| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Fan-Fan Zhao, Han-Chang Huang, Feng-Xue La. Independent and Correlated Role of Apolipoprotein E ɛ4 Genotype and Herpes Simplex Virus Type 1 in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32804091. |
the ɛ4 allele of the apolipoprotein e (apoe) gene in individuals infected by herpes simplex virus type 1 (hsv-1) has been demonstrated to be a risk factor in alzheimer's disease (ad). |
2021-09-08 |
2023-08-13 |
human |
| S Kothari, N Bala, A B Patel, A Donovan, V Narayanaswam. The LDL receptor binding domain of apolipoprotein E directs the relative orientation of its C-terminal segment in reconstituted nascent HDL. Biochimica et biophysica acta. Biomembranes. vol 1863. issue 7. 2021-09-08. PMID:33831404. |
in humans, there are two major apoe isoforms, apoe3 and apoe4, which differ in a single residue in the nt domain, with apoe4 strongly increasing risk of alzheimer's disease (ad) and cardiovascular diseases (cvd). |
2021-09-08 |
2023-08-13 |
Not clear |
| Hua Lin, Muwei Li, Yang Zhan, Li Lin, Kun Yang, Shimin Hu, Ying Ha. Disrupted white matter functional connectivity in aMCI APOEε4 carriers: a resting-state study. Brain imaging and behavior. vol 15. issue 4. 2021-09-06. PMID:32715396. |
the ε4 allele of the apoe gene is thought to increase risk from amnestic mild cognitive impairment (amci) to alzheimer's disease. |
2021-09-06 |
2023-08-13 |
human |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-05. PMID:34482628. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-09-05 |
2023-08-13 |
Not clear |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-05. PMID:34482628. |
not all apolipoprotein e (apoe) ε4 carriers who survive to advanced age develop alzheimer's disease (ad); factors attenuating the risk of ε4 on ad may exist. |
2021-09-05 |
2023-08-13 |
Not clear |
| Efthalia Angelopoulou, Yam Nath Paudel, Sokratis G Papageorgiou, Christina Piper. APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors. ACS chemical neuroscience. vol 12. issue 15. 2021-09-03. PMID:34275270. |
apoe genotype and alzheimer's disease: the influence of lifestyle and environmental factors. |
2021-09-03 |
2023-08-13 |
Not clear |
| Yiyi Ma, Gyungah R Jun, Xiaoling Zhang, Jaeyoon Chung, Adam C Naj, Yuning Chen, Celine Bellenguez, Kara Hamilton-Nelson, Eden R Martin, Brian W Kunkle, Joshua C Bis, Stéphanie Debette, Anita L DeStefano, Myriam Fornage, Gaël Nicolas, Cornelia van Duijn, David A Bennett, Philip L De Jager, Richard Mayeux, Jonathan L Haines, Margaret A Pericak-Vance, Sudha Seshadri, Jean-Charles Lambert, Gerard D Schellenberg, Kathryn L Lunetta, Lindsay A Farre. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA neurology. vol 76. issue 9. 2021-08-30. PMID:31180460. |
analysis of whole-exome sequencing data for alzheimer disease stratified by apoe genotype. |
2021-08-30 |
2023-08-13 |
Not clear |
| Yiyi Ma, Gyungah R Jun, Xiaoling Zhang, Jaeyoon Chung, Adam C Naj, Yuning Chen, Celine Bellenguez, Kara Hamilton-Nelson, Eden R Martin, Brian W Kunkle, Joshua C Bis, Stéphanie Debette, Anita L DeStefano, Myriam Fornage, Gaël Nicolas, Cornelia van Duijn, David A Bennett, Philip L De Jager, Richard Mayeux, Jonathan L Haines, Margaret A Pericak-Vance, Sudha Seshadri, Jean-Charles Lambert, Gerard D Schellenberg, Kathryn L Lunetta, Lindsay A Farre. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA neurology. vol 76. issue 9. 2021-08-30. PMID:31180460. |
previous genome-wide association studies of common variants identified associations for alzheimer disease (ad) loci evident only among individuals with particular apoe alleles. |
2021-08-30 |
2023-08-13 |
Not clear |
| Zonghua Li, Francis Shue, Na Zhao, Mitsuru Shinohara, Guojun B. APOE2: protective mechanism and therapeutic implications for Alzheimer's disease. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:33148290. |
investigations of apolipoprotein e (apoe) gene, the major genetic risk modifier for alzheimer's disease (ad), have yielded significant insights into the pathogenic mechanism. |
2021-08-26 |
2023-08-13 |
human |
| Kristina Endre. Apolipoprotein A1, the neglected relative of Apolipoprotein E and its potential role in Alzheimer's disease. Neural regeneration research. vol 16. issue 11. 2021-08-24. PMID:33818485. |
apoe, for example, is well-accepted as one of the major risk factors for sporadic alzheimer's disease with a protective allele variant (ε2) and a risk-causing allele variant (ε4). |
2021-08-24 |
2023-08-13 |
Not clear |
| Isabel Hernandez, Ellen Gelpi, Laura Molina-Porcel, Sara Bernal, Benjamín Rodríguez-Santiago, Oriol Dols-Icardo, Agustín Ruiz, Daniel Alcolea, Mercè Boada, Alberto Lleó, Jordi Clarimó. Heterozygous APOE Christchurch in familial Alzheimer's disease without mutations in other Mendelian genes. Neuropathology and applied neurobiology. vol 47. issue 4. 2021-08-18. PMID:33095930. |
