| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrycja Dzianok, Ewa Kubli. Association between APOE gene and stress coping strategies, memory, and family history of AD in a healthy middle-aged Polish population: Preliminary results. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109275. |
one of the best-known genes associated with late-onset alzheimer's disease (ad) is the apolipoprotein e (apoe). |
2022-02-03 |
2023-08-13 |
Not clear |
| Christina Wheeler, Jing Wang, Matthew Lucas, Haizhen Liu, Cathy Chang, Gerhard Frey, Jay M Shor. Protein-associated chemical switches differentially modulate the binding activities of human apolipoprotein E isoforms with their receptors and with amyloid beta peptides. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109277. |
the apoe gene is polymorphic, having three prominent alleles which are the main genetic determinants of alzheimer disease (ad) risk in humans. |
2022-02-03 |
2023-08-13 |
human |
| Courtney M Kloske, Erica M Weekman, Kevin Xie, Ela Patel, Sonya Anderson, Adam D Bachstetter, Josh M Morganti, David W Fardo, Peter T Nelson, Donna M Wilcoc. APOE-e4 alters the microglial phenotype in the presence of Alzheimer's disease pathology compared to APOE-e3. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109287. |
apoe is the largest genetic risk factor for late-onset alzheimer's disease (ad) with the apoe-e4 allele conferring an increased risk for ad compared to the apoe- e3 allele. |
2022-02-03 |
2023-08-13 |
human |
| Eder Lucio da Fonseca, Melissa N Jean-Francois, Jiji Thulaseedhara Kurup, Susan H Slifer, Eden R Martin, Brian W Kunkle, Gerard D Schellenberg, Margaret A Pericak-Vance, Victoria Fernandez, Carlos Cruchaga, Christiane Reitz, Gary W Beecha. Heritability analyses show partial genetic overlap between (non-Mendelian) early and late onset Alzheimer disease due to an intriguing APOE effect. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109349. |
heritability analyses show partial genetic overlap between (non-mendelian) early and late onset alzheimer disease due to an intriguing apoe effect. |
2022-02-03 |
2023-08-13 |
Not clear |
| John C Thorstenson, Margo B Heston, Katie R Zarbock, Cynthia M Carlsson, Corinne D Engelman, Yuetiva Deming, Sterling C Johnson, Tyler K Ulland, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Kaj Blennow, Henrik Zetterberg, Nathaniel A Chin, Federico E Rey, Barbara B Bendli. Diet and APOE as moderators of the relationship between trimethylamine N-oxide and biomarkers of Alzheimer's disease and glial activation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109388. |
diet and apoe as moderators of the relationship between trimethylamine n-oxide and biomarkers of alzheimer's disease and glial activation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tingting Wang, Kevin Huynh, Corey Giles, Natalie A Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex At Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Kevin Taddei, Vincent Doré, Jürgen Fripp, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, Rebecca Baillie, Xianlin Han, Ralph N Martins, Eric K Moses, Rima Kaddurah-Daouk, Peter J Meikl. APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-25. PMID:35077012. |
apoe ε2 resilience for alzheimer's disease is mediated by plasma lipid species: analysis of three independent cohort studies. |
2022-01-25 |
2023-08-13 |
Not clear |
| Tingting Wang, Kevin Huynh, Corey Giles, Natalie A Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex At Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Kevin Taddei, Vincent Doré, Jürgen Fripp, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, Rebecca Baillie, Xianlin Han, Ralph N Martins, Eric K Moses, Rima Kaddurah-Daouk, Peter J Meikl. APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-25. PMID:35077012. |
the apolipoprotein e (apoe) genotype is the strongest genetic risk factor for late-onset alzheimer's disease. |
2022-01-25 |
2023-08-13 |
Not clear |
| Kaushik Ravipati, Yunxiao Chen, Joseph R Mann. Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 37. 2022-01-18. PMID:35041557. |
reassessing diabetes and apoe genotype as potential interacting risk factors for alzheimer's disease. |
2022-01-18 |
2023-08-13 |
Not clear |
| Hee-Jung Moon, Vahram Haroutunian, Liqin Zha. Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation. Neurobiology of disease. 2022-01-18. PMID:35041991. |
the apoe genotype is the most prominent genetic risk factor for the development of late-onset alzheimer's disease (load); however, the underlying mechanisms remain unclear. |
2022-01-18 |
2023-08-13 |
human |
| Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou, Makoto Michikaw. Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-06. PMID:34987110. |
presenilin is essential for apoe secretion, a novel role of presenilin involved in alzheimer's disease pathogenesis. |
2022-01-06 |
2023-08-13 |
Not clear |
