| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Teresa Periñán, Daniel Macías-García, Miguel Ángel Labrador-Espinosa, Silvia Jesús, Dolores Buiza-Rueda, Astrid D Adarmes-Gómez, Laura Muñoz-Delgado, Pilar Gómez-Garre, Pablo Mi. Association of PICALM with Cognitive Impairment in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 1. 2021-04-27. PMID:32914893. |
recently, a genome-wide association study in alzheimer's disease has identified the picalm rs3851179 polymorphism as one of the most significant susceptibility genes for alzheimer's disease after apoe. |
2021-04-27 |
2023-08-13 |
Not clear |
| Shima Safaiyan, Simon Besson-Girard, Tuğberk Kaya, Ludovico Cantuti-Castelvetri, Lu Liu, Hao Ji, Martina Schifferer, Garyfallia Gouna, Fumere Usifo, Nirmal Kannaiyan, Dirk Fitzner, Xianyuan Xiang, Moritz J Rossner, Matthias Brendel, Ozgun Gokce, Mikael Simon. White matter aging drives microglial diversity. Neuron. vol 109. issue 7. 2021-04-27. PMID:33606969. |
in the aged brain, wams form independent of apolipoprotein e (apoe), in contrast to mouse models of alzheimer's disease, in which microglia with the wam gene signature are generated prematurely and in an apoe-dependent pathway similar to dams. |
2021-04-27 |
2023-08-13 |
mouse |
| Francisca S Rodriguez, Susanne Roehr, Alexander Pabst, Luca Kleineidam, Angela Fuchs, Birgitt Wiese, Dagmar Lühmann, Christian Brettschneider, Steffen Wolfsgruber, Michael Pentzek, Hendrik van den Bussche, Hans-Helmut König, Siegfried Weyerer, Jochen Werle, Horst Bickel, Dagmar Weeg, Wolfgang Maier, Martin Scherer, Michael Wagner, Steffi G Riedel-Helle. Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). International journal of geriatric psychiatry. vol 36. issue 1. 2021-04-23. PMID:32819031. |
we investigated to what extent eight different types of mental demands at work together with the apoe e4 allele, a major risk gene for late-onset alzheimer's disease, affect cognitive functioning in late life. |
2021-04-23 |
2023-08-13 |
human |
| Hee-Jin Kim, Junhui Park, Yong Sung Kim, Jinseok Par. The sex-specific effect of the apolipoprotein E allele and methylenetetrahydrofolate reductase gene polymorphism on the biochemical, anatomical, and cognitive profiles of patients clinically diagnosed with probable Alzheimer's disease. International journal of geriatric psychiatry. vol 36. issue 4. 2021-04-23. PMID:33166415. |
we aimed to evaluate the sex-specific effect of apolipoprotein e (apoe) alleles and methylenetetrahydrofolate reductase (mthfr) c677t polymorphism on the biochemical, anatomical, and cognitive profiles of alzheimer's disease (ad) patients. |
2021-04-23 |
2023-08-13 |
Not clear |
| Chelsea C Hays, Zvinka Z Zlatar, M J Meloy, Jessica Osuna, Thomas T Liu, Douglas R Galasko, Christina E Wiereng. Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-20. PMID:31743999. |
significant interactions of csf tau and apoe on cth/cbf were not observed in two posterior reference regions implicated in alzheimer's disease. |
2021-04-20 |
2023-08-13 |
Not clear |
| Katerina Cechova, Ross Andel, Francesco Angelucci, Zuzana Chmatalova, Hana Markova, Jan Laczó, Martin Vyhnalek, Vaclav Matoska, Vojtech Kaplan, Zuzana Nedelska, David D Ward, Jakub Hor. Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31771052. |
apolipoprotein (apoe) ɛ4 is a well-known risk factor for late-onset alzheimer's disease (ad), but other ad-related gene polymorphisms might also be important, such as the polymorphism within the brain-derived neurotrophic factor (bdnf) gene. |
2021-04-19 |
2023-08-13 |
Not clear |
| Natalie Tomaszewski, Xulei He, Victoria Solomon, Mitchell Lee, Wendy J Mack, Joseph F Quinn, Meredith N Braskie, Hussein N Yassin. Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial. Journal of Alzheimer's disease : JAD. vol 74. issue 3. 2021-04-19. PMID:32116250. |
effect of apoe genotype on plasma docosahexaenoic acid (dha), eicosapentaenoic acid, arachidonic acid, and hippocampal volume in the alzheimer's disease cooperative study-sponsored dha clinical trial. |
2021-04-19 |
2023-08-13 |
Not clear |
| Natalie Tomaszewski, Xulei He, Victoria Solomon, Mitchell Lee, Wendy J Mack, Joseph F Quinn, Meredith N Braskie, Hussein N Yassin. Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial. Journal of Alzheimer's disease : JAD. vol 74. issue 3. 2021-04-19. PMID:32116250. |
in a pre-planned subgroup analysis of the alzheimer's disease cooperative study-sponsored dha clinical trial, apoe4 carriers with mild probable ad had no improvements in cognitive outcomes compared to placebo, while apoe 4 non-carriers showed a benefit from dha supplementation. |
2021-04-19 |
2023-08-13 |
Not clear |
