| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunpeng Wang, Håkon Grydeland, James M Roe, Mengyu Pan, Fredrik Magnussen, Inge K Amlien, Leiv Otto Watne, Ane-Victoria Idland, Lars Bertram, Thomas E Gundersen, Alvaro Pascual-Leone, Maria Cabello-Toscano, Jose M Tormos, David Bartres-Faz, Christian A Drevon, Anders M Fjell, Kristine W Walhov. Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan. Brain, behavior, and immunity. 2021-12-17. PMID:34920091. |
associations of circulating c-reactive proteins, apoe ε4, and brain markers for alzheimer's disease in healthy samples across the lifespan. |
2021-12-17 |
2023-08-13 |
Not clear |
| Yunpeng Wang, Håkon Grydeland, James M Roe, Mengyu Pan, Fredrik Magnussen, Inge K Amlien, Leiv Otto Watne, Ane-Victoria Idland, Lars Bertram, Thomas E Gundersen, Alvaro Pascual-Leone, Maria Cabello-Toscano, Jose M Tormos, David Bartres-Faz, Christian A Drevon, Anders M Fjell, Kristine W Walhov. Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan. Brain, behavior, and immunity. 2021-12-17. PMID:34920091. |
the apolipoprotein e gene ε4 allele (apoe ε4) and higher circulating level of c-reactive protein (crp) have been extensively investigated as risk factors for alzheimer's disease (ad). |
2021-12-17 |
2023-08-13 |
Not clear |
| Thanaphong Phongpreecha, Chandresh R Gajera, Candace C Liu, Kausalia Vijayaragavan, Alan L Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin Latimer, Carol A Shively, Thomas C Register, Suzanne Craft, Kathleen S Montine, Edward J Fox, Kathleen L Poston, C Dirk Keene, Michael Angelo, Sean C Bendall, Nima Aghaeepour, Thomas J Montin. Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Science advances. vol 7. issue 51. 2021-12-15. PMID:34910503. |
single-synapse analyses of alzheimer's disease implicate pathologic tau, dj1, cd47, and apoe. |
2021-12-15 |
2023-08-13 |
Not clear |
| Ioanna Katzourou, Ganna Leonenko, Dobril Ivanov, Alun Meggy, Rachel Marshall, Rebecca Sims, Julie Williams, Peter Holmans, Valentina Escott-Pric. Cognitive Decline in Alzheimer's Disease Is Not Associated with APOE. Journal of Alzheimer's disease : JAD. vol 84. issue 1. 2021-12-10. PMID:34487047. |
cognitive decline in alzheimer's disease is not associated with apoe. |
2021-12-10 |
2023-08-13 |
Not clear |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
microglia-specific apoe knock-out does not alter alzheimer's disease plaque pathogenesis or gene expression. |
2021-12-10 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
previous studies suggest that microglial-expressed apolipoprotein e (apoe) is necessary to shift microglia into a neurodegenerative transcriptional state in alzheimer's disease (ad) mouse models. |
2021-12-10 |
2023-08-13 |
mouse |
| Mariah J Novy, Samantha F Newbury, Braison Liemisa, Jose Morales-Corraliza, Melissa J Alldred, Stephen D Ginsberg, Paul M Mathew. Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice. Neurobiology of aging. vol 110. 2021-12-10. PMID:34875506. |
the 3 human apolipoprotein e (apoe) gene alleles modify an individual's risk of developing alzheimer's disease (ad): compared to the risk-neutral apoe ε3 allele, the ε4 allele (apoe4) is strongly associated with increased ad risk while the ε2 allele is protective. |
2021-12-10 |
2023-08-13 |
mouse |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Yanxiao Li, Weihua Li, Xiuying Wang, Tammie L S Benzinger, Jie Lu, Yun Zho. Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33876815. |
these results have important clinical implications towards developing sex and genotype-guided therapeutics in alzheimer's disease and uncovers a potential explanation underlying differential apoe ε4-associated alzheimer's risk in males and females. |
2021-12-09 |
2023-08-13 |
Not clear |
| b' Mirjana B Leko, Matea N Perkovi\\xc4\\x87, Gordana N Erjavec, Nata\\xc5\\xa1a Klepac, Dubravka \\xc5\\xa0 \\xc5\\xa0trac, Fran Borove\\xc4\\x8dki, Nela Pivac, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE \\xce\\xb54 Allele in Alzheimer\'s Disease. Current Alzheimer research. vol 18. issue 7. 2021-12-09. PMID:34533445.' |
association of the maob rs1799836 single nucleotide polymorphism and apoe ε4 allele in alzheimer's disease. |
2021-12-09 |
2023-08-13 |
Not clear |
| Liling Dong, Jie Li, Caiyan Liu, Chenhui Mao, Jie Wang, Dan Lei, Xinying Huang, Shanshan Chu, Bo Hou, Feng Feng, Longze Sha, Qi Xu, Jing Ga. Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort. Brain and behavior. vol 11. issue 11. 2021-12-09. PMID:34555265. |
effects of apoe genotype on clinical phenotypes in early-onset and late-onset alzheimer's disease in china: data from the pumch dementia cohort. |
2021-12-09 |
2023-08-13 |
Not clear |
| Liling Dong, Jie Li, Caiyan Liu, Chenhui Mao, Jie Wang, Dan Lei, Xinying Huang, Shanshan Chu, Bo Hou, Feng Feng, Longze Sha, Qi Xu, Jing Ga. Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort. Brain and behavior. vol 11. issue 11. 2021-12-09. PMID:34555265. |
