| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Wider, Owen A Ross, Kenya Nishioka, Michael G Heckman, Carles Vilariño-Güell, Barbara Jasinska-Myga, Nilufer Erketin-Taner, Rosa Rademakers, Neill R Graff-Radford, Deborah C Mash, Spiridon Papapetropoulos, Ranjan Duara, Hirotake Uchikado, Zbigniew K Wszolek, Matthew J Farrer, Dennis W Dickso. An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 4. 2012-04-27. PMID:22291217. |
an evaluation of the impact of mapt, snca and apoe on the burden of alzheimer's and lewy body pathology. |
2012-04-27 |
2023-08-12 |
Not clear |
| C Dirk Keene, Eiron Cudaback, Xianwu Li, Kathleen S Montine, Thomas J Montin. Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease. Current opinion in neurobiology. vol 21. issue 6. 2012-04-23. PMID:21907569. |
the largest genetic risk for late-onset alzheimer's disease (ad) resides at the apolipoprotein e gene (apoe) locus, which has three common alleles (ɛ2, ɛ3, ɛ4) that encode three isoforms (apoe2, apoe3, apoe4). |
2012-04-23 |
2023-08-12 |
Not clear |
| Aaron J Trachtenberg, Nicola Filippini, Clare E Macka. The effects of APOE-ε4 on the BOLD response. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20409610. |
these inconsistencies were addressed by examining the effect of task, family history of alzheimer's disease, and age on the relationship between apoe genotype and the bold response, but no clear pattern emerged. |
2012-04-19 |
2023-08-12 |
Not clear |
| Mary Jo LaDu, Gregory W Munson, Lisa Jungbauer, Godfrey S Getz, Catherine A Reardon, Leon M Tai, Chunjiang Y. Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. Biochimica et biophysica acta. vol 1821. issue 2. 2012-04-12. PMID:22138302. |
the association between apolipoprotein e (apoe) and amyloid-β peptide (aβ) may significantly impact the function of both proteins, thus affecting the etiology of alzheimer's disease (ad). |
2012-04-12 |
2023-08-12 |
human |
| Paige E Cramer, John R Cirrito, Daniel W Wesson, C Y Daniel Lee, J Colleen Karlo, Adriana E Zinn, Brad T Casali, Jessica L Restivo, Whitney D Goebel, Michael J James, Kurt R Brunden, Donald A Wilson, Gary E Landret. ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Science (New York, N.Y.). vol 335. issue 6075. 2012-04-09. PMID:22323736. |
alzheimer's disease (ad) is associated with impaired clearance of β-amyloid (aβ) from the brain, a process normally facilitated by apolipoprotein e (apoe). |
2012-04-09 |
2023-08-12 |
mouse |
| Yue Huang, Lan Zheng, Glenda Halliday, Carol Dobson-Stone, Ying Wang, Hui-Dong Tang, Li Cao, Yu-Lei Deng, Gang Wang, Yu-Mei Zhang, Jian-Hua Wang, Marianne Hallupp, John Kwok, Sheng-Di Che. Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease. Current Alzheimer research. vol 8. issue 7. 2012-04-04. PMID:21605063. |
apolipoprotein e (apoe) ε4 allele and sigma-1 receptor (sigmar1) c.5c (q2p) polymorphisms have been acknowledged as risk factors for developing alzheimer's disease (ad). |
2012-04-04 |
2023-08-12 |
Not clear |
| Gerbrand J Izaks, Ron T Gansevoort, Aafke M van der Knaap, Gerjan Navis, Robin P F Dullaart, Joris P J Slaet. The association of APOE genotype with cognitive function in persons aged 35 years or older. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110642. |
apoe genotype is associated with the risk of alzheimer's disease. |
2012-03-26 |
2023-08-12 |
Not clear |
| Oleg F Sharifov, Gaurav Nayyar, David W Garber, Shaila P Handattu, Vinod K Mishra, Dennis Goldberg, G M Anantharamaiah, Himanshu Gupt. Apolipoprotein E mimetics and cholesterol-lowering properties. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 11. issue 6. 2012-03-26. PMID:22149316. |
a number of synthetic peptides that encompass different regions of apoe have been studied for inhibiting inflammatory states, including alzheimer disease. |
2012-03-26 |
2023-08-12 |
mouse |
| Elena Lebedeva, Julia C Stingl, Dietmar R Thal, Estifanos Ghebremedhin, Joachim Strauss, Esra Özer, Lars Bertram, Björn von Einem, Hayrettin Tumani, Markus Otto, Matthias W Riepe, Josef Högel, Albert C Ludolph, Christine A F von Arni. Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD. Neurobiology of aging. vol 33. issue 1. 2012-03-13. PMID:20850903. |
haplotype analysis of psen2 and apoe genotyping were performed in 175 alzheimer's disease patients, as defined by clinical diagnosis and aβ42 levels. |
2012-03-13 |
2023-08-12 |
Not clear |
| Deborah Finkel, Chandra A Reynolds, Maria Larsson, Margaret Gatz, Nancy L Pederse. Both odor identification and ApoE-ε4 contribute to normative cognitive aging. Psychology and aging. vol 26. issue 4. 2012-03-07. PMID:21517181. |
