| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew J Sharman, Michael Morici, Eugene Hone, Tamar Berger, Kevin Taddei, Ian J Martins, Wei Ling F Lim, Sajla Singh, Markus R Wenk, Jorge Ghiso, Joseph D Buxbaum, Sam Gandy, Ralph N Martin. APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. Journal of Alzheimer's disease : JAD. vol 21. issue 2. 2010-12-20. PMID:20555142. |
the epsilon4 allele of apolipoprotein e (apoe) is currently the major genetic risk factor identified for alzheimer's disease (ad). |
2010-12-20 |
2023-08-12 |
mouse |
| Danielle C Whitehair, Abdullah Sherzai, Jennifer Emond, Rema Raman, Paul S Aisen, Ronald C Petersen, Adam S Fleishe. Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 5. 2010-12-20. PMID:20813342. |
apolipoprotein e varepsilon4 (apoe varepsilon4) allele carrier status has been well established as a risk factor for developing alzheimer's disease. |
2010-12-20 |
2023-08-12 |
human |
| Bernadette McGuinness, Robyn Carson, Suzanne Lucia Barrett, David Craig, Anthony Peter Passmor. Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia. Neuroscience letters. vol 483. issue 1. 2010-12-13. PMID:20678545. |
the apolipoprotein (apoe) epsilon4 allele is a genetic risk factor for the development of alzheimer's disease (ad). |
2010-12-13 |
2023-08-12 |
Not clear |
| Bernhard Rosengarten, Sönke Paulsen, Ole Burr, Manfred Kap. Effect of ApoE epsilon4 allele on visual evoked potentials and resultant flow coupling in patients with Alzheimer. Journal of geriatric psychiatry and neurology. vol 23. issue 3. 2010-12-02. PMID:20430978. |
effect of apoe epsilon4 allele on visual evoked potentials and resultant flow coupling in patients with alzheimer. |
2010-12-02 |
2023-08-12 |
Not clear |
| Bernhard Rosengarten, Sönke Paulsen, Ole Burr, Manfred Kap. Effect of ApoE epsilon4 allele on visual evoked potentials and resultant flow coupling in patients with Alzheimer. Journal of geriatric psychiatry and neurology. vol 23. issue 3. 2010-12-02. PMID:20430978. |
the apolipoprotein e epsilon4 (apoe epsilon4) allele is a strong susceptibility factor for alzheimer disease, which promotes neurodegeneration and cerebrovascular dysfunction. |
2010-12-02 |
2023-08-12 |
Not clear |
| Christie Cluett, Carol Brayne, Robert Clarke, Grimley Evans, Fiona Matthews, David C Rubinsztein, Felicia Huppert, David J Llewellyn, Neil Rice, William Henley, Timothy M Frayling, Anna Murray, David Melze. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiology of aging. vol 31. issue 9. 2010-11-30. PMID:18848371. |
a recent genome-wide association (gwa) study of late-onset alzheimer's disease (load) identified 15 novel single nucleotide polymorphisms (snps) independent of apoe. |
2010-11-30 |
2023-08-12 |
Not clear |
| Hua Cheng, Yunhua Zhou, David M Holtzman, Xianlin Ha. Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease. Neurobiology of aging. vol 31. issue 7. 2010-11-24. PMID:18762354. |
herein, we tested a recently proposed working model of apolipoprotein e (apoe)-mediated sulfatide metabolism/trafficking/homeostasis with two well-characterized amyloid precursor protein (app) transgenic (tg) animal models of alzheimer's disease (ad) (i.e., app(v717f) and appsw) on a wild-type murine apoe background or after being bred onto an apoe(-/-) background. |
2010-11-24 |
2023-08-12 |
mouse |
| K B Walhovd, A M Fjell, A M Dale, L K McEvoy, J Brewer, D S Karow, D P Salmon, C Fennema-Notestin. Multi-modal imaging predicts memory performance in normal aging and cognitive decline. Neurobiology of aging. vol 31. issue 7. 2010-11-24. PMID:18838195. |
this study (n=161) related morphometric mr imaging, fdg-pet and apoe genotype to memory scores in normal controls (nc), mild cognitive impairment (mci) and alzheimer's disease (ad). |
2010-11-24 |
2023-08-12 |
Not clear |
| James J Donkin, Sophie Stukas, Veronica Hirsch-Reinshagen, Dhananjay Namjoshi, Anna Wilkinson, Sharon May, Jeniffer Chan, Jianjia Fan, Jon Collins, Cheryl L Wellingto. ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20739291. |
the cholesterol transporter atp-binding cassette transporter a1 (abca1) moves lipids onto apolipoproteins including apolipoprotein e (apoe), which is the major cholesterol carrier in the brain and an established genetic risk factor for late-onset alzheimer disease (ad). |
2010-11-16 |
2023-08-12 |
mouse |
| Valerio Leoni, Alina Solomon, Miia Kivipelt. Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment. Biochemical Society transactions. vol 38. issue 4. 2010-11-12. PMID:20658997. |
in csf (cerebrospinal fluid) collected form from patients with cognitive impairment (alzheimer's disease and patients with mild cognitive impairment) the levels of apoe, tau, p-tau (hyperphosphorylated tau) were significantly increased, together with 24ohc, compared with controls. |
2010-11-12 |
2023-08-12 |
Not clear |
