| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianglei Chen, Qianqian Li, Jianjun Wan. Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 36. 2011-11-02. PMID:21873229. |
apoe also interacts with beta amyloid peptide, manifests critical isoform-specific effects on alzheimer's disease. |
2011-11-02 |
2023-08-12 |
human |
| S J Connelly, E B Mukaetova-Ladinska, Z Abdul-All, J Alves da Silva, C Brayne, W G Honer, D M A Man. Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype. Neuropathology and applied neurobiology. vol 37. issue 4. 2011-11-01. PMID:21073671. |
this immunohistochemical study quantified synaptic changes (synaptophysin and snap-25) in the frontal lobe of subjects with frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad), and related these to apoe genotype and mapt haplotype. |
2011-11-01 |
2023-08-12 |
human |
| Amy E Taylor, Philip A I Guthrie, George Davey Smith, Jean Golding, Naveed Sattar, Aroon D Hingorani, John E Deanfield, Ian N M Da. IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children. Biological psychiatry. vol 70. issue 2. 2011-10-27. PMID:21215387. |
apolipoprotein e (apoe) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and alzheimer's disease. |
2011-10-27 |
2023-08-12 |
Not clear |
| Fei Ma, Jianhua Wang, Rujuan Miao, Wei Zhao, Qian Wan. Association between apolipoprotein E ε4 and longitudinal cognitive decline: nested case-control study among chinese community-dwelling elders. Neuropsychobiology. vol 64. issue 2. 2011-10-25. PMID:21701228. |
the apolipoprotein e (apoe) ε4 allele is considered an important genetic determinant of alzheimer's disease (ad), and strongly suspected to play a role in cognitive variation. |
2011-10-25 |
2023-08-12 |
Not clear |
| Joseph M Castellano, Jungsu Kim, Floy R Stewart, Hong Jiang, Ronald B DeMattos, Bruce W Patterson, Anne M Fagan, John C Morris, Kwasi G Mawuenyega, Carlos Cruchaga, Alison M Goate, Kelly R Bales, Steven M Paul, Randall J Bateman, David M Holtzma. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science translational medicine. vol 3. issue 89. 2011-10-25. PMID:21715678. |
the apolipoprotein e (apoe) ε4 allele is the strongest genetic risk factor for late-onset, sporadic alzheimer's disease (ad). |
2011-10-25 |
2023-08-12 |
mouse |
| Carlos Cruchaga, Petra Nowotny, John S K Kauwe, Perry G Ridge, Kevin Mayo, Sarah Bertelsen, Anthony Hinrichs, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goat. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of neurology. vol 68. issue 8. 2011-10-13. PMID:21825236. |
apolipoprotein e (apoe) is the most statistically significant genetic risk factor for late-onset alzheimer disease (load). |
2011-10-13 |
2023-08-12 |
Not clear |
| Qian Liu, Wei-hui Wu, Chuan-lin Fang, Ren-wang Li, Peng Liu, Peng Lei, Jia Hu, Xun Sun, Yi-zhe Zheng, Yu-fen Zhao, Yan-mei L. Mapping ApoE/Aβ binding regions to guide inhibitor discovery. Molecular bioSystems. vol 7. issue 5. 2011-09-30. PMID:21409287. |
blocking the interaction between the e4 isoform of apolipoprotein e (apoe) and amyloid beta-peptide (aβ) may be an avenue for pharmacological intervention in alzheimer's disease (ad). |
2011-09-30 |
2023-08-12 |
Not clear |
| Gillian Chilibeck, Margaret Lock, Megha Sehde. Postgenomics, uncertain futures, and the familiarization of susceptibility genes. Social science & medicine (1982). vol 72. issue 11. 2011-09-21. PMID:20570031. |
the case of the apoe gene and its relationship to alzheimer's disease is used as an illustrative example. |
2011-09-21 |
2023-08-12 |
Not clear |
| Kanchan Garai, Berevan Baban, Carl Friede. Self-association and stability of the ApoE isoforms at low pH: implications for ApoE-lipid interactions. Biochemistry. vol 50. issue 29. 2011-09-19. PMID:21699199. |
apolipoprotein e (apoe) isoforms are known to differentially accumulate in the lysosomes of neuronal cells, and the deleterious effects of the apoe4 isoform in alzheimer's disease may relate to its properties at the low lysosomal ph. |
2011-09-19 |
2023-08-12 |
Not clear |
| Robert M DeKroon, Cristina Osorio, Jennifer B Robinette, Mihaela Mocanu, Witold M Winnik, Oscar Alzat. Simultaneous detection of changes in protein expression and oxidative modification as a function of age and APOE genotype. Journal of proteome research. vol 10. issue 4. 2011-09-16. PMID:21210719. |
to better elucidate temporal changes in protein oxidation resulting from aging and the alzheimer's disease-associated apolipoprotein e (apoe), we developed a 2d-dige-based method for simultaneously detecting differential expression and carbonyl oxidation of proteins. |
2011-09-16 |
2023-08-12 |
mouse |
| Shixin Li, Hao Zhang, Ping Gao, Zanmou Chen, Chong Wang, Jiaqi L. A functional mutation at position -155 in porcine APOE promoter affects gene expression. BMC genetics. vol 12. 2011-09-07. PMID:21549015. |
three single nucleotide polymorphisms (snps) -491a>t, -219t>g and +113g>c in the regulatory region of human apolipoprotein e gene (apoe) change the promoter activity and are associated with a wide variety of disorders including alzheimer disease (ad). |
2011-09-07 |
2023-08-12 |
human |
