| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yury Loika, Fan Feng, Elena Loiko, Alexander M Kulminsk. Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids. GeroScience. 2021-09-23. PMID:34554385. |
the apoe ε2/ε3/ε4 polymorphism is associated with multiple non-mendelian traits, including high- (hdl-c) and low- (ldl-c) density lipoprotein cholesterol, triglycerides, body mass index (bmi), coronary heart disease (chd), and alzheimer's disease (ad). |
2021-09-23 |
2023-08-13 |
Not clear |
| Adam J Dugan, Peter T Nelson, Yuriko Katsumata, Lincoln M P Shade, Kevin L Boehme, Merilee A Teylan, Matthew D Cykowski, Shubhabrata Mukherjee, John S K Kauwe, Timothy J Hohman, Julie A Schneider, David W Fard. Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study. Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34526147. |
single nucleotide variants (snvs) within 10 kb of tmem106b, grn, abcc9, kcnmb2, and apoe were tested for association with hs and late-nc, and separately for alzheimer's pathologies, i.e. |
2021-09-22 |
2023-08-13 |
human |
| b' Mirjana Babi\\xc4\\x87 Leko, Jasna Jurasovi\\xc4\\x87, Matea Nikolac Perkovi\\xc4\\x87, Ena \\xc5\\xa0pani\\xc4\\x87, Ankica Sekovani\\xc4\\x87, Tatjana Orct, Vesna Lukinovi\\xc4\\x87 \\xc5\\xa0kudar, Koraljka Ba\\xc4\\x8di\\xc4\\x87 Baronica, Spomenka Ki\\xc4\\x91emet-Piska\\xc4\\x8d, \\xc5\\xbdeljka Vogrinc, Nela Pivac, Fran Borove\\xc4\\x8dki, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. The Association of Essential Metals with APOE Genotype in Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 82. issue 2. 2021-09-20. PMID:34057084.' |
the association of essential metals with apoe genotype in alzheimer's disease. |
2021-09-20 |
2023-08-13 |
Not clear |
| b' Mirjana Babi\\xc4\\x87 Leko, Jasna Jurasovi\\xc4\\x87, Matea Nikolac Perkovi\\xc4\\x87, Ena \\xc5\\xa0pani\\xc4\\x87, Ankica Sekovani\\xc4\\x87, Tatjana Orct, Vesna Lukinovi\\xc4\\x87 \\xc5\\xa0kudar, Koraljka Ba\\xc4\\x8di\\xc4\\x87 Baronica, Spomenka Ki\\xc4\\x91emet-Piska\\xc4\\x8d, \\xc5\\xbdeljka Vogrinc, Nela Pivac, Fran Borove\\xc4\\x8dki, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. The Association of Essential Metals with APOE Genotype in Alzheimer\'s Disease. Journal of Alzheimer\'s disease : JAD. vol 82. issue 2. 2021-09-20. PMID:34057084.' |
the major confirmed genetic risk factor for late-onset, sporadic alzheimer's disease (ad) is variant ɛ4 of apolipoprotein e gene (apoe). |
2021-09-20 |
2023-08-13 |
Not clear |
| Mitsuru Shinohara, Kaoru Suzuki, Guojun Bu, Naoyuki Sat. Interaction Between APOE Genotype and Diabetes in Longevity. Journal of Alzheimer's disease : JAD. vol 82. issue 2. 2021-09-20. PMID:34092638. |
while both apolipoprotein e (apoe) genotype and diabetes affect longevity as well as alzheimer's disease, their relationship remains to be elucidated. |
2021-09-20 |
2023-08-13 |
Not clear |
| Samantha B Kemp, Eileen S Carpenter, Nina G Steele, Katelyn L Donahue, Zeribe C Nwosu, Amanda Pacheco, Ashley Velez-Delgado, Rosa E Menjivar, Fatima Lima, Stephanie The, Carlos E Espinoza, Kristee Brown, Daniel Long, Costas A Lyssiotis, Arvind Rao, Yaqing Zhang, Marina Pasca di Magliano, Howard C Crawfor. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer research. vol 81. issue 16. 2021-09-18. PMID:34049975. |
tams in human and murine pdac are characterized by elevated expression of apolipoprotein e (apoe), an apolipoprotein that mediates cholesterol metabolism and has known roles in cardiovascular and alzheimer's disease but no known role in pdac. |
2021-09-18 |
