| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grace M Christensen, Zhenjiang Li, Donghai Liang, Stefanie Ebelt, Marla Gearing, Allan I Levey, James J Lah, Aliza P Wingo, Thomas S Wingo, Anke Huel. Fine particulate air pollution and neuropathology markers of Alzheimer's disease in donors with and without APOE ε4 alleles - results from an autopsy cohort. medRxiv : the preprint server for health sciences. 2023-04-17. PMID:37066193. |
fine particulate air pollution and neuropathology markers of alzheimer's disease in donors with and without apoe ε4 alleles - results from an autopsy cohort. |
2023-04-17 |
2023-08-14 |
Not clear |
| Isabel J Sible, Daniel A Natio. Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes. Journal of Alzheimer's disease : JAD. 2023-04-17. PMID:37066910. |
blood pressure variability (bpv) is associated with cognitive decline and alzheimer's disease (ad), but relationships with ad risk gene apolipoprotein (apoe) ɛ4 remain understudied. |
2023-04-17 |
2023-08-14 |
Not clear |
| Haimeng Bai, Adam C Naj, Penelope Benchek, Logan Dumitrescu, Timothy Hohman, Kara Hamilton-Nelson, Asha R Kallianpur, Anthony J Griswold, Badri Vardarajan, Eden R Martin, Gary W Beecham, Jennifer E Below, Gerard Schellenberg, Richard Mayeux, Lindsay Farrer, Margaret A Pericak-Vance, Jonathan L Haines, William S Bus. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-13. PMID:37051669. |
a haptoglobin (hp) structural variant alters the effect of apoe alleles on alzheimer's disease. |
2023-04-13 |
2023-08-14 |
Not clear |
| Katrina Celis, Maria D M Muniz Moreno, Farid Rajabli, Patrice Whitehead, Kara Hamilton-Nelson, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Margaret Flanagan, Sandra Weintraub, Changiz Geula, Marla Gearing, Clifton L Dalgard, Fulai Jin, David A Bennett, Theresa Schuck, Margaret A Pericak-Vance, Anthony J Griswold, Juan I Young, Jeffery M Vanc. Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-10. PMID:37037656. |
ancestry-related differences in chromatin accessibility and gene expression of apoe ε4 are associated with alzheimer's disease risk. |
2023-04-10 |
2023-08-14 |
Not clear |
| Katrina Celis, Maria D M Muniz Moreno, Farid Rajabli, Patrice Whitehead, Kara Hamilton-Nelson, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Margaret Flanagan, Sandra Weintraub, Changiz Geula, Marla Gearing, Clifton L Dalgard, Fulai Jin, David A Bennett, Theresa Schuck, Margaret A Pericak-Vance, Anthony J Griswold, Juan I Young, Jeffery M Vanc. Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-04-10. PMID:37037656. |
european local ancestry (ela) surrounding apolipoprotein e (apoe) ε4 confers higher risk for alzheimer's disease (ad) compared to african local ancestry (ala). |
2023-04-10 |
2023-08-14 |
Not clear |
| Dylan James Mah, Yanan Zhu, Guowei Su, Jing Zhao, Ashely Canning, James Gibson, Xuehong Song, Eduardo Stancanelli, Yongmei Xu, Fuming Zhang, Robert J Linhardt, Jian Liu, Lianchun Wang, Chunyu Wan. Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate. Angewandte Chemie (International ed. in English). 2023-04-04. PMID:37014788. |
apolipoprotein e (apoe)'s ε4 alle is the most important genetic risk factor for late onset alzheimer's disease (ad). |
2023-04-04 |
2023-08-14 |
Not clear |
| Matthias Jung, Carla Hartmann, Toni Ehrhardt, Lisa-Maria Peter, Chaudhry Luqman Abid, Bernadette Harwardt, Jana Hirschfeld, Claudia Claus, Undine Haferkamp, Ole Pless, Marina Nastainczyk-Wulf, Astrid Kehlen, Dietmar Schlote, Insa S Schroder, Dan Rujesc. Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease. Stem cell research. vol 69. 2023-03-31. PMID:37001364. |
