| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer L Whitwell, Nirubol Tosakulwong, Stephen D Weigand, Jonathan Graff-Radford, Nilufer Ertekin-Taner, Mary M Machulda, Joseph R Duffy, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, Keith A Joseph. Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease. Neurobiology of aging. vol 108. 2021-11-27. PMID:34551374. |
relationship of apoe, age at onset, amyloid and clinical phenotype in alzheimer disease. |
2021-11-27 |
2023-08-13 |
Not clear |
| Jennifer L Whitwell, Nirubol Tosakulwong, Stephen D Weigand, Jonathan Graff-Radford, Nilufer Ertekin-Taner, Mary M Machulda, Joseph R Duffy, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, Val J Lowe, Keith A Joseph. Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease. Neurobiology of aging. vol 108. 2021-11-27. PMID:34551374. |
the apolipoprotein e (apoe) ε4 allele is the most well-established risk factor for alzheimer's disease (ad), although its relationship to age at onset and clinical phenotype is unclear. |
2021-11-27 |
2023-08-13 |
Not clear |
| Alexandra Tudor, Antonia Ioana Vasile, Simona Corina Trifu, Mihai Bogdan Criste. Morphological classification and changes in dementia (Review). Experimental and therapeutic medicine. vol 23. issue 1. 2021-11-27. PMID:34824641. |
apoeε4, which is one of the apolipoprotein e (apoe) alleles, is the major genetic risk factor for late-onset of the most common form of dementia, alzheimer's. |
2021-11-27 |
2023-08-13 |
Not clear |
| Tianqi Li, Colleen Pappas, Scott T Le, Qian Wang, Brandon S Klinedinst, Brittany A Larsen, Amy Pollpeter, Ling Yi Lee, Mike W Lutz, William K Gottschalk, Russell H Swerdlow, Kwangsik Nho, Auriel A Willett. APOE, TOMM40, and sex interactions on neural network connectivity. Neurobiology of aging. vol 109. 2021-11-26. PMID:34740077. |
the apolipoprotein e ε4 (apoe ε4) haplotype is the strongest genetic risk factor for late-onset alzheimer's disease (ad). |
2021-11-26 |
2023-08-13 |
human |
| Sarang Kang, Jungsoo Gim, Jiwoon Lee, Tamil Iniyan Gunasekaran, Kyu Yeong Choi, Jang Jae Lee, Eun Hyun Seo, Pan-Woo Ko, Ji Yeon Chung, Seong-Min Choi, Young Min Lee, Jee Hyang Jeong, Kyung Won Park, Min Kyung Song, Ho-Won Lee, Ki Woong Kim, Seong Hye Choi, Dong Young Lee, Sang Yun Kim, Hoowon Kim, Byeong C Kim, Takeshi Ikeuchi, Kun Ho Le. Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study. Journal of Alzheimer's disease : JAD. vol 82. issue 4. 2021-11-23. PMID:34151794. |
the present study reports two novel genome-wide significant loci for late-onset alzheimer's disease (load) identified from apoe ε4 non-carrier subjects of east asian origin. |
2021-11-23 |
2023-08-13 |
human |
| Mirjam Frank, Jonas Hensel, Lisa Baak, Sara Schramm, Nico Dragano, Christian Weimar, Per Hoffmann, Markus M Nöthen, Raimund Erbel, Karl-Heinz Jöckel, Martha Jokisch, Börge Schmid. Interaction of Alzheimer's Disease-Associated Genetic Risk with Indicators of Socioeconomic Position on Mild Cognitive Impairment in the Heinz Nixdorf Recall Study. Journal of Alzheimer's disease : JAD. vol 82. issue 4. 2021-11-23. PMID:34219719. |
the apolipoprotein e (apoe) ɛ4 allele is reported to be a strong genetic risk factor for mild cognitive impairment (mci) and alzheimer's disease (ad). |
2021-11-23 |
2023-08-13 |
Not clear |
| Zhengrong Zhang, Hana Na, Qini Gan, Qiushan Tao, Yuriy Alekseyev, Junming Hu, Zili Yan, Jack B Yang, Hua Tian, Shenyu Zhu, Qiang Li, Ibraheem M Rajab, Jan Krizysztof Blusztajn, Benjamin Wolozin, Andrew Emili, Xiaoling Zhang, Thor Stein, Lawrence A Potempa, Wei Qiao Qi. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging cell. vol 20. issue 11. 2021-11-21. PMID:34687487. |
monomeric c-reactive protein via endothelial cd31 for neurovascular inflammation in an apoe genotype-dependent pattern: a risk factor for alzheimer's disease? |
2021-11-21 |
2023-08-13 |
mouse |
| Antonino Asaro, Anne-Sophie Carlo-Spiewok, Anna R Malik, Michael Rothe, Carola G Schipke, Oliver Peters, Joerg Heeren, Thomas E Willno. Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32588544. |
apolipoprotein e (apoe) is a carrier for brain lipids and the most important genetic risk factor for alzheimer's disease (ad). |
2021-11-19 |
2023-08-13 |
Not clear |
| Anthony J Griswold, Katrina Celis, Parker L Bussies, Farid Rajabli, Patrice L Whitehead, Kara L Hamilton-Nelson, Gary W Beecham, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K Gardner, Daniel A Dorfsman, Eileen H Bigio, Marek Marsel Mesulam, Sandra Weintraub, Changiz Geula, Marla Gearing, Elisa McGrath-Martinez, Clifton L Dalgard, William K Scott, Jonathan L Haines, Margaret A Pericak-Vance, Juan I Young, Jeffery M Vanc. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 7. 2021-11-18. PMID:33522086. |
