| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huiyi Chen, Feng Chen, Miaoping Zhang, Yanting Chen, Lili Cui, Chunmei Lian. A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 2. 2021-11-15. PMID:34569952. |
a review of apoe genotype-dependent autophagic flux regulation in alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Hee-Young Sohn, Seong-Ik Kim, Jee-Yun Park, Sung-Hye Park, Young Ho Koh, Joon Kim, Chulman J. ApoE4 attenuates autophagy via FoxO3a repression in the brain. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34475505. |
in particular, the ε4 allele of apoe is the highest genetic risk factor for developing late-onset alzheimer's disease (ad). |
2021-11-12 |
2023-08-13 |
human |
| Che-Yuan Wu, Michael Ouk, Yuen Yan Wong, Natasha Z Anita, Jodi D Edwards, Pearl Yang, Baiju R Shah, Nathan Herrmann, Krista L Lanctôt, Moira K Kapral, Bradley J MacIntosh, Jennifer S Rabin, Sandra E Black, Walter Swardfage. Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 12. 2021-11-11. PMID:32803865. |
relationships between memory decline and the use of metformin or dpp4 inhibitors in people with type 2 diabetes with normal cognition or alzheimer's disease, and the role apoe carrier status. |
2021-11-11 |
2023-08-13 |
Not clear |
| Katrine L Rasmussen, Anne Tybjaerg-Hansen, Børge G Nordestgaard, Ruth Frikke-Schmid. APOE and dementia - resequencing and genotyping in 105,597 individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 12. 2021-11-11. PMID:32808727. |
the mechanism behind the strong association between the ɛ2/ɛ3/ɛ4 apolipoprotein e gene (apoe) polymorphism and alzheimer's disease is not well-characterized. |
2021-11-11 |
2023-08-13 |
Not clear |
| Longfei Jia, Hui Xu, Shuoqi Chen, Xiu Wang, Jianwei Yang, Min Gong, Cuibai Wei, Yi Tang, Qiumin Qu, Lan Chu, Lu Shen, Chunkui Zhou, Qi Wang, Tan Zhao, Aihong Zhou, Ying Li, Fangyu Li, Yan Li, Hongmei Jin, Qi Qin, Haishan Jiao, Yan Li, Heng Zhang, Diyang Lyu, Yuqing Shi, Yang Song, Jianping Ji. The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 12. 2021-11-11. PMID:32881347. |
the apoe ε4 exerts differential effects on familial and other subtypes of alzheimer's disease. |
2021-11-11 |
2023-08-13 |
Not clear |
| Longfei Jia, Hui Xu, Shuoqi Chen, Xiu Wang, Jianwei Yang, Min Gong, Cuibai Wei, Yi Tang, Qiumin Qu, Lan Chu, Lu Shen, Chunkui Zhou, Qi Wang, Tan Zhao, Aihong Zhou, Ying Li, Fangyu Li, Yan Li, Hongmei Jin, Qi Qin, Haishan Jiao, Yan Li, Heng Zhang, Diyang Lyu, Yuqing Shi, Yang Song, Jianping Ji. The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 12. 2021-11-11. PMID:32881347. |
the genetic risk effects of apolipoprotein e (apoe) on familial alzheimer's disease (fad) with or without gene mutations, sporadic ad (sad), and normal controls (nc) remain unclear in the chinese population. |
2021-11-11 |
2023-08-13 |
Not clear |
| Emily J Van Etten, Pradyumna K Bharadwaj, Georg A Hishaw, Matthew J Huentelman, Theodore P Trouard, Matthew D Grilli, Gene E Alexande. Influence of regional white matter hyperintensity volume and apolipoprotein E ε4 status on hippocampal volume in healthy older adults. Hippocampus. vol 31. issue 5. 2021-11-11. PMID:33586848. |
our findings indicate that in cognitively healthy older adults, elevated wmh volume regionally localized to the temporal lobes in apoe ε4 carriers is associated with reduced hippocampal volume, suggesting greater vulnerability to brain aging and the risk for alzheimer's disease. |
2021-11-11 |
2023-08-13 |
Not clear |
| Lin Li, Wei Xu, Chen-Chen Tan, Xi-Peng Cao, Bao-Zhen Wei, Cheng-Wen Dong, Lan Ta. A gene-environment interplay between omega-3 supplementation and APOE ε4 provides insights for Alzheimer's disease precise prevention amongst high-genetic-risk population. European journal of neurology. 2021-11-11. PMID:34710256. |
a gene-environment interplay between omega-3 supplementation and apoe ε4 provides insights for alzheimer's disease precise prevention amongst high-genetic-risk population. |
2021-11-11 |
2023-08-13 |
Not clear |
| Young Won Kim, Ismael Al-Ramahi, Amanda Koire, Stephen J Wilson, Daniel M Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarg. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 5. 2021-11-10. PMID:33576571. |
harnessing the paradoxical phenotypes of apoe ɛ2 and apoe ɛ4 to identify genetic modifiers in alzheimer's disease. |
2021-11-10 |
2023-08-13 |
drosophila_melanogaster |
| Young Won Kim, Ismael Al-Ramahi, Amanda Koire, Stephen J Wilson, Daniel M Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarg. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 5. 2021-11-10. PMID:33576571. |
the strongest genetic risk factor for idiopathic late-onset alzheimer's disease (load) is apolipoprotein e (apoe) ɛ4, while the apoe ɛ2 allele is protective. |
2021-11-10 |
2023-08-13 |
drosophila_melanogaster |
| Young Won Kim, Ismael Al-Ramahi, Amanda Koire, Stephen J Wilson, Daniel M Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarg. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 5. 2021-11-10. PMID:33576571. |
