| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Knut Hestad, Knut Engedal, Peter Horndalsveen, Bjørn Heine Stran. Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status. Frontiers in psychology. vol 12. 2021-07-02. PMID:34194377. |
the aim of this study was to investigate whether cognitive performance was equally influenced by apolipoprotein e (apoe, with its three alleles, e2, e3, and e4) in patients with subjective cognitive decline (scd), mild cognitive impairment (mci), and alzheimer's disease (ad). |
2021-07-02 |
2023-08-13 |
Not clear |
| Benjamin Schmid, Bjørn Holst, Christian Clausen, Lamiaa Bahnassawy, Peter Reinhardt, Margot H M Bakker, Eva Díaz-Guerra, Carlos Vicario, Pamela V Martino-Adami, Michaela Thoenes, Alfredo Ramirez, Klaus Fliessbach, Clara Grezella, Oliver Brüstle, Michael Peitz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease. Stem cell research. vol 52. 2021-06-30. PMID:33556820. |
apoe genotype is the strongest genetic risk factor for alzheimer's disease (ad). |
2021-06-30 |
2023-08-13 |
mouse |
| Benjamin Schmid, Bjørn Holst, Christian Clausen, Lamiaa Bahnassawy, Peter Reinhardt, Margot H M Bakker, Eva Díaz-Guerra, Carlos Vicario, Pamela V Martino-Adami, Michaela Thoenes, Alfredo Ramirez, Klaus Fliessbach, Clara Grezella, Oliver Brüstle, Michael Peitz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease. Stem cell research. vol 52. 2021-06-30. PMID:33556820. |
a key objective of adapted (alzheimer's disease apolipoprotein pathology for treatment elucidation and development) project was to generate in vitro models that better recapitulate human apoe biology. |
2021-06-30 |
2023-08-13 |
mouse |
| Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Selected LDLR and APOE Polymorphisms Affect Cognitive and Functional Response to Lipophilic Statins in Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 70. issue 10. 2021-06-29. PMID:32474901. |
selected ldlr and apoe polymorphisms affect cognitive and functional response to lipophilic statins in alzheimer's disease. |
2021-06-29 |
2023-08-13 |
Not clear |
| Amanda L Lumsden, Anwar Mulugeta, Ang Zhou, Elina Hyppöne. Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. EBioMedicine. vol 59. 2021-06-28. PMID:32818802. |
the three main alleles of the apoe gene (ε4, ε3 and ε2) carry differential risks for conditions including alzheimer's disease (ad) and cardiovascular disease. |
2021-06-28 |
2023-08-13 |
Not clear |
| Hao Hu, Lan Tan, Yan-Lin Bi, Wei Xu, Lin Tan, Xue-Ning Shen, Xiao-He Hou, Ya-Hui Ma, Qiang Dong, Jin-Tai Y. Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33531457. |
the bridging integrator 1 (bin1) gene is the second most important susceptibility gene for late-onset alzheimer's disease (load) after apolipoprotein e (apoe) gene. |
2021-06-28 |
2023-08-13 |
human |
| Jong-Ho Park, Inho Park, Emilia Moonkyung Youm, Sejoon Lee, June-Hee Park, Jongan Lee, Dong Young Lee, Min Soo Byun, Jun Ho Lee, Dahyun Yi, Sun Ju Chung, Kye Won Park, Nari Choi, Seong Yoon Kim, Woon Yoon, Hoyoung An, Ki Woong Kim, Seong Hye Choi, Jee Hyang Jeong, Eun-Joo Kim, Hyojin Kang, Junehawk Lee, Younghoon Kim, Eunjung Alice Lee, Sang Won Seo, Duk L Na, Jong-Won Ki. Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:34011927. |
novel alzheimer's disease risk variants identified based on whole-genome sequencing of apoe ε4 carriers. |
2021-06-28 |
2023-08-13 |
Not clear |
| Elles Konijnenberg, Betty M Tijms, Johan Gobom, Valerija Dobricic, Isabelle Bos, Stephanie Vos, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, Lutz Frölich, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Charlotte E Teunissen, Robert Veerhuis, August B Smit, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visse. APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:32460813. |
apoe ε4 genotype-dependent cerebrospinal fluid proteomic signatures in alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33129364. |
effect of apoe ε4 genotype on amyloid-β and tau accumulation in alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33129364. |
to assess the effects of apolipoprotein e (apoe) ε4 genotype on amyloid-β (aβ) and tau burden and their longitudinal changes in alzheimer's disease (ad) spectrum. |
2021-06-24 |
2023-08-13 |
Not clear |