| Nunzio Pomara, Davide Bruno, Jay J Nierenberg, John J Sidtis, Frank T Martiniuk, Pankaj D Mehta, Henrik Zetterberg, Kaj Blenno. TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderly. Neurochemical research. vol 36. issue 6. 2011-09-01. PMID:21455713. |
a variable poly-t polymorphism in the tomm40 gene, which is in linkage disequilibrium with apoe, was recently implicated with increased risk and earlier onset age for late-onset alzheimer's disease in apoe ε3 carriers. |
2011-09-01 |
2023-08-12 |
human |
| S M Laws, K Eckart, P Friedrich, T Eisele, A Kurz, H Förstl, M Riemenschneide. No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of aging. vol 31. issue 12. 2011-08-29. PMID:19155102. |
hepatic lipase, also known as hepatic triglyceride lipase (lipc), much like the major genetic risk factor for alzheimer's disease (ad), apolipoprotein e (apoe), is associated with altered lipid metabolism. |
2011-08-29 |
2023-08-12 |
Not clear |
| Jean-Charles Lambert, Kristel Sleegers, Antonio González-Pérez, Martin Ingelsson, Gary W Beecham, Mikko Hiltunen, Onofre Combarros, Maria J Bullido, Nathalie Brouwers, Karolien Bettens, Claudine Berr, Florence Pasquier, Florence Richard, Steven T Dekosky, Didier Hannequin, Jonathan L Haines, Gloria Tognoni, Nathalie Fiévet, Jean-François Dartigues, Christophe Tzourio, Sebastiaan Engelborghs, Beatrice Arosio, Elicer Coto, Peter De Deyn, Maria Del Zompo, Ignacio Mateo, Merce Boada, Carmen Antunez, Jesus Lopez-Arrieta, Jacques Epelbaum, Brit-Maren Michaud Schjeide, Ana Frank-Garcia, Vilmentas Giedraitis, Seppo Helisalmi, Elisa Porcellini, Alberto Pilotto, Paola Forti, Raffaele Ferri, Marc Delepine, Diana Zelenika, Mark Lathrop, Elio Scarpini, Gabriele Siciliano, Vincenzo Solfrizzi, Sandro Sorbi, Gianfranco Spalletta, Giovanni Ravaglia, Fernando Valdivieso, Saila Vepsäläinen, Victoria Alvarez, Paolo Bosco, Michelangelo Mancuso, Francesco Panza, Benedetta Nacmias, Paola Bossù, Olivier Hanon, Paola Piccardi, Giorgio Annoni, David Mann, Philippe Marambaud, Davide Seripa, Daniela Galimberti, Rudolph E Tanzi, Lars Bertram, Corinne Lendon, Lars Lannfelt, Federico Licastro, Dominique Campion, Margaret A Pericak-Vance, Hilkka Soininen, Christine Van Broeckhoven, Annick Alpérovitch, Agustin Ruiz, M Ilyas Kamboh, Philippe Amouye. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's disease : JAD. vol 22. issue 1. 2011-08-29. PMID:20847397. |
the only established genetic determinant of non-mendelian forms of alzheimer's disease (ad) is the ε4 allele of the apolipoprotein e gene (apoe). |
2011-08-29 |
2023-08-12 |
Not clear |
| Jon Valla, Roy Yaari, Andrew B Wolf, Yael Kusne, Thomas G Beach, Alex E Roher, Jason J Corneveaux, Matthew J Huentelman, Richard J Caselli, Eric M Reima. Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene. Journal of Alzheimer's disease : JAD. vol 22. issue 1. 2011-08-29. PMID:20847408. |
reduced posterior cingulate mitochondrial activity in expired young adult carriers of the apoe ε4 allele, the major late-onset alzheimer's susceptibility gene. |
2011-08-29 |
2023-08-12 |
Not clear |
| Kurt D Christensen, J Scott Roberts, Wendy R Uhlmann, Robert C Gree. Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk. Genetics in medicine : official journal of the American College of Medical Genetics. vol 13. issue 5. 2011-08-25. PMID:21270636. |
changes to perceptions of the pros and cons of genetic susceptibility testing after apoe genotyping for alzheimer disease risk. |
2011-08-25 |
2023-08-12 |
Not clear |
| Seiju Kobayashi, Masaru Tateno, Tae Woo Park, Kumiko Utsumi, Hitoshi Sohma, Yoichi M Ito, Yasuo Kokai, Toshikazu Sait. Apolipoprotein E4 frequencies in a Japanese population with Alzheimer's disease and dementia with Lewy bodies. PloS one. vol 6. issue 4. 2011-08-23. PMID:21552550. |
the apolipoprotein e (apoe) ε4 allele has been reported to be a risk factor for alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2011-08-23 |
2023-08-12 |
human |
| Eiron Cudaback, Xianwu Li, Kathleen S Montine, Thomas J Montine, C Dirk Keen. Apolipoprotein E isoform-dependent microglia migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 6. 2011-08-18. PMID:21385991. |
apolipoprotein e (apoe) influences microglial function, and different human apoe isoforms confer variable risk for development of neurodegenerative disorders, especially alzheimer's disease. |
2011-08-18 |
2023-08-12 |
mouse |
| John Provias, Brian Jeyne. Correlation analysis of capillary APOE, VEGF and eNOS expression in Alzheimer brains. Current Alzheimer research. vol 8. issue 2. 2011-08-12. PMID:21143177. |
correlation analysis of capillary apoe, vegf and enos expression in alzheimer brains. |
2011-08-12 |
2023-08-12 |
Not clear |
| Richard Sherva, Lindsay A Farre. Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease. Current psychiatry reports. vol 13. issue 2. 2011-08-11. PMID:21312009. |
until recently, the search for genes contributing to alzheimer's disease (ad) had been slow and disappointing, with the notable exception of the apoe ε4 allele, which increases risk and reduces the age at onset of ad in a dose-dependent fashion. |
2011-08-11 |
2023-08-12 |
Not clear |