| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yueming Hu, Cristiana Meuret, Ashley Martinez, Hussein N Yassine, Dobrin Nedelko. Distinct patterns of apolipoprotein C-I, C-II, and C-III isoforms are associated with markers of Alzheimer's disease. Journal of lipid research. vol 62. 2021-10-13. PMID:33518512. |
apolipoproteins c-i, c-ii, and c-iii interact with apoe to regulate lipoprotein metabolism and contribute to alzheimer's disease pathophysiology. |
2021-10-13 |
2023-08-13 |
Not clear |
| Yueming Hu, Cristiana Meuret, Ashley Martinez, Hussein N Yassine, Dobrin Nedelko. Distinct patterns of apolipoprotein C-I, C-II, and C-III isoforms are associated with markers of Alzheimer's disease. Journal of lipid research. vol 62. 2021-10-13. PMID:33518512. |
these patterns were accentuated in apoe Ɛ4 allele carriers, suggesting an association between apoe4 genotype and alzheimer's disease pathology with apocs processing and function in the brain. |
2021-10-13 |
2023-08-13 |
Not clear |
| Lei Wang, Wei Kong, Shuaiqun Wan. Detecting genetic associations with brain imaging phenotypes in Alzheimer's disease via a novel structured KCCA approach. Journal of bioinformatics and computational biology. vol 19. issue 4. 2021-10-13. PMID:33950804. |
we evaluate this model using alzheimer's disease neuroimaging initiative (adni) cohort to discover the relationships among snps from alzheimer's disease (ad) risk gene apoe, imaging qts extracted from structural magnetic resonance imaging (mri) scans. |
2021-10-13 |
2023-08-13 |
human |
| Nicholas Brookhouser, Sreedevi Raman, Carlye Frisch, Gayathri Srinivasan, David A Brafma. APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease. Molecular psychiatry. 2021-10-12. PMID:33837271. |
genome-wide association studies (gwas) have identified polymorphism in the apolipoprotein e gene (apoe) to be the most prominent risk factor for alzheimer's disease (ad). |
2021-10-12 |
2023-08-13 |
human |
| Matteo De Marco, Riccardo Manca, Janine Kirby, Guillaume M Hautbergue, Daniel J Blackburn, Stephen B Wharton, Annalena Venneri, Alzheimer's Disease Neuroimaging Initiativ. The Association between Polygenic Hazard and Markers of Alzheimer's Disease Following Stratification for APOE Genotype. Current Alzheimer research. vol 17. issue 7. 2021-10-11. PMID:33023447. |
the association between polygenic hazard and markers of alzheimer's disease following stratification for apoe genotype. |
2021-10-11 |
2023-08-13 |
Not clear |
| Paula Duarte-Guterman, Arianne Y Albert, Cindy K Barha, Liisa A M Galea, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory. Psychoneuroendocrinology. vol 129. 2021-10-11. PMID:33962245. |
sex influences the effects of apoe genotype and alzheimer's diagnosis on neuropathology and memory. |
2021-10-11 |
2023-08-13 |
Not clear |
| Lance A Johnso. APOE and metabolic dysfunction in Alzheimer's disease. International review of neurobiology. vol 154. 2021-10-07. PMID:32739002. |
apoe and metabolic dysfunction in alzheimer's disease. |
2021-10-07 |
2023-08-13 |
Not clear |
| Lance A Johnso. APOE and metabolic dysfunction in Alzheimer's disease. International review of neurobiology. vol 154. 2021-10-07. PMID:32739002. |
the strongest genetic risk factor for sporadic alzheimer's disease (ad) is carriage of the e4 allele of apoe. |
2021-10-07 |
2023-08-13 |
Not clear |
| Praveen Kulkarni, Simone Grant, Thomas R Morrison, Xuezhu Cai, Sade Iriah, Bruce S Kristal, Jennifer Honeycutt, Heather Brenhouse, Jochen C Hartner, Dan Madularu, Craig F Ferri. Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging. Brain research. vol 1747. 2021-10-07. PMID:32745658. |
the apoe Ɛ4 genotype is the most prevalent genetic risk for alzheimer's disease (ad). |
2021-10-07 |
2023-08-13 |
human |
| Xurui Jin, Wanying He, Yan Zhang, Enying Gong, Zhangming Niu, John Ji, Yaxi Li, Yi Zeng, Lijing L Ya. Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study. PLoS medicine. vol 18. issue 6. 2021-10-04. PMID:34061824. |
apolipoprotein e (apoe) ε4 is the single most important genetic risk factor for cognitive impairment and alzheimer disease (ad), while lifestyle factors such as smoking, drinking, diet, and physical activity also have impact on cognition. |
