| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ellen E H Johnson, Claire Alexander, Grace J Lee, Kaley Angers, Diarra Ndiaye, Julie Suh. Examination of race and gender differences in predictors of neuropsychological decline and development of Alzheimer's disease. The Clinical neuropsychologist. 2021-08-13. PMID:34218735. |
we examined race, apoe status, vascular risk factors, education, and the interaction of apoe e4 status and race as predictors of cognitive decline and the development of alzheimer's disease between genders in a large longitudinal sample of older adults. |
2021-08-13 |
2023-08-13 |
Not clear |
| Cynthia A Lemere, Elizabeth Head, David M Holtzma. APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA neurology. vol 78. issue 8. 2021-08-13. PMID:34228117. |
apoe ε4 association with cognition and alzheimer disease biomarkers in down syndrome-implications for clinical trials and treatments for all. |
2021-08-13 |
2023-08-13 |
Not clear |
| Joseph O Ojo, Jon M Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford, Corbin Bachmeie. APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34238312. |
apoe genotype dependent molecular abnormalities in the cerebrovasculature of alzheimer's disease and age-matched non-demented brains. |
2021-08-12 |
2023-08-13 |
Not clear |
| Hikaru Takeuchi, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashim. Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-11. PMID:32954402. |
the apoe ɛ4 allele is associated with a risk of alzheimer's disease in the elderly, with the association being pronounced in females. |
2021-08-11 |
2023-08-13 |
Not clear |
| Philip Scheltens, Bart De Strooper, Miia Kivipelto, Henne Holstege, Gael Chételat, Charlotte E Teunissen, Jeffrey Cummings, Wiesje M van der Flie. Alzheimer's disease. Lancet (London, England). vol 397. issue 10284. 2021-08-11. PMID:33667416. |
the risk of alzheimer's disease is 60-80% dependent on heritable factors, with more than 40 alzheimer's disease-associated genetic risk loci already identified, of which the apoe alleles have the strongest association with the disease. |
2021-08-11 |
2023-08-13 |
human |
| Andrew S Mendiola, Reshmi Tognatta, Zhaoqi Yan, Katerina Akassoglo. ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue. Neuron. vol 109. issue 15. 2021-08-11. PMID:34352209. |
apoe and immunity in alzheimer's disease and related tauopathies: low-density lipoprotein receptor to the rescue. |
2021-08-11 |
2023-08-13 |
Not clear |
| Jenna Najar, Sven J van der Lee, Erik Joas, Hanna Wetterberg, John Hardy, Rita Guerreiro, Jose Bras, Margda Waern, Silke Kern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergre. Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-08-06. PMID:33532541. |
polygenic risk scores for alzheimer's disease are related to dementia risk in apoe ɛ4 negatives. |
2021-08-06 |
2023-08-13 |
Not clear |
| Xiaowei Ma, Jun Ma, Ruiyun Guo, Juan Du, Baofeng Feng, Xin Liu, Xiaofeng Du, Zhenhuan Ma, Huixian Cu. Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype. Stem cell research. vol 54. 2021-08-05. PMID:34218115. |
apolipoprotein e ε4 allele (apoe4) is a minor allele of the apoe gene associated with a higher risk for alzheimer's disease (ad) and vascular dementia (vd). |
2021-08-05 |
2023-08-13 |
Not clear |
| Silke Szymczak, Janina Dose, Guillermo G Torres, Femke-Anouska Heinsen, Geetha Venkatesh, Paul Datlinger, Marianne Nygaard, Jonas Mengel-From, Friederike Flachsbart, Wolfram Klapper, Kaare Christensen, Wolfgang Lieb, Stefan Schreiber, Robert Häsler, Christoph Bock, Andre Franke, Almut Nebe. DNA methylation QTL analysis identifies new regulators of human longevity. Human molecular genetics. vol 29. issue 7. 2021-08-04. PMID:32160291. |
notably, two candidates (pvrl2, ercc1) are located on chromosome 19q, in close proximity to the well-known longevity- and alzheimer's disease-associated loci apoe and tomm40. |
2021-08-04 |
2023-08-13 |
human |
| Kamesh Krishnamurthy, Viviana Cantillana, Haichen Wang, Patrick M Sullivan, Bradley J Kolls, Xintong Ge, Yufeng Lin, Brian Mace, Daniel T Laskowit. ApoE mimetic improves pathology and memory in a model of Alzheimer's disease. Brain research. vol 1733. 2021-07-29. PMID:32007397. |
apoe mimetic improves pathology and memory in a model of alzheimer's disease. |
2021-07-29 |
2023-08-13 |
mouse |
| Heather M Wilkins, Xiaowan Wang, Blaise W Menta, Scott J Koppel, Rebecca Bothwell, Annette M Becker, Heidi Anderson, Erin Schwartz, Dong Pei, Nanda K Yellapu, Prabhakar Chalise, Cynthia M Gouvion, Mohammad Haeri, Jeffrey M Burns, Russell H Swerdlo. Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers. Aging cell. vol 20. issue 5. 2021-07-28. PMID:33939248. |
bioenergetic and inflammatory systemic phenotypes in alzheimer's disease apoe ε4-carriers. |
2021-07-28 |
2023-08-13 |
human |
