| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian Fyf. Brain organoids shed light on APOE genotype and Alzheimer disease pathology. Nature reviews. Neurology. vol 17. issue 1. 2021-01-06. PMID:33219337. |
brain organoids shed light on apoe genotype and alzheimer disease pathology. |
2021-01-06 |
2023-08-13 |
Not clear |
| Jin Li, Chenyuan Bian, Dandan Chen, Xianglian Meng, Haoran Luo, Hong Liang, Li She. Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study. BMC bioinformatics. vol 21. issue Suppl 21. 2021-01-06. PMID:33371873. |
although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in alzheimer's disease (ad), little is understood about how apolipoprotein e (apoe) ε4 allele, the best-known genetic risk for ad, affect brain connectivity before the onset of symptomatic ad. |
2021-01-06 |
2023-08-13 |
Not clear |
| Corey W Bown, Dandan Liu, Katie E Osborn, Deepak K Gupta, Lisa A Mendes, Kimberly R Pechman, Timothy J Hohman, Thomas J Wang, Katherine A Gifford, Angela L Jefferso. Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults. Journal of the American Heart Association. vol 8. issue 15. 2021-01-04. PMID:31364446. |
apolipoprotein e (apoe)-ε4 is a genetic susceptibility risk factor for alzheimer's disease that also moderates vascular damage. |
2021-01-04 |
2023-08-13 |
human |
| Lijun Wang, Tianhao Gao, Tengteng Cai, Kunyi Li, Ping Zheng, Jun Li. Cerebrospinal fluid levels of YKL-40 in prodromal Alzheimer's disease. Neuroscience letters. vol 715. 2021-01-04. PMID:31794792. |
to detect how apoe ε4 affects csf ykl-40 levels in cognitively normal (cn) states, mild cognitive impairment (mci) and ad dementia, data from 35 cn subjects, 63 patients with mci, and 11 patients with ad from a cross-sectional study in the alzheimer's disease neuroimaging initiative (adni) database were investigated. |
2021-01-04 |
2023-08-13 |
human |
| Holden C Williams, Brandon C Farmer, Margaret A Piron, Adeline E Walsh, Ronald C Bruntz, Matthew S Gentry, Ramon C Sun, Lance A Johnso. APOE alters glucose flux through central carbon pathways in astrocytes. Neurobiology of disease. vol 136. 2021-01-04. PMID:31931141. |
the apolipoprotein e (apoe) gene is a major genetic risk factor associated with alzheimer's disease (ad). |
2021-01-04 |
2023-08-13 |
Not clear |
| Elizabeth E Blue, Anqi Cheng, Sunny Chen, Chang-En Y. Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry. JAMA network open. vol 3. issue 10. 2021-01-04. PMID:33090224. |
association of uncommon, noncoding variants in the apoe region with risk of alzheimer disease in adults of european ancestry. |
2021-01-04 |
2023-08-13 |
Not clear |
| Elizabeth E Blue, Anqi Cheng, Sunny Chen, Chang-En Y. Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry. JAMA network open. vol 3. issue 10. 2021-01-04. PMID:33090224. |
the ε2 and ε4 alleles of the apolipoprotein e (apoe) gene are associated with alzheimer disease (ad) risk. |
2021-01-04 |
2023-08-13 |
Not clear |
| Simon L Evans, Nicholas G Dowell, Fenella Prowse, Naji Tabet, Sarah L King, Jennifer M Ruste. Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions. Scientific reports. vol 10. issue 1. 2020-12-30. PMID:32080211. |
carriers of the apoe e4 allele are at higher risk of age-related cognitive decline and alzheimer's disease (ad). |
2020-12-30 |
2023-08-13 |
Not clear |
| Logan Dumitrescu, Emily R Mahoney, Shubhabrata Mukherjee, Michael L Lee, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel Buckley, Michael Properzi, Elizabeth Mormino, Hyun-Sik Yang, Tessa Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Doug Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Annah M Moore, Francis Cambronero, Xiaoyuan Zhong, Neha S Raghavan, Badri Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li-San Wang, Carlos Cruchaga, Gerard Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, Timothy J Hohma. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 8. 2020-12-30. PMID:32844198. |
notably, neither resilience metric was genetically correlated with clinical alzheimer's disease (p-values > 0.42) nor associated with apoe (p-values > 0.13). |
2020-12-30 |
2023-08-13 |
human |
| Manja Koch, Steven T DeKosky, Matthew Goodman, Jiehuan Sun, Jeremy D Furtado, Annette L Fitzpatrick, Rachel H Mackey, Tianxi Cai, Oscar L Lopez, Lewis H Kuller, Kenneth J Mukamal, Majken K Jense. Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia. JAMA network open. vol 3. issue 7. 2020-12-25. PMID:32648923. |
the ε4 allele of the apolipoprotein e (apoe) gene and lower apolipoprotein e (apoe) protein levels in plasma are risk factors for alzheimer disease, but the underlying biological mechanisms are not fully understood. |
