| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Panizzon, R Hauger, A M Dale, L J Eaves, L T Eyler, B Fischl, C Fennema-Notestine, C E Franz, M D Grant, A J Jak, K C Jacobson, M J Lyons, S P Mendoza, M C Neale, E C Prom-Wormley, L J Seidman, M T Tsuang, H Xian, W S Kreme. Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology. vol 75. issue 10. 2010-09-27. PMID:20819998. |
the apoe epsilon4 allele is an established risk factor for alzheimer disease (ad), yet findings are mixed for how early its effects are manifest. |
2010-09-27 |
2023-08-12 |
Not clear |
| Ge Li, Jane B Shofer, Isaac C Rhew, Walter A Kukull, Elaine R Peskind, Wayne McCormick, James D Bowen, Gerard D Schellenberg, Paul K Crane, John C S Breitner, Eric B Larso. Age-varying association between statin use and incident Alzheimer's disease. Journal of the American Geriatrics Society. vol 58. issue 7. 2010-09-14. PMID:20533968. |
to determine whether risk reduction of statins for alzheimer's disease (ad) varies by age or presence of apolipoprotein e (apoe) epsilon4 allele. |
2010-09-14 |
2023-08-12 |
Not clear |
| D J Stone, C Molony, C Suver, E E Schadt, W Z Potte. ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease. The pharmacogenomics journal. vol 10. issue 3. 2010-08-23. PMID:19997085. |
apoe genotyping as a progression-rate biomarker in phase ii disease-modification trials for alzheimer's disease. |
2010-08-23 |
2023-08-12 |
Not clear |
| J Kukolja, C M Thiel, T Eggermann, K Zerres, G R Fin. Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE epsilon4 carriers. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20350587. |
presence of the apolipoprotein e (apoe) epsilon4 allele is linked to an increased risk to develop alzheimer's dementia (ad). |
2010-08-19 |
2023-08-12 |
human |
| Kangguang Lin, Muni Tang, Haiying Han, Yangbo Guo, Yuhua Lin, Cui M. GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 3. 2010-08-18. PMID:19924507. |
it has recently been shown that gab2 alleles modify the risk for late-onset alzheimer disease (load) in apolipoprotein e (apoe)epsilon4 allele carriers in a genome-wide association study. |
2010-08-18 |
2023-08-12 |
Not clear |
| Ying Chen, Murat S Durakoglugil, Xunde Xian, Joachim Her. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 26. 2010-08-11. PMID:20547867. |
apolipoprotein e (apoe) genotype is a powerful genetic modifier of alzheimer's disease (ad). |
2010-08-11 |
2023-08-12 |
mouse |
| Zoë van Helmond, James S Miners, Patrick G Kehoe, Seth Lov. Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy. Brain pathology (Zurich, Switzerland). vol 20. issue 2. 2010-08-10. PMID:19725829. |
oligomeric abeta in alzheimer's disease: relationship to plaque and tangle pathology, apoe genotype and cerebral amyloid angiopathy. |
2010-08-10 |
2023-08-12 |
human |
| Christina E Wierenga, Nikki H Stricker, Ashley McCauley, Alan Simmons, Amy J Jak, Yu-Ling Chang, Lisa Delano-Wood, Katherine J Bangen, David P Salmon, Mark W Bond. Increased functional brain response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer's disease. NeuroImage. vol 51. issue 3. 2010-08-05. PMID:20298792. |
recent language studies in aging and dementia provide two complementary lines of evidence that: (1) measures of semantic knowledge and word-finding ability show declines comparable to those of episodic memory, and greater impairment than executive function measures, during the prodromal period of alzheimer's disease and (2) cognitively intact older adult carriers of the apolipoprotein e (apoe) epsilon4 allele also demonstrate poorer object naming than their low-risk peers. |
2010-08-05 |
2023-08-12 |
Not clear |
| Xiao-Yu Xin, Jian-Qing Ding, Sheng-Di Che. Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis. Journal of Alzheimer's disease : JAD. vol 19. issue 4. 2010-07-22. PMID:20061606. |
apolipoprotein e (apoe) promoter polymorphisms have long been linked to alzheimer disease (ad) susceptibility, although the established data remains controversial. |
2010-07-22 |
2023-08-12 |
human |
| M Degerman Gunnarsson, M Lindau, A Wall, K Blennow, T Darreh-Shori, S Basu, A Nordberg, A Larsson, L Lannfelt, H Basun, L Kilande. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study. Dementia and geriatric cognitive disorders. vol 29. issue 3. 2010-07-09. PMID:20332638. |
associations between pet pib and cerebrospinal fluid (csf) abeta1-42 and apolipoprotein e epsilon4 (apoe epsilon4) have been observed in several studies, but the relations between pib uptake and other biomarkers of alzheimer's disease (ad) are less investigated. |
2010-07-09 |
2023-08-12 |
Not clear |
