| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael A van Es, Leonard H van den Ber. Alzheimer's disease beyond APOE. Nature genetics. vol 41. issue 10. 2009-10-14. PMID:19786950. |
alzheimer's disease beyond apoe. |
2009-10-14 |
2023-08-12 |
Not clear |
| P van Vliet, R G J Westendorp, P Eikelenboom, H C Comijs, M Frölich, E Bakker, W van der Flier, E van Exe. Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels. Neurology. vol 73. issue 9. 2009-10-13. PMID:19720974. |
variation in apoe genotype is a determinant of alzheimer disease (ad), but the risk associated with variation in plasma apoe levels has yet to be determined. |
2009-10-13 |
2023-08-12 |
Not clear |
| Alessandra Bizzarro, Davide Seripa, Adele Acciarri, Maria Giovanna Matera, Alberto Pilotto, Francesco Danilo Tiziano, Christina Brahe, Carlo Masull. The complex interaction between APOE promoter and AD: an Italian case-control study. European journal of human genetics : EJHG. vol 17. issue 7. 2009-10-02. PMID:19172988. |
the single nucleotide polymorphisms (snps) rs449647, rs769446 and rs405509 in the promoter region of the apoe gene have been variously suggested to be epsilon 4-independent risk factors for alzheimer's disease (ad). |
2009-10-02 |
2023-08-12 |
Not clear |
| Salvatore Oddo, Antonella Caccamo, David Cheng, Frank M LaFerl. Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain pathology (Zurich, Switzerland). vol 19. issue 3. 2009-10-01. PMID:18657136. |
the inheritance of the epsilon4 allele of the apolipoprotein e (apoe) gene is the major genetic risk factor for developing late-onset alzheimer disease. |
2009-10-01 |
2023-08-12 |
mouse |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
mri of hippocampal volume loss in early alzheimer's disease in relation to apoe genotype and biomarkers. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
6-12 months, with mri in the large multicentre setting of the alzheimer's disease neuroimaging initiative (adni); (ii) to determine the extent to which the polymorphism of the apolipoprotein e (apoe) gene modulates hippocampal change; and (iii) to determine if rates of hippocampal loss correlate with cerebrospinal fluid (csf) biomarkers of alzheimer's disease, such as the beta-amyloid (abeta(1-42)) and tau proteins (tau). |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
moreover, increased rates of hippocampal loss were associated with presence of the apoe allele epsilon4 gene in alzheimer's disease and lower csf abeta(1-42) in mild cognitive impairment, irrespective of apoe genotype, whereas relations with tau were only trends. |
2009-10-01 |
2023-08-12 |
Not clear |
| N Schuff, N Woerner, L Boreta, T Kornfield, L M Shaw, J Q Trojanowski, P M Thompson, C R Jack, M W Weine. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain : a journal of neurology. vol 132. issue Pt 4. 2009-10-01. PMID:19251758. |
furthermore, the relations between faster hippocampal loss in the presence of apoe allele epsilon4 and decreased csf abeta(1-42) supports the concept that increased hippocampal loss is an indicator of alzheimer's disease pathology and a potential marker for the efficacy of therapeutic interventions in alzheimer's disease. |
2009-10-01 |
2023-08-12 |
Not clear |
| Akinori Miyashita, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Shinichi Toyabe, Kohei Akazawa, Ichiro Kanazawa, Yasuo Ihara, Ryozo Kuwan. GAB2 is not associated with late-onset Alzheimer's disease in Japanese. European journal of human genetics : EJHG. vol 17. issue 5. 2009-09-28. PMID:18854865. |
the varepsilon4 allele of the apolipoprotein e gene (apoe) is unequivocally recognized as a genetic risk factor for late-onset alzheimer's disease (load). |
2009-09-28 |
2023-08-12 |
Not clear |
| Claire Murphy, Ethan S Solomon, Lori Haase, Miran Wang, Charlie D Morga. Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686207. |
olfaction in aging and alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate apoe epsilon4+ and apoe epsilon 4- individuals. |
2009-09-25 |
2023-08-12 |
mouse |
| Claire Murphy, Ethan S Solomon, Lori Haase, Miran Wang, Charlie D Morga. Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686207. |
