| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelly R Bales, Feng Liu, Su Wu, Suizhen Lin, Deanna Koger, Cynthia DeLong, Jeffrey C Hansen, Patrick M Sullivan, Steven M Pau. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 21. 2009-06-23. PMID:19474305. |
therapeutic strategies aimed at increasing the soluble levels of apoe protein, regardless of isoform, may effectively prevent and (or) treat alzheimer's disease. |
2009-06-23 |
2023-08-12 |
mouse |
| Veera Venkata Ratnam Bandaru, Juan Troncoso, David Wheeler, Olga Pletnikova, Jessica Wang, Kathy Conant, Norman J Haughe. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiology of aging. vol 30. issue 4. 2009-06-22. PMID:17888544. |
the epsilon 4 allele of apoe is associated with an earlier onset and faster progression of alzheimer's disease in patients with the familial form of this neurodegenerative condition. |
2009-06-22 |
2023-08-12 |
human |
| Simon P Selwood, S Parvathy, Barbara Cordell, Heather S Ryan, Farshid Oshidari, Valerie Vincent, Jerome Yesavage, Laura C Lazzeroni, Greer M Murph. Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E. Neurobiology of aging. vol 30. issue 4. 2009-06-22. PMID:17904698. |
gene expression profile of the pdapp mouse model for alzheimer's disease with and without apolipoprotein e. the apoe epsilon 4 allele is a strong risk factor for alzheimer's disease (ad). |
2009-06-22 |
2023-08-12 |
mouse |
| Lidia Glodzik-Sobanska, Elizabeth Pirraglia, Miroslaw Brys, Susan de Santi, Lisa Mosconi, Kenneth E Rich, Remigiusz Switalski, Leslie Saint Louis, Martin J Sadowski, Frank Martiniuk, Pankaj Mehta, Domenico Pratico, Raymond P Zinkowski, Kaj Blennow, Mony J de Leo. The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiology of aging. vol 30. issue 5. 2009-06-22. PMID:17920160. |
the effects of normal aging and apoe genotype on the levels of csf biomarkers for alzheimer's disease. |
2009-06-22 |
2023-08-12 |
human |
| Lidia Glodzik-Sobanska, Elizabeth Pirraglia, Miroslaw Brys, Susan de Santi, Lisa Mosconi, Kenneth E Rich, Remigiusz Switalski, Leslie Saint Louis, Martin J Sadowski, Frank Martiniuk, Pankaj Mehta, Domenico Pratico, Raymond P Zinkowski, Kaj Blennow, Mony J de Leo. The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiology of aging. vol 30. issue 5. 2009-06-22. PMID:17920160. |
while cerebrospinal fluid (csf) biomarkers are of use in the prediction and diagnosis of alzheimer's disease our understanding of the background effects of age and the apoe genotype is limited. |
2009-06-22 |
2023-08-12 |
human |
| M Pievani, P E Rasser, S Galluzzi, L Benussi, R Ghidoni, F Sabattoli, M Bonetti, G Binetti, P M Thompson, G B Frison. Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo. NeuroImage. vol 45. issue 4. 2009-06-16. PMID:19349226. |
mapping the effect of apoe epsilon4 on gray matter loss in alzheimer's disease in vivo. |
2009-06-16 |
2023-08-12 |
human |
| M Pievani, P E Rasser, S Galluzzi, L Benussi, R Ghidoni, F Sabattoli, M Bonetti, G Binetti, P M Thompson, G B Frison. Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo. NeuroImage. vol 45. issue 4. 2009-06-16. PMID:19349226. |
previous studies suggest that in alzheimer's disease (ad) the apolipoprotein e (apoe) epsilon4 allele is associated with greater vulnerability of medial temporal lobe structures. |
2009-06-16 |
2023-08-12 |
human |
| Susan Hiraki, Clara A Chen, J Scott Roberts, L Adrienne Cupples, Robert C Gree. Perceptions of familial risk in those seeking a genetic risk assessment for Alzheimer's disease. Journal of genetic counseling. vol 18. issue 2. 2009-05-28. PMID:18949541. |
reveal is a randomized trial assessing the impact of apoe disclosure and genetic risk assessment for alzheimer's disease (ad). |
2009-05-28 |
2023-08-12 |
human |
| E V Kutakova, M N Zakharova, S N Illarioshkin, S A Kliushnikov, I A Zavalishin, I A Ivanova-Smolenskai. [The role of apolipoprotein E in patients with amyotrophic lateral sclerosis (a clinical and genetic study)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 109. issue 2. 2009-05-28. PMID:19365373. |
the apolipoprotein e (apoe) gene plays an important role in forming predisposition and modulating the course of alzheimer's disease, primary parkinsonism and some other human neurodegenerative disorders. |
2009-05-28 |
2023-08-12 |
human |
| V P Prasher, S G Sajith, S D Rees, A Patel, S Tewari, N Schupf, W B Zigma. Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome. International journal of geriatric psychiatry. vol 23. issue 11. 2009-05-21. PMID:18464295. |
significant effect of apoe epsilon 4 genotype on the risk of dementia in alzheimer's disease and mortality in persons with down syndrome. |