to investigate the heterogeneous effect of apolipoprotein e (apoe) genotype on clinical phenotypes in early-onset alzheimer's disease (eoad) and late-onset alzheimer's disease (load), respectively. |
2021-12-09 |
2023-08-13 |
Not clear |
| Alexander M Kulminski, Ian Philipp, Yury Loika, Liang He, Irina Culminskay. Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 11. 2021-12-08. PMID:34310032. |
despite advances, understanding the protective role of the apolipoprotein e (apoe) ε2 allele in alzheimer's disease (ad) remains elusive. |
2021-12-08 |
2023-08-13 |
Not clear |
| Brendan P Lucey, Julie Wisch, Anna H Boerwinkle, Eric C Landsness, Cristina D Toedebusch, Jennifer S McLeland, Omar H Butt, Jason Hassenstab, John C Morris, Beau M Ances, David M Holtzma. Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-12-08. PMID:34668959. |
to test this hypothesis, we monitored sleep-wake activity over 4-6 nights in 100 participants who underwent standardized cognitive testing longitudinally, apoe genotyping, and measurement of alzheimer's disease biomarkers, total tau and amyloid-β42 in the csf. |
2021-12-08 |
2023-08-13 |
human |
| Gemma Salvadó, Daniel Ferreira, Grégory Operto, Irene Cumplido-Mayoral, Eider M Arenaza-Urquijo, Raffaele Cacciaglia, Carles Falcon, Natàlia Vilor-Tejedor, Carolina Minguillon, Colin Groot, Wiesje M van der Flier, Frederik Barkhof, Philip Scheltens, Rik Ossenkoppele, Silke Kern, Anna Zettergren, Ingmar Skoog, Jakub Hort, Erik Stomrud, Danielle van Westen, Oskar Hansson, José Luis Molinuevo, Lars-Olof Wahlund, Eric Westman, Juan Domingo Gisper. The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-12-08. PMID:34877786. |
harboring two copies of the apolipoprotein e (apoe) ε2 allele strongly protects against alzheimer's disease (ad). |
2021-12-08 |
2023-08-13 |
Not clear |
| Tzong-Shiue Yu, Yacine Tensaouti, Elizabeth P Stephanz, Sana Chintamen, Elizabeth E Rafikian, Mu Yang, Steven G Kerni. Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice. Communications biology. vol 4. issue 1. 2021-12-07. PMID:34795427. |
polymorphisms in the apolipoprotein e (apoe) gene confer a major genetic risk for the development of late-onset alzheimer's disease (ad) and are predictive of outcome following traumatic brain injury (tbi). |
2021-12-07 |
2023-08-13 |
mouse |
| Renata Valle Pedroso, Francisco José Fraga, Carla Manuela Crispim Nascimento, Henrique Pott-Junior, Márcia Regina Cominett. APOLIPOPROTEIN E ε4 ALLELE IMPAIRS CORTICAL ACTIVITY IN HEALTHY AGING AND ALZHEIMER'S DISEASE. Behavioural brain research. 2021-12-06. PMID:34871705. |
to investigate the influence of apolipoprotein e (apoe) genotype on cortical activity, using the event-related potential p300 in healthy older adults and individuals with alzheimer's disease (ad). |
2021-12-06 |
2023-08-13 |
Not clear |
| Emily A Largent, Twisha Bhardwaj, Maramawit Abera, Shana D Stites, Kristin Harkins, Alan J Lerner, Angela R Bradbury, Jason Karlawis. Disclosing Genetic Risk of Alzheimer's Disease to Cognitively Unimpaired Older Adults: Findings from the Study of Knowledge and Reactions to APOE Testing (SOKRATES II). Journal of Alzheimer's disease : JAD. vol 84. issue 3. 2021-12-03. PMID:34602479. |
disclosing genetic risk of alzheimer's disease to cognitively unimpaired older adults: findings from the study of knowledge and reactions to apoe testing (sokrates ii). |
2021-12-03 |
2023-08-13 |
Not clear |
| Maria Victoria Marca-Ysabel, Farid Rajabli, Mario Cornejo-Olivas, Patrice G Whitehead, Natalia K Hofmann, Maryenela Zaida Illanes Manrique, Diego Martin Veliz Otani, Ana Karina Milla Neyra, Sheila Castro Suarez, Maria Meza Vega, Larry D Adams, Pedro R Mena, Isasi Rosario, Michael L Cuccaro, Jeffery M Vance, Gary W Beecham, Nilton Custodio, Rosa Montesinos, Pilar E Mazzetti Soler, Margaret A Pericak-Vanc. Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population. Neurobiology of aging. vol 101. 2021-11-30. PMID:33541779. |
dissecting the role of amerindian genetic ancestry and the apoe ε4 allele on alzheimer disease in an admixed peruvian population. |
2021-11-30 |
2023-08-13 |
Not clear |
| Elizabeth M Rhea, Kim Hansen, Sarah Pemberton, Eileen Ruth S Torres, Sarah Holden, Jacob Raber, William A Bank. Effects of apolipoprotein E isoform, sex, and diet on insulin BBB pharmacokinetics in mice. Scientific reports. vol 11. issue 1. 2021-11-29. PMID:34545146. |
age, apolipoprotein e (apoe) isoform, sex, and diet can independently affect the risk for the development of alzheimer's disease (ad). |
2021-11-29 |
2023-08-13 |
mouse |
| Karissa Barthelson, Morgan Newman, Michael Lardell. Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. Disease models & mechanisms. 2021-11-29. PMID:34842276. |
we extended our analysis to knock-in mouse models of apoe alleles and found the same effect for the late onset alzheimer's disease risk allele ε4. |
2021-11-29 |
2023-08-13 |
mouse |