| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louise Hedskog, Jesper Brohede, Birgitta Wiehager, Catarina Moreira Pinho, Priya Revathikumar, Lena Lilius, Elzbieta Glaser, Caroline Graff, Helena Karlström, Maria Ankarcron. Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene. Journal of Alzheimer's disease : JAD. vol 31. issue 3. 2013-05-21. PMID:22596268. |
the apolipoprotein e (apoe) gene remains the most strongly established risk factor for late onset alzheimer's disease (load). |
2013-05-21 |
2023-08-12 |
human |
| Joakim Hertze, Sebastian Palmqvist, Lennart Minthon, Oskar Hansso. Tau pathology and parietal white matter lesions have independent but synergistic effects on early development of Alzheimer's disease. Dementia and geriatric cognitive disorders extra. vol 3. issue 1. 2013-05-21. PMID:23687506. |
this study investigates the relationship between wmls, hyperphosphorylated tau (p-tau) in cerebrospinal fluid (csf) and apolipoprotein e (apoe) ε4 genotype in prodromal alzheimer's disease (ad). |
2013-05-21 |
2023-08-12 |
Not clear |
| Christian Schmidt, Stephane Haïk, Katsuya Satoh, Alberto Rábano, Pablo Martinez-Martin, Sigrun Roeber, Jean-Philippe Brandel, Miguel Calero-Lara, Jesús de Pedro-Cuesta, Jean-Louis Laplanche, Jean-Jaques Hauw, Hans Kretzschmar, Inga Zer. Rapidly progressive Alzheimer's disease: a multicenter update. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22460329. |
the apoe profile is intriguing, suggesting that this very rapid disease form might represent a distinct subtype of alzheimer's disease. |
2013-05-15 |
2023-08-12 |
Not clear |
| David Bunce, Kaarin J Anstey, Nicolas Cherbuin, Prapti Gautam, Perminder Sachdev, Simon Eastea. APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22475794. |
the apolipoprotein e (apoe) ε4 allele is a risk factor for the neuropathological decline accompanying alzheimer's disease (ad) while, conversely, the ε2 allele offers protection. |
2013-05-15 |
2023-08-12 |
Not clear |
| Stephanie J B Vos, Ineke A van Rossum, Frans Verhey, Dirk L Knol, Hilkka Soininen, Lars-Olof Wahlund, Harald Hampel, Magda Tsolaki, Lennart Minthon, Giovanni B Frisoni, Lutz Froelich, Flavio Nobili, Wiesje van der Flier, Kaj Blennow, Robin Wolz, Philip Scheltens, Pieter Jelle Visse. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology. vol 80. issue 12. 2013-05-14. PMID:23446677. |
to compare the predictive accuracy of β-amyloid (aβ)1-42 and total tau in csf, hippocampal volume (hcv), and apoe genotype for alzheimer disease (ad)-type dementia in subjects with amnestic mild cognitive impairment (amci) and nonamnestic mild cognitive impairment (namci). |
2013-05-14 |
2023-08-12 |
human |
| Ilan Dar-Nimrod, Benjamin P Chapman, Peter Franks, John Robbins, Anton Porsteinsson, Mark Mapstone, Paul R Duberstei. Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 20. issue 12. 2013-05-06. PMID:23079898. |
we tested the hypothesis that neuroticism moderates the association between apoe (apolipoprotein e) genotype and two major outcomes, cognitive function and alzheimer disease. |
2013-05-06 |
2023-08-12 |
Not clear |
| Richard J Caselli, Amylou C Dueck, Matthew J Huentelman, Michael W Lutz, Ann M Saunders, Eric M Reiman, Allen D Rose. Longitudinal modeling of cognitive aging and the TOMM40 effect. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 8. issue 6. 2013-05-03. PMID:23102119. |
to assess the possible contribution of tomm40 to alzheimer's disease onset, we compared the effects of tomm40 and apoe genotype on preclinical longitudinal memory decline. |
2013-05-03 |
2023-08-12 |
Not clear |
| Laurence O'Dwyer, Franck Lamberton, Silke Matura, Colby Tanner, Monika Scheibe, Julia Miller, Dan Rujescu, David Prvulovic, Harald Hampe. Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. PloS one. vol 7. issue 11. 2013-05-01. PMID:23152815. |
the e4 allele of the apoe gene has consistently been shown to be related to an increased risk of alzheimer's disease (ad). |
2013-05-01 |
2023-08-12 |
human |
| Hillary D Protas, Kewei Chen, Jessica B S Langbaum, Adam S Fleisher, Gene E Alexander, Wendy Lee, Daniel Bandy, Mony J de Leon, Lisa Mosconi, Shannon Buckley, Diana Truran-Sacrey, Norbert Schuff, Michael W Weiner, Richard J Caselli, Eric M Reima. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA neurology. vol 70. issue 3. 2013-04-29. PMID:23599929. |
to characterize and compare measurements of the posterior cingulate glucose metabolism, the hippocampal glucose metabolism, and hippocampal volume so as to distinguish cognitively normal, late-middle-aged persons with 2, 1, or 0 copies of the apolipoprotein e (apoe) ε4 allele, reflecting 3 levels of risk for late-onset alzheimer disease. |
2013-04-29 |
2023-08-12 |
Not clear |
