| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ximena S Rossello, Urule Igbavboa, Gary A Weisman, Grace Y Sun, W Gibson Woo. AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. Brain research. vol 1444. 2012-11-13. PMID:22325097. |
two key players involved in alzheimer's disease (ad) are amyloid beta protein (aβ) and apolipoprotein e (apoe). |
2012-11-13 |
2023-08-12 |
mouse |
| E Gozalpour, K Kamali, K Mohammd, Hr Khorram Khorshid, M Ohadi, M Karimloo, A Mirabzadeh, A Fotouh. Association between Alzheimer's Disease and Apolipoprotein E Polymorphisms. Iranian journal of public health. vol 39. issue 2. 2012-11-01. PMID:23112999. |
apolipoprotein e (apoe), which its ε4 allele has been reported as a risk factor in late onset alzheimer's disease (ad), is the main cholesterol carrier in the brain. |
2012-11-01 |
2023-08-12 |
Not clear |
| B Dongés, L M Haupt, R A Lea, R C K Chan, D H K Shum, L R Griffith. Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits. Gene. vol 506. issue 1. 2012-10-25. PMID:22771913. |
by combining psychological and molecular genetics expertise, we examined the apoe ε4 allele, a known risk factor for alzheimer's disease, and the comt val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults. |
2012-10-25 |
2023-08-12 |
Not clear |
| Lisa M Nichols, Joseph C Masdeu, Venkata S Mattay, Philip Kohn, Matthew Emery, Fabio Sambataro, Bhaskar Kolachana, Brita Elvevåg, Shane Kippenhan, Daniel R Weinberger, Karen F Berma. Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults. Archives of general psychiatry. vol 69. issue 8. 2012-10-18. PMID:22868934. |
although the apolipoprotein e (apoe) ϵ4 allele is a major genetic risk factor for late-onset alzheimer disease, its effect on hippocampal function during episodic memory is controversial because studies have yielded mixed results. |
2012-10-18 |
2023-08-12 |
mouse |
| Ya-Jing Liu, Fan-Tao Meng, Li-Li Wang, Li-Feng Zhang, Xin-Ping Cheng, Jiang-Ning Zho. Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. Journal of pineal research. vol 52. issue 4. 2012-10-17. PMID:22225631. |
previous studies have demonstrated that apolipoprotein e (apoe) genotype and melatonin are closely associated with alzheimer's disease (ad). |
2012-10-17 |
2023-08-12 |
rat |
| Christina E Wierenga, Sheena I Dev, David D Shin, Lindsay R Clark, Katherine J Bangen, Amy J Jak, Robert A Rissman, Thomas T Liu, David P Salmon, Mark W Bond. Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 8. 2012-10-15. PMID:22549621. |
findings support dynamic pathophysiologic processes in the brain associated with alzheimer's disease risk and indicate that cognitive status and apoe genotype have interactive effects on cbf. |
2012-10-15 |
2023-08-12 |
human |
| Kristin R Wildsmith, Jacob M Basak, Bruce W Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E Yarasheski, Jennifer X Wang, Kwasi G Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C Sigurdson, Chengjie Xiong, Alison Goate, David M Holtzman, Randall J Batema. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PloS one. vol 7. issue 6. 2012-10-11. PMID:22675504. |
apolipoprotein e (apoe) is the strongest genetic risk factor for alzheimer's disease and has been implicated in the risk for other neurological disorders. |
2012-10-11 |
2023-08-12 |
mouse |
| Kristin R Wildsmith, Jacob M Basak, Bruce W Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E Yarasheski, Jennifer X Wang, Kwasi G Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C Sigurdson, Chengjie Xiong, Alison Goate, David M Holtzman, Randall J Batema. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. PloS one. vol 7. issue 6. 2012-10-11. PMID:22675504. |
the three common apoe isoforms (apoe2, e3, and e4) each differ by a single amino acid, with apoe4 increasing and apoe2 decreasing the risk of alzheimer's disease (ad). |
2012-10-11 |
2023-08-12 |
mouse |
| I N Day, M Bolla, L Haddad, S O'Dell, S E Humphrie. Microtiter Array Diagonal Gel Electrophoresis (MADGE) for Population Scale Genotype Analyses. Methods in molecular medicine. vol 5. 2012-10-02. PMID:21374524. |
for these reasons, many associations, such as those between apolipoprotein e (apoe) genotype, hypercholesterolaemia and premature vascular disease (2), apoe genotype and late-onset alzheimer disease (3), and angiotensinogen-converting enzyme (ace) genotype and cardiovascular disease (4), have mainly been researched on groups of a few hundred individuals. |
2012-10-02 |
2023-08-12 |
human |
