| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d'Ydewalle, Renzo Mancus. Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease. Molecular neurodegeneration. vol 19. issue 1. 2024-04-24. PMID:38654375. |
the discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2), as the strongest risk factors for alzheimer's disease (ad) highlights the importance of microglial biology in the brain. |
2024-04-24 |
2024-04-26 |
human |
| Xueli Zhang, Zhuoting Zhu, Yu Huang, Xianwen Shang, Terence J O'Brien, Patrick Kwan, Jason Ha, Wei Wang, Shunming Liu, Xiayin Zhang, Katerina Kiburg, Yining Bao, Jing Wang, Honghua Yu, Mingguang He, Lei Zhan. Shared genetic aetiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes. BMJ neurology open. vol 6. issue 1. 2024-04-22. PMID:38646507. |
shared genetic aetiology of alzheimer's disease and age-related macular degeneration by apoc1 and apoe genes. |
2024-04-22 |
2024-04-24 |
Not clear |
| Colleen Lacey, Theone Paterson, Jodie R Gawrylu. Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study. PloS one. vol 19. issue 4. 2024-04-18. PMID:38635499. |
the apolipoprotein e (apoe) gene has been established in the alzheimer's disease (ad) literature to impact brain structure and function and may also show congruent effects in healthy older adults, although findings in this population are much less consistent. |
2024-04-18 |
2024-04-21 |
Not clear |
| Dong Yan Zhang, Jian Wang, Gangtong Huang, Sara Langberg, Feng Ding, Nikolay V Dokholya. APOE regulates the transport of GM1. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617316. |
while the ε4 allele of apoe (apoe4) is associated with a significant genetic risk factor for late-onset alzheimer's disease (ad), no mechanistic understanding of its contribution to ad etiology has been established yet. |
2024-04-15 |
2024-04-17 |
Not clear |
| Haixu Ma, Zhuoyu Shi, Minjeong Kim, Bin Liu, Patrick J Smith, Yufeng Liu, Guorong W. Disentangling Sex-Dependent Effects of APOE on Diverse Trajectories of Cognitive Decline in Alzheimer's Disease. NeuroImage. 2024-04-13. PMID:38614371. |
disentangling sex-dependent effects of apoe on diverse trajectories of cognitive decline in alzheimer's disease. |
2024-04-13 |
2024-04-16 |
Not clear |
| Chiara Giuseppina Bonomi, Alessandro Martorana, Denise Fiorelli, Marzia Nuccetelli, Fabio Placidi, Nicola Biagio Mercuri, Caterina Mott. Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612537. |
constitutive nos production is modulated by alzheimer's disease pathology depending on apoe genotype. |
2024-04-13 |
2024-04-15 |
Not clear |
| Chiara Giuseppina Bonomi, Alessandro Martorana, Denise Fiorelli, Marzia Nuccetelli, Fabio Placidi, Nicola Biagio Mercuri, Caterina Mott. Constitutive NOS Production Is Modulated by Alzheimer's Disease Pathology Depending on APOE Genotype. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612537. |
we aimed to explore the relationship between amyloid pathology and no dynamics by comparing the cerebrospinal fluid (csf) levels of nnos and enos of 8 healthy controls (hc) and 27 patients with a clinical diagnosis of alzheimer's disease and isolated csf amyloid changes, stratified according to apoe ε genotype (apoe ε3 = 13, apoe ε4 = 14). |
2024-04-13 |
2024-04-15 |
Not clear |
| Natalia S Ogonowski, Luis M García-Marín, Amali S Fernando, Victor Flores-Ocampo, Miguel E Renterí. Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure. Translational psychiatry. vol 14. issue 1. 2024-04-11. PMID:38605018. |
overall, our review found several studies focused on apoe haplotypes and alzheimer's risk, but a limited number of studies leveraging polygenic risk scores or focused on genetic susceptibility to other late-onset conditions. |
2024-04-11 |
2024-04-14 |
Not clear |
| Jordan N Williamson, Shirley A James, Sean P Mullen, Bradley P Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yan. Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease. GeroScience. 2024-04-10. PMID:38598069. |
the purpose of this study was to determine if the apoe genotype plays a role in the observed sex differences in hippocampal functional connectivity in alzheimer's disease. |
2024-04-10 |
2024-04-12 |
human |
| Sarah K Royse, Beth E Snitz, Ashley V Hill, Alexandria C Reese, Rebecca E Roush, M Ilyas Kamboh, Marnie Bertolet, Anum Saeed, Brian J Lopresti, Victor L Villemagne, Oscar L Lopez, Steven E Reis, James T Becker, Ann D Cohe. Apolipoprotein E and Alzheimer's disease pathology in African American older adults. Neurobiology of aging. vol 139. 2024-04-06. PMID:38582070. |
the apolipoprotein-e4 (apoe*4) and apolipoprotein-e2 (apoe*2) alleles are more common in african american versus non-hispanic white populations, but relationships of both alleles with alzheimer's disease (ad) pathology among african american individuals are unclear. |
