal participants who are apoe ε4 carriers. |
2022-05-26 |
2023-08-13 |
human |