| Cutler T Lewandowski, Juan Maldonado Weng, Mary Jo LaD. Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How. Neurobiology of disease. vol 139. 2021-04-12. PMID:32087290. |
alzheimer's disease pathology in apoe transgenic mouse models: the who, what, when, where, why, and how. |
2021-04-12 |
2023-08-13 |
mouse |
| Ai-Ling Lin, Ishita Parikh, Lucille M Yanckello, Renee S White, Anika M S Hartz, Chase E Taylor, Scott D McCulloch, Scott W Thalman, Mengfan Xia, Katie McCarty, Margo Ubele, Elizabeth Head, Fahmeed Hyder, Basavaraju G Sanganahall. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology of disease. vol 139. 2021-04-12. PMID:32173556. |
apoe genotype-dependent pharmacogenetic responses to rapamycin for preventing alzheimer's disease. |
2021-04-12 |
2023-08-13 |
mouse |
| D Allan Butterfield, Lance A Johnso. APOE in Alzheimer's disease and neurodegeneration. Neurobiology of disease. vol 139. 2021-04-12. PMID:32209402. |
apoe in alzheimer's disease and neurodegeneration. |
2021-04-12 |
2023-08-13 |
Not clear |
| Terry E Goldberg, Edward D Huey, Davangere P Devanan. Associations of APOE e2 genotype with cerebrovascular pathology: a postmortem study of 1275 brains. Journal of neurology, neurosurgery, and psychiatry. 2021-04-07. PMID:33148816. |
we assessed the association of apolipoprotein e (apoe) genotype with cerebrovascular disease (cvd) in a large neuropathological database maintained by the national alzheimer's coordinating center (nacc). |
2021-04-07 |
2023-08-13 |
Not clear |
| Terry E Goldberg, Edward D Huey, Davangere P Devanan. Associations of APOE e2 genotype with cerebrovascular pathology: a postmortem study of 1275 brains. Journal of neurology, neurosurgery, and psychiatry. 2021-04-07. PMID:33148816. |
we focused on apoe e2, an established neuroprotective genetic variant against alzheimer's disease. |
2021-04-07 |
2023-08-13 |
Not clear |
| Heidi M Leskinen, Maaria Tringham, Heli Karjalainen, Terhi K Iso-Touru, Hanna-Leena Hietaranta-Luoma, Pertti J Marnila, Juha-Matti Pihlava, Timo Hurme, Santeri J Kankaanpää, Hannu Puolijoki, Kari Åkerman, Laura Tanner, Mari Sandell, Kirsi Vähäkangas, Anu Hopia, Raija Tahvonen, L Susanna Rokk. APOE Genotype Disclosure and Lifestyle Advice in a Randomized Intervention Study with Finnish Participants. The Journal of nutrition. vol 151. issue 1. 2021-04-05. PMID:33188400. |
the apoe ε4 allele is associated with higher risks of cardiovascular diseases and alzheimer disease than ε3 and ε2. |
2021-04-05 |
2023-08-13 |
human |
| P M Sulliva. Influence of Western diet and APOE genotype on Alzheimer's disease risk. Neurobiology of disease. vol 138. 2021-03-30. PMID:32032732. |
influence of western diet and apoe genotype on alzheimer's disease risk. |
2021-03-30 |
2023-08-13 |
Not clear |
| Sreedevi Raman, Nicholas Brookhouser, David A Brafma. Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk. Neurobiology of disease. vol 138. 2021-03-30. PMID:32032733. |
using human induced pluripotent stem cells (hipscs) to investigate the mechanisms by which apolipoprotein e (apoe) contributes to alzheimer's disease (ad) risk. |
2021-03-30 |
2023-08-13 |
human |
| Ana B Martínez-Martínez, Elena Torres-Perez, Nicholas Devanney, Raquel Del Moral, Lance A Johnson, Jose M Arbones-Maina. Beyond the CNS: The many peripheral roles of APOE. Neurobiology of disease. vol 138. 2021-03-30. PMID:32087284. |
historically, the vast majority of research on apoe has centered on the important role it plays in modulating risk for cardiovascular disease and alzheimer's disease. |
2021-03-30 |
2023-08-13 |
Not clear |
| Maria Fe Lanfranco, Christi Anne Ng, G William Rebec. ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 17. 2021-03-29. PMID:32882843. |
apoe lipidation as a therapeutic target in alzheimer's disease. |
2021-03-29 |
2023-08-13 |
Not clear |
| Anita Yee, Nancy B Y Tsui, Rick Y C Kwan, Angela Y M Leung, Claudia K Y Lai, Teresa Chung, Johnson Y N Lau, Manson Fok, David L K Dai, Lok-Ting La. Apolipoprotein E Gene Revisited: Contribution of Rare Variants to Alzheimer's Disease Susceptibility in Southern Chinese. Current Alzheimer research. 2021-03-25. PMID:33761857. |
apoe ε4 is the best-known risk factor for late-onset alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Carolin Koriath, Tammaryn Lashley, William Taylor, Ronald Druyeh, Athanasios Dimitriadis, Nicola Denning, Julie Williams, Jason D Warren, Nick C Fox, Jonathan M Schott, James B Rowe, John Collinge, Jonathan D Rohrer, Simon Mea. ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2021-03-24. PMID:30949567. |
apolipoprotein e (apoe) is the most important genetic risk factor for alzheimer's disease (ad), with apoe4 thought to enhance and accelerate amyloid-β (aβ) pathology. |
2021-03-24 |
2023-08-13 |
mouse |