| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David G Le Couteur, Fiona Stanaway, Louise M Waite, John Cullen, Richard I Lindley, Fiona M Blyth, Vasi Naganathan, Robert G Cumming, David J Handelsma. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 10. 2021-02-16. PMID:32342099. |
apoe ε4 was associated with a clinical diagnosis of alzheimer's disease when adjusted for age and region of birth (ε4 homozygotes odds ratio (or) 7.0; ε4 heterozygotes or 2.4, p < .05), and apoe ε2 had a small positive association with cognition. |
2021-02-16 |
2023-08-13 |
Not clear |
| David G Le Couteur, Fiona Stanaway, Louise M Waite, John Cullen, Richard I Lindley, Fiona M Blyth, Vasi Naganathan, Robert G Cumming, David J Handelsma. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 10. 2021-02-16. PMID:32342099. |
although apoe ε4 was associated with alzheimer's disease, overall cognitive function in the cohort was associated more strongly with frailty than apoe genotype. |
2021-02-16 |
2023-08-13 |
Not clear |
| Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. |
apolipoprotein e (apoe) has been reported to lead to the initiation of neurodegeneration in patients with alzheimer's disease (ad) and may serve an important role in anesthesia‑induced neurotoxicity. |
2021-02-16 |
2023-08-13 |
mouse |
| Yuan Li, Zhijun Yao, Yongqing Yang, Feng Zhao, Yu Fu, Ying Zou, Bin H. A Study on PHF-Tau Network Effected by Apolipoprotein E4. American journal of Alzheimer's disease and other dementias. vol 35. 2021-02-15. PMID:33258666. |
apolipoprotein e 4 allele (apoe 4) is an important factors in mild cognitive impairment (mci) and alzheimer's disease(ad). |
2021-02-15 |
2023-08-13 |
human |
| Parichita Choudhury, Vijay K Ramanan, Bradley F Boev. APOE ɛ4 Allele Testing and Risk of Alzheimer Disease. JAMA. vol 325. issue 5. 2021-02-15. PMID:33443531. |
apoe ɛ4 allele testing and risk of alzheimer disease. |
2021-02-15 |
2023-08-13 |
Not clear |
| Dena B Dubal, Jennifer S Yokoyam. Longevity Gene KLOTHO and Alzheimer Disease-A Better Fate for Individuals Who Carry APOE ε4. JAMA neurology. vol 77. issue 7. 2021-02-09. PMID:32282012. |
longevity gene klotho and alzheimer disease-a better fate for individuals who carry apoe ε4. |
2021-02-09 |
2023-08-13 |
Not clear |
| Naoyuki Sat. The Emerging Role of the Apolipoproteins APOE and APOJ in the Interaction Between Diabetes and Alzheimer Disease. The Journal of clinical endocrinology and metabolism. vol 105. issue 11. 2021-02-08. PMID:32895708. |
the emerging role of the apolipoproteins apoe and apoj in the interaction between diabetes and alzheimer disease. |
2021-02-08 |
2023-08-13 |
Not clear |
| Jessica Alber, Dominique Popescu, Louisa I Thompson, Gina-Marie Tonini, Edmund Arthur, Hwamee Oh, Stephen Correia, Stephen P Salloway, Athene K Le. Safety and Tolerability of APOE Genotyping and Disclosure in Cognitively Normal Volunteers From the Butler Alzheimer's Prevention Registry. Journal of geriatric psychiatry and neurology. 2021-02-08. PMID:33550928. |
safety and tolerability of apoe genotyping and disclosure in cognitively normal volunteers from the butler alzheimer's prevention registry. |
2021-02-08 |
2023-08-13 |
human |
| Mitsuru Shinohara, Yoshitaka Tashiro, Kaoru Suzuki, Akio Fukumori, Guojun Bu, Naoyuki Sat. Interaction between Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-02-06. PMID:32211501. |
interaction between although diabetes and apolipoprotein e (apoe) are both significant risk factors for dementia, including alzheimer's disease, it remains to be clarified how they are related to each other in contributing to the risk of dementia. |
2021-02-06 |
2023-08-13 |
Not clear |
| M E S Colovati, I P Novais, M Zampol, G D Mendes, M C S Cernach, A Zanesc. Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 2. 2021-02-02. PMID:33331535. |
we aimed to present an overview of the literature regarding the interaction between physical exercise and apoe gene polymorphism on cognitive function, particularly in patients with alzheimer's disease (ad). |
2021-02-02 |
2023-08-13 |
Not clear |
| Alberto Serrano-Pozo, Sudeshna Das, Bradley T Hyma. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. vol 20. issue 1. 2021-01-28. PMID:33340485. |
apoe and alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. |
2021-01-28 |
2023-08-13 |
mouse |
| Alberto Serrano-Pozo, Sudeshna Das, Bradley T Hyma. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. vol 20. issue 1. 2021-01-28. PMID:33340485. |
