| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdo. APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia. PLoS biology. vol 20. issue 12. 2022-12-13. PMID:36512526. |
by leveraging the power of the approximately 40,000 participants of the uk biobank cohort, we assessed impacts from the protective apoe ɛ2 and the deleterious apoe ɛ4 alzheimer's disease alleles on these structural relationships. |
2022-12-13 |
2023-08-14 |
human |
| Jermon A Drake, John M Jakicic, Renee J Rogers, Sarah L Aghjayan, Chelsea M Stillman, Shannon D Donofry, Kathryn A Roecklein, Wei Lang, Kirk I Erickso. Reduced brain activity during a working memory task in middle-aged apolipoprotein E ε4 carriers with overweight/obesity. Frontiers in human neuroscience. vol 16. 2022-12-12. PMID:36504632. |
the apolipoprotein e ε4 (apoe ε4) allele and midlife obesity are independent risk factors for alzheimer's disease (ad). |
2022-12-12 |
2023-08-14 |
Not clear |
| Boung Chul Lee, Young Min Choe, Guk-Hee Suh, Ihn-Geun Choi, Jun Ho Lee, Hyun Soo Kim, Jaeuk Hwang, Dahyun Yi, Jee Wook Ki. A combination of midlife diabetes mellitus and the apolipoprotein E ε4 allele increase risk for cognitive decline. Frontiers in aging neuroscience. vol 14. 2022-12-05. PMID:36466611. |
it has been suggested that diabetes mellitus (dm) and the apolipoprotein e (apoe) ε4 allele (apoe4) increase the risk for alzheimer's disease (ad) and cognitive decline. |
2022-12-05 |
2023-08-14 |
Not clear |
| b' Gonzalo Forno, Jose Contador, Agn\\xc3\\xa8s P\\xc3\\xa9rez-Millan, Nuria Guillen, Neus Falg\\xc3\\xa0s, Jordi Sarto, Adri\\xc3\\xa0 Tort-Merino, Magdalena Castellv\\xc3\\xad, Beatriz Bosch, Guadalupe Fern\\xc3\\xa1ndez-Villullas, Mircea Balasa, Anna Antonell, Roser Sala-Llonch, Raquel Sanchez-Valle, Michael Hornberger, Albert Llad\\xc3\\xb. The APOE4 effect: Structural brain differences in Alzheimer\'s disease according to the age at symptom onset. European journal of neurology. 2022-12-04. PMID:36463489.' |
assess how apoe genotype can differentially affect cortical and subcortical memory structures in biomarker-confirmed early and late-onset alzheimer's disease (eoad-load). |
2022-12-04 |
2023-08-14 |
Not clear |
| T L Stephen, B Breningstall, S Suresh, C J McGill, C J Pik. APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer's disease mice. Journal of neuroinflammation. vol 19. issue 1. 2022-12-02. PMID:36457019. |
apoe genotype and biological sex regulate astroglial interactions with amyloid plaques in alzheimer's disease mice. |
2022-12-02 |
2023-08-14 |
mouse |
| Jason A Watts, Christopher Grunseich, Yesenia Rodriguez, Yaojuan Liu, Dongjun Li, Joshua T Burdick, Alan Bruzel, Robert J Crouch, Robert W Mahley, Samuel H Wilson, Vivian G Cheun. A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE. Nucleic acids research. 2022-12-01. PMID:36453989. |
dna sequence variants in aancr are associated significantly with apoe expression and alzheimer's disease, thus aancr is a modifier of alzheimer's disease. |
2022-12-01 |
2023-08-14 |
human |
| Weihua Li, Runtian Li, Shaozhen Yan, Zhilian Zhao, Yi Shan, Zhigang Qi, Jie L. Effect of APOE ε4 genotype on amyloid-β, glucose metabolism, and grey matter volume in cognitively normal individuals and amnestic mild cognitive impairment. European journal of neurology. 2022-11-30. PMID:36448771. |
the presence of apolipoprotein e ε4 (apoe ε4) is associated with an increased risk of developing alzheimer's disease (ad). |
2022-11-30 |
2023-08-14 |
Not clear |
| Claire J C Huguenard, Adam Cseresznye, James E Evans, Teresa Darcey, Aurore Nkiliza, Andrew P Keegan, Cheryl Luis, David A Bennett, Zoe Arvanitakis, Hussein N Yassine, Michael Mullan, Fiona Crawford, Laila Abdulla. APOE ε4 and Alzheimer's disease diagnosis associated differences in L-carnitine, GBB, TMAO, and acylcarnitines in blood and brain. Current research in translational medicine. vol 71. issue 1. 2022-11-27. PMID:36436355. |
apoe ε4 and alzheimer's disease diagnosis associated differences in l-carnitine, gbb, tmao, and acylcarnitines in blood and brain. |
2022-11-27 |
2023-08-14 |
Not clear |
| Claire J C Huguenard, Adam Cseresznye, James E Evans, Teresa Darcey, Aurore Nkiliza, Andrew P Keegan, Cheryl Luis, David A Bennett, Zoe Arvanitakis, Hussein N Yassine, Michael Mullan, Fiona Crawford, Laila Abdulla. APOE ε4 and Alzheimer's disease diagnosis associated differences in L-carnitine, GBB, TMAO, and acylcarnitines in blood and brain. Current research in translational medicine. vol 71. issue 1. 2022-11-27. PMID:36436355. |
the apolipoprotein e (apoe) ε4 allele, involved in fatty acid (fa) metabolism, is a major genetic risk factor for alzheimer's disease (ad). |
2022-11-27 |
2023-08-14 |
Not clear |
