| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanneke de Waal, Cornelis J Stam, Willem de Haan, Elisabeth C W van Straaten, Marinus A Blankenstein, Philip Scheltens, Wiesje M van der Flie. Alzheimer's disease patients not carrying the apolipoprotein E ε4 allele show more severe slowing of oscillatory brain activity. Neurobiology of aging. vol 34. issue 9. 2014-01-17. PMID:23587637. |
the objective of this study was to quantitatively assess the relationship between apolipoprotein (apoe) genotype and electroencephalographic oscillatory brain dynamics in alzheimer's disease (ad) patients and control subjects and its regional distribution. |
2014-01-17 |
2023-08-12 |
human |
| Michela Pievani, Martina Bocchetta, Marina Boccardi, Enrica Cavedo, Matteo Bonetti, Paul M Thompson, Giovanni B Frison. Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study. Neurobiology of aging. vol 34. issue 7. 2014-01-16. PMID:23428181. |
we investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (eoad) and 18 late-onset (load) alzheimer's disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein e (apoe) genotype. |
2014-01-16 |
2023-08-12 |
Not clear |
| Veena Theendakara, Alexander Patent, Clare A Peters Libeu, Brittany Philpot, Sonia Flores, Olivier Descamps, Karen S Poksay, Qiang Zhang, Gabriellee Cailing, Matthew Hart, Varghese John, Rammohan V Rao, Dale E Bredese. Neuroprotective Sirtuin ratio reversed by ApoE4. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 45. 2013-12-31. PMID:24145446. |
the canonical pathogenesis of alzheimer's disease links the expression of apolipoprotein e ε4 allele (apoe) to amyloid precursor protein (app) processing and aβ peptide accumulation by a set of mechanisms that is incompletely defined. |
2013-12-31 |
2023-08-12 |
Not clear |
| Giselle Izzo, Orestes V Forlenza, Bernardo dos Santos, Paulo H F Bertolucci, Elida B Ojopi, Wagner F Gattaz, Daniel Shikanai Ker. Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype. Clinics (Sao Paulo, Brazil). vol 68. issue 2. 2013-12-19. PMID:23525328. |
single-nucleotide polymorphisms of gsk3b, gab2 and sorl1 in late-onset alzheimer's disease: interactions with the apoe genotype. |
2013-12-19 |
2023-08-12 |
Not clear |
| Giselle Izzo, Orestes V Forlenza, Bernardo dos Santos, Paulo H F Bertolucci, Elida B Ojopi, Wagner F Gattaz, Daniel Shikanai Ker. Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype. Clinics (Sao Paulo, Brazil). vol 68. issue 2. 2013-12-19. PMID:23525328. |
in this study, we investigated the associations between single-nucleotide polymorphisms in gab2 (rs2373115), gsk3b (rs6438552) and sorl1 (rs641120) and alzheimer's disease (ad), both alone and in combination with the apoe*4 allele. |
2013-12-19 |
2023-08-12 |
Not clear |
| Amy Claxton, Laura D Baker, Charles W Wilkinson, Emily H Trittschuh, Darla Chapman, G Stennis Watson, Brenna Cholerton, Stephen R Plymate, Matthew Arbuckle, Suzanne Craf. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23507773. |
sex and apoe genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or alzheimer's disease. |
2013-12-10 |
2023-08-12 |
human |
| Amy Claxton, Laura D Baker, Charles W Wilkinson, Emily H Trittschuh, Darla Chapman, G Stennis Watson, Brenna Cholerton, Stephen R Plymate, Matthew Arbuckle, Suzanne Craf. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23507773. |
a previous clinical trial demonstrated that four months of treatment with intranasal insulin improves cognition and function for patients with alzheimer's disease (ad) or mild cognitive impairment (mci), but prior studies suggest that response to insulin treatment may differ by sex and apoe ε4 carriage. |
2013-12-10 |
2023-08-12 |
human |
| T Holden, A Nguyen, E Lin, E Cheung, S Dehipawala, J Ye, G Tremberger, D Lieberman, T Cheun. Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development. Computational and mathematical methods in medicine. vol 2013. 2013-12-10. PMID:23662159. |
long noncoding rna (lncrna) within mrna sequences of alzheimer's disease genes, namely, app, apoe, psen1, and psen2, has been analyzed using fractal dimension (fd) computation and correlation analysis. |
2013-12-10 |
2023-08-12 |
mouse |
| T Holden, A Nguyen, E Lin, E Cheung, S Dehipawala, J Ye, G Tremberger, D Lieberman, T Cheun. Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development. Computational and mathematical methods in medicine. vol 2013. 2013-12-10. PMID:23662159. |
selection of higher fd cdss could indicate interaction of alzheimer's gene products app, apoe, and psen1. |
2013-12-10 |
2023-08-12 |
mouse |
| T Holden, A Nguyen, E Lin, E Cheung, S Dehipawala, J Ye, G Tremberger, D Lieberman, T Cheun. Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development. Computational and mathematical methods in medicine. vol 2013. 2013-12-10. PMID:23662159. |