| Yi-Fang Chuang, Kathleen M Hayden, Maria C Norton, Joann Tschanz, John C S Breitner, Kathleen A Welsh-Bohmer, Peter P Zand. Association between APOE epsilon4 allele and vascular dementia: The Cache County study. Dementia and geriatric cognitive disorders. vol 29. issue 3. 2010-07-09. PMID:20375505. |
the apoe epsilon4 allele is an established risk factor for alzheimer's disease, but reports of its association with vascular dementia (vad) have been inconsistent. |
2010-07-09 |
2023-08-12 |
Not clear |
| Akemi Hosoda, Takashi Inoue, Chang C Mao, Young-Hee Jeong, Azumi Yamagishi, Mingjuan Ye, Tokuo Yamamoto, Dong-Ho Kim, Shigeru Saek. Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer's disease patients. Bioscience, biotechnology, and biochemistry. vol 74. issue 3. 2010-07-01. PMID:20208369. |
apolipoprotein e (apoe) polymorphism is associated with onset of alzheimer's disease (ad). |
2010-07-01 |
2023-08-12 |
human |
| Allen D Rose. An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Archives of neurology. vol 67. issue 5. 2010-07-01. PMID:20457951. |
i coauthored a recently published research article describing a variable length, poly-t polymorphism in the tomm40 gene, adjacent to apolipoprotein e (apoe) on chromosome 19, that accounts for the age at onset distribution for a complex disease, late-onset alzheimer disease. |
2010-07-01 |
2023-08-12 |
Not clear |
| José R Carrión-Baralt, Josefina Meléndez-Cabrero, Heide Rodríguez-Ubiñas, James Schmeidler, Michal Schnaider Beeri, Gary Angelo, Mary Sano, Jeremy M Silverma. Impact of APOE epsilon4 on the cognitive performance of a sample of non-demented Puerto Rican nonagenarians. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19584451. |
apoe epsilon4 is a major risk factor for alzheimer's disease. |
2010-06-30 |
2023-08-12 |
Not clear |
| David A Wolk, Bradford C Dickerso. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 22. 2010-06-29. PMID:20479234. |
apolipoprotein e (apoe) genotype has dissociable effects on memory and attentional-executive network function in alzheimer's disease. |
2010-06-29 |
2023-08-12 |
Not clear |
| David A Wolk, Bradford C Dickerso. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 22. 2010-06-29. PMID:20479234. |
the epsilon4 allele of the apolipoprotein e (apoe) gene is the major genetic risk factor for alzheimer's disease (ad), but limited work has suggested that apoe genotype may modulate disease phenotype. |
2010-06-29 |
2023-08-12 |
Not clear |
| Xiao-hui Zhou, Shi-feng Xing, Xiao-mei Lu. [Association of the neprilysin and apolipoprotein E gene polymorphisms with Alzheimer's disease in Xinjiang Uygur population]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 27. issue 2. 2010-06-28. PMID:20376800. |
to assess the association between the neprilysin (nep) gene and apolipoprotein e (apoe) gene polymorphisms and sporadic alzheimer's disease (sad) in xinjiang uygur population. |
2010-06-28 |
2023-08-12 |
Not clear |
| Gary W Beecham, Eden R Martin, John R Gilbert, Jonathan L Haines, Margaret A Pericak-Vanc. APOE is not associated with Alzheimer disease: a cautionary tale of genotype imputation. Annals of human genetics. vol 74. issue 3. 2010-06-24. PMID:20529013. |
apoe is not associated with alzheimer disease: a cautionary tale of genotype imputation. |
2010-06-24 |
2023-08-12 |
Not clear |
| Birgir Hrafnkelsson, Agnar Helgason, Gudbjorn F Jonsson, Daniel F Gudbjartsson, Thorlakur Jonsson, Sverrir Thorvaldsson, Hreinn Stefansson, Valgerdur Steinthorsdottir, Nanna Vidarsdottir, Derek Middleton, Henning S Petersen, Conrado Martinez, Jon Snaedal, Palmi V Jonsson, Sigurbjorn Bjornsson, Jeffrey R Gulcher, Kari Stefansso. Evaluating differences in linkage disequilibrium between populations. Annals of human genetics. vol 74. issue 3. 2010-06-24. PMID:20529015. |
second, we examine evidence for ld differences between alzheimer cases and controls from the icelandic population using 19 single nucleotide polymorphisms (snps) from a 97 kb region flanking the apolipoprotein e (apoe) gene on chromosome 19. |
2010-06-24 |
2023-08-12 |
Not clear |
| Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panz. Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing research reviews. vol 9. issue 2. 2010-06-15. PMID:19643207. |
however, recent findings from clinical trials with n-3 pufa supplementation showed efficacy on depressive symptoms only in non-apolipoprotein e (apoe) epsilon4 carriers, and on cognitive symptoms only in very mild alzheimer's disease (ad) subgroups, mci patients, and cognitively unimpaired subjects non-apoe epsilon4 carriers. |
2010-06-15 |
2023-08-12 |
human |