heterozygous apoe christchurch in familial alzheimer's disease without mutations in other mendelian genes. |
2021-08-18 |
2023-08-13 |
human |
| Kelly A Zalocusky, Ramsey Najm, Alice L Taubes, Yanxia Hao, Seo Yeon Yoon, Nicole Koutsodendris, Maxine R Nelson, Antara Rao, David A Bennett, Jason Bant, Dah-Eun J Amornkul, Qin Xu, Alice An, Olga Cisne-Thomson, Yadong Huan. Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. Nature neuroscience. vol 24. issue 6. 2021-08-18. PMID:33958804. |
neuronal apoe upregulates mhc-i expression to drive selective neurodegeneration in alzheimer's disease. |
2021-08-18 |
2023-08-13 |
mouse |
| b' Raul S Freitas, C\\xc3\\xa1ssia R Roque, Gabriella A Matos, Ludmila Belayev, Orle\\xc3\\xa2ncio G R de Azevedo, Jacqueline I Alvarez-Leite, Richard L Guerrant, Reinaldo B Ori\\xc3\\xa. Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments. Nutrition reviews. 2021-08-18. PMID:34406390.' |
the immunomodulatory functions of the human polymorphic apoe gene have gained particular interest because apoe4, a well-recognized risk factor for late-onset alzheimer's disease, has also been recently linked to increased risk of covid-19 infection severity in a large uk biobank study. |
2021-08-18 |
2023-08-13 |
human |
| Daimei Sasayama, Kotaro Hattori, Yuuki Yokota, Ryo Matsumura, Toshiya Teraishi, Sumiko Yoshida, Hiroshi Kunug. Increased apolipoprotein E and decreased TNF-α in the cerebrospinal fluid of nondemented APOE-ε4 carriers. Neuropsychopharmacology reports. vol 40. issue 2. 2021-08-16. PMID:32426945. |
the ε4 allele of apolipoprotein e gene (apoe) is a well-known risk factor of late-onset alzheimer's disease. |
2021-08-16 |
2023-08-13 |
Not clear |
| Liang He, Jose Davila-Velderrain, Tomokazu S Sumida, David A Hafler, Manolis Kellis, Alexander M Kulminsk. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34040149. |
using nebula in alzheimer's disease cohort data sets, we found that the cell-level expression of apoe correlated with that of other genetic risk factors (including clu, cst3, trem2, c1q, and itm2b) in a cell-type-specific pattern and an isoform-dependent manner in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Shuang Lv, Xiao Zhou, Yiming Li, Shujuan Zhang, Yu Wang, Shuhong Jia, Xiaoqian Niu, Lei Wang, Dantao Pen. The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ε4) Alleles and Cognitive Decline in 60 Patients with Alzheimer's Disease Compared with 28 Age-Matched Normal Individuals. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-08-14. PMID:34312362. |
the association between plasma α-synuclein (α-syn) protein, urinary alzheimer-associated neuronal thread protein (ad7c-ntp), and apolipoprotein epsilon 4 (apoe ε4) alleles and cognitive decline in 60 patients with alzheimer's disease compared with 28 age-matched normal individuals. |
2021-08-14 |
2023-08-13 |
human |
| Yosra Nadhimi, Daniel A Llan. Does hearing loss lead to dementia? A review of the literature. Hearing research. vol 402. 2021-08-13. PMID:32814645. |
therefore, we conclude that an additional "hit", such as aging, apoe genotype, microvascular disease or others, may be necessary to trigger an ongoing degenerative process such as alzheimer disease. |
2021-08-13 |
2023-08-13 |
human |
| John L Robinson, Hayley Richardson, Sharon X Xie, EunRan Suh, Vivianna M Van Deerlin, Brian Alfaro, Nicholas Loh, Matias Porras-Paniagua, Jeffrey J Nirschl, David Wolk, Virginia M-Y Lee, Edward B Lee, John Q Trojanowsk. The development and convergence of co-pathologies in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 3. 2021-08-13. PMID:33449993. |
to investigate how plaques, tangles, age and apolipoprotein e ε4 (apoe ε4) interact with co-pathologies in alzheimer's disease, we analysed 522 participants ≥50 years of age with and without dementia from the center for neurodegenerative disease research (cndr) autopsy program and 1340 participants in the national alzheimer's coordinating center (nacc) database. |
2021-08-13 |
2023-08-13 |
human |
| Scott Ayton, Shorena Janelidze, Blaine Roberts, Sebastian Palmqvist, Pawel Kalinowski, Ibrahima Diouf, Abdel A Belaidi, Erik Stomrud, Ashley I Bush, Oskar Hansso. Erratum to: "Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age" [Prog. Neurobiol. 198 (2021) 101904]. Progress in neurobiology. vol 204. 2021-08-13. PMID:33966892. |
erratum to: "acute phase markers in csf reveal inflammatory changes in alzheimer's disease that intersect with pathology, apoe ε4, sex and age" [prog. |
2021-08-13 |
2023-08-13 |
Not clear |
| Yang Shi, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L Snipes, Kevin Boyer, Stephanie Lawson, Kaoru Yamada, Wei Qin, Melissa Manis, Javier Remolina Serrano, Bruno A Benitez, Robert E Schmidt, Maxim Artyomov, Jason D Ulrich, David M Holtzma. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron. vol 109. issue 15. 2021-08-13. PMID:34157306. |
apoe is the strongest genetic risk factor for late-onset alzheimer's disease. |
2021-08-13 |
2023-08-13 |
mouse |