| Suhng Wook Kim, Ji Hye Heo, Chun Huem Kim, Dong Chul Yoo, Dong Hwan Won, Seung Gwan Lee, Kyoung Jin Cho, Jung Han Song, Su Jeong Park, Young Geun Yang, Dal Woong Cho. Rapid and direct detection of apolipoprotein E genotypes using whole blood from humans. Journal of toxicology and environmental health. Part A. vol 73. issue 21-22. 2010-11-05. PMID:20954076. |
the apolipoprotein e (apoe) gene contains two single-nucleotide polymorphisms (snp) located at codons 112 and 158, producing three apoe protein isoforms known to be associated with the risks of developing cardiovascular disease and susceptibility to alzheimer's disease. |
2010-11-05 |
2023-08-12 |
Not clear |
| S A Golenkina, A Iu Gol'tsov, I L Kuznetsova, A P Grigorenko, T V Andreeva, D A Reshetov, S S Kunizheva, L I Shagam, I Iu Morozova, I V Goldenkova-Pavlova, Kh Shimshilashvili, A O Viacheslavova, G Faskhutdinova, A É Gareeva, A G Zaĭnullina, É K Khusnutdinova, V P Puzyrev, V A Stepanov, A V Kolotvin, L M Samokhodskaia, N D Selezneva, S I Gavrilova, E I Rogae. [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations]. Molekuliarnaia biologiia. vol 44. issue 4. 2010-11-03. PMID:20873220. |
three genes mutations in which cause familial forms of alzheimer's disease are known to date:psen1, psen2 and app; and apoe gene polymorphism is a strong risk factor for alzheimer's disease. |
2010-11-03 |
2023-08-12 |
Not clear |
| S A Golenkina, A Iu Gol'tsov, I L Kuznetsova, A P Grigorenko, T V Andreeva, D A Reshetov, S S Kunizheva, L I Shagam, I Iu Morozova, I V Goldenkova-Pavlova, Kh Shimshilashvili, A O Viacheslavova, G Faskhutdinova, A É Gareeva, A G Zaĭnullina, É K Khusnutdinova, V P Puzyrev, V A Stepanov, A V Kolotvin, L M Samokhodskaia, N D Selezneva, S I Gavrilova, E I Rogae. [Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations]. Molekuliarnaia biologiia. vol 44. issue 4. 2010-11-03. PMID:20873220. |
although our resultsdo not confirm the role of clu gene as a majorgenetic factor forcommon form of alzheimer's disease, the data do not rule out the possibility of modest effect of clu and interaction between clu and apoe genotypes in etiology of alzheimer's disease. |
2010-11-03 |
2023-08-12 |
Not clear |
| Sandra Iurescia, Daniela Fioretti, Francesca Mangialasche, Monica Rinald. The pathological cross talk between apolipoprotein E and amyloid-beta peptide in Alzheimer's disease: emerging gene-based therapeutic approaches. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20182014. |
this review summarizes the pathological cross talk between apoe and abeta peptide in alzheimer's disease. |
2010-11-02 |
2023-08-12 |
Not clear |
| Sandra Iurescia, Daniela Fioretti, Francesca Mangialasche, Monica Rinald. The pathological cross talk between apolipoprotein E and amyloid-beta peptide in Alzheimer's disease: emerging gene-based therapeutic approaches. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20182014. |
lastly, we examine emerging gene-based therapeutic approaches encompassing the use of apoe and their potential opportunities to preventing or treating alzheimer's disease. |
2010-11-02 |
2023-08-12 |
Not clear |
| Amy Chan, Thomas B She. Apolipoprotein e3 as a risk factor for Alzheimer's disease under conditions of nutritional imbalance. Journal of Alzheimer's disease : JAD. vol 21. issue 1. 2010-11-02. PMID:20413864. |
the presence of one or more copies of the e4 allele of apolipoprotein e (apoe) is strongly associated with of alzheimer's disease (ad). |
2010-11-02 |
2023-08-12 |
mouse |
| Maartje I Kester, Wiesje M van der Flier, Gorana Mandic, Marinus A Blankenstein, Philip Scheltens, Majon Mulle. Joint effect of hypertension and APOE genotype on CSF biomarkers for Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20. issue 4. 2010-10-12. PMID:20413898. |
joint effect of hypertension and apoe genotype on csf biomarkers for alzheimer's disease. |
2010-10-12 |
2023-08-12 |
Not clear |
| Kyle Steenland, Jessica MacNeil, Ryan Seals, Allan Leve. Factors affecting survival of patients with neurodegenerative disease. Neuroepidemiology. vol 35. issue 1. 2010-10-08. PMID:20389122. |
data on the role of the mini mental state examination (mmse) and apolipoprotein e (apoe) in survival are sparse except for alzheimer's disease (ad). |
2010-10-08 |
2023-08-12 |
Not clear |
| Dietmar Rudolf Thal, Andreas Papassotiropoulos, Takaomi C Saido, W Sue T Griffin, Robert E Mrak, Heike Kölsch, Kelly Del Tredici, Johannes Attems, Estifanos Ghebremedhi. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20535486. |
capillary cerebral amyloid angiopathy identifies a distinct apoe epsilon4-associated subtype of sporadic alzheimer's disease. |
2010-09-28 |
2023-08-12 |
Not clear |
| Dietmar Rudolf Thal, Andreas Papassotiropoulos, Takaomi C Saido, W Sue T Griffin, Robert E Mrak, Heike Kölsch, Kelly Del Tredici, Johannes Attems, Estifanos Ghebremedhi. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20535486. |
in addition, as in alzheimer's disease, risk for capillary caa is associated with the apolipoprotein e (apoe) epsilon4-allele. |
2010-09-28 |
2023-08-12 |
Not clear |