research indicates that apoliprotein e (apoe) plays a role in the development of alzheimer's disease (ad) and possibly in the cognitive decline associated with normative aging. |
2012-03-07 |
2023-08-12 |
Not clear |
| Daniela Varges, Klaus Jung, Joanna Gawinecka, Uta Heinemann, Matthias Schmitz, Nicolas von Ahsen, Anna Krasnianski, Victor W Armstrong, Inga Zer. Amyloid-β 1-42 levels are modified by apolipoprotein E ε4 in Creutzfeldt-Jakob disease in a similar manner as in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 23. issue 4. 2012-03-06. PMID:21157024. |
the presence of apolipoprotein e (apoe) ε4 allele is a risk factor for alzheimer's disease (ad) and associated with a more pronounced reduction of amyloid-β 1-42 (aβ1-42) in the cerebrospinal fluid (csf). |
2012-03-06 |
2023-08-12 |
Not clear |
| P K Krishnan Namboori, K V Vineeth, V Rohith, Ibnul Hassan, Lekshmi Sekhar, Akhila Sekhar, M Nidhees. The ApoE gene of Alzheimer's disease (AD). Functional & integrative genomics. vol 11. issue 4. 2012-03-06. PMID:21769591. |
the apoe gene of alzheimer's disease (ad). |
2012-03-06 |
2023-08-12 |
Not clear |
| P K Krishnan Namboori, K V Vineeth, V Rohith, Ibnul Hassan, Lekshmi Sekhar, Akhila Sekhar, M Nidhees. The ApoE gene of Alzheimer's disease (AD). Functional & integrative genomics. vol 11. issue 4. 2012-03-06. PMID:21769591. |
the apoe gene responsible for the alzheimer's disease has been examined to identify functional consequences of single-nucleotide polymorphisms (snps). |
2012-03-06 |
2023-08-12 |
Not clear |
| C Y Daniel Lee, Wayne Tse, Jonathan D Smith, Gary E Landret. Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. The Journal of biological chemistry. vol 287. issue 3. 2012-03-05. PMID:22130662. |
allelic variation in the apolipoprotein e (apoe) gene is the major risk factor of sporadic alzheimer disease. |
2012-03-05 |
2023-08-12 |
Not clear |
| Charles J Brainerd, Valerie F Reyna, Ronald C Petersen, Glenn E Smith, Emily S Tau. Is the apolipoprotein e genotype a biomarker for mild cognitive impairment? Findings from a nationally representative study. Neuropsychology. vol 25. issue 6. 2012-02-29. PMID:21728427. |
although the ε4 allele of the apolipoprotein e (apoe) genotype is a known risk factor for alzheimer's dementia (ad), prior findings on whether it is also a risk factor for mild cognitive impairment (mci) have been inconsistent. |
2012-02-29 |
2023-08-12 |
Not clear |
| Debra L Schutte, David Reed, Susan Decrane, Anne L Ersi. Saitohin and APOE polymorphisms influence cognition and function in persons with advanced Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 32. issue 2. 2012-02-27. PMID:21934306. |
saitohin and apoe polymorphisms influence cognition and function in persons with advanced alzheimer disease. |
2012-02-27 |
2023-08-12 |
Not clear |
| J Norberg, C Graff, O Almkvist, M Ewers, G B Frisoni, L Frölich, H Hampel, R W Jones, P G Kehoe, H Lenoir, L Minthon, F Nobili, M Olde Rikkert, A-S Rigaud, P Scheltens, H Soininen, L Spiru, M Tsolaki, L-O Wahlund, B Vellas, G Wilcock, L S Elias-Sonnenschein, F R J Verhey, P J Visse. Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects. Dementia and geriatric cognitive disorders. vol 32. issue 2. 2012-02-27. PMID:21952537. |
the apoe ε4 allele is a risk factor for alzheimer's disease (ad). |
2012-02-27 |
2023-08-12 |
human |
| Hua Geng, Peggy P Y Law, Maggie C Y Ng, Ting Li, Li-Yun Liang, Tian-Fang Ge, Kam-Bo Wong, Chun Liang, Ronald C Ma, Wing-Yee So, Juliana C N Chan, Yuan-Yuan H. APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk. PloS one. vol 6. issue 10. 2012-02-24. PMID:22028770. |
the apolipoprotein e gene (apoe) coding polymorphism modifies the risks of alzheimer's disease, type 2 diabetes, and coronary heart disease. |
2012-02-24 |
2023-08-12 |
Not clear |
| Hua Geng, Peggy P Y Law, Maggie C Y Ng, Ting Li, Li-Yun Liang, Tian-Fang Ge, Kam-Bo Wong, Chun Liang, Ronald C Ma, Wing-Yee So, Juliana C N Chan, Yuan-Yuan H. APOE genotype-function relationship: evidence of -491 A/T promoter polymorphism modifying transcription control but not type 2 diabetes risk. PloS one. vol 6. issue 10. 2012-02-24. PMID:22028770. |
aside from the coding variants, single nucleotide polymorphism (snp) of the apoe promoter has also been shown to modify the risk of alzheimer's disease. |
2012-02-24 |
2023-08-12 |
Not clear |
| Aaron J Trachtenberg, Nicola Filippini, Klaus P Ebmeier, Steve M Smith, Fredrik Karpe, Clare E Macka. The effects of APOE on the functional architecture of the resting brain. NeuroImage. vol 59. issue 1. 2012-02-13. PMID:21851856. |
there is a well-established association between apoe genotype and the risk of developing alzheimer's disease (ad). |
2012-02-13 |
2023-08-12 |
human |