generation of a set of induced pluripotent stem cell lines from two alzheimer disease patients carrying apoe4 (mlui007-j; mlui008-a) and healthy old donors carrying apoe3 (mlui009-a; mlui010-b) to study apoe in aging and disease. |
2023-03-31 |
2023-08-14 |
human |
| Matthias Jung, Carla Hartmann, Toni Ehrhardt, Lisa-Maria Peter, Chaudhry Luqman Abid, Bernadette Harwardt, Jana Hirschfeld, Claudia Claus, Undine Haferkamp, Ole Pless, Marina Nastainczyk-Wulf, Astrid Kehlen, Dietmar Schlote, Insa S Schroder, Dan Rujesc. Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease. Stem cell research. vol 69. 2023-03-31. PMID:37001364. |
late-onset alzheimer disease (load) is the most frequent neurodegenerative disease, and the apoe ε4 allele is the most prominent risk factor for load. |
2023-03-31 |
2023-08-14 |
human |
| Einat Granot-Hershkovitz, Rui Xia, Yunju Yang, Brian Spitzer, Wassim Tarraf, Priscilla M Vásquez, Richard B Lipton, Martha Daviglus, Maria Argos, Jianwen Cai, Robert Kaplan, Myriam Fornage, Charles DeCarli, Hector M Gonzalez, Tamar Sofe. Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging. Scientific reports. vol 13. issue 1. 2023-03-29. PMID:36991100. |
apoe-ɛ4 risk on mild cognitive impairment (mci) and alzheimer's disease (ad) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the apoe locus. |
2023-03-29 |
2023-08-14 |
Not clear |
| Courtney M Kloske, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Adam M Brickman, Guojun Bu, Jessica Dennison, Mary D Gearon, Alison M Goate, Christian Haass, Michael T Heneka, William T Hu, Lenique K L Huggins, Nahdia S Jones, Radosveta Koldamova, Cynthia A Lemere, Shane A Liddelow, Edoardo Marcora, Samuel E Marsh, Henrietta M Nielsen, Kellen K Petersen, Melissa Petersen, Stefanie D Piña-Escudero, Wei Qiao Qiu, Yakeel T Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia Tcw, Charlotte E Teunissen, Betty M Tijms, Rik van der Kant, Rebecca Wallings, Stacie C Weninger, Whitney Wharton, Donna M Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C Carrill. APOE and immunity: Research highlights. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-28. PMID:36975090. |
at the alzheimer's association's apoe and immunity virtual conference, held in october 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein e gene (apoe) and facets of immunity play in neurodegenerative diseases, including alzheimer's disease and other dementias. |
2023-03-28 |
2023-08-14 |
Not clear |
| Adil Supiyev, Robert Karlsson, Yunzhang Wang, Elise Koch, Sara Hägg, Karolina Kaupp. Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging. Neurobiology of aging. vol 126. 2023-03-25. PMID:36965205. |
apolipoprotein e (apoe) ε4, the strongest genetic risk factor for late onset alzheimer's disease (load), has been associated with cognitive decline independent from ad pathology, but the role for other load risk genes in normal cognitive aging is less studied. |
2023-03-25 |
2023-08-14 |
Not clear |
| A K W Lee, M K Collier, L I Thompson, D Popescu, E Arthur, S Correia, S P Salloway, J Albe. The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer's Prevention Registry. The journal of prevention of Alzheimer's disease. vol 10. issue 2. 2023-03-22. PMID:36946441. |
the effects of subjective cognitive decline on apoe genotype disclosure in the butler hospital alzheimer's prevention registry. |
2023-03-22 |
2023-08-14 |
Not clear |
| A K W Lee, M K Collier, L I Thompson, D Popescu, E Arthur, S Correia, S P Salloway, J Albe. The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer's Prevention Registry. The journal of prevention of Alzheimer's disease. vol 10. issue 2. 2023-03-22. PMID:36946441. |
subjective cognitive decline (scd) and apoe genotyping are both instrumental in identifying high-risk individuals for alzheimer's disease (ad) prevention trials. |
