| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew Paul Lennol, Irene Sánchez-Domínguez, Inmaculada Cuchillo-Ibañez, Elena Camporesi, Gunnar Brinkmalm, Daniel Alcolea, Juan Fortea, Alberto Lleó, Guadalupe Soria, Fernando Aguado, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valer. Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease patients. Alzheimer's research & therapy. vol 14. issue 1. 2022-11-03. PMID:36324176. |
the purpose of this study was to examine the levels of cerebrospinal fluid (csf) apolipoprotein e (apoe) species in alzheimer's disease (ad) patients. |
2022-11-03 |
2023-08-14 |
Not clear |
| Hongwon Kim, Siyoung Kim, Byounggook Cho, Jaein Shin, Jongpil Ki. APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-10-26. PMID:36284363. |
apoe ε4-dependent effects on the early amyloid pathology in induced neurons of patients with alzheimer's disease. |
2022-10-26 |
2023-08-14 |
Not clear |
| Hongwon Kim, Siyoung Kim, Byounggook Cho, Jaein Shin, Jongpil Ki. APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer's disease. Translational neurodegeneration. vol 11. issue 1. 2022-10-26. PMID:36284363. |
the ε4 allele of apolipoprotein e (apoe ε4) is the strongest known genetic risk factor for late-onset alzheimer's disease (ad), associated with amyloid pathogenesis. |
2022-10-26 |
2023-08-14 |
Not clear |
| Kanika Mehta, Mohammadreza Mohebbi, Julie A Pasco, Lana J Williams, Ken Walder, Boon Lung Ng, Veer Bala Gupt. Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia. Scientific reports. vol 12. issue 1. 2022-10-25. PMID:36280690. |
our aim was to investigate the association of the genetic variant, rs744373 in the bridging integrator 1 gene (bin1), the strongest genetic risk factor for alzheimer's disease after the apoe ε4 allele, with different cognitive domains among non-demented older men. |
2022-10-25 |
2023-08-14 |
Not clear |
| Kanika Mehta, Mohammadreza Mohebbi, Julie A Pasco, Lana J Williams, Ken Walder, Boon Lung Ng, Veer Bala Gupt. Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia. Scientific reports. vol 12. issue 1. 2022-10-25. PMID:36280690. |
to the best of our knowledge, this is the first study that demonstrates genetic variation in bin1 to be a better predictor of recognition memory than apoe, which remains the biggest genetic risk factor for alzheimer's disease. |
2022-10-25 |
2023-08-14 |
Not clear |
| Gökhan Doğukan Akarsu, Aysun Çeti. The Effect of Thymoquinone on Oxidative Stress Parameters and Apolipoprotein E in Alzheimer Model in Rats. Dementia and geriatric cognitive disorders. 2022-10-23. PMID:36273456. |
in this study, it was aimed to investigate the effect of thymoquinone (tq) on oxidative stress and apolipoprotein e (apoe) in an experimental alzheimer's model created with alcl3 and d-galactose in rats. |
2022-10-23 |
2023-08-14 |
rat |
| Esmée Essers, Anne-Claire Binter, Alexander Neumann, Tonya White, Silvia Alemany, Mònica Guxen. Air pollution exposure during pregnancy and childhood, APOE ε4 status and alzheimer polygenic risk score, and brain structural morphology in preadolescents. Environmental research. 2022-10-18. PMID:36257450. |
air pollution exposure during pregnancy and childhood, apoe ε4 status and alzheimer polygenic risk score, and brain structural morphology in preadolescents. |
2022-10-18 |
2023-08-14 |
Not clear |
| Saloua Fray, Afef Achouri-Rassas, Samir Belal, Taieb Messaou. Missing apolipoprotein E ε4 allele associated with nonamnestic Alzheimer's disease in a Tunisian population. Journal of genetics. vol 101. 2022-10-13. PMID:36226340. |
in this study, we investigate the impact of apolipoprotein e epsilon 4 (apoe ε4) as a major risk factor of alzheimer's disease (ad), based on the clinical presentation of the disease in our population on the one hand, and comparison of the results with the findings from the literature on the other hand. |
2022-10-13 |
2023-08-14 |
Not clear |
| Paul J Dunn, Rodney A Lea, Neven Maksemous, Robert A Smith, Heidi G Sutherland, Larisa M Haupt, Lyn R Griffith. Investigating a Genetic Link Between Alzheimer's Disease and CADASIL-Related Cerebral Small Vessel Disease. Molecular neurobiology. 2022-09-29. PMID:36175824. |
monogenic forms of alzheimer's disease (ad) have been identified through mutations in genes such as app, psen1, and psen2, whilst other genetic markers such as the apoe ε carrier allele status have been shown to increase the likelihood of having the disease. |
2022-09-29 |
2023-08-14 |
Not clear |
| Rosalía Fernández-Calle, Sabine C Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M Nielsen, Gunnar K Gouras, Tomas Deierbor. APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-09-24. PMID:36153580. |
apoe in the bullseye of neurodegenerative diseases: impact of the apoe genotype in alzheimer's disease pathology and brain diseases. |
2022-09-24 |
2023-08-14 |
human |
| Jianfeng Wu, Yi Su, Eric M Reiman, Richard J Caselli, Kewei Chen, Paul M Thompson, Junwen Wang, Yalin Wan. INVESTIGATING THE EFFECT OF TAU DEPOSITION AND APOE ON HIPPOCAMPAL MORPHOMETRY IN ALZHEIMER'S DISEASE: A FEDERATED CHOW TEST MODEL. Proceedings. IEEE International Symposium on Biomedical Imaging. vol 2022. 2022-09-23. PMID:36147309. |