2023-08-13 |
mouse |
| Kathleen H Elverman, Elizabeth R Paitel, Christina M Figueroa, Ryan J McKindles, Kristy A Nielso. Event-Related Potentials, Inhibition, and Risk for Alzheimer's Disease Among Cognitively Intact Elders. Journal of Alzheimer's disease : JAD. vol 80. issue 4. 2021-09-17. PMID:33682720. |
despite advances in understanding alzheimer's disease (ad), prediction of ad prior to symptom onset remains severely limited, even when primary risk factors such as the apolipoprotein e (apoe) ɛ4 allele are known. |
2021-09-17 |
2023-08-13 |
Not clear |
| Brandon C Farmer, Holden C Williams, Nicholas A Devanney, Margaret A Piron, Grant K Nation, David J Carter, Adeline E Walsh, Rebika Khanal, Lyndsay E A Young, Jude C Kluemper, Gabriela Hernandez, Elizabeth J Allenger, Rachel Mooney, Lesley R Golden, Cathryn T Smith, J Anthony Brandon, Vedant A Gupta, Philip A Kern, Matthew S Gentry, Josh M Morganti, Ramon C Sun, Lance A Johnso. APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis. Molecular neurodegeneration. vol 16. issue 1. 2021-09-17. PMID:34488832. |
cerebral glucose hypometabolism is consistently observed in individuals with alzheimer's disease (ad), as well as in young cognitively normal carriers of the Ε4 allele of apolipoprotein e (apoe), the strongest genetic predictor of late-onset ad. |
2021-09-17 |
2023-08-13 |
Not clear |
| Maria Basta, Ioannis Zaganas, Panagiotis Simos, Eirini Koutentaki, Christina Dimovasili, Lambros Mathioudakis, Mara Bourbouli, Symeon Panagiotakis, Stefania Kapetanaki, Alexandros Vgontza. Apolipoprotein E ɛ4 (APOE ɛ4) Allele is Associated with Long Sleep Duration Among Elderly with Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 79. issue 2. 2021-09-16. PMID:33361595. |
apolipoprotein e gene (apoe) ɛ4 allele increases the risk for alzheimer's disease (ad). |
2021-09-16 |
2023-08-13 |
Not clear |
| Amanda B Chai, Hin Hei Julian Lam, Maaike Kockx, Ingrid C Gelisse. Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1866. issue 9. 2021-09-16. PMID:34044125. |
since the identification of the apolipoprotein e (apoe) *ε4 allele as a major genetic risk factor for late-onset alzheimer's disease, significant efforts have been aimed at elucidating how apoe4 expression confers greater brain amyloid-β (aβ) burden, earlier disease onset and worse clinical outcomes compared to apoe2 and apoe3. |
2021-09-16 |
2023-08-13 |
Not clear |
| Amanda B Chai, Hin Hei Julian Lam, Maaike Kockx, Ingrid C Gelisse. Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1866. issue 9. 2021-09-16. PMID:34044125. |
traditionally, apoe-oriented therapeutic strategies for alzheimer's disease have been proposed to non-specifically enhance or inhibit apoe activity. |
2021-09-16 |
2023-08-13 |
Not clear |
| Anna K Edlund, Kewei Chen, Wendy Lee, Hillary Protas, Yi Su, Eric Reiman, Richard Caselli, Henrietta M Nielse. Plasma Apolipoprotein E3 and Glucose Levels Are Associated in APOE ɛ3/ɛ4 Carriers. Journal of Alzheimer's disease : JAD. vol 81. issue 1. 2021-09-15. PMID:33814450. |
altered cerebral glucose metabolism, especially prominent in apoe ɛ4 carriers, occurs years prior to symptoms in alzheimer's disease (ad). |
2021-09-15 |
2023-08-13 |
human |
| Na An, Yu Fu, Jie Shi, Han-Ning Guo, Zheng-Wu Yang, Yong-Chao Li, Shan Li, Yin Wang, Zhi-Jun Yao, Bin H. Synergistic Effects of APOE and CLU May Increase the Risk of Alzheimer's Disease: Acceleration of Atrophy in the Volumes and Shapes of the Hippocampus and Amygdala. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33682707. |
