| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew B Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M Reiman, Richard J Casell. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 5. 2014-06-24. PMID:23998393. |
apoe, which encodes apolipoprotein e, is the most prevalent and best established genetic risk factor for late-onset alzheimer's disease. |
2014-06-24 |
2023-08-12 |
Not clear |
| Carl Frieden, Kanchan Gara. Concerning the structure of apoE. Protein science : a publication of the Protein Society. vol 22. issue 12. 2014-06-19. PMID:24115173. |
while studies initially focused on its role in cholesterol and lipid metabolism, one apoe isoform (apoe4) is a major risk factor for development of late onset alzheimer's disease. |
2014-06-19 |
2023-08-12 |
Not clear |
| Florence F Roussotte, Boris A Gutman, Sarah K Madsen, John B Colby, Paul M Thompso. Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 19. 2014-06-17. PMID:24806679. |
combined effects of alzheimer risk variants in the clu and apoe genes on ventricular expansion patterns in the elderly. |
2014-06-17 |
2023-08-13 |
human |
| Jing Zhao, Yuan Fu, Chia-Chen Liu, Mitsuru Shinohara, Henrietta M Nielsen, Qiang Dong, Takahisa Kanekiyo, Guojun B. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. The Journal of biological chemistry. vol 289. issue 16. 2014-06-04. PMID:24599963. |
among the three human apoe alleles (apoe2, apoe3, and apoe4), apoe4 is the strongest genetic risk factor for late-onset alzheimer disease (ad). |
2014-06-04 |
2023-08-12 |
mouse |
| Jing Guan, Hai-Lu Zhao, Yi Sui, Lan He, Heung-Man Lee, Fernand M M Lai, Peter C Y Tong, Juliana C N Cha. Histopathological correlations of islet amyloidosis with apolipoprotein E polymorphisms in type 2 diabetic Chinese patients. Pancreas. vol 42. issue 7. 2014-06-02. PMID:24005233. |
apoe [latin small letter open e]4 allele is associated with arteriosclerosis and cerebral amyloidosis in alzheimer disease. |
2014-06-02 |
2023-08-12 |
Not clear |
| Christina Rose Kyrtsos, John S Bara. Studying the role of ApoE in Alzheimer's disease pathogenesis using a systems biology model. Journal of bioinformatics and computational biology. vol 11. issue 5. 2014-06-02. PMID:24131052. |
studying the role of apoe in alzheimer's disease pathogenesis using a systems biology model. |
2014-06-02 |
2023-08-12 |
Not clear |
| Simon Evans, Nicholas G Dowell, Naji Tabet, Paul S Tofts, Sarah L King, Marcus Gray, Jennifer M Ruste. Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status. Journal of psychopharmacology (Oxford, England). vol 27. issue 11. 2014-05-26. PMID:23958867. |
the apoe e4 allele is associated with increased risk of alzheimer's disease (ad), and increased sensitivity to nicotine might reflect early cholinergic differences that relate to an enhanced risk of ad. |
2014-05-26 |
2023-08-12 |
human |
| Christopher A Hostage, Kingshuk Roy Choudhury, P Murali Doraiswamy, Jeffrey R Petrell. Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network. Radiology. vol 271. issue 1. 2014-05-21. PMID:24475827. |
to determine the effect of the apolipoprotein e (apoe) genotype on atrophy rates of specific brain gray matter regions hypothesized to be key components of cognitive networks disrupted in alzheimer disease. |
2014-05-21 |
2023-08-12 |
Not clear |
| Lei Yu, Patricia Boyle, Julie A Schneider, Eisuke Segawa, Robert S Wilson, Sue Leurgans, David A Bennet. APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. Psychology and aging. vol 28. issue 4. 2014-05-19. PMID:23647000. |
apoe ε4, alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. |
2014-05-19 |
2023-08-12 |
human |
| Lei Yu, Patricia Boyle, Julie A Schneider, Eisuke Segawa, Robert S Wilson, Sue Leurgans, David A Bennet. APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. Psychology and aging. vol 28. issue 4. 2014-05-19. PMID:23647000. |
the goal of this study was to examine the association of the apoe ε4 allele with the late-life cognitive trajectory and test the hypothesis that the association of ε4 with cognitive decline is explained by alzheimer's disease (ad) neuropathology. |
2014-05-19 |
2023-08-12 |
human |
| Jianjia Fan, Yoko Shimizu, Jeniffer Chan, Anna Wilkinson, Ayaka Ito, Peter Tontonoz, Edie Dullaghan, Liisa A M Galea, Tom Pfeifer, Cheryl L Wellingto. Hormonal modulators of glial ABCA1 and apoE levels. Journal of lipid research. vol 54. issue 11. 2014-05-14. PMID:23999864. |
as apoe plays a major role in the pathogenesis of alzheimer disease (ad) and also mediates repair pathways after several forms of acute brain injury, modulating the expression, secretion, or function of apoe may provide potential therapeutic approaches for several neurological disorders. |
