| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew Wai Kin Wong, Nady Braidy, John Crawford, Russell Pickford, Fei Song, Karen A Mather, John Attia, Henry Brodaty, Perminder Sachdev, Anne Polja. APOE Genotype Differentially Modulates Plasma Lipids in Healthy Older Individuals, with Relevance to Brain Health. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31640095. |
apolipoprotein e (apoe) genotype is an established genetic risk factor for sporadic alzheimer's disease (ad) but the extent to which apoe genotype influences the plasma lipidome is unknown, even though lipids are potential diagnostic or prognostic biomarkers for ad. |
2020-11-30 |
2023-08-13 |
human |
| Sonja Blumenau, Marco Foddis, Susanne Müller, Manuel Holtgrewe, Kajetan Bentele, Daniel Berchtold, Dieter Beule, Ulrich Dirnagl, Celeste Sass. Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32345996. |
investigating apoe, app-aβ metabolism genes and alzheimer's disease gwas hits in brain small vessel ischemic disease. |
2020-11-30 |
2023-08-13 |
mouse |
| Sonja Blumenau, Marco Foddis, Susanne Müller, Manuel Holtgrewe, Kajetan Bentele, Daniel Berchtold, Dieter Beule, Ulrich Dirnagl, Celeste Sass. Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32345996. |
therefore we used taqman genotyping, exome and rna sequencing to investigate alzheimer's disease known pathogenic variants and pathways: apoe ε4 allele, app-aβ metabolism and late-onset alzheimer's disease main genome-wide association loci (apoe, bin1, cd33, ms4a6a, cd2ap, picalm, clu, cr1, epha1, abca7) in 96 early-onset small vessel ischemic disease caucasian patients and 368 elderly neuropathologically proven controls (hex database) and in a mouse model of cerebral hypoperfusion. |
2020-11-30 |
2023-08-13 |
mouse |
| Estela Area-Gomez, Delfina Larrea, Marta Pera, Rishi R Agrawal, David N Guilfoyle, Leila Pirhaji, Kathleen Shannon, Hirra A Arain, Archana Ashok, Qiuying Chen, Allissa A Dillman, Helen Y Figueroa, Mark R Cookson, Steven S Gross, Ernest Fraenkel, Karen E Duff, Tal Nurie. APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific reports. vol 10. issue 1. 2020-11-23. PMID:32152337. |
the ε4 allele of apolipoprotein e (apoe) is the dominant genetic risk factor for late-onset alzheimer's disease (ad). |
2020-11-23 |
2023-08-13 |
mouse |
| Carmen Peña-Bautista, Marta Roca, Rogelio López-Cuevas, Miguel Baquero, Máximo Vento, Consuelo Cháfer-Pericá. Metabolomics study to identify plasma biomarkers in alzheimer disease: ApoE genotype effect. Journal of pharmaceutical and biomedical analysis. vol 180. 2020-11-20. PMID:31923717. |
metabolomics study to identify plasma biomarkers in alzheimer disease: apoe genotype effect. |
2020-11-20 |
2023-08-13 |
Not clear |
| N D Selezneva, S I Gavrilova, I V Kolykhalo. [Delayed effects of cerebrolysin in the prevention of cognitive impairment progression in the first degree relatives of patients with Alzheimer's disease: the role of the ApoE genotype]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 120. issue 10. Vyp. 2. 2020-11-20. PMID:33205928. |
[delayed effects of cerebrolysin in the prevention of cognitive impairment progression in the first degree relatives of patients with alzheimer's disease: the role of the apoe genotype]. |
2020-11-20 |
2023-08-13 |
Not clear |
| Manigandan Krishnan, Jong Su Hwang, Mikyung Kim, Yun Jin Kim, Ji Hae Seo, Jeeyoun Jung, Eunyoung H. β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice. Nutrients. vol 12. issue 2. 2020-11-19. PMID:32069870. |
apolipoprotein-e (apoe) is strongly associated with atherosclerosis and alzheimer's disease (ad). |
2020-11-19 |
2023-08-13 |
mouse |
| Sergio Veiga, Andrés Rodríguez-Martín, Guillermo Garcia-Ribas, Ignacio Arribas, Miriam Menacho-Román, Miguel Caler. Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32034174. |
the allele ε4 of the apolipoprotein e gene (apoe ε4) is the major genetic risk factor for non-dominantly inherited alzheimer's disease (ad). |
2020-11-12 |
2023-08-13 |
human |
| Anthoula C Tsolaki, Magda Tsolaki, Niki Pandria, Eftychia Lazarou, Olymbia Gkatzima, Vasiliki Zilidou, Maria Karagianni, Zafiroula Iakovidou-Kritsi, Vasilios K Kimiskidis, Panagiotis D Bamidi. Web-Based Intervention Effects on Mild Cognitive Impairment Based on Apolipoprotein E Genotype: Quasi-Experimental Study. Journal of medical Internet research. vol 22. issue 5. 2020-11-12. PMID:32379048. |
apolipoprotein e (apoe) ε4 allele is a major genetic risk factor for alzheimer disease and mild cognitive impairment (mci). |
2020-11-12 |
2023-08-13 |
Not clear |
| Anna Oudin, John Andersson, Anna Sundström, Annelie Nordin Adolfsson, Daniel Oudin Åström, Rolf Adolfsson, Bertil Forsberg, Maria Nordi. Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOEɛ4 in the Betula Cohort. Journal of Alzheimer's disease : JAD. vol 71. issue 3. 2020-11-05. PMID:31450491. |