2023-03-22 |
2023-08-14 |
Not clear |
| Min Qiao, Annie J Lee, Dolly Reyes-Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak-Vance, Jonathan L Haines, Roger Rosenberg, Debby Tsuang, Robert A Sweet, David A Bennett, Robert S Wilson, Tatiana Foroud, Richard Mayeux, Badri N Vardaraja. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Annals of clinical and translational neurology. 2023-03-22. PMID:36946865. |
to compute penetrance and recurrence risk using a genome-wide prs (including and excluding the apoe region) in families with alzheimer's disease. |
2023-03-22 |
2023-08-14 |
Not clear |
| Q Gao, P Daunt, A M Gibson, R J Pithe. Utility of Polygenic Risk Scoring to Predict Cognitive Impairment as Measured by Preclinical Alzheimer Cognitive Composite Score. JAR life. vol 11. 2023-03-16. PMID:36923235. |
the utility of polygenic risk scores (prs) is gaining increasing attention for generating an individual genetic risk profile to predict subsequent likelihood of future onset of alzheimer's disease (ad), especially those carry two copies of the apoe e3 allele, currently considered at neutral risk in all populations studied. |
2023-03-16 |
2023-08-14 |
Not clear |
| G Wang, D E Vance, W L. A Cross-Sectional Analysis of APOE Gene Polymorphism and the Risk of Cognitive Impairments in the Alzheimer's Disease Neuroimaging Initiative Study. JAR life. vol 10. 2023-03-16. PMID:36923510. |
a cross-sectional analysis of apoe gene polymorphism and the risk of cognitive impairments in the alzheimer's disease neuroimaging initiative study. |
2023-03-16 |
2023-08-14 |
Not clear |
| G Wang, D E Vance, W L. A Cross-Sectional Analysis of APOE Gene Polymorphism and the Risk of Cognitive Impairments in the Alzheimer's Disease Neuroimaging Initiative Study. JAR life. vol 10. 2023-03-16. PMID:36923510. |
it is inconclusive on how apolipoprotein epsilon (apoe) gene polymorphism is associated with the risk of having mild cognitive impairment (mci) or alzheimer's disease (ad). |
2023-03-16 |
2023-08-14 |
Not clear |
| Heather Buchanan, Claire Hull, Maria Cacho Barraza, Mirela Delibegovic, Bettina Plat. Apolipoprotein E loss of function: Influence on murine brain markers of physiology and pathology. Aging brain. vol 2. 2023-03-13. PMID:36908879. |
given the association of apoe with diseases such as alzheimer's disease (ad), it is clear that further characterisation of its roles, especially within the brain, is needed. |
2023-03-13 |
2023-08-14 |
mouse |
| Chiara Giuseppina Bonomi, Martina Assogna, Martina Gaia Di Donna, Francesca Bernocchi, Vincenzo De Lucia, Marzia Nuccetelli, Denise Fiorelli, Stefano Loizzo, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Mott. Cerebrospinal Fluid sTREM-2, GFAP, and β-S100 in Symptomatic Sporadic Alzheimer's Disease: Microglial, Astrocytic, and APOE Contributions Along the Alzheimer's Disease Continuum. Journal of Alzheimer's disease : JAD. 2023-03-13. PMID:36911936. |
cerebrospinal fluid strem-2, gfap, and β-s100 in symptomatic sporadic alzheimer's disease: microglial, astrocytic, and apoe contributions along the alzheimer's disease continuum. |
2023-03-13 |
2023-08-14 |
Not clear |
| A G Costigan, K Umla-Runge, C J Evans, R Raybould, K S Graham, A D Lawrenc. Evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult APOE E4 carriers: A resting state Neuroimage. Reports. vol 1. issue 4. 2023-03-10. PMID:36896169. |
evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult apoe e4 carriers: a resting state a strategy to gain insight into early changes that may predispose people to alzheimer's disease (ad) is to study the brains of younger cognitively healthy people that are at increased genetic risk of ad. |
2023-03-10 |
2023-08-14 |
mouse |