2021-10-04 |
2023-08-13 |
Not clear |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
prediction of clinical diagnosis of alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and apoe status in a community-based cohort prospectively followed over 17 years. |
2021-10-02 |
2023-08-13 |
human |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:32404947. |
the strongest genetic risk factor for alzheimer's disease (ad) is the ε4 allele of apolipoprotein e (apoe) and recent genome-wide association meta-analyses have confirmed additional associated genetic loci with smaller effects. |
2021-10-02 |
2023-08-13 |
human |
| Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David A Bennett, Kathryn L Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Ju. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Molecular psychiatry. 2021-10-02. PMID:34480088. |
integrative brain transcriptome analysis links complement component 4 and hspa2 to the apoe ε2 protective effect in alzheimer disease. |
2021-10-02 |
2023-08-13 |
Not clear |
| Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David A Bennett, Kathryn L Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Ju. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Molecular psychiatry. 2021-10-02. PMID:34480088. |
mechanisms underlying the protective effect of apolipoprotein e (apoe) ε2 against alzheimer disease (ad) are not well understood. |
2021-10-02 |
2023-08-13 |
Not clear |
| H Stocker, L Perna, K Weigl, T Möllers, B Schöttker, H Thomsen, B Holleczek, D Rujescu, H Brenne. Correction: Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry. 2021-10-02. PMID:34599279. |
correction: prediction of clinical diagnosis of alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and apoe status in a community-based cohort prospectively followed over 17 years. |
2021-10-02 |
2023-08-13 |
Not clear |
| Masaki Ikeda, Koichi Okamoto, Keiji Suzuki, Masakuni Amari, Eriko Takai, Masamitsu Takatama, Hideaki Yokoo, Shun Ishibashi, Yoshio Iked. Polygenic variants related to familial hypobetalipoproteinemia in a patient with Alzheimer's disease homozygotic for the APOE ε2 allele presenting multiple cortical superficial siderosis and recurrent lobar hemorrhages. Neurogenetics. 2021-10-02. PMID:34599737. |
polygenic variants related to familial hypobetalipoproteinemia in a patient with alzheimer's disease homozygotic for the apoe ε2 allele presenting multiple cortical superficial siderosis and recurrent lobar hemorrhages. |
2021-10-02 |
2023-08-13 |
Not clear |
| Marloes Verkerke, Elly M Hol, Jinte Middeldor. Physiological and Pathological Ageing of Astrocytes in the Human Brain. Neurochemical research. vol 46. issue 10. 2021-09-30. PMID:33559106. |
in addition to ageing, apoe ε4 is genetically the strongest risk factor for alzheimer's disease and is highly expressed in astrocytes. |
2021-09-30 |
2023-08-13 |
human |
| Se-In Lee, Woojin Jeong, Heejin Lim, Sukhee Cho, Hyein Lee, Yonghee Jang, Joonho Cho, Simsung Bae, Yuan-Ta Lin, Li-Huei Tsai, Dae Won Moon, Jinsoo Se. APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation. Stem cell reports. vol 16. issue 9. 2021-09-29. PMID:34450034. |
the ε4 allele of apoe-encoding apolipoprotein (apoe) is one of the strongest genetic risk factors for alzheimer's disease (ad). |
2021-09-29 |
2023-08-13 |
human |
| Asiamah Ernest Amponsah, Baofeng Feng, Ruiyun Guo, Wei Zhang, Jingjing He, Desheng Kong, Tianyu Dong, Jun Ma, Huixian Cu. Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. Reviews in the neurosciences. vol 31. issue 6. 2021-09-24. PMID:32364519. |
fragmentation of brain apolipoprotein e (apoe) and its relevance in alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yury Loika, Fan Feng, Elena Loiko, Alexander M Kulminsk. Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids. GeroScience. 2021-09-23. PMID:34554385. |
mediation of the apoe associations with alzheimer's and coronary heart diseases through body mass index and lipids. |
2021-09-23 |
2023-08-13 |
Not clear |