| Karita Isotalo, Eloise Helena Kok, Teemu M Luoto, Satu Haikonen, Hannu Haapasalo, Terho Lehtimäki, Pekka J Karhune. Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer's disease-related neuropathological lesions: Tampere Autopsy Study. Brain pathology (Zurich, Switzerland). vol 22. issue 6. 2013-04-23. PMID:22390463. |
the apolipoprotein e (apoe) gene associates with alzheimer's disease (ad) and cholesterol levels. |
2013-04-23 |
2023-08-12 |
Not clear |
| Camilla Ferrari, Wei-Li Xu, Hui-Xin Wang, Bengt Winblad, Sandro Sorbi, Chengxuan Qiu, Laura Fratiglion. How can elderly apolipoprotein E ε4 carriers remain free from dementia? Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22503000. |
apolipoprotein e (apoe) ε4 is a major risk factor for alzheimer's disease (ad) and dementia, but not all ε4 carriers develop dementia. |
2013-04-23 |
2023-08-12 |
human |
| Peng Yu, Robert A Dean, Stephen D Hall, Yuan Qi, Gopalan Sethuraman, Brian A Willis, Eric R Siemers, Ferenc Martenyi, Johannes T Tauscher, Adam J Schwar. Enriching amnestic mild cognitive impairment populations for clinical trials: optimal combination of biomarkers to predict conversion to dementia. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22796873. |
by comparing individual modalities, we found that mri measures had the best predictive power (accuracy = 78%), followed by apoe, fdg-pet, csf, and the alzheimer's disease assessment scale-cognitive subscale. |
2013-04-23 |
2023-08-12 |
human |
| Silvia Maioli, Elena Puerta, Paula Merino-Serrais, Laura Fusari, Francisco Gil-Bea, Roberto Rimondini, Angel Cedazo-Mingue. Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22836186. |
the presence of the e4 allele of apolipoprotein e (apoe) is the strongest known genetic risk factor for sporadic alzheimer's disease (ad). |
2013-04-23 |
2023-08-12 |
mouse |
| Romain Simon, Marion Girod, Catherine Fonbonne, Arnaud Salvador, Yohann Clément, Pierre Lantéri, Philippe Amouyel, Jean Charles Lambert, Jérôme Lemoin. Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. Molecular & cellular proteomics : MCP. vol 11. issue 11. 2013-04-23. PMID:22918225. |
total apoe and apoe4 isoform assays in an alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. |
2013-04-23 |
2023-08-12 |
human |
| Romain Simon, Marion Girod, Catherine Fonbonne, Arnaud Salvador, Yohann Clément, Pierre Lantéri, Philippe Amouyel, Jean Charles Lambert, Jérôme Lemoin. Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. Molecular & cellular proteomics : MCP. vol 11. issue 11. 2013-04-23. PMID:22918225. |
inheritance of the apoe ε4 allele is a risk factor for developing alzheimer's disease (ad). |
2013-04-23 |
2023-08-12 |
human |
| Q W Fan, I Iosbe, H Asou, K Yanagisawa, M Michikaw. Expression and regulation of apolipoprotein E receptors in the cells of the central nervous system in culture: A review. Journal of the American Aging Association. vol 24. issue 1. 2013-04-23. PMID:23604870. |
the importance of apolipoprotein e (apoe) in the central nervous system (cns) became increasingly clear since the descovery that apoe ε4 allele is a major risk factor for alzheimer's disease. |
2013-04-23 |
2023-08-12 |
rat |
| Eiron Cudaback, Xianwu Li, Yue Yang, Thomas Yoo, Kathleen S Montine, Suzanne Craft, Thomas J Montine, Christopher Dirk Keen. Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation. Journal of neuroinflammation. vol 9. 2013-04-19. PMID:22883744. |
inheritance of the human ε4 allele of the apolipoprotein (apo) e gene (apoe) significantly increases the risk of developing alzheimer's disease (ad), in addition to adversely influencing clinical outcomes of other neurologic diseases. |
2013-04-19 |
2023-08-12 |
human |
| Yuan Zhong, Xueli Zheng, Ya Miao, Lili Wan, Hong Yan, Beiyun Wan. Effect of CYP2D6*10 and APOE polymorphisms on the efficacy of donepezil in patients with Alzheimer's disease. The American journal of the medical sciences. vol 345. issue 3. 2013-04-19. PMID:22986607. |
effect of cyp2d6*10 and apoe polymorphisms on the efficacy of donepezil in patients with alzheimer's disease. |
2013-04-19 |
2023-08-12 |
Not clear |
| Yuan Zhong, Xueli Zheng, Ya Miao, Lili Wan, Hong Yan, Beiyun Wan. Effect of CYP2D6*10 and APOE polymorphisms on the efficacy of donepezil in patients with Alzheimer's disease. The American journal of the medical sciences. vol 345. issue 3. 2013-04-19. PMID:22986607. |
the aim of this study was to evaluate the effect of cyp2d6*10 and apoe polymorphisms on both steady-state plasma concentrations (cp) and clinical response of donepezil in patients with mild-to-moderate alzheimer's disease (ad). |
2013-04-19 |
2023-08-12 |
Not clear |
| V Garibotto, B Borroni, S Sorbi, S F Cappa, A Padovani, D Peran. Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 5. 2013-04-18. PMID:22173784. |
education and occupation provide reserve in both apoe ε4 carrier and noncarrier patients with probable alzheimer's disease. |
2013-04-18 |
2023-08-12 |
human |