| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuting Dai, Wenxin Zhang, Jinghui Guo, Weihao Di, Jian Zhao, Bei Zhang, Ying Wan. Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79-year-old patient with Alzheimer's disease having APOE3/4 genetic background. Stem cell research. vol 48. 2021-05-28. PMID:32822964. |
the genotype of apolipoprotein e (apoe) is closely associated with susceptibility to alzheimer's disease. |
2021-05-28 |
2023-08-13 |
human |
| Liang Zhang, Hao Wang, Glen M Abel, Daniel R Storm, Zhengui Xi. The Effects of Gene-Environment Interactions Between Cadmium Exposure and Apolipoprotein E4 on Memory in a Mouse Model of Alzheimer's Disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 173. issue 1. 2021-05-27. PMID:31626305. |
the ε4 allele, compared with the common ε3 allele, of the human apolipoprotein e gene (apoe) is associated with accelerated cognitive decline and increased risks for alzheimer's disease (ad). |
2021-05-27 |
2023-08-13 |
mouse |
| Hannah L Chandler, Carl J Hodgetts, Xavier Caseras, Kevin Murphy, Thomas M Lancaste. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 7. 2021-05-27. PMID:31896120. |
preclinical models of alzheimer's disease (ad) suggest apoe modulates brain function in structures vulnerable to ad pathophysiology. |
2021-05-27 |
2023-08-13 |
Not clear |
| Alexandra Litvinchuk, Tien-Phat V Huynh, Yang Shi, Rosemary J Jackson, Mary B Finn, Melissa Manis, Caroline M Francis, Ainsley C Tran, Patrick M Sullivan, Jason D Ulrich, Bradley T Hyman, Tracy Cole, David M Holtzma. Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model. Annals of neurology. vol 89. issue 5. 2021-05-26. PMID:33550655. |
apolipoprotein e (apoe) genotype is the strongest genetic risk factor for late-onset alzheimer's disease, with the ε4 allele increasing risk in a dose-dependent fashion. |
2021-05-26 |
2023-08-13 |
Not clear |
| Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Hui Hong, Shuyue Wang, Xiaojun Guan, Jingjing Wu, Ruiting Zhang, Tianyi Zhang, Zheyu Li, Yanv Fu, Tao Wang, Chao Wang, Xiaojun Xu, Peiyu Huang, Minming Zhan. Effects of APOE ε2 on the Fractional Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment: A Study Based on the Resting-State Functional MRI. Frontiers in aging neuroscience. vol 13. 2021-05-18. PMID:33994988. |
apolipoprotein e (apoe) ε2 is a protective genetic factor for alzheimer's disease (ad). |
2021-05-18 |
2023-08-13 |
Not clear |
| Sarah Waldie, Federica Sebastiani, Martine Moulin, Rita Del Giudice, Nicolò Paracini, Felix Roosen-Runge, Yuri Gerelli, Sylvain Prevost, John C Voss, Tamim A Darwish, Nageshwar Yepuri, Harald Pichler, Selma Maric, V Trevor Forsyth, Michael Haertlein, Marité Cárdena. ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. Frontiers in chemistry. vol 9. 2021-05-18. PMID:33996741. |
apolipoprotein e (apoe), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and alzheimer's. |
2021-05-18 |
2023-08-13 |
Not clear |
| Kunie Ando, Robert De Decker, Cristina Vergara, Zehra Yilmaz, Salwa Mansour, Valérie Suain, Kristel Sleegers, Marie-Ange de Fisenne, Sarah Houben, Marie-Claude Potier, Charles Duyckaerts, Toshio Watanabe, Luc Buée, Karelle Leroy, Jean-Pierre Brio. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31925534. |
genome-wide association studies (gwas) have identified picalm as one of the most significant susceptibility loci for late-onset alzheimer's disease (ad) after apoe and bin1. |
2021-05-17 |
2023-08-13 |
mouse |
| Hanwen Lu, Binrong Ding, Liujuan Tong, Fan Wu, Xinyao Yi, Jianxiu Wan. Toehold-Mediated Strand Displacement Reaction for Dual-Signal Electrochemical Assay of Apolipoprotein E Genotyping. ACS sensors. vol 5. issue 9. 2021-05-14. PMID:32869976. |
apolipoprotein e (apoe) polymorphic genes are one of the main genetic determinants of alzheimer's disease (ad) risk. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang-En Yu, Sunny Chen, Suman Jayadev, Thomas Bir. Lack of APOE Christchurch variant in five age of onset outliers with PSEN1, PSEN2 Alzheimer's disease and MAPT frontotemporal dementia. Journal of the neurological sciences. vol 418. 2021-05-14. PMID:32977230. |
lack of apoe christchurch variant in five age of onset outliers with psen1, psen2 alzheimer's disease and mapt frontotemporal dementia. |
2021-05-14 |
2023-08-13 |
human |
| Ming Huang, Yu Wang, Lu Wang, Bo Chen, Xiong Wang, Yu H. APOE rs405509 polymorphism and Parkinson's disease risk in the Chinese population. Neuroscience letters. vol 736. 2021-05-13. PMID:32682842. |
apolipoprotein e (apoe) rs405509 (-219 t/g), a promoter snp, controls the expression of apoe gene, and plays a modifier effect of apoe ε4 on the susceptibility of alzheimer's disease. |
2021-05-13 |