the findings also suggest that cross-modal erp studies of recognition memory discriminate early neurocognitive changes in apoe epsilon4(+) and apoe epsilon4(-) individuals and may contribute to identifying the phenotype of persons who will develop alzheimer's disease. |
2009-09-25 |
2023-08-12 |
mouse |
| David L Mount, Angela V Ashley, James J Lah, Allan I Levey, Felicia C Goldstei. Is ApoE epsilon4 associated with cognitive functioning in African Americans diagnosed with Alzheimer Disease? An exploratory study. Southern medical journal. vol 102. issue 9. 2009-09-23. PMID:19668025. |
is apoe epsilon4 associated with cognitive functioning in african americans diagnosed with alzheimer disease? |
2009-09-23 |
2023-08-12 |
Not clear |
| David L Mount, Angela V Ashley, James J Lah, Allan I Levey, Felicia C Goldstei. Is ApoE epsilon4 associated with cognitive functioning in African Americans diagnosed with Alzheimer Disease? An exploratory study. Southern medical journal. vol 102. issue 9. 2009-09-23. PMID:19668025. |
the effect of the apolipoprotein epsilon4 allele (apoe epsilon4) on cognitive performance in patients with probable alzheimer disease (ad) has been studied in primarily caucasian samples. |
2009-09-23 |
2023-08-12 |
Not clear |
| M Seidenberg, L Guidotti, K A Nielson, J L Woodard, S Durgerian, P Antuono, Q Zhang, S M Ra. Semantic memory activation in individuals at risk for developing Alzheimer disease. Neurology. vol 73. issue 8. 2009-09-14. PMID:19704080. |
to determine whether whole-brain, event-related fmri can distinguish healthy older adults with known alzheimer disease (ad) risk factors (family history, apoe epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. |
2009-09-14 |
2023-08-12 |
Not clear |
| Ana Pocivavsek, G William Rebec. Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo. Biochemical and biophysical research communications. vol 387. issue 3. 2009-09-01. PMID:19615334. |
apolipoprotein e (apoe), a ligand for the low-density lipoprotein receptor family, has been implicated in modulating glial inflammatory responses and the risk of neurodegeneration associated with alzheimer's disease. |
2009-09-01 |
2023-08-12 |
mouse |
| A Barabash, A Marcos, I Ancín, B Vázquez-Alvarez, C de Ugarte, P Gil, C Fernández, M Encinas, J J López-Ibor, J A Cabrane. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18078695. |
apoe, act and chrna7 genes in the conversion from amnestic mild cognitive impairment to alzheimer's disease. |
2009-08-31 |
2023-08-12 |
human |
| A Barabash, A Marcos, I Ancín, B Vázquez-Alvarez, C de Ugarte, P Gil, C Fernández, M Encinas, J J López-Ibor, J A Cabrane. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18078695. |
we have investigated whether the -86 c/t promoter polymorphism in chrna7 gene, the signal peptide polymorphism of the alpha1-antichymotripsin (act) gene or the apoe genotype are associated with an increased risk of mild cognitive impairment (mci) or affect the risk of evolution to alzheimer's disease (ad). |
2009-08-31 |
2023-08-12 |
human |
| Rochelle E Tractenberg, Paul S Aisen, Gregory R Hancock, G William Rebec. No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18083276. |
no cross-sectional influence of apoe epsilon4 dose on clinical tests in alzheimer's disease. |
2009-08-31 |
2023-08-12 |
Not clear |
| Rochelle E Tractenberg, Paul S Aisen, Gregory R Hancock, G William Rebec. No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease. Neurobiology of aging. vol 30. issue 8. 2009-08-31. PMID:18083276. |
this study sought to determine if there are detectible influences on the symptoms of alzheimer's disease (ad) from the genetic risk factor for ad, the epsilon4 allele of apolipoprotein-e (apoe). |
2009-08-31 |
2023-08-12 |
Not clear |
| Jungsu Kim, Jacob M Basak, David M Holtzma. The role of apolipoprotein E in Alzheimer's disease. Neuron. vol 63. issue 3. 2009-08-28. PMID:19679070. |
the epsilon4 allele of apolipoprotein e (apoe) is the major genetic risk factor for alzheimer's disease (ad). |
2009-08-28 |
2023-08-12 |
Not clear |