| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonie N C Visser, Carolina Minguillon, Gonzalo Sánchez-Benavides, Marc Abramowicz, Daniele Altomare, Karine Fauria, Giovanni B Frisoni, Jean Georges, Federica Ribaldi, Philip Scheltens, Jetske van der Schaar, Marissa Zwan, Wiesje M van der Flier, José Luis Molinuev. Dementia risk communication. A user manual for Brain Health Services-part 3 of 6. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34635169. |
however, communicating about dementia risk is complex and challenging.in this paper, we provide an overview of (i) perspectives on communicating dementia risk from an ethical, clinical, and societal viewpoint; (ii) insights gained from memory clinical practice; (iii) available evidence on the impact of disclosing apoe and alzheimer's disease biomarker test results gathered from clinical trials and observational studies; (iv) the value of established registries in light of bhs; and (v) practical recommendations regarding effective strategies for communicating about dementia risk.in addition, we identify challenges, i.e., the current lack of evidence on what to tell on an individual level-the actual risk-and on how to optimally communicate about dementia risk, especially concerning worried yet cognitively unimpaired individuals. |
2021-10-28 |
2023-08-13 |
Not clear |
| Jihye Lee, Zhong Liu, Ying Gai Tusing, Chao Li, Erik Westin, Wei Li, Rui Zha. Generation of inducible pluripotent stem cell lines from Alzheimer's disease patients with APOE e3/e3 genotype. Stem cell research. vol 55. 2021-10-26. PMID:34392011. |
generation of inducible pluripotent stem cell lines from alzheimer's disease patients with apoe e3/e3 genotype. |
2021-10-26 |
2023-08-13 |
Not clear |
| Jihye Lee, Zhong Liu, Ying Gai Tusing, Chao Li, Erik Westin, Wei Li, Rui Zha. Generation of inducible pluripotent stem cell lines from Alzheimer's disease patients with APOE e3/e3 genotype. Stem cell research. vol 55. 2021-10-26. PMID:34392011. |
ipscs were generated from b lymphocytes of two alzheimer's disease (ad) patients homozygous for the apoe e3 allele. |
2021-10-26 |
2023-08-13 |
Not clear |
| Merilee A Teylan, Charles Mock, Kathryn Gauthreaux, Jessica E Culhane, Gregory Jicha, Yen-Chi Chen, Kwun C G Chan, Walter A Kukull, Peter T Nelson, Yuriko Katsumat. Differences in Symptomatic Presentation and Cognitive Performance Among Participants With LATE-NC Compared to FTLD-TDP. Journal of neuropathology and experimental neurology. 2021-10-26. PMID:34597386. |
late-nc participants were older at death, more likely to carry apoe ε4, more likely to have alzheimer disease neuropathology, and had lower (i.e. |
2021-10-26 |
2023-08-13 |
human |
| Alexandra J Weigand, Kelsey R Thomas, Katherine J Bangen, Graham M L Eglit, Lisa Delano-Wood, Paul E Gilbert, Adam M Brickman, Mark W Bond. APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:32886451. |
apolipoprotein e (apoe) interacts with alzheimer's disease pathology to promote disease progression. |
2021-10-25 |
2023-08-13 |
Not clear |
| Philip S Insel, Oskar Hansson, Niklas Mattsson-Carlgre. Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment. JAMA neurology. vol 78. issue 2. 2021-10-22. PMID:33044487. |
although the most common recent approach in alzheimer disease drug discovery is to directly target the β-amyloid (aβ) pathway, the high prevalence of apolipoprotein e ε4 (apoe ε4) in alzheimer disease and the ease of identifying ε4 carriers make the apoe genotype and its corresponding protein (apoe) an appealing therapeutic target to slow aβ accumulation. |
2021-10-22 |
2023-08-13 |
Not clear |
| Cecilia Camarda, Paola Torelli, Carmela Pipia, Gianluca Sottile, Giovanna Cilluffo, Rosolino Camard. APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: A Longitudinal Study. Current Alzheimer research. vol 17. issue 8. 2021-10-22. PMID:33167837. |
apoe genotypes and brain imaging classes in normal cognition, mild cognitive impairment, and alzheimer's disease: a longitudinal study. |
2021-10-22 |
2023-08-13 |
human |
| Cecilia Camarda, Paola Torelli, Carmela Pipia, Gianluca Sottile, Giovanna Cilluffo, Rosolino Camard. APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: A Longitudinal Study. Current Alzheimer research. vol 17. issue 8. 2021-10-22. PMID:33167837. |
to evaluate in 419 stroke-free cognitively normal subjects (cn) aged 45-82 years covering during a long prospective study (11.54 ± 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (v) and brain atrophy (a) aggregated as following: v-/a-, v-/a+, v+/a-, v+/a+; 2) the relationship of these imaging classes with individual apolipoprotein e (apoe) genotypes; 3) the risk of progression to alzheimer disease (ad) of the individual apoe genotypes. |
2021-10-22 |
2023-08-13 |
human |
| Feifei Zang, Yao Zhu, Qianqian Zhang, Chang Tan, Qing Wang, Chunming Xi. APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network. CNS neuroscience & therapeutics. vol 27. issue 11. 2021-10-22. PMID:34387022. |
apoe genotype moderates the relationship between lrp1 polymorphism and cognition across the alzheimer's disease spectrum via disturbing default mode network. |
2021-10-22 |
2023-08-13 |