2023-08-13 |
human |
| Gurjeet Kaur, Anne Poljak, Nady Braidy, John D Crawford, Jessica Lo, Perminder S Sachde. Fluid Biomarkers and APOE Status of Early Onset Alzheimer's Disease Variants: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. vol 75. issue 3. 2021-05-10. PMID:32333592. |
fluid biomarkers and apoe status of early onset alzheimer's disease variants: a systematic review and meta-analysis. |
2021-05-10 |
2023-08-13 |
Not clear |
| Erin B Ware, Jessica D Faul, Colter M Mitchell, Kelly M Bakulsk. Considering the APOE locus in Alzheimer's disease polygenic scores in the Health and Retirement Study: a longitudinal panel study. BMC medical genomics. vol 13. issue 1. 2021-05-10. PMID:33143703. |
considering the apoe locus in alzheimer's disease polygenic scores in the health and retirement study: a longitudinal panel study. |
2021-05-10 |
2023-08-13 |
Not clear |
| Erin B Ware, Jessica D Faul, Colter M Mitchell, Kelly M Bakulsk. Considering the APOE locus in Alzheimer's disease polygenic scores in the Health and Retirement Study: a longitudinal panel study. BMC medical genomics. vol 13. issue 1. 2021-05-10. PMID:33143703. |
with phenotypes like alzheimer's disease, which have a strong and well-established genomic locus (apoe), the cumulative effect of genetic variants outside of this area has not been well established in a population-representative sample. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hyun Ju Yang, Na Ri Kang, Young Eun Jung, Moon Doo Kim, Hyun Ghang Jeong, Tae Jin Lee, Ji Won Han, Ki Woong Kim, Joon Hyuk Par. "Choosing Wisely": Apolipoprotein E Genetic Testing for the Diagnosis of Alzheimer's Disease in Dementia Clinics. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32176640. |
apolipoprotein e (apoe) ɛ4 allele carriers have an increased risk of late-onset alzheimer's disease (ad). |
2021-05-07 |
2023-08-13 |
Not clear |
| Paula Duarte-Guterman, Arianne Y Albert, Amy M Inkster, Cindy K Barha, Liisa A M Gale. Inflammation in Alzheimer's Disease: Do Sex and APOE Matter? Journal of Alzheimer's disease : JAD. vol 78. issue 2. 2021-05-07. PMID:33016923. |
inflammation in alzheimer's disease: do sex and apoe matter? |
2021-05-07 |
2023-08-13 |
Not clear |
| Janik Goltermann, Jonathan Repple, Ronny Redlich, Katharina Dohm, Claas Flint, Dominik Grotegerd, Lena Waltemate, Hannah Lemke, Stella Mercedes Fingas, Susanne Meinert, Verena Enneking, Tim Hahn, Jochen Bauer, Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Olaf Steinsträter, Andreas Jansen, Axel Krug, Igor Nenadić, Bernhard T Baune, Marcella Rietschel, Stephanie Witt, Andreas J Forstner, Markus Nöthen, Andreas Johnen, Judith Alferink, Tilo Kircher, Udo Dannlowski, Nils Ope. Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 46. 2021-05-03. PMID:33648793. |
apolipoprotein e (apoe) genotype is the strongest single gene predictor of alzheimer's disease (ad) and has been frequently associated with ad-related brain structural alterations before the onset of dementia. |
2021-05-03 |
2023-08-13 |
human |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
interplay between microglia and alzheimer's disease-focus on the most relevant risks: apoe genotype, sex and age. |
2021-04-28 |
2023-08-13 |
Not clear |
| Ting Li, Bin Wang, Yuan Gao, Xin Wang, Ting Yan, Jie Xiang, Yan Niu, Tiantian Liu, Duanduan Chen, Boyan Fang, Yunyan Xie, Shintaro Funahashi, Tianyi Ya. APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum. Brain imaging and behavior. vol 15. issue 2. 2021-04-27. PMID:32314201. |
apoe ε4 and cognitive reserve effects on the functional network in the alzheimer's disease spectrum. |
2021-04-27 |
2023-08-13 |
Not clear |
| Ting Li, Bin Wang, Yuan Gao, Xin Wang, Ting Yan, Jie Xiang, Yan Niu, Tiantian Liu, Duanduan Chen, Boyan Fang, Yunyan Xie, Shintaro Funahashi, Tianyi Ya. APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum. Brain imaging and behavior. vol 15. issue 2. 2021-04-27. PMID:32314201. |
the apolipoprotein e (apoe) ε4 allele is a genetic risk factor for alzheimer's disease, whereas educational attainments have protective effects against cognitive decline in aging and patients with alzheimer's disease. |
2021-04-27 |
2023-08-13 |
Not clear |
| Ting Li, Bin Wang, Yuan Gao, Xin Wang, Ting Yan, Jie Xiang, Yan Niu, Tiantian Liu, Duanduan Chen, Boyan Fang, Yunyan Xie, Shintaro Funahashi, Tianyi Ya. APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum. Brain imaging and behavior. vol 15. issue 2. 2021-04-27. PMID:32314201. |
we examined the possible effects of years of education and apoe genotype on the topological properties of the functional network in normal aging, mild cognitive impairment and alzheimer's disease. |
2021-04-27 |
2023-08-13 |
Not clear |