| Sheina Emrani, Hirra A Arain, Cassandra DeMarshall, Tal Nurie. APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33148345. |
possession of the ε4 allele of apolipoprotein e (apoe) is the primary genetic risk factor for the sporadic form of alzheimer's disease (ad). |
2021-06-24 |
2023-08-13 |
Not clear |
| Amin Gharbi-Meliani, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, Julien Dumurgie. The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33397450. |
approximately 25% of the general population carries at least one ε4 allele of the apolipoprotein e (apoe ε4), the strongest genetic risk factor for late onset alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Jagan A Pillai, James Bena, Aaron Bonner-Jackson, James B Leveren. Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer's and Lewy body neuropathology. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33485373. |
impact of apoe ε4 genotype on initial cognitive symptoms differs for alzheimer's and lewy body neuropathology. |
2021-06-24 |
2023-08-13 |
Not clear |
| Jagan A Pillai, James Bena, Aaron Bonner-Jackson, James B Leveren. Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer's and Lewy body neuropathology. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33485373. |
apoe ε4 carrier status is known to increase odds of amnestic presentations with alzheimer's pathology. |
2021-06-24 |
2023-08-13 |
Not clear |
| Jagan A Pillai, James Bena, Aaron Bonner-Jackson, James B Leveren. Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer's and Lewy body neuropathology. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33485373. |
here we evaluate the impact of apoe ε4 genotype on initial cognitive symptoms among those with alzheimer's disease pathology (adp) and lewy-related pathology (lrp). |
2021-06-24 |
2023-08-13 |
Not clear |
| Michael Ouk, Che-Yuan Wu, Jennifer S Rabin, Aaron Jackson, Jodi D Edwards, Joel Ramirez, Mario Masellis, Richard H Swartz, Nathan Herrmann, Krista L Lanctôt, Sandra E Black, Walter Swardfage. The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33573702. |
the use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in alzheimer's disease: the importance of blood-brain barrier penetration and apoe ε4 carrier status. |
2021-06-24 |
2023-08-13 |
Not clear |
| Yuka A Martens, Siming Xu, Richard Tait, Gary Li, Xinping C Zhao, Wenyan Lu, Chia-Chen Liu, Takahisa Kanekiyo, Guojun Bu, Jing Zha. Generation and validation of STAR protocols. vol 2. issue 2. 2021-06-22. PMID:34151296. |
generation and validation of apolipoprotein e (apoe) is a major lipid carrier in the brain and closely associated with the pathogenesis of alzheimer's disease (ad). |
2021-06-22 |
2023-08-13 |
Not clear |
| Yi Yan, Yinghui Qiu, Aonan Zhao, Jian Zhao, Ying Wang, Yulei Den. Establishment of SIAISi002-A, an induced pluripotent stem cell (iPSC) line from 39-year old healthy female donor with a family history of Alzheimer's disease (AD) and two copies of APOE4 gene. Stem cell research. vol 45. 2021-06-21. PMID:32339902. |
a 39-year old healthy female with a family history of alzheimer's disease (ad) and two copies of apolipoprotein e(apoe) ε4 allele donated her peripheral blood mononuclear cells (pbmc). |
2021-06-21 |
2023-08-13 |
human |
| Juan Ma, Christopher Qian, Yong Bao, Meng-Yue Liu, Hui-Min Ma, Meng-Qi Shen, Wei Li, Jiao-Jiao Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qia. Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice. Redox biology. vol 40. 2021-06-21. PMID:33493903. |
association of both iron/hepcidin and apolipoprotein e (apoe) with development of alzheimer disease (ad) and atherosclerosis led us to hypothesize that apoe might be required for body iron homeostasis. |
2021-06-21 |
2023-08-13 |
mouse |
| Chao Wang, Monica Xiong, Maud Gratuze, Xin Bao, Yang Shi, Prabhakar Sairam Andhey, Melissa Manis, Caitlin Schroeder, Zhuoran Yin, Charlotte Madore, Oleg Butovsky, Maxim Artyomov, Jason D Ulrich, David M Holtzma. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron. vol 109. issue 10. 2021-06-21. PMID:33831349. |
the apolipoprotein e (apoe) gene is the strongest genetic risk factor for alzheimer's disease and directly influences tauopathy and tau-mediated neurodegeneration. |
2021-06-21 |
2023-08-13 |
Not clear |