increased apoe ε4 expression is associated with the difference in alzheimer's disease risk from diverse ancestral backgrounds. |
2021-11-18 |
2023-08-13 |
Not clear |
| Anthony J Griswold, Katrina Celis, Parker L Bussies, Farid Rajabli, Patrice L Whitehead, Kara L Hamilton-Nelson, Gary W Beecham, Derek M Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K Gardner, Daniel A Dorfsman, Eileen H Bigio, Marek Marsel Mesulam, Sandra Weintraub, Changiz Geula, Marla Gearing, Elisa McGrath-Martinez, Clifton L Dalgard, William K Scott, Jonathan L Haines, Margaret A Pericak-Vance, Juan I Young, Jeffery M Vanc. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 7. 2021-11-18. PMID:33522086. |
apolipoprotein e (apoe) ε4 confers less risk for alzheimer's disease (ad) in carriers with african local genomic ancestry (ala) than apoe ε4 carriers with european local ancestry (ela). |
2021-11-18 |
2023-08-13 |
Not clear |
| Jacopo Teneggi, Xin Chen, Alan Balu, Connor Barrett, Giulia Grisolia, Umberto Lucia, Rhonda Dzakpas. Entropy estimation within in vitro neural-astrocyte networks as a measure of development instability. Physical review. E. vol 103. issue 4-1. 2021-11-18. PMID:34005938. |
brain cells were harvested from mice with mutations to a gene associated with the strongest known genetic risk factor for alzheimer's disease, apoe. |
2021-11-18 |
2023-08-13 |
mouse |
| Wei Qin, Wenwen Li, Qi Wang, Min Gong, Tingting Li, Yuqing Shi, Yang Song, Ying Li, Fangyu Li, Jianping Ji. Race-Related Association between APOE Genotype and Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34334408. |
race-related association between apoe genotype and alzheimer's disease: a systematic review and meta-analysis. |
2021-11-18 |
2023-08-13 |
Not clear |
| Wei Qin, Wenwen Li, Qi Wang, Min Gong, Tingting Li, Yuqing Shi, Yang Song, Ying Li, Fangyu Li, Jianping Ji. Race-Related Association between APOE Genotype and Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34334408. |
the global race-dependent association of alzheimer's disease (ad) and apolipoprotein e (apoe) genotype is not well understood. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue Suppl 2. 2021-11-18. PMID:34393677. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yassin Watson, Brenae Nelson, Jamie Hernandez Kluesner, Caroline Tanzy, Shreya Ramesh, Zoey Patel, Kaci Hernandez Kluesner, Anita Singh, Vibha Murthy, Cassie S Mitchel. Aggregate Trends of Apolipoprotein E on Cognition in Transgenic Alzheimer's Disease Mice. Journal of Alzheimer's disease : JAD. vol 83. issue 1. 2021-11-17. PMID:34334405. |
apolipoprotein e (apoe) genotypes typically increase risk of amyloid-β deposition and onset of clinical alzheimer's disease (ad). |
2021-11-17 |
2023-08-13 |
mouse |
| Yulin Luo, Li Tan, Joseph Therriault, Hua Zhang, Ying Ga. The Role of Apolipoprotein E ε4 in Early and Late Mild Cognitive Impairment. European neurology. vol 84. issue 6. 2021-11-17. PMID:34340229. |
our goal was to evaluate the association of apoe ε4 with cerebrospinal fluid (csf) tau levels and cognition in emci and lmci patients in the alzheimer's disease neuroimaging initiative database, and whether this association was mediated by amyloid-β (aβ). |
2021-11-17 |
2023-08-13 |
Not clear |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
neuroinflammation is a common feature in neurodegenerative diseases, modulated by the alzheimer's disease risk factor, apolipoprotein e (apoe). |
2021-11-16 |
2023-08-13 |
mouse |
| Andrew E Weller, Glenn A Doyle, Benjamin C Reiner, Richard C Crist, Wade H Berrettin. Analysis of differential gene expression and transcript usage in hippocampus of Apoe null mutant mice: Implications for Alzheimer's disease. Neuroscience research. 2021-11-16. PMID:34757086. |
analysis of differential gene expression and transcript usage in hippocampus of apoe null mutant mice: implications for alzheimer's disease. |
2021-11-16 |
2023-08-13 |
mouse |
| Andrew E Weller, Glenn A Doyle, Benjamin C Reiner, Richard C Crist, Wade H Berrettin. Analysis of differential gene expression and transcript usage in hippocampus of Apoe null mutant mice: Implications for Alzheimer's disease. Neuroscience research. 2021-11-16. PMID:34757086. |
apoe regulation of gene transcription and co-transcriptional rna processing may underlie alzheimer's disease. |
2021-11-16 |
2023-08-13 |
mouse |
| Nahid Zokaei, Alexander G Board, Ellie Slavkova, Clare E Mackay, Anna Christina Nobre, Masud Husai. Superior short-term memory in APOE ε2 carriers across the age range. Behavioural brain research. vol 397. 2021-11-15. PMID:32961217. |
however, while the apoe ε4 allele confers significantly increased risk of developing alzheimer's disease (ad), the apoe ε2 allele is hypothesized to be protective against the development of ad. |
2021-11-15 |
2023-08-13 |
human |