including hypocretin sequences (where all cdss have higher fractal dimensions than mrna) in the app, apoe, and psen1 sequence analyses improves correlation, but the inclusion of erythropoietin (where all cdss have higher fd than mrna) would suppress correlation, suggesting that hcrt, a hypothalamus neurotransmitter related to the wake/sleep cycle, might be better when compared to epo, a glycoprotein hormone, for targeting alzheimer's disease drug development. |
2013-12-10 |
2023-08-12 |
mouse |
| Ma Fei, Wang Jianhu. Apolipoprotein ε4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer's disease: a meta-analysis of prospective studies. Journal of molecular neuroscience : MN. vol 50. issue 2. 2013-12-05. PMID:23242623. |
recent studies of the relationship between progression from mild cognitive impairment (mci) to alzheimer disease (ad) and apoe ε4-allele revealed inconsistent results. |
2013-12-05 |
2023-08-12 |
human |
| Christopher A Hostage, Kingshuk Roy Choudhury, Pudugramam Murali Doraiswamy, Jeffrey R Petrell. Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease. PloS one. vol 8. issue 2. 2013-12-02. PMID:23405083. |
dissecting the gene dose-effects of the apoe ε4 and ε2 alleles on hippocampal volumes in aging and alzheimer's disease. |
2013-12-02 |
2023-08-12 |
Not clear |
| Christopher A Hostage, Kingshuk Roy Choudhury, Pudugramam Murali Doraiswamy, Jeffrey R Petrell. Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease. PloS one. vol 8. issue 2. 2013-12-02. PMID:23405083. |
to investigate whether there is a specific dose-dependent effect of the apolipoprotein e (apoe) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to alzheimer's disease (ad). |
2013-12-02 |
2023-08-12 |
Not clear |
| Markus Donix, Maria Scharf, Kira Marschner, Annett Werner, Cathrin Sauer, Antje Gerner, Josef A Nees, Shirin Meyer, Katharina L Donix, Rüdiger Von Kummer, Vjera A Holthof. Cardiovascular risk and hippocampal thickness in Alzheimer's disease. International journal of Alzheimer's disease. vol 2013. 2013-11-14. PMID:24228185. |
apoe genotype, a family history of alzheimer's disease, and age did not influence cortical thickness. |
2013-11-14 |
2023-08-12 |
Not clear |
| Boris Decourt, Amanda Gonzales, Thomas G Beach, Michael Malek-Ahmadi, Aaron Walker, Lucia Sue, Douglas G Walker, Marwan N Sabbag. BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains. Current Alzheimer research. vol 10. issue 3. 2013-11-11. PMID:23036023. |
bace1 levels by apoe genotype in non-demented and alzheimer's post-mortem brains. |
2013-11-11 |
2023-08-12 |
human |
| Boris Decourt, Amanda Gonzales, Thomas G Beach, Michael Malek-Ahmadi, Aaron Walker, Lucia Sue, Douglas G Walker, Marwan N Sabbag. BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains. Current Alzheimer research. vol 10. issue 3. 2013-11-11. PMID:23036023. |
the apoe genotype is a known susceptibility factor for alzheimer's disease (ad). |
2013-11-11 |
2023-08-12 |
human |
| E Rodríguez-Rodríguez, P Sánchez-Juan, J L Vázquez-Higuera, I Mateo, A Pozueta, J Berciano, S Cervantes, D Alcolea, P Martínez-Lage, J Clarimón, A Lleó, P Pastor, O Combarro. Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 5. 2013-11-05. PMID:23180304. |
aside from apoe, the genetic factors that influence the progression from mild cognitive impairment (mci) to alzheimer's disease (ad) remain largely unknown. |
2013-11-05 |
2023-08-12 |
human |
| Beniamino Sciacca, Alexandre François, Manuela Klingler-Hoffmann, Julie Brazzatti, Megan Penno, Peter Hoffmann, Tanya M Monr. Radiative-surface plasmon resonance for the detection of apolipoprotein E in medical diagnostics applications. Nanomedicine : nanotechnology, biology, and medicine. vol 9. issue 4. 2013-10-29. PMID:23178281. |
here, we demonstrate that by bringing together this novel emission-based fiber spr platform with an improved surface functionalization process aimed at properly orienting the antibodies, it is possible to rapidly and specifically detect the regulation of human apolipoprotein e (apoe), a low-molecular-weight protein (~39 kda) known to be involved in cardiovascular diseases, alzheimer's disease and gastric cancer. |
2013-10-29 |
2023-08-12 |
human |
| Marwan N Sabbagh, Michael Malek-Ahmadi, Brittany N Dugger, Katarina Lee, Lucia I Sue, Geidy Serrano, Douglas G Walker, Kathryn Davis, Sandra A Jacobson, Thomas G Beac. The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease. BMC neurology. vol 13. 2013-10-28. PMID:23663404. |
carriers of the apoe ϵ4 allele are at a greater risk for developing alzheimer's disease (ad) and those who do develop ad tend to have a much greater neuropathological disease burden. |
2013-10-28 |
2023-08-12 |
Not clear |
| Karin Hultman, Sidney Strickland, Erin H Norri. The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23652625. |
the apoe ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of alzheimer's disease patients. |
2013-10-22 |
2023-08-12 |
human |