investigating the effect of tau deposition and apoe on hippocampal morphometry in alzheimer's disease: a federated chow test model. |
2022-09-23 |
2023-08-14 |
Not clear |
| Jeyashree Alagarsamy, Anja Jaeschke, David Y Hu. Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077289. |
a preponderance of evidence obtained from genetically modified mice and human population studies reveals the association of apolipoprotein e (apoe) deficiency and polymorphisms with pathogenesis of numerous chronic diseases, including atherosclerosis, obesity/diabetes, and alzheimer's disease. |
2022-09-09 |
2023-08-14 |
mouse |
| Michel Satya Naslavsky, Claudia K Suemoto, Luciano Abreu Brito, Marília Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E P Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T Grinber. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. Molecular psychiatry. 2022-09-07. PMID:36071110. |
global and local ancestry modulate apoe association with alzheimer's neuropathology and cognitive outcomes in an admixed sample. |
2022-09-07 |
2023-08-14 |
Not clear |
| Michel Satya Naslavsky, Claudia K Suemoto, Luciano Abreu Brito, Marília Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E P Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T Grinber. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. Molecular psychiatry. 2022-09-07. PMID:36071110. |
paradoxically, clinical studies suggest an attenuation of apoe ε4 risk of dementia in african ancestry (afr), but a dearth of neuropathological data preclude the interpretation of the biological factors underlying these findings, including the association between apoe ε4 risk and alzheimer's disease (ad) pathology, the most frequent cause of dementia. |
2022-09-07 |
2023-08-14 |
Not clear |
| Ove Almkvist, Charlotte Johansson, Jose Laffita-Mesa, Steinunn Thordardottir, Caroline Graf. APOE ε4 influences cognitive decline positively in APP and negatively in PSEN1 mutation carriers of autosomal-dominant Alzheimer's disease. European journal of neurology. 2022-08-30. PMID:36039401. |
apoe ε4 influences cognitive decline positively in app and negatively in psen1 mutation carriers of autosomal-dominant alzheimer's disease. |
2022-08-30 |
2023-08-14 |
Not clear |
| Ove Almkvist, Charlotte Johansson, Jose Laffita-Mesa, Steinunn Thordardottir, Caroline Graf. APOE ε4 influences cognitive decline positively in APP and negatively in PSEN1 mutation carriers of autosomal-dominant Alzheimer's disease. European journal of neurology. 2022-08-30. PMID:36039401. |
the apoe ε4 allele reduces age of symptom onset, increases disease progression, and lowers cognitive performance in sporadic alzheimer's disease (sad), while the impact of the apoe ε4 allele in autosomal-dominant ad (adad) is incompletely known. |
2022-08-30 |
2023-08-14 |
Not clear |
| Daniela Passarella, Silvia Ciampi, Valentina Di Liberto, Mariachiara Zuccarini, Maurizio Ronci, Alessandro Medoro, Emanuele Foderà, Monica Frinchi, Donatella Mignogna, Claudio Russo, Carola Porcil. Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012187. |
from one side, its overexpression has been highlighted in many types of cancer including breast, gastric, prostate, lung and melanoma; from the other side, lrp8 has a potential role in neurodegeneration as apolipoprotein e (apoe) and reelin receptor, which are, respectively, the major risk factor for developing alzheimer's disease (ad) and the main driver of neuronal migration, and as a γ-secretase substrate, the main enzyme responsible for amyloid formation in ad. |
2022-08-26 |
2023-08-14 |
Not clear |
| Johanna Rueter, Gerald Rimbach, Patricia Huebb. Functional diversity of apolipoprotein E: from subcellular localization to mitochondrial function. Cellular and molecular life sciences : CMLS. vol 79. issue 9. 2022-08-26. PMID:36018414. |
the ε4 allele is a genetic risk factor for alzheimer's disease (ad); therefore, the vast majority of apoe research focuses on its role in ad pathology. |
2022-08-26 |
2023-08-14 |
human |
| Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Gøril Rolfseng Grøntvedt, Geir Bråthen, Linda R White, Kim Kultima, Henrietta M Nielse. Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer's disease. Alzheimer's research & therapy. vol 14. issue 1. 2022-08-24. PMID:36002891. |
low levels of plasma apolipoprotein e (apoe) and presence of the apoe ε4 allele are associated with an increased risk of alzheimer's disease (ad). |
2022-08-24 |
2023-08-14 |
Not clear |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
by leveraging a large harmonized database from 8 biomarker studies with longitudinal data from 2609 participants in cognition, 873 in mri biomarkers, 519 in pet pib imaging and 475 in csf biomarkers for a median follow-up of 5-6 years, we estimated the longitudinal trajectories of all major alzheimer disease biomarkers as functions of baseline age that spanned from 18 to 103 years, located the baseline age window at which the longitudinal rates of change accelerated and further examined possible modifying effects of apolipoprotein e (apoe) genotype. |
2022-08-04 |
2023-08-14 |
human |