| Karen Nuytemans, Marina Lipkin Vasquez, Liyong Wang, Derek Van Booven, Antony J Griswold, Farid Rajabli, Katrina Celis, Oded Oron, Natalia Hofmann, Sophie Rolati, Catherine Garcia-Serje, Shanshan Zhang, Fulai Jin, Mariana Argenziano, Struan F A Grant, Alessandra Chesi, Christopher D Brown, Juan I Young, Derek M Dykxhoorn, Margaret A Pericak-Vance, Jeffery M Vanc. Identifying differential regulatory control of APOE ɛP on African versus European haplotypes as potential therapeutic targets. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978147. |
we previously demonstrated that in alzheimer's disease (ad) patients, european apolipoprotein e (apoe) ε4 carriers express significantly more apoe ε4 in their brains than african ad carriers. |
2022-01-03 |
2023-08-13 |
Not clear |
| Alireza Nazarian, Yury Loika, Liang He, Irina Culminskaya, Alexander M Kulminsk. Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978151. |
the apolipoprotein e (apoe) ε2 and ε4 alleles have beneficial and adverse impacts on alzheimer's disease (ad), respectively, with incomplete penetrance, which may be modulated by other genetic variants. |
2022-01-03 |
2023-08-13 |
Not clear |
| Tianqi Li, Colleen Pappas, Scott T Le, Qian Wang, Brandon S Klinedinst, Brittany A Larsen, Amy Pollpeter, Ling Yi Lee, Michael W Lutz, William Kirby Gottschalk, Russell H Swerdlow, Kwangsik Nho, Auriel A Willett. APOE, TOMM40, and Sex Interactions on Neural Network Connectivity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 12. 2021-12-31. PMID:34971096. |
the apolipoprotein e ε4 (apoe ε4) haplotype is the strongest genetic risk factor for late-onset alzheimer's disease (ad). |
2021-12-31 |
2023-08-13 |
Not clear |
| Daniel Nevo, Malka Gorfin. Causal inference for semi-competing risks data. Biostatistics (Oxford, England). 2021-12-30. PMID:34969069. |
the causal effects of apolipoprotein e $\epsilon4$ allele (apoe) on late-onset alzheimer's disease (ad) and death are complicated to define because ad may occur under one intervention but not under the other, and because ad occurrence may affect age of death. |
2021-12-30 |
2023-08-13 |
Not clear |
| Liling Dong, Chenhui Mao, Caiyan Liu, Jie Li, Xinying Huang, Jie Wang, Dan Lei, Shanshan Chu, Longze Sha, Qi Xu, Bin Peng, Liying Cui, Jing Ga. Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort. Journal of Alzheimer's disease : JAD. 2021-12-27. PMID:34958020. |
association between common variants of apoe, abca7, a2m, bace1, and cerebrospinal fluid biomarkers in alzheimer's disease: data from the pumch dementia cohort. |
2021-12-27 |
2023-08-13 |
Not clear |
| Makoto Kurano, Kazuhisa Tsukamoto, Eri Sakai, Masumi Hara, Yutaka Yatom. Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells. Journal of Alzheimer's disease : JAD. 2021-12-27. PMID:34958030. |
apolipoprotein e (apoe) isoforms are also involved in the development of alzheimer's disease. |
2021-12-27 |
2023-08-13 |
Not clear |
| Carmen Peña-Bautista, Lourdes Álvarez-Sánchez, Lorena García, Miguel Baquero, Consuelo Cháfer-Pericá. Assessment of apolipoprotein E genotype for β-amyloid status prediction. Current Alzheimer research. 2021-12-24. PMID:34951383. |
apolipoprotein e (apoe) is the major genetic risk factor for sporadic alzheimer's disease (ad). |
2021-12-24 |
2023-08-13 |
Not clear |
| Heidi Leskinen, Maaria Tringham, Heli Karjalainen, Terhi Iso-Touru, Hanna-Leena Hietaranta-Luoma, Pertti Marnila, Juha-Matti Pihlava, Timo Hurme, Hannu Puolijoki, Kari Åkerman, Sari Mäkinen, Mari Sandell, Kirsi Vähäkangas, Raija Tahvonen, Susanna Rokka, Anu Hopi. APOE genotypes, lipid profiles and associated clinical markers in a Finnish population with cardiovascular disease risk factors. Lifestyle genomics. 2021-12-23. PMID:34942620. |
apoe ɛ4 allele predisposes to high cholesterol and increases the risk for lifestyle-related diseases such as alzheimer's disease (ad) and cardiovascular diseases (cvd). |
2021-12-23 |
2023-08-13 |
Not clear |
| Alireza Salami, Rolf Adolfsson, Micael Andersson, Kaj Blennow, Anders Lundquist, Annelie Nordin Adolfsson, Michael Schöll, Henrik Zetterberg, Lars Nyber. Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924376. |
association of apoe ɛ4 and plasma p-tau181 with preclinical alzheimer's disease and longitudinal change in hippocampus function. |
2021-12-20 |
2023-08-13 |
Not clear |
| Naili Wei, Jian Che. Repetitive Transcranial Magnetic Stimulation for Alzheimer's Disease Based on Apolipoprotein E Genotyping: Protocol for a Randomized Controlled Study. Frontiers in aging neuroscience. vol 13. 2021-12-20. PMID:34924994. |
to date, there is a shortage of effective treatment strategies for alzheimer's disease (ad), and although repetitive transcranial magnetic stimulation (rtms) can improve ad cognitive function, there are obvious individual differences, which may be related to different apolipoprotein e (apoe) genotypes. |
2021-12-20 |
2023-08-13 |
Not clear |