the apoe ε4 allele remains the strongest genetic risk factor for sporadic alzheimer's disease and the apoe ε2 allele the strongest genetic protective factor after multiple large scale genome-wide association studies and genome-wide association meta-analyses. |
2021-01-28 |
2023-08-13 |
mouse |
| Y I Yan, Yinghui Qiu, Aonan Zhao, Jian Zhao, Ying Wang, Yulei Den. Establishment of SIAISi001-A, an induced pluripotent stem cell (iPSC) line from 66-year old mild cognitive impairment (MCI) with two copies of APOE4 gene. Stem cell research. vol 43. 2021-01-21. PMID:32007762. |
the apolipoprotein e (apoe) ε4 allele, is considered to be the strongest genetic risk factor for sporadic alzheimer's disease (ad). |
2021-01-21 |
2023-08-13 |
Not clear |
| Mehak Agarwal, Safeera Kha. Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review. Cureus. vol 12. issue 12. 2021-01-19. PMID:33457117. |
genetic mutations in apolipoprotein e (apoe), apolipoprotein b (apob), apolipoprotein a (apoa), atp binding cassette transporter 1 (abca1), atp binding cassette transporter 7 (abca7), amyloid precursor protein (app), cytochrome p450 family 46 subfamilies a member 1 (cyp46a1), presenilin 1 (psen1), presenilin 2 (psen2) are also associated with increased risk of alzheimer's disease. |
2021-01-19 |
2023-08-13 |
Not clear |
| D Diane Zheng, Rosie E Curiel Cid, Ranjan Duara, Marcela Kitaigorodsky, Elizabeth Crocco, David A Loewenstei. Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis. International psychogeriatrics. 2021-01-18. PMID:33455613. |
to examine the direct and indirect effects of age, apoe ϵ4 genotype, amyloid positivity, and volumetric reductions in ad-prone brain regions as it relates to semantic intrusion errors reflecting proactive semantic interference (psi) and the failure to recover from proactive semantic interference (frpsi) on the loewenstein-acevedo scales of semantic interference and learning (lassi-l), a cognitive stress test that has been consistently more predictive of preclinical and prodromal alzheimer's disease (ad) than traditional list-learning tests. |
2021-01-18 |
2023-08-13 |
Not clear |
| Eftychia Bellou, Emily Baker, Ganna Leonenko, Matthew Bracher-Smith, Paula Daunt, Georgina Menzies, Julie Williams, Valentina Escott-Pric. Age-dependent effect of APOE and polygenic component on Alzheimer's disease. Neurobiology of aging. vol 93. 2021-01-15. PMID:32464432. |
age-dependent effect of apoe and polygenic component on alzheimer's disease. |
2021-01-15 |
2023-08-13 |
human |
| Annette Offringa-Hu. Alzheimer's disease: The derailed repair hypothesis. Medical hypotheses. vol 136. 2021-01-12. PMID:31825804. |
a lot of research has been done on alzheimer's disease, especially focused on factors like amyloid beta, apoe and tau-protein. |
2021-01-12 |
2023-08-13 |
Not clear |
| Milica A Margeta, Sophia M Letcher, Robert P Igo, Jessica N Cooke Bailey, Louis R Pasquale, Jonathan L Haines, Oleg Butovsky, Janey L Wigg. Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4. Investigative ophthalmology & visual science. vol 61. issue 8. 2021-01-07. PMID:32614373. |
here we sought to identify genetic associations between poag and variants in apoe and trem2, genes associated with alzheimer disease (ad) that critically regulate microglial neurodegeneration-associated molecular signature. |
2021-01-07 |
2023-08-13 |
Not clear |
| Shahzad Ahmad, Marta Del Campo Milan, Oskar Hansson, Ayse Demirkan, Ruiz Agustin, Maria E Sáez, Nikolaos Giagtzoglou, Alfredo Cabrera-Socorro, Margot H M Bakker, Alfredo Ramirez, Thomas Hankemeier, Erik Stomrud, Niklas Mattsson-Carlgren, Philip Scheltens, Wiesje M van der Flier, M Arfan Ikram, Anders Malarstig, Charlotte E Teunissen, Najaf Amin, Cornelia M van Duij. CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32427856. |
cdh6 and hagh protein levels in plasma associate with alzheimer's disease in apoe ε4 carriers. |
2021-01-06 |
2023-08-13 |
human |
| Shahzad Ahmad, Marta Del Campo Milan, Oskar Hansson, Ayse Demirkan, Ruiz Agustin, Maria E Sáez, Nikolaos Giagtzoglou, Alfredo Cabrera-Socorro, Margot H M Bakker, Alfredo Ramirez, Thomas Hankemeier, Erik Stomrud, Niklas Mattsson-Carlgren, Philip Scheltens, Wiesje M van der Flier, M Arfan Ikram, Anders Malarstig, Charlotte E Teunissen, Najaf Amin, Cornelia M van Duij. CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32427856. |
many alzheimer's disease (ad) genes including apolipoprotein e (apoe) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. |
2021-01-06 |
2023-08-13 |
human |