| Eloise H Kok, Teemu Luoto, Satu Haikonen, Sirkka Goebeler, Hannu Haapasalo, Pekka J Karhune. CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques. Alzheimer's research & therapy. vol 3. issue 2. 2012-10-02. PMID:21466683. |
apoe is the strongest risk gene for sporadic alzheimer's disease (ad) so far. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Zamani, M Mehri, A Kollaee, P Yenki, M Ghaffarpor, M H Harirchian, M Shahbaz. Pharmacogenetic Study on the Effect of Rivastigmine on PS2 and APOE Genes in Iranian Alzheimer Patients. Dementia and geriatric cognitive disorders extra. vol 1. issue 1. 2012-10-02. PMID:22163243. |
pharmacogenetic study on the effect of rivastigmine on ps2 and apoe genes in iranian alzheimer patients. |
2012-10-02 |
2023-08-12 |
Not clear |
| Hye Guk Ryu, Sung-Won Youn, Oh Dae Kwo. Lack of Association between Apolipoprotein E Polymorphism with Age at Onset of Subcortical Vascular Dementia. Dementia and geriatric cognitive disorders extra. vol 2. issue 1. 2012-10-02. PMID:22323902. |
the aim of this study was to evaluate the relationship between apoe polymorphism and the onset of subcortical vascular dementia (svad) compared to alzheimer's disease (ad) and normal controls. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lea T Drye, Peter P Zand. Role of APOE and Age at Enrollment in the Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). Dementia and geriatric cognitive disorders extra. vol 2. issue 1. 2012-10-02. PMID:22962554. |
role of apoe and age at enrollment in the alzheimer's disease anti-inflammatory prevention trial (adapt). |
2012-10-02 |
2023-08-12 |
Not clear |
| Rita J Guerreiro, Deborah R Gustafson, John Hard. The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20594621. |
the genetic architecture of alzheimer's disease: beyond app, psens and apoe. |
2012-09-28 |
2023-08-12 |
Not clear |
| Aaron J Trachtenberg, Nicola Filippini, Jane Cheeseman, Eugene P Duff, Matt J Neville, Klaus P Ebmeier, Fredrik Karpe, Clare E Macka. The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21232817. |
the effects of apoe on brain activity do not simply reflect the risk of alzheimer's disease. |
2012-09-28 |
2023-08-12 |
human |
| Afia Akram, James Schmeidler, Pavel Katsel, Patrick R Hof, Vahram Haroutunia. Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21676498. |
inheritance of the ε4 allele of apolipoprotein e (apoe) is the only confirmed and consistently replicated risk factor for late onset alzheimer's disease (ad). |
2012-09-28 |
2023-08-12 |
Not clear |
| Jessica S Damoiseaux, William W Seeley, Juan Zhou, William R Shirer, Giovanni Coppola, Anna Karydas, Howard J Rosen, Bruce L Miller, Joel H Kramer, Michael D Greiciu. Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 24. 2012-09-24. PMID:22699906. |
together, these results converge with previous work showing a higher prevalence of the ε4 allele among women with alzheimer's disease and, critically, demonstrate that this interaction between apoe genotype and gender is detectable in the preclinical period. |
2012-09-24 |
2023-08-12 |
human |
| Andreas Ihle, David Bunce, Matthias Kliege. APOE ε4 and cognitive function in early life: a meta-analysis. Neuropsychology. vol 26. issue 3. 2012-09-14. PMID:22329498. |
it is well established that the apolipoprotein e (apoe) ε4 allele is associated with cognitive impairment and alzheimer's disease in old age. |
2012-09-14 |
2023-08-12 |
Not clear |
| Cheng-Sheng Chen, Pei Ouyang, Yi-Chun Yeh, Chiou-Lian Lai, Ching-Kuan Liu, Cheng-Fang Yen, Chih-Hung Ko, Ju-Yu Yen, Gin-Chun Liu, Suh-Hang Hank Ju. Apolipoprotein E polymorphism and behavioral and psychological symptoms of dementia in patients with Alzheimer disease. Alzheimer disease and associated disorders. vol 26. issue 2. 2012-09-13. PMID:21617520. |
the aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (bpsd) in alzheimer disease (ad), and to investigate whether the apolipoprotein e (apoe) gene confers a risk of distinct bpsd subsyndromes. |
2012-09-13 |
2023-08-12 |
Not clear |
| Lilian Calderón-Garcidueñas, Michael Kavanaugh, Michelle Block, Amedeo D'Angiulli, Ricardo Delgado-Chávez, Ricardo Torres-Jardón, Angelica González-Maciel, Rafael Reynoso-Robles, Norma Osnaya, Rodolfo Villarreal-Calderon, Ruixin Guo, Zhaowei Hua, Hongtu Zhu, George Perry, Philippe Dia. Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults. Journal of Alzheimer's disease : JAD. vol 28. issue 1. 2012-09-12. PMID:21955814. |
the effect of apolipoprotein e (apoe) genotype on the presence of protein aggregates associated with alzheimer's disease (ad) pathology was also explored. |
2012-09-12 |
2023-08-12 |
human |