| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianjia Fan, James Donkin, Cheryl Wellingto. Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E. BioFactors (Oxford, England). vol 35. issue 3. 2009-08-25. PMID:19472365. |
greasing the wheels of abeta clearance in alzheimer's disease: the role of lipids and apolipoprotein e. although apolipoprotein e (apoe) is the most common genetic risk factor for alzheimer's disease (ad), how apoe participates in ad pathogenesis remains incompletely understood. |
2009-08-25 |
2023-08-12 |
mouse |
| Yonghong Zhang, Jianglei Chen, Jianjun Wan. A complete backbone spectral assignment of lipid-free human apolipoprotein E (apoE). Biomolecular NMR assignments. vol 2. issue 2. 2009-08-19. PMID:19636906. |
recent evidence indicates that apoe is also critical in several other important biological processes, including alzheimer's disease, cognitive function, immunoregulation, cell signaling and infectious diseases. |
2009-08-19 |
2023-08-12 |
human |
| Anália Nusya Garcia, Helker Albuquerque da Silva, Renan Carlos Silva, Eliane Maria Medeiros Leal, Lorena Rodrigues, Vanessa Cavalcante da Silva, Edileine Dellalibera, Elizabete Malaquias Freitas, Luiz Ataíde, Maria Tereza Cartaxo Muni. APOE-epsilon4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha. Arquivos de neuro-psiquiatria. vol 66. issue 2B. 2009-08-14. PMID:18641859. |
polymorphism of the gene for apolipoprotein e (apoe) is an important risk factor for the development of alzheimer's disease. |
2009-08-14 |
2023-08-12 |
Not clear |
| Elin S Blom, Vilmantas Giedraitis, Henrik Zetterberg, Hiroaki Fukumoto, Kaj Blennow, Bradley T Hyman, Michael C Irizarry, Lars-Olof Wahlund, Lars Lannfelt, Martin Ingelsso. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19420940. |
rapid progression from mild cognitive impairment to alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the apoe epsilon4/epsilon4 genotype. |
2009-08-12 |
2023-08-12 |
human |
| Elin S Blom, Vilmantas Giedraitis, Henrik Zetterberg, Hiroaki Fukumoto, Kaj Blennow, Bradley T Hyman, Michael C Irizarry, Lars-Olof Wahlund, Lars Lannfelt, Martin Ingelsso. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and geriatric cognitive disorders. vol 27. issue 5. 2009-08-12. PMID:19420940. |
increased cerebrospinal fluid (csf) tau, decreased csf amyloid-beta42 (abeta42) and the apolipoprotein e gene (apoe) epsilon4 allele predict progression from mild cognitive impairment (mci) to alzheimer's disease (ad). |
2009-08-12 |
2023-08-12 |
human |
| Eloise Kok, Satu Haikonen, Teemu Luoto, Heini Huhtala, Sirkka Goebeler, Hannu Haapasalo, Pekka J Karhune. Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Annals of neurology. vol 65. issue 6. 2009-08-12. PMID:19557866. |
to study the prevalence and age dependency of senile plaques (sp) and neurofibrillary tangles (nft), the brain changes characteristic of alzheimer disease (ad), and their association with apolipoprotein e (apoe) genotypes in a community-dwelling normal population. |
2009-08-12 |
2023-08-12 |
Not clear |
| Caroline H Williams-Gray, An Goris, Misuzu Saiki, Thomas Foltynie, D Alastair S Compston, Stephen J Sawcer, Roger A Barke. Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease. Journal of neurology. vol 256. issue 3. 2009-08-10. PMID:19308307. |
further to the well-established association between apolipoprotein e (apoe) and alzheimer's disease, this gene has also been implicated in both susceptibility to, and dementia in, parkinson's disease (pd). |
2009-08-10 |
2023-08-12 |
Not clear |
| Roger M Lane, Yunsheng H. Emerging hypotheses regarding the influences of butyrylcholinesterase-K variant, APOE epsilon 4, and hyperhomocysteinemia in neurodegenerative dementias. Medical hypotheses. vol 73. issue 2. 2009-08-05. PMID:19359103. |
non-enzymatic functions of the buche protein, apoe epsilon 4 status and hyperhomocysteinemia influence the progression of pathology, symptom expression, and response to cholinesterase inhibition in a stage-specific manner in neurodegenerative disorders associated with alzheimer, lewy body and vascular pathology. |
2009-08-05 |
2023-08-12 |
Not clear |
| Norihiro Takei, Akinori Miyashita, Tamao Tsukie, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Hideo Kimura, Akiyoshi Kakita, Hitoshi Takahashi, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Shoji Odani, Ryozo Kuwan. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics. vol 93. issue 5. 2009-08-03. PMID:19442637. |
genetic association study on in and around the apoe in late-onset alzheimer disease in japanese. |
2009-08-03 |
2023-08-12 |
Not clear |
| Norihiro Takei, Akinori Miyashita, Tamao Tsukie, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Hideo Kimura, Akiyoshi Kakita, Hitoshi Takahashi, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Shoji Odani, Ryozo Kuwan. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics. vol 93. issue 5. 2009-08-03. PMID:19442637. |