| Verona E Mulgrave, Abdulrahman A Alsayegh, Aida Jaldi, DianneMarie T Omire-Mayor, Niaya James, Oyonumo Ntekim, Eric Walters, Emanuel O Akala, Joanne S Allar. Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice. Neuropeptides. vol 97. 2022-11-26. PMID:36434832. |
apolipoprotein e (apoe) is the main cholesterol carrier of the brain and the ε4 gene variant (apoe4) is the most prevalent genetic risk factor for alzheimer's disease (ad), increasing risk up to 15-fold. |
2022-11-26 |
2023-08-14 |
mouse |
| Ana C Valencia-Olvera, Juan Maldonado Weng, Amy Christensen, Mary Jo LaDu, Christian J Pik. Role of estrogen in women's Alzheimer's disease risk as modified by APOE. Journal of neuroendocrinology. 2022-11-24. PMID:36420620. |
role of estrogen in women's alzheimer's disease risk as modified by apoe. |
2022-11-24 |
2023-08-14 |
Not clear |
| Angelina J Polsinelli, Paige E Logan, Kathleen A Lane, Mohit K Manchella, Sára Nemes, Apoorva Bharthur Sanjay, Sujuan Gao, Liana G Apostolov. APOE ε4 carrier status and sex differentiate rates of cognitive decline in early- and late-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-17. PMID:36394443. |
apoe ε4 carrier status and sex differentiate rates of cognitive decline in early- and late-onset alzheimer's disease. |
2022-11-17 |
2023-08-14 |
Not clear |
| Angelina J Polsinelli, Paige E Logan, Kathleen A Lane, Mohit K Manchella, Sára Nemes, Apoorva Bharthur Sanjay, Sujuan Gao, Liana G Apostolov. APOE ε4 carrier status and sex differentiate rates of cognitive decline in early- and late-onset Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-17. PMID:36394443. |
we studied the effect of apolipoprotein e (apoe) ε4 status and sex on rates of cognitive decline in early- (eo) and late- (lo) onset alzheimer's disease (ad). |
2022-11-17 |
2023-08-14 |
Not clear |
| Katrine L Rasmussen, Anne Tybjærg-Hansen, Børge G Nordestgaard, Ruth Frikke-Schmid. Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration. JAMA ophthalmology. 2022-11-17. PMID:36394841. |
associations of alzheimer disease-protective apoe variants with age-related macular degeneration. |
2022-11-17 |
2023-08-14 |
Not clear |
| Jinghan Huang, Thor D Stein, Yixuan Wang, Ting Fang Alvin Ang, Qiushan Tao, Kathryn L Lunetta, Joseph Massaro, Samia C Akhter-Khan, Jesse Mez, Rhoda Au, Lindsay A Farrer, Xiaoling Zhang, Wei Qiao Qi. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-17. PMID:36396603. |
blood levels of mcp-1 modulate the genetic risks of alzheimer's disease mediated by hla-drb1 and apoe for alzheimer's disease. |
2022-11-17 |
2023-08-14 |
Not clear |
| Jinghan Huang, Thor D Stein, Yixuan Wang, Ting Fang Alvin Ang, Qiushan Tao, Kathryn L Lunetta, Joseph Massaro, Samia C Akhter-Khan, Jesse Mez, Rhoda Au, Lindsay A Farrer, Xiaoling Zhang, Wei Qiao Qi. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-17. PMID:36396603. |
since the blood crp level increases alzheimer's disease (ad) risk depending on the apolipoprotein e (apoe) genotype, we hypothesized that the blood mcp-1 level exerts different effects on the ad risk depending on the genotypes. |
2022-11-17 |
2023-08-14 |
Not clear |
| Anthony Maus, Dan Figdore, Dragana Milosevic, Alicia Algeciras-Schimnich, Joshua Bornhors. Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE. Clinical proteomics. vol 19. issue 1. 2022-11-15. PMID:36380282. |
apolipoprotein e (apoe) genotyping has been shown to have diagnostic value in the evaluation of cardiovascular diseases and neurodegenerative disorders such as alzheimer's disease. |
2022-11-15 |
2023-08-14 |
Not clear |
| Erica Staurenghi, Valerio Leoni, Marco Lo Iacono, Barbara Sottero, Gabriella Testa, Serena Giannelli, Gabriella Leonarduzzi, Paola Gamb. ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358540. |
the strongest genetic risk factor for sporadic alzheimer's disease (ad) is the presence of the ε4 allele of the apolipoprotein e (apoe) gene, the major apolipoprotein involved in brain cholesterol homeostasis. |
2022-11-11 |
2023-08-14 |
mouse |
| Scott Ayton, Shorena Janelidze, Pawel Kalinowski, Sebastian Palmqvist, Abdel Ali Belaidi, Erik Stomrud, Anne Roberts, Blaine Roberts, Oskar Hansson, Ashley Ian Bus. CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers. Journal of neurology, neurosurgery, and psychiatry. 2022-11-10. PMID:36357168. |
csf ferritin in the clinicopathological progression of alzheimer's disease and associations with apoe and inflammation biomarkers. |
2022-11-10 |
2023-08-14 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Zachary A Trottier, Tadafumi C Ikezu, Guojun Bu, Chia-Chen Li. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. Molecular neurodegeneration. vol 17. issue 1. 2022-11-08. PMID:36348357. |
apoe in alzheimer's disease: pathophysiology and therapeutic strategies. |
2022-11-08 |
2023-08-14 |
Not clear |