it is widely known that the apolipoprotein e (apoe) ɛ4 allele imposes a higher risk for alzheimer's disease (ad). |
2020-11-05 |
2023-08-13 |
human |
| Stephanie Folley, Ang Zhou, David J Llewellyn, Elina Hyppöne. Physical Activity, APOE Genotype, and Cognitive Decline: Exploring Gene-Environment Interactions in the UK Biobank. Journal of Alzheimer's disease : JAD. vol 71. issue 3. 2020-11-05. PMID:31450492. |
apolipoprotein e (apoe) genotype affects the risk of alzheimer's disease (ad) with inconclusive evidence on the opportunity to mitigate related adverse effects by lifestyle changes. |
2020-11-05 |
2023-08-13 |
Not clear |
| Shin Bi Oh, Jung Ah Kim, SuJi Park, Joo-Yong Le. Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology. International journal of molecular sciences. vol 21. issue 3. 2020-11-05. PMID:31991844. |
zinc and apolipoprotein e (apoe) are reportedly involved in the pathology of alzheimer's disease. |
2020-11-05 |
2023-08-13 |
mouse |
| Risa Mitsumori, Kazuya Sakaguchi, Daichi Shigemizu, Taiki Mori, Shintaro Akiyama, Kouichi Ozaki, Shumpei Niida, Nobuyoshi Shimod. Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients. PloS one. vol 15. issue 9. 2020-11-05. PMID:32991610. |
the aim of the present study was to (1) investigate the relationship between late-onset alzheimer's disease (ad) and dna methylation levels in six of the top seven ad-associated genes identified through a meta-analysis of recent genome wide association studies, apoe, bin1, picalm, cr1, clu, and abca7, in blood, and (2) examine its applicability to the diagnosis of ad. |
2020-11-05 |
2023-08-13 |
human |
| David Bradle. Clusterin as a Potential Biomarker of Obesity-Related Alzheimer's Disease Risk. Biomarker insights. vol 15. 2020-10-30. PMID:33110346. |
in turn, excess adiposity increases the risk of multiple complications including type 2 diabetes (t2d), insulin resistance, and cardiovascular disease; yet, obesity also independently heightens risk of alzheimer's disease (ad), even after adjusting for other important confounding risk factors including blood pressure, sociodemographics, cholesterol levels, smoking status, and apolipoprotein e (apoe) genotype. |
2020-10-30 |
2023-08-13 |
Not clear |
| Matt Huentelman, Matthew De Both, Wayne Jepsen, Ignazio S Piras, Joshua S Talboom, Mari Willeman, Eric M Reiman, John Hardy, Amanda J Myer. Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31270419. |
common bace2 polymorphisms are associated with altered risk for alzheimer's disease and csf amyloid biomarkers in apoe ε4 non-carriers. |
2020-10-23 |
2023-08-13 |
Not clear |
| Adam H Dyer, Brian Lawlor, Sean P Kennell. Sexual dimorphism in the association of APOE ε4 genotype with cognitive decline and dementia progression in mild-to-moderate Alzheimer disease. International journal of geriatric psychiatry. vol 35. issue 6. 2020-10-21. PMID:32196752. |
sexual dimorphism in the association of apoe ε4 genotype with cognitive decline and dementia progression in mild-to-moderate alzheimer disease. |
2020-10-21 |
2023-08-13 |
Not clear |
| Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtman. APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke. Journal of Alzheimer's disease : JAD. vol 71. issue 1. 2020-10-13. PMID:31381519. |
the apolipoprotein e (apoe) gene ɛ4 allele is a risk factor for alzheimer's disease and cardiovascular disease. |
2020-10-13 |
2023-08-13 |
Not clear |
| Yao Zhu, Liang Gong, Cancan He, Qing Wang, Qingguo Ren, Chunming Xi. Default Mode Network Connectivity Moderates the Relationship Between the APOE Genotype and Cognition and Individualizes Identification Across the Alzheimer's Disease Spectrum. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31282419. |
default mode network connectivity moderates the relationship between the apoe genotype and cognition and individualizes identification across the alzheimer's disease spectrum. |
2020-10-09 |
2023-08-13 |
human |
| Yao Zhu, Liang Gong, Cancan He, Qing Wang, Qingguo Ren, Chunming Xi. Default Mode Network Connectivity Moderates the Relationship Between the APOE Genotype and Cognition and Individualizes Identification Across the Alzheimer's Disease Spectrum. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31282419. |
although previous studies have investigated the effects of the apolipoprotein e (apoe) ɛ4 genotype on the default mode network (dmn) in the alzheimer's disease (ad) spectrum, it is still unclear how the apoe genotype regulates the dmn and subsequently affects cognitive decline in the ad spectrum. |
2020-10-09 |
2023-08-13 |
human |
| Amber Watts, Heather M Wilkins, Elias Michaelis, Russell H Swerdlo. TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE ɛ3 Homozygotes. Journal of Alzheimer's disease : JAD. vol 70. issue 4. 2020-10-09. PMID:31322569. |
tomm40 '523 is associated with alzheimer's disease (ad), but apoe linkage disequilibrium confounds this association. |
2020-10-09 |
2023-08-13 |
Not clear |