2020-12-25 |
2023-08-13 |
Not clear |
| Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Ubert. A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer's disease. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32694537. |
genome-wide association studies (gwas) have revealed a plethora of putative susceptibility genes for alzheimer's disease (ad), with the sole exception of apoe gene unequivocally validated in independent study. |
2020-12-21 |
2023-08-13 |
Not clear |
| Yiyuan Xia, Zhi-Hao Wang, Jichun Zhang, Xia Liu, Shan Ping Yu, Karen X Ye, Jian-Zhi Wang, Keqiang Ye, Xiao-Chuan Wan. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Molecular psychiatry. 2020-12-19. PMID:33339957. |
c/ebpβ is a key transcription factor for apoe and preferentially mediates apoe4 expression in alzheimer's disease. |
2020-12-19 |
2023-08-13 |
mouse |
| Hanna Cho, Young-Eun Kim, Wonjeong Chae, Ko Woon Kim, Jong-Won Kim, Hee Jin Kim, Duk L Na, Chang-Seok Ki, Sang Won Se. Distribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32770103. |
the apolipoprotein e (apoe) e4 allele is the most common genetic variant associated with alzheimer's disease (ad). |
2020-12-14 |
2023-08-13 |
Not clear |
| Susan Abushakra, Anton P Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, John A Hey, David Scott, Joyce Suhy, Martin Tola. APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2020-12-12. PMID:33304988. |
apoe ε4/ε4 homozygotes with early alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. |
2020-12-12 |
2023-08-13 |
human |
| Lisa Marie Munte. The lipid component of Alzheimer's disease research: An Editorial Highlight for "Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease mice" on page 84. Journal of neurochemistry. vol 154. issue 1. 2020-12-07. PMID:32374412. |
the lipid component of alzheimer's disease research: an editorial highlight for "brain region-specific amyloid plaque-associated myelin lipid loss, apoe deposition and disruption of the myelin sheath in familial alzheimer's disease mice" on page 84. |
2020-12-07 |
2023-08-13 |
mouse |
| Nahid Zokaei, John Grogan, Sean James Fallon, Ellie Slavkova, Jonathan Hadida, Sanjay Manohar, Anna Christina Nobre, Masud Husai. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific reports. vol 10. issue 1. 2020-12-07. PMID:32528115. |
the apolipoprotein-e (apoe) ε4 gene allele, the highest known genetic risk factor for alzheimer's disease, has paradoxically been well preserved in the human population. |
2020-12-07 |
2023-08-13 |
human |
| Nahid Zokaei, John Grogan, Sean James Fallon, Ellie Slavkova, Jonathan Hadida, Sanjay Manohar, Anna Christina Nobre, Masud Husai. Short-term memory advantage for brief durations in human APOE ε4 carriers. Scientific reports. vol 10. issue 1. 2020-12-07. PMID:32528115. |
here, we tested stm performance in a large cohort of individuals (n = 1277); nine hundred and fifty-nine of which included carrier and non-carriers of the apoe ε4 gene, those at highest risk of developing alzheimer's disease. |
2020-12-07 |
2023-08-13 |
human |
| Monica Emili Garcia-Segura, Corinne E Fischer, Tom A Schweizer, David G Muno. APOE ɛ4/ɛ4 Is Associated with Aberrant Motor Behavior Through Both Lewy Body and Cerebral Amyloid Angiopathy Pathology in High Alzheimer's Disease Pathological Load. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31744003. |
apoe ɛ4/ɛ4 is associated with aberrant motor behavior through both lewy body and cerebral amyloid angiopathy pathology in high alzheimer's disease pathological load. |
2020-12-04 |
2023-08-13 |
Not clear |
| Ibrahim Kaya, Eva Jennische, Stefan Lange, Ahmet Tarik Baykal, Per Malmberg, John S Fletche. Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease mice. Journal of neurochemistry. vol 154. issue 1. 2020-12-04. PMID:32141089. |
brain region-specific amyloid plaque-associated myelin lipid loss, apoe deposition and disruption of the myelin sheath in familial alzheimer's disease mice. |
2020-12-04 |
2023-08-13 |
mouse |
| Junyang Wang, Guoping Peng, Ping Liu, Xufei Tan, Benyan Lu. Regulating effect of CBF on memory in cognitively normal older adults with different ApoE genotype: the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cognitive neurodynamics. vol 13. issue 6. 2020-12-01. PMID:31741688. |
regulating effect of cbf on memory in cognitively normal older adults with different apoe genotype: the alzheimer's disease neuroimaging initiative (adni). |
2020-12-01 |
2023-08-13 |
human |