| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Carte. APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle. Neuroscience letters. vol 483. issue 2. 2011-05-31. PMID:20674675. |
the major alzheimer's disease susceptibility genes (apoe, clusterin, complement receptor 1 (cr1) and phosphatidylinositol binding clathrin assembly protein, picalm) can be implicated directly (apoe, cr1) or indirectly (clusterin and picalm) in the herpes simplex life cycle. |
2011-05-31 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
to address the complex misfolding and aggregation that initiates the toxic cascade resulting in alzheimer's disease (ad), we have developed a 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid spin-labeled amyloid-β (aβ) peptide to observe its isoform-dependent interaction with the apoe protein. |
2011-05-27 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
although most individuals carry the e3 isoform of apoe, ∼15% of humans carry the e4 isoform, which is recognized as the most significant genetic determinant for alzheimer's. |
2011-05-27 |
2023-08-12 |
Not clear |
| Jitka Petrlova, Hyun-Seok Hong, Daniel A Bricarello, Ghimire Harishchandra, Gary A Lorigan, Lee-Way Jin, John C Vos. A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins. vol 79. issue 2. 2011-05-27. PMID:21069870. |
these findings support the hypothesis that apoe polymorphism and alzheimer's risk can largely be attributed to the reduced ability of apoe4 to function as a clearance vehicle for the toxic form of aβ. |
2011-05-27 |
2023-08-12 |
Not clear |
| Frauke Glöckner, Volker Meske, Dieter Lütjohann, Thomas G Oh. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. Journal of neuropathology and experimental neurology. vol 70. issue 4. 2011-05-27. PMID:21412171. |
to elucidate the relationship between cholesterol and tau, we studied mice expressing p301l mutant human tau but not apoe (htau-apoe) and p301l mice with wild-type apoe (htau- apoe); both genotypes develop neuron cytoskeletal changes similar to those found in alzheimer disease. |
2011-05-27 |
2023-08-12 |
mouse |
| Hannah Tayler, Thomas Fraser, J Scott Miners, Patrick G Kehoe, Seth Lov. Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-β. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930272. |
oxidative balance in alzheimer's disease: relationship to apoe, braak tangle stage, and the concentrations of soluble and insoluble amyloid-β. |
2011-05-25 |
2023-08-12 |
Not clear |
| Lluís Samaranch, Sebastián Cervantes, Ana Barabash, Alvaro Alonso, José Antonio Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez-Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez-Isla, Pau Pasto. The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia. Journal of Alzheimer's disease : JAD. vol 22. issue 4. 2011-05-25. PMID:20930301. |
microtubule-associated protein tau (mapt) and apolipoprotein e (apoe) are involved in the pathogenic mechanisms of alzheimer's disease (ad). |
2011-05-25 |
2023-08-12 |
human |
| Sheila Crean, Alex Ward, Catherine J Mercaldi, Jenna M Collins, Michael N Cook, Nicole L Baker, H Michael Arrigh. Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. Dementia and geriatric cognitive disorders. vol 31. issue 1. 2011-05-19. PMID:21124030. |
the ε4 allele of apolipoprotein e (apoe) is associated with alzheimer's disease (ad). |
2011-05-19 |
2023-08-12 |
Not clear |
| Yvonne Newhouse, Karl H Weisgrabe. Apolipoprotein E expression and purification. Methods in molecular biology (Clifton, N.J.). vol 670. 2011-05-02. PMID:20967588. |
since the discovery of the association of apolipoprotein e (apoe) 4 with alzheimer's disease 17 years ago, numerous in vitro experiments with the apoe isoforms (apoe2, apoe3, and apoe4) have been performed to try to understand the basis for this association. |
2011-05-02 |
2023-08-12 |
Not clear |
| Nasim Mansoori, Manjari Tripathi, Rizwan Alam, Kalpana Luthra, Lakshmy Ramakrishnan, Shama Parveen, Asok K Mukhopadhya. IL-6-174 G/C and ApoE gene polymorphisms in Alzheimer's and vascular dementia patients attending the cognitive disorder clinic of the All India Institute of Medical Sciences, New Delhi. Dementia and geriatric cognitive disorders. vol 30. issue 6. 2011-04-25. PMID:21252539. |