synergistic effects of apoe and clu may increase the risk of alzheimer's disease: acceleration of atrophy in the volumes and shapes of the hippocampus and amygdala. |
2021-09-14 |
2023-08-13 |
Not clear |
| Young-Gun Lee, Mincheol Park, Seong Ho Jeong, Sung Woo Kang, Kyoungwon Baik, Jin Ho Jung, Phil Hyu Lee, Young Ho Sohn, Byoung Seok Y. Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism. Neurobiology of aging. vol 106. 2021-09-14. PMID:34311431. |
to investigate the effect of serum uric acid on longitudinal cognitive and brain metabolic changes, we utilized data on baseline serum uric acid levels, apoe genotyping, and longitudinal cognitive scores from the alzheimer's disease neuroimaging initiative for 1,343 participants with normal cognition (nc), mild cognitive impairment (mci), or dementia. |
2021-09-14 |
2023-08-13 |
human |
| Chenxi Li, Di Wu, Qing L. Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics. Genetic epidemiology. vol 45. issue 1. 2021-09-13. PMID:32896012. |
the analysis identifies two genes, apoe and apoc1, associated with age to alzheimer's disease onset. |
2021-09-13 |
2023-08-13 |
human |
| Lilah M Besser, Gina S Lovasi, Yvonne L Michael, Parveen Garg, Jana A Hirsch, David Siscovick, Phil Hurvitz, Mary L Biggs, James E Galvin, Traci M Bartz, W T Longstret. Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study. Social psychiatry and psychiatric epidemiology. vol 56. issue 9. 2021-09-13. PMID:33388800. |
we investigated associations between neighborhood greenspace and brain-based magnetic resonance imaging (mri) measures and potential effect modification by sex or apolipoprotein e genotype (apoe), a risk factor for alzheimer's disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Rosie M Walker, Kadi Vaher, Mairead L Bermingham, Stewart W Morris, Andrew D Bretherick, Yanni Zeng, Konrad Rawlik, Carmen Amador, Archie Campbell, Chris S Haley, Caroline Hayward, David J Porteous, Andrew M McIntosh, Riccardo E Marioni, Kathryn L Evan. Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles. Genome medicine. vol 13. issue 1. 2021-09-13. PMID:33397400. |
the apolipoprotein e (apoe) ε4 allele is the strongest genetic risk factor for late onset alzheimer's disease, whilst the ε2 allele confers protection. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiaopu Zhou, Amy Ky Fu, Nancy Y I. APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33647674. |
apoe (apolipoprotein e) is a key regulator of lipid metabolism and a leading genetic risk factor for alzheimer's disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Xiaopu Zhou, Amy Ky Fu, Nancy Y I. APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33647674. |
however, emerging evidence suggests that some noncoding alzheimer's disease risk variants residing in apoe and its nearby regions exert apoe-ε4-independent risks and modify apoe gene expression. |
2021-09-13 |
2023-08-13 |
Not clear |
| Jesus D Melgarejo, Daniel C Aguirre-Acevedo, Ciro Gaona, Carlos A Chavez, Gustavo E Calmón, Eglé R Silva, Gabriel A de Erausquin, Mario Gil, Luis J Mena, Joseph D Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H Lee, Gladys E Maestr. Nighttime Blood Pressure Interacts with APOE Genotype to Increase the Risk of Incident Dementia of the Alzheimer's Type in Hispanics. Journal of Alzheimer's disease : JAD. vol 77. issue 2. 2021-09-09. PMID:32675415. |
nighttime blood pressure interacts with apoe genotype to increase the risk of incident dementia of the alzheimer's type in hispanics. |
2021-09-09 |
2023-08-13 |
Not clear |