2024-04-06 |
2024-04-10 |
human |
| Mason D Tate, Hande Karahan, Jungsu Ki. APOE loss of function: A genetic shield against Alzheimer's disease. Neuron. vol 112. issue 7. 2024-04-04. PMID:38574724. |
apoe loss of function: a genetic shield against alzheimer's disease. |
2024-04-04 |
2024-04-07 |
Not clear |
| Hannah E Ison, Mohammad Mowaswes, Ronen Durst, Thorsten Leucker, Joshua W Knowles, Emily E Brow. Is it time for a paradigm shift? Inclusion of APOE on genetic dyslipidemia panels. Journal of genetic counseling. 2024-03-29. PMID:38549201. |
despite these known associations, there is often hesitancy around ordering apoe genetic testing due to the association with alzheimer's disease. |
2024-03-29 |
2024-03-31 |
Not clear |
| Pin Wang, Wenxian Sun, Jin Gong, Xiaodong Han, Chang Xu, Yufei Chen, Yuting Yang, Heya Luan, Shaoqi Li, Ruina Li, Boye Wen, Sirong Lv, Runqi Chen, Jinxuan Guo, Cuibai We. Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation. Stem cell research. vol 77. 2024-03-29. PMID:38552354. |
genetic polymorphism of apolipoprotein e (apoe) confers differential susceptibility to alzheimer's disease (ad), and apoe ɛ4 variants is the most powerful risk factor for this disease. |
2024-03-29 |
2024-04-01 |
human |
| Mohammad Haddadi, Mehrnaz Haghi, Niloofar Rezaei, Zahra Kiani, Taha Akkülah, Arzu Celi. APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster. Archives of gerontology and geriatrics. vol 123. 2024-03-27. PMID:38537387. |
apoe and alzheimer's disease: pathologic clues from transgenic drosophila melanogaster. |
2024-03-27 |
2024-03-30 |
human |
| Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V Pearse, Atlas Khan, Badri N Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A Bennett, Vilas Menon, Philip L De Jage. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain. Nature genetics. 2024-03-22. PMID:38514782. |
a new variant influences apoe expression only in microglia and is associated with greater cerebral amyloid angiopathy but not alzheimer's disease pathology, after adjusting for apoeε4, providing mechanistic insights into both pathologies. |
2024-03-22 |
2024-03-24 |
Not clear |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-20. PMID:38504517. |
epidemiological studies show that individuals who carry the relatively uncommon apoe ε2 allele rarely develop alzheimer disease, and if they do they have a later age of onset, milder clinical course, and less severe neuropathological findings. |
2024-03-20 |
2024-03-23 |
mouse |
| Rosemary J Jackson, Megan S Keiser, Jonah C Meltzer, Dustin P Fykstra, Steven E Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Morris, Alexandra Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T Ranum, Ellie Carrell, YongHong Chen, Maryam A Nishtar, David M Holtzman, Wilhelm Haas, Beverly L Davidson, Bradley T Hyma. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-03-20. PMID:38504517. |
the contrast is especially stark when compared with the major genetic risk factor for alzheimer disease, apoe ε4, which has an age of onset several decades earlier, a more aggressive clinical course and more severe neuropathological findings, especially in terms of the amount of amyloid deposition. |
2024-03-20 |
2024-03-23 |
mouse |
| Verena Heise, Alison Offer, William Whiteley, Clare E Mackay, Jane M Armitage, Sarah Paris. A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank. Translational psychiatry. vol 14. issue 1. 2024-03-13. PMID:38472178. |
alzheimer's disease (ad) risk is increased in carriers of the apolipoprotein e (apoe) ε4 allele and decreased in ε2 allele carriers compared with the ε3ε3 genotype. |
2024-03-13 |
2024-03-15 |
human |
| Patrycja Dzianok, Ewa Kubli. PEARL-Neuro Database: EEG, fMRI, health and lifestyle data of middle-aged people at risk of dementia. Scientific data. vol 11. issue 1. 2024-03-07. PMID:38453963. |
here we describe a database that includes genetic data on apolipoprotein e (apoe) and phosphatidylinositol binding clathrin assembly protein (picalm) genes, both of which are known to increase the risk of late-onset alzheimer's disease, paired with psychometric (memory, intelligence, mood, personality, stress coping strategies), basic demographic and health data on a cohort of 192 healthy middle-aged (50-63) individuals. |
2024-03-07 |
2024-03-10 |
human |
| Xianfeng Yu, Xia Zhou, Zhengbo He, Beiqi He, Ke Wan, Min Wei, Tengfei Guo, Ying Ha. Sleep and APOE-ε4 have a synergistic effect on plasma biomarkers and longitudinal cognitive decline in older adults. CNS neuroscience & therapeutics. vol 30. issue 2. 2024-02-29. PMID:38421124. |
sleep disorders are prevalent among patients with alzheimer's disease (ad), and the apoe ε4 genotype is a key genetic risk factor for sporadic ad. |
2024-02-29 |
2024-03-02 |
Not clear |