il-6-174 g/c and apoe gene polymorphisms in alzheimer's and vascular dementia patients attending the cognitive disorder clinic of the all india institute of medical sciences, new delhi. |
2011-04-25 |
2023-08-12 |
Not clear |
| Oh Dae Kwon, Aisha Khaleeq, Wenyaw Chan, Valory N Pavlik, Rachelle S Dood. Apolipoprotein E polymorphism and age at onset of Alzheimer's disease in a quadriethnic sample. Dementia and geriatric cognitive disorders. vol 30. issue 6. 2011-04-25. PMID:21252542. |
the relationship between the apolipoprotein e (apoe) genotype and the risk for developing alzheimer's disease (ad) or age at onset of ad is relatively well established in caucasians, but less established in other ethnicities. |
2011-04-25 |
2023-08-12 |
Not clear |
| Wiesje M van der Flier, Yolande Al Pijnenburg, Nick C Fox, Philip Schelten. Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele. The Lancet. Neurology. vol 10. issue 3. 2011-04-21. PMID:21185234. |
early-onset versus late-onset alzheimer's disease: the case of the missing apoe ɛ4 allele. |
2011-04-21 |
2023-08-12 |
Not clear |
| Andrew Stuart Gibbons, Madhara Udawela, Won Je Jeon, Myoung Suk Seo, Lucy Brooks, Brian Dea. The neurobiology of APOE in schizophrenia and mood disorders. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196212. |
polymorphisms within the apoe gene have been associated with the incidence of alzheimer's disease. |
2011-04-21 |
2023-08-12 |
Not clear |
| Andrew Stuart Gibbons, Madhara Udawela, Won Je Jeon, Myoung Suk Seo, Lucy Brooks, Brian Dea. The neurobiology of APOE in schizophrenia and mood disorders. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196212. |
in light of the similarities in the cognitive deficits experienced in both alzheimer's disease and schizophrenia as well as the comorbidity of depression in alzheimer's disease, aberrant apoe signalling has been implicated in the pathologies of schizophrenia and mood disorders. |
2011-04-21 |
2023-08-12 |
Not clear |
| Philip B Verghese, Joseph M Castellano, David M Holtzma. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet. Neurology. vol 10. issue 3. 2011-04-21. PMID:21349439. |
apoe ɛ2, ɛ3, and ɛ4 alleles strongly alter, in a dose-dependent manner, the likelihood of developing alzheimer's disease and cerebral amyloid angiopathy. |
2011-04-21 |
2023-08-12 |
Not clear |
| Philip B Verghese, Joseph M Castellano, David M Holtzma. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet. Neurology. vol 10. issue 3. 2011-04-21. PMID:21349439. |
in particular, apoe ɛ4 is associated with increased risk for alzheimer's disease whereas apoe ɛ2 is associated with decreased risk. |
2011-04-21 |
2023-08-12 |
Not clear |
| Philip B Verghese, Joseph M Castellano, David M Holtzma. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet. Neurology. vol 10. issue 3. 2011-04-21. PMID:21349439. |
response to treatment for alzheimer's disease might differ according to apoe genotype. |
2011-04-21 |
2023-08-12 |
Not clear |
| Philip B Verghese, Joseph M Castellano, David M Holtzma. Apolipoprotein E in Alzheimer's disease and other neurological disorders. The Lancet. Neurology. vol 10. issue 3. 2011-04-21. PMID:21349439. |
because convincing evidence ties the apoe genotype to risk of alzheimer's disease and cerebral amyloid angiopathy, apoe has been studied in other neurological diseases. |
2011-04-21 |
2023-08-12 |
Not clear |
| Paul S Hauser, Vasanthy Narayanaswami, Robert O Rya. Apolipoprotein E: from lipid transport to neurobiology. Progress in lipid research. vol 50. issue 1. 2011-04-08. PMID:20854843. |
the strong and enduring correlation between the apoe4 isoform and age of onset and increased risk of alzheimer's disease has catapulted apoe to the forefront of neurobiology. |
2011-04-08 |
2023-08-12 |
mouse |
| Olivia Belbin, Minerva M Carrasquillo, Michael Crump, Oliver J Culley, Talisha A Hunter, Li Ma, Gina Bisceglio, Fanggeng Zou, Mariet Allen, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Kevin Morgan, Steven G Younki. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Human genetics. vol 129. issue 3. 2011-04-06. PMID:21132329. |
the 12 genome-wide association studies (gwas) published to-date for late-onset alzheimer's disease (load) have identified over 40 candidate load risk modifiers, in addition to apolipoprotein (apoe) ε4. |
2011-04-06 |
2023-08-12 |
Not clear |