| Heather M Wilkins, Xiaowan Wang, Blaise W Menta, Scott J Koppel, Rebecca Bothwell, Annette M Becker, Heidi Anderson, Erin Schwartz, Dong Pei, Nanda K Yellapu, Prabhakar Chalise, Cynthia M Gouvion, Mohammad Haeri, Jeffrey M Burns, Russell H Swerdlo. Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers. Aging cell. vol 20. issue 5. 2021-07-28. PMID:33939248. |
we examined the impact of an apoe ε4 genotype on alzheimer's disease (ad) subject platelet and lymphocyte metabolism. |
2021-07-28 |
2023-08-13 |
human |
| Masaki Ikeda, Koichi Okamoto, Keiji Suzuki, Eriko Takai, Hiroo Kasahara, Natsumi Furuta, Minori Furuta, Yuichi Tashiro, Chisato Shimizu, Shin Takatama, Isao Naito, Mie Sato, Yasujiro Sakai, Manabu Takahashi, Masakuni Amari, Masamitsu Takatama, Tetsuya Higuchi, Yoshito Tsushima, Hideaki Yokoo, Masahiko Kurabayashi, Shun Ishibashi, Kenji Ishii, Yoshio Iked. Recurrent Lobar Hemorrhages and Multiple Cortical Superficial Siderosis in a Patient of Alzheimer's Disease With Homozygous APOE ε2 Allele Presenting Hypobetalipoproteinemia and Pathological Findings of Frontiers in neurology. vol 12. 2021-07-27. PMID:34305778. |
recurrent lobar hemorrhages and multiple cortical superficial siderosis in a patient of alzheimer's disease with homozygous apoe ε2 allele presenting hypobetalipoproteinemia and pathological findings of in alzheimer's disease, the apolipoprotein e gene |
2021-07-27 |
2023-08-13 |
Not clear |
| Sevilay Tokgöz, Jurgen A H R Claasse. Exercise as Potential Therapeutic Target to Modulate Alzheimer's Disease Pathology in APOE ε4 Carriers: A Systematic Review. Cardiology and therapy. vol 10. issue 1. 2021-07-22. PMID:33403644. |
exercise as potential therapeutic target to modulate alzheimer's disease pathology in apoe ε4 carriers: a systematic review. |
2021-07-22 |
2023-08-13 |
Not clear |
| Omar H Butt, Karin L Meeker, Julie K Wisch, Suzanne E Schindler, Anne M Fagan, Tammie L S Benzinger, Carlos Cruchaga, David M Holtzman, John C Morris, Beau M Ance. Network dysfunction in cognitively normal APOE ε4 carriers is related to subclinical tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-07-22. PMID:34002449. |
apolipoprotein e (apoe) ε4 allele status is associated with amyloid and tau-related pathological changes related to alzheimer's disease (ad). |
2021-07-22 |
2023-08-13 |
Not clear |
| Sonia Sanz Muñoz, Brett Garner, Lezanne Oo. Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer's disease research. Bioscience reports. vol 41. issue 2. 2021-07-21. PMID:33600562. |
generation of apoe knock-down sk-n-sh human neuroblastoma cells using crispr/cas9: a novel cellular model relevant to alzheimer's disease research. |
2021-07-21 |
2023-08-13 |
human |
| Sonia Sanz Muñoz, Brett Garner, Lezanne Oo. Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer's disease research. Bioscience reports. vol 41. issue 2. 2021-07-21. PMID:33600562. |
apoe ε4 is the major genetic risk factor for alzheimer's disease (ad). |
2021-07-21 |
2023-08-13 |
human |
| Nicholette D Palmer, Bratati Kahali, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F Feitosa, Lawrence F Bielak, Jeffrey R O'Connell, Solomon K Musani, Xiuqing Guo, Albert V Smith, Kathleen A Ryan, Gudny Eirksdottir, Matthew A Allison, Donald W Bowden, Matthew J Budoff, J Jeffrey Carr, Yii-Der I Chen, Kent D Taylor, Adolfo Correa, Breland F Crudup, Brian Halligan, Jian Yang, Sharon L R Kardia, Lenore J Launer, Yi-Ping Fu, Thomas H Mosley, Jill M Norris, James G Terry, Christopher J O'Donnell, Jerome I Rotter, Lynne E Wagenknecht, Vilmundur Gudnason, Michael A Province, Patricia A Peyser, Elizabeth K Speliote. Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction. Human molecular genetics. vol 30. issue 15. 2021-07-21. PMID:33856023. |
allele-specific variation at apoe increases nonalcoholic fatty liver disease and obesity but decreases risk of alzheimer's disease and myocardial infarction. |
2021-07-21 |
2023-08-13 |
Not clear |
| Scott Ayton, Shorena Janelidze, Blaine Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel A Belaidi, Erik Stomrud, Ashley I Bush, Oskar Hansso. Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age. Progress in neurobiology. vol 198. 2021-07-14. PMID:32882319. |
acute phase markers in csf reveal inflammatory changes in alzheimer's disease that intersect with pathology, apoe ε4, sex and age. |
2021-07-14 |
2023-08-13 |
human |
| Inés López-Cuenca, Rosa de Hoz, Celia Alcántara-Rey, Elena Salobrar-García, Lorena Elvira-Hurtado, José A Fernández-Albarral, Ana Barabash, Federico Ramírez-Toraño, Jaisalmer de Frutos-Lucas, Juan J Salazar, Ana I Ramírez, José M Ramíre. Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer's Disease. Biomedicines. vol 9. issue 6. 2021-07-05. PMID:34199664. |
a family history (fh+) of alzheimer's disease (ad) and ɛ4 allele of the apoe gene are the main genetic risk factors for developing ad, whereas ɛ4 allele plays a protective role in age-related macular degeneration. |
2021-07-05 |
2023-08-13 |
human |