2009-05-21 |
2023-08-12 |
Not clear |
| Benedetta Nacmias, Andrea Tedde, Silvia Bagnoli, Elena Cellini, Bianca Maria Guarnieri, Silvia Piacentini, Sandro Sorb. Implication of GAB2 gene polymorphism in Italian patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276544. |
a common polymorphism (rs2373115) in the grb-associated binding protein 2 (gab2) gene has been recently associated with the risk of developing alzheimer's disease (ad) in 644 apolipoprotein e (apoe) epsilon4 carriers. |
2009-05-18 |
2023-08-12 |
human |
| Maartje I Kester, Marinus A Blankenstein, Femke H Bouwman, Evert J van Elk, Philip Scheltens, Wiesje M van der Flie. CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age. Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276554. |
csf biomarkers in alzheimer's disease and controls: associations with apoe genotype are modified by age. |
2009-05-18 |
2023-08-12 |
Not clear |
| Alzheimer Research Forum Live Discussion: sports concussions, dementia, and ApoE genotyping: what can scientists tell the public? What's up for research? Journal of Alzheimer's disease : JAD. vol 16. issue 3. 2009-05-18. PMID:19276560. |
alzheimer research forum live discussion: sports concussions, dementia, and apoe genotyping: what can scientists tell the public? |
2009-05-18 |
2023-08-12 |
Not clear |
| R Hashimoto, Y Hirata, T Asada, F Yamashita, K Nemoto, T Mori, Y Moriguchi, H Kunugi, K Arima, T Ohnish. Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease. Genes, brain, and behavior. vol 8. issue 1. 2009-05-11. PMID:18786162. |
genetic factors, such as apolipoprotein e (apoe) polymorphisms, are thought to play an important role in the etiology of alzheimer's disease (ad). |
2009-05-11 |
2023-08-12 |
human |
| Michelle Luciano, Alan J Gow, Sarah E Harris, Caroline Hayward, Mike Allerhand, John M Starr, Peter M Visscher, Ian J Dear. Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study. Psychology and aging. vol 24. issue 1. 2009-05-11. PMID:19290744. |
the e4 allele of the apolipoprotein e (apoe) gene confers risk of alzheimer's disease and, in some studies, relates to cognitive ability and decline in older people without alzheimer's disease. |
2009-05-11 |
2023-08-12 |
human |
| Stefan Boehringer, Ruth M Pfeiffe. A model for fine mapping in family based association studies. Human heredity. vol 67. issue 4. 2009-05-08. PMID:19172082. |
we apply the model to an alzheimer data set and confirm previous findings in the apoe region. |
2009-05-08 |
2023-08-12 |
Not clear |
| Mario Ezquerra, Jaume Campdelacreu, Carles Gaig, Yaroslau Compta, Esteban Muñoz, Maria Jose Martí, Francesc Valldeoriola, Eduardo Tolos. Lack of association of APOE and tau polymorphisms with dementia in Parkinson's disease. Neuroscience letters. vol 448. issue 1. 2009-04-16. PMID:18930114. |
some apoe or tau gene polymorphisms have been associated with alzheimer's disease (ad), progressive supranuclear palsy (psp) and parkinson's disease (pd). |
2009-04-16 |
2023-08-12 |
Not clear |
| Selam Negash, Pamela M Greenwood, Trey Sunderland, Raja Parasuraman, Yonas E Geda, David S Knopman, Bradley F Boeve, Robert J Ivnik, Ronald C Petersen, Glenn E Smit. The influence of apolipoprotein E genotype on visuospatial attention dissipates after age 80. Neuropsychology. vol 23. issue 1. 2009-04-15. PMID:19210035. |
although it is established that apolipoprotein e (apoe) e4 allele increases the risk of alzheimer's disease (ad), epidemiological studies indicate that genetic risk decreases late in life. |
2009-04-15 |
2023-08-12 |
Not clear |
| Lingzhi Zhao, Suizhen Lin, Kelly R Bales, Valentina Gelfanova, Deanna Koger, Cynthia Delong, John Hale, Feng Liu, Jesse M Hunter, Steven M Pau. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 11. 2009-04-13. PMID:19295164. |
these apoe isoform-dependent effects of macrophages on abeta degradation suggest a novel "peripheral" mechanism for abeta clearance from brain that may also, in part, explain the isoform-dependent effects of apoe in determining the genetic risk for alzheimer's disease. |
2009-04-13 |
2023-08-12 |
mouse |
| Kristel Sleegers, Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Helen van Miegroet, Peter P De Deyn, Christine Van Broeckhove. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. Human mutation. vol 30. issue 2. 2009-04-10. PMID:18853460. |
grb-associated binding protein 2 (gab2) was recently reported to be a modifier of late-onset alzheimer dementia (ad) risk in carriers of the apoe epsilon4 allele in a genome-wide association analysis. |
2009-04-10 |
2023-08-12 |
Not clear |