the epsilon4 allele of apoe is a well-characterized genetic risk factor for late-onset alzheimer disease (load). |
2009-08-03 |
2023-08-12 |
Not clear |
| Robert C Green, J Scott Roberts, L Adrienne Cupples, Norman R Relkin, Peter J Whitehouse, Tamsen Brown, Susan LaRusse Eckert, Melissa Butson, A Dessa Sadovnick, Kimberly A Quaid, Clara Chen, Robert Cook-Deegan, Lindsay A Farre. Disclosure of APOE genotype for risk of Alzheimer's disease. The New England journal of medicine. vol 361. issue 3. 2009-07-30. PMID:19605829. |
disclosure of apoe genotype for risk of alzheimer's disease. |
2009-07-30 |
2023-08-12 |
Not clear |
| Robert C Green, J Scott Roberts, L Adrienne Cupples, Norman R Relkin, Peter J Whitehouse, Tamsen Brown, Susan LaRusse Eckert, Melissa Butson, A Dessa Sadovnick, Kimberly A Quaid, Clara Chen, Robert Cook-Deegan, Lindsay A Farre. Disclosure of APOE genotype for risk of Alzheimer's disease. The New England journal of medicine. vol 361. issue 3. 2009-07-30. PMID:19605829. |
the apolipoprotein e (apoe) genotype provides information on the risk of alzheimer's disease, but the genotyping of patients and their family members has been discouraged. |
2009-07-30 |
2023-08-12 |
Not clear |
| Richard J Caselli, Amylou C Dueck, David Osborne, Marwan N Sabbagh, Donald J Connor, Geoffrey L Ahern, Leslie C Baxter, Steven Z Rapcsak, Jiong Shi, Bryan K Woodruff, Dona E C Locke, Charlene Hoffman Snyder, Gene E Alexander, Rosa Rademakers, Eric M Reima. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. The New England journal of medicine. vol 361. issue 3. 2009-07-30. PMID:19605830. |
the apoe epsilon4 allele is associated with the risk of late-onset alzheimer's disease. |
2009-07-30 |
2023-08-12 |
Not clear |
| Roy O Weller, Delphine Boche, James A R Nicol. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19234858. |
the introduction of immunotherapy and its ultimate success will require re-evaluation of the pathogenesis of alzheimer's disease particularly with regard to the role of the ageing microvasculature and the effects of apoe genotype. |
2009-07-29 |
2023-08-12 |
Not clear |
| Roger Lane, Yunsheng He, Christopher Morris, James B Leverenz, Murat Emre, Clive Ballar. BuChE-K and APOE epsilon4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 3. 2009-07-27. PMID:19006190. |
apolipoprotein e (apoe) epsilon4 and butyrylcholinesterase-k (buche-k) are associated with an increased risk for alzheimer's disease. |
2009-07-27 |
2023-08-12 |
human |
| James A Mortimer, David A Snowdon, William R Markesber. The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology. Alzheimer disease and associated disorders. vol 23. issue 2. 2009-07-23. PMID:19484916. |
the present study was undertaken to determine the roles of alzheimer disease (ad) and vascular pathology in mediating the effect of apolipoprotein e (apoe)-epsilon4 alleles on dementia. |
2009-07-23 |
2023-08-12 |
Not clear |
| M Mrkonjic, E Chappell, V V Pethe, M Manno, D Daftary, C M Greenwood, S Gallinger, B W Zanke, J A Knight, B Bapa. Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer. British journal of cancer. vol 100. issue 12. 2009-07-02. PMID:19455140. |
apoe single nucleotide polymorphisms (snps) cys112arg (epsilon-4), and arg158cys (epsilon-2) have been implicated in cardiovascular and alzheimer's disease, but their role in colorectal cancer (crc) has not been extensively studied. |
2009-07-02 |
2023-08-12 |
Not clear |
| b' Marianna Trebunov\\xc3\\xa1, Eva Slab\\xc3\\xa1, Viera Habalov\\xc3\\xa1, Zuzana Gdovinov\\xc3\\xa. The role of the -427T/C apolipoprotein E promoter polymorphism in the pathogenesis of Alzheimer\'s disease, vascular dementia and mixed dementia. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 3. 2009-07-01. PMID:19142571.' |
we investigated newly reported -427t/c promoter polymorphism in association with sporadic alzheimer's disease (ad), vascular (vd) and mixed dementia (md) along with apoe genotype and gender. |
2009-07-01 |
2023-08-12 |
human |
| A Drzezga, T Grimmer, G Henriksen, M Mühlau, R Perneczky, I Miederer, C Praus, C Sorg, A Wohlschläger, M Riemenschneider, H J Wester, H Foerstl, M Schwaiger, A Kur. Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology. vol 72. issue 17. 2009-06-23. PMID:19339712. |
effect of apoe genotype on amyloid plaque load and gray matter volume in alzheimer disease. |
2009-06-23 |
2023-08-12 |
Not clear |
| A Drzezga, T Grimmer, G Henriksen, M Mühlau, R Perneczky, I Miederer, C Praus, C Sorg, A Wohlschläger, M Riemenschneider, H J Wester, H Foerstl, M Schwaiger, A Kur. Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology. vol 72. issue 17. 2009-06-23. PMID:19339712. |
to examine the influence of the apoe genotype on levels of beta-amyloid (abeta) plaque load and atrophy in patients with alzheimer disease (ad) in vivo. |
2009-06-23 |
2023-08-12 |
Not clear |