Not clear |
| Feifei Zang, Yao Zhu, Qianqian Zhang, Chang Tan, Qing Wang, Chunming Xi. APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network. CNS neuroscience & therapeutics. vol 27. issue 11. 2021-10-22. PMID:34387022. |
this study aims to investigate the mechanisms by which apolipoprotein e (apoe) genotype modulates the relationship between low-density lipoprotein receptor-related protein 1 (lrp1) rs1799986 variant on the default mode network (dmn) and cognition in alzheimer's disease (ad) spectrum populations. |
2021-10-22 |
2023-08-13 |
Not clear |
| Alan David Snow, Joel A Cummings, Thomas Lak. The Unifying Hypothesis of Alzheimer's Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago. Frontiers in aging neuroscience. vol 13. 2021-10-22. PMID:34671250. |
the updated "unifying hypothesis of alzheimer's disease" (ad) is described that links all the observed neuropathology in ad brain (i.e., plaques, tangles, and cerebrovascular amyloid deposits), as well as inflammation, genetic factors (involving apoe), "ad-in-a-dish" studies, beta-amyloid protein (aβ) as a microbial peptide; and theories that bacteria, gut microflora, gingivitis and viruses all play a role in the cause of ad. |
2021-10-22 |
2023-08-13 |
Not clear |
| Lars N G Nilsson, Sylvia Gografe, David A Costa, Tiffany Hughes, David Dressler, Huntington Potte. USE OF FUSED CIRCULATIONS TO INVESTIGATE THE ROLE OF APOLIPOPROTEIN E AS AMYLOID CATALYST AND PERIPHERAL SINK IN ALZHEIMER'S DISEASE. Technology and innovation. vol 14. issue 2. 2021-10-21. PMID:23626867. |
apolipoprotein e (apoe) synthesized in liver and brain plays a key role in both cholesterol transport and alzheimer's disease (ad): apoe-knockout mice develop hypercholesterolemia and atherosclerosis and cannot support ad amyloid deposition. |
2021-10-21 |
2023-08-12 |
mouse |
| Jean-Numa Gille. Alzheimer's disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics. Journal of biomolecular structure & dynamics. vol 39. issue 14. 2021-10-21. PMID:32580638. |
the apolipoprotein e (apoe) involved in lipid metabolism participates in the clearance and deposition of the amyloid-beta peptide of the alzheimer's disease (ad). |
2021-10-21 |
2023-08-13 |
Not clear |
| Elena Posse de Chaves, Vasanthy Narayanaswam. Apolipoprotein E and cholesterol in aging and disease in the brain. Future lipidology. vol 3. issue 5. 2021-10-20. PMID:19649144. |
one indication is that the apoe ε4 allele is associated with hypercholesterolemia and a proatherogenic profile on the vascular side and with increased risk of alzheimer's disease on the cns side. |
2021-10-20 |
2023-08-12 |
Not clear |
| Mary N Haan, Elizabeth R Mayed. Apolipoprotein E Genotype and Cardiovascular Diseases in the Elderly. Current cardiovascular risk reports. vol 4. issue 5. 2021-10-20. PMID:20694037. |
the apolipoprotein e (apoe) genotype is a genetic risk factor for dementia, alzheimer's disease, and cardiovascular disease (cvd). |
2021-10-20 |
2023-08-12 |
Not clear |
| Chengjie Xiong, J Philip Miller, John C Morri. Measuring Study-Specific Heterogeneity in Meta-Analysis: Application to an Antecedent Biomarker Study of Alzheimer's Disease. Statistics in biopharmaceutical research. vol 2. issue 3. 2021-10-20. PMID:20703369. |
finally, we demonstrate the proposed methodology by assessing the effect of individual studies on the overall estimate to the difference of an antecedent biomarker of alzheimer's disease (ad) between different apolipoprotein e (apoe) genotypes. |
2021-10-20 |
2023-08-12 |
Not clear |
| Mary M Ryan, Chelsea G Cox, Megan Witbracht, Dan Hoang, Daniel L Gillen, Joshua D Gril. Using Direct-to-Consumer Genetic Testing Results to Accelerate Alzheimer Disease Clinical Trial Recruitment. Alzheimer disease and associated disorders. vol 35. issue 2. 2021-10-19. PMID:33060367. |
the apolipoprotein e (apoe) gene is the strongest known genetic risk factor for sporadic alzheimer disease (ad). |
2021-10-19 |
2023-08-13 |
Not clear |
| Xiru Xu, Biao Zhang, Xu Wang, Qing Zhang, Xiang Wu, Jing Zhang, Yu Bai, Xiaoqun G. A meta-analysis of Alzheimer's disease's relationship with human ApoE gene variants. American journal of translational research. vol 13. issue 9. 2021-10-16. PMID:34650676. |
a meta-analysis of alzheimer's disease's relationship with human apoe gene variants. |
2021-10-16 |
2023-08-13 |
human |
| Xiru Xu, Biao Zhang, Xu Wang, Qing Zhang, Xiang Wu, Jing Zhang, Yu Bai, Xiaoqun G. A meta-analysis of Alzheimer's disease's relationship with human ApoE gene variants. American journal of translational research. vol 13. issue 9. 2021-10-16. PMID:34650676. |
to explore the association between alzheimer's disease and apolipoprotein e (apoe). |
2021-10-16 |
2023-08-13 |
human |
| Jessica Sarahi Alavez-Rubio, Nancy Martínez-Rodríguez, Jorge Escobedo-de-la-Peña, Osvaldo Garrido-Acosta, Teresa Juárez-Cedill. Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study). Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057949. |
this study evaluates the relationship between acat1 and apoe genetic variants with susceptibility for the development of alzheimer's disease and other dementias. |
2021-10-13 |
2023-08-13 |
human |