we compared exomes of healthy apoe ɛ4 carriers and apoe ɛ2 alzheimer's disease (ad) patients, prioritizing coding variants based on their predicted functional impact, and identified 216 genes with differential mutational load between these two populations. |
2021-11-10 |
2023-08-13 |
drosophila_melanogaster |
| Sayantan Chakraborty, Anindita Joardar, Sarnava Roy, Gautam Gangopadhyay, Atanu Biswa. ApoE ε4 and IL-6-174G/C Polymorphism may Lead to Early Onset of Alzheimer's Disease with Atypical Presentation. Neurology India. vol 69. issue 5. 2021-11-10. PMID:34747789. |
apoe ε4 and il-6-174g/c polymorphism may lead to early onset of alzheimer's disease with atypical presentation. |
2021-11-10 |
2023-08-13 |
Not clear |
| Andrew C Robinson, Yvonne S Davidson, Federico Roncaroli, James Minshull, Phillip Tinkler, Michael A Horan, Antony Payton, Neil Pendleton, David M A Man. Influence of APOE genotype in primary age-related tauopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33287896. |
genetically, apolipoprotein e (apoe) ε4 has been shown to occur less commonly in part than in alzheimer's disease (ad). |
2021-11-09 |
2023-08-13 |
human |
| Xiaoyue Li, Yelei Zhang, Xinyu Chen, Hongwei Yuan, Zhiqiang Wang, Guoqiang Wang, Kai Zhang, Huanzhong Li. Association of Gene Polymorphisms in APOE and BIN1 With Dementia of Alzheimer's Type Susceptibility in Chinese Han Population. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733192. |
association of gene polymorphisms in apoe and bin1 with dementia of alzheimer's type susceptibility in chinese han population. |
2021-11-05 |
2023-08-13 |
Not clear |
| Einat Granot-Hershkovitz, Wassim Tarraf, Nuzulul Kurniansyah, Martha Daviglus, Carmen R Isasi, Robert Kaplan, Melissa Lamar, Krista M Perreira, Sylvia Wassertheil-Smoller, Ariana Stickel, Bharat Thyagarajan, Donglin Zeng, Myriam Fornage, Charles S DeCarli, Hector M González, Tamar Sofe. APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL). Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 3. 2021-11-04. PMID:33155766. |
apolipoprotein e (apoe) alleles are associated with cognitive decline, mild cognitive impairment (mci), and alzheimer's disease in whites, but have weaker and inconsistent effects reported in latinos. |
2021-11-04 |
2023-08-13 |
Not clear |
| Dong W Kang, Sheng-Min Wang, Hae-Ran Na, Chang U Lee, In-Ho Baek, Hyun K Li. Differential Effects of the Interaction Between the Education and APOE ε4 Allele on Amyloid-beta Retention and Memory Performances in Cognitively Normal Older Adults and Alzheimer's Disease Patients. Current Alzheimer research. vol 17. issue 11. 2021-11-04. PMID:33372875. |
differential effects of the interaction between the education and apoe ε4 allele on amyloid-beta retention and memory performances in cognitively normal older adults and alzheimer's disease patients. |
2021-11-04 |
2023-08-13 |
Not clear |
| Dong W Kang, Sheng-Min Wang, Hae-Ran Na, Chang U Lee, In-Ho Baek, Hyun K Li. Differential Effects of the Interaction Between the Education and APOE ε4 Allele on Amyloid-beta Retention and Memory Performances in Cognitively Normal Older Adults and Alzheimer's Disease Patients. Current Alzheimer research. vol 17. issue 11. 2021-11-04. PMID:33372875. |
despite the effect of education and apoe ε4 allele on amyloid-beta (aβ) retention and memory, previous studies have not dealt with an interaction between two factors on aβ deposition and memory function in the course of alzheimer's disease (ad). |
2021-11-04 |
2023-08-13 |
Not clear |
| Jing Zhang, Lanyan Lin, Xiaoman Dai, Nai'an Xiao, Qinyong Ye, Xiaochun Che. ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment. Journal of psychiatric research. vol 143. 2021-11-02. PMID:34530340. |
though apolipoprotein e ε4 (apoe ε4) is a major genetic risk factor for late-onset alzheimer's disease, its association with depression remains controversial. |
2021-11-02 |
2023-08-13 |
mouse |
| Riki E Slayday, Daniel E Gustavson, Jeremy A Elman, Asad Beck, Linda K McEvoy, Xin M Tu, Bin Fang, Richard L Hauger, Michael J Lyons, Ruth E McKenzie, Mark E Sanderson-Cimino, Hong Xian, William S Kremen, Carol E Fran. Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. Journal of the International Neuropsychological Society : JINS. vol 27. issue 1. 2021-10-28. PMID:32662384. |
although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (apoe) ε4 allele, a risk factor for alzheimer's disease. |
2021-10-28 |
2023-08-13 |
Not clear |
| Thomas Wooten, Danielle R Sullivan, Mark W Logue, Jennifer R Fonda, Catherine B Fortier, Joseph DeGutis, Regina McGlinchey, William Milberg, Michael Esterma. Apolipoprotein E ( Journal of the International Neuropsychological Society : JINS. vol 27. issue 4. 2021-10-28. PMID:33138883. |
one potential genetic risk factor that may impact recovery and explain the heterogeneity of blast injury's long-term cognitive outcomes is the inheritance of an apolipoprotein (apoe) ε4 allele, a well-known genetic risk factor for alzheimer's disease. |
2021-10-28 |
2023-08-13 |
Not clear |