2014-05-14 |
2023-08-12 |
human |
| Ivar Reinvang, Thomas Espeseth, Lars Tjelta Westly. APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease. Neuroscience and biobehavioral reviews. vol 37. issue 8. 2014-05-08. PMID:23701948. |
individuals carrying the *e4 allele of the apolipoprotein e gene (apoe) are at increased risk of developing alzheimer's disease (ad). |
2014-05-08 |
2023-08-12 |
Not clear |
| Meng-Shan Tan, Jin-Tai Yu, Lan Ta. Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease. Trends in molecular medicine. vol 19. issue 10. 2014-05-05. PMID:23871436. |
the bridging integrator 1 (bin1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset alzheimer's disease (load), after apolipoprotein e (apoe). |
2014-05-05 |
2023-08-12 |
Not clear |
| K Nho, J J Corneveaux, S Kim, H Lin, S L Risacher, L Shen, S Swaminathan, V K Ramanan, Y Liu, T Foroud, M H Inlow, A L Siniard, R A Reiman, P S Aisen, R C Petersen, R C Green, C R Jack, M W Weiner, C T Baldwin, K Lunetta, L A Farrer, S J Furney, S Lovestone, A Simmons, P Mecocci, B Vellas, M Tsolaki, I Kloszewska, H Soininen, B C McDonald, M R Farlow, B Ghetti, M J Huentelman, A J Sayki. Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment. Molecular psychiatry. vol 18. issue 7. 2014-05-02. PMID:23608917. |
matched unrelated apoe ε3 homozygous male caucasian participants from the alzheimer's disease neuroimaging initiative (adni) were selected at the extremes of the 2-year longitudinal change distribution of hippocampal volume (eight subjects with rapid rates of atrophy and eight with slow/stable rates of atrophy). |
2014-05-02 |
2023-08-12 |
human |
| Yong Ji, Mengyuan Liu, Ya Ruth Huo, Shuling Liu, Zhihong Shi, Shuai Liu, Thomas Wisniewski, Jinhuan Wan. Apolipoprotein Ε ε4 frequency is increased among Chinese patients with frontotemporal dementia and Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 36. issue 3-4. 2014-04-28. PMID:23887281. |
the relationship between the apolipoprotein e (apoe) ε4 genotype and an increased risk of developing alzheimer's disease (ad) has been well established in caucasians but is less established among other ethnicities. |
2014-04-28 |
2023-08-12 |
Not clear |
| Takahisa Kanekiyo, Huaxi Xu, Guojun B. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. vol 81. issue 4. 2014-04-23. PMID:24559670. |
apoe and aβ in alzheimer's disease: accidental encounters or partners? |
2014-04-23 |
2023-08-12 |
human |
| Takahisa Kanekiyo, Huaxi Xu, Guojun B. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. vol 81. issue 4. 2014-04-23. PMID:24559670. |
among the three human apolipoprotein e (apoe) isoforms, apoe4 increases the risk of alzheimer's disease (ad). |
2014-04-23 |
2023-08-12 |
human |
| Cécilia Samieri, Simon Lorrain, Benjamin Buaud, Carole Vaysse, Claudine Berr, Evelyne Peuchant, Stephen C Cunnane, Pascale Barberger-Gatea. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. Journal of lipid research. vol 54. issue 9. 2014-04-22. PMID:23801662. |
the main risk factors for alzheimer's disease, age and the ε4 allele of the apoe gene (apoe4), might modify the metabolism of n-3 pufas and in turn, their impact on cognition. |
2014-04-22 |
2023-08-12 |
human |
| J Scott Roberts, Wendy R Uhlman. Genetic susceptibility testing for neurodegenerative diseases: ethical and practice issues. Progress in neurobiology. vol 110. 2014-04-21. PMID:23583530. |
apoe gene testing for risk of alzheimer's disease is used throughout as an instructive case example, drawing upon the authors' experience as investigators in a series of multisite randomized clinical trials that have examined the impact of disclosing apoe genotype status to interested individuals (e.g., first-degree relatives of ad patients, persons with mild cognitive impairment). |
2014-04-21 |
2023-08-12 |
Not clear |
| Livia Bernardi, Maura Gallo, Maria Anfossi, Maria Elena Conidi, Rosanna Colao, Gianfranco Puccio, Sabrina A M Curcio, Francesca Frangipane, Alessandra Clodomiro, Maria Mirabelli, Franca Vasso, Nicoletta Smirne, Raffaele Di Lorenzo, Raffaele Maletta, Amalia C Brun. Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation. Journal of Alzheimer's disease : JAD. vol 37. issue 2. 2014-04-15. PMID:23792692. |
we investigated the association between tomm40 rs10524523, age of onset, and memory performance in patients with the psen1 m146l mutation in a large familial alzheimer's disease calabrian kindred, with a wide variability of onset not attributable to apoe. |
2014-04-15 |
2023-08-12 |
Not clear |