| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katrin Morgen, Lutz Frölich, Heike Tost, Michael M Plichta, Heike Kölsch, Fabian Rakebrandt, Otto Rienhoff, Frank Jessen, Oliver Peters, Holger Jahn, Christian Luckhaus, Michael Hüll, Hermann-Josef Gertz, Johannes Schröder, Harald Hampel, Stefan J Teipel, Johannes Pantel, Isabella Heuser, Jens Wiltfang, Eckart Rüther, Johannes Kornhuber, Wolfgang Maier, Andreas Meyer-Lindenber. APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 37. issue 2. 2014-04-15. PMID:23948881. |
the e4 isoform of the apoe genotype is the most significant genetic risk factor for sporadic alzheimer's disease (ad) and has recently been found to modulate disease expression in patients with ad. |
2014-04-15 |
2023-08-12 |
human |
| Wei Qiao Qiu, Mkaya Mwamburi, Lilah M Besser, Haihao Zhu, Huajie Li, Max Wallack, Leslie Phillips, Liyan Qiao, Andrew E Budson, Robert Stern, Neil Kowal. Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer's disease in the absence of apolipoprotein E4 allele. Journal of Alzheimer's disease : JAD. vol 37. issue 2. 2014-04-15. PMID:23948883. |
using the longitudinal data from the national alzheimer's coordinating center (nacc) with apoe genotyping and documentation of ace inhibitors use, we found that in the absence of apoe4, subjects who had been taking central ace inhibitor use (χ2 test: 21% versus 27%, p = 0.0002) or peripheral ace inhibitor use (χ2 test: 13% versus 27%, p < 0.0001) had lower incidence of ad compared with those who had not been taking an ace inhibitor. |
2014-04-15 |
2023-08-12 |
human |
| Michael Malek-Ahmadi, Thomas Beach, Aleksandra Obradov, Lucia Sue, Christine Belden, Kathryn Davis, Douglas G Walker, LihFen Lue, Abdu Adem, Marwan N Sabbag. Increased Alzheimer's disease neuropathology is associated with type 2 diabetes and ApoE ε.4 carrier status. Current Alzheimer research. vol 10. issue 6. 2014-04-11. PMID:23627755. |
increased alzheimer's disease neuropathology is associated with type 2 diabetes and apoe ε.4 carrier status. |
2014-04-11 |
2023-08-12 |
human |
| Jesse Mez, Stephanie Cosentino, Adam M Brickman, Edward D Huey, Richard Mayeu. Different demographic, genetic, and longitudinal traits in language versus memory Alzheimer's subgroups. Journal of Alzheimer's disease : JAD. vol 37. issue 1. 2014-04-08. PMID:23788008. |
the study's objective was to compare demographics, apoe genotypes, and rate of rise over time in functional impairment in neuropsychologically defined language, typical, and memory subgroups of clinical alzheimer's disease (ad). |
2014-04-08 |
2023-08-12 |
human |
| Jessica Mc Donald, Dimitri Krain. Alzheimer gene APOE ε4 linked to brain development in infants. JAMA. vol 311. issue 3. 2014-04-07. PMID:24430322. |
alzheimer gene apoe ε4 linked to brain development in infants. |
2014-04-07 |
2023-08-12 |
Not clear |
| Tara T Lineweaver, Mark W Bondi, Douglas Galasko, David P Salmo. Effect of knowledge of APOE genotype on subjective and objective memory performance in healthy older adults. The American journal of psychiatry. vol 171. issue 2. 2014-04-03. PMID:24170170. |
the knowledge that one carries the apolipoprotein e (apoe) ε4 allele risk factor for alzheimer's disease was recently found to have little short-term psychological risk. |
2014-04-03 |
2023-08-12 |
Not clear |
| Ge Li, Lynn M Bekris, Lesley Leong, Ellen J Steinbart, Jane B Shofer, Paul K Crane, Eric B Larson, Elaine R Peskind, Thomas D Bird, Chang-En Y. TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 5. 2014-03-25. PMID:23183136. |
this study investigates the association between tomm40 poly-t length, age at onset, and neuropathology in individuals with alzheimer's disease (ad) with the apolipoprotein e (apoe) ε3/ε3 allele. |
2014-03-25 |
2023-08-12 |
Not clear |
| Emma L Jones, Kin Mok, Marisa Hanney, Denise Harold, Rebecca Sims, Julie Williams, Clive Ballar. Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome. Neurobiology of aging. vol 34. issue 10. 2014-03-25. PMID:23601808. |
we tested for association with loci previously associated with alzheimer's disease risk and, despite the small size of the study, we detected associations with age at onset of alzheimer's disease in down syndrome with picalm (β = 3.31, p = 0.011) and the apoe loci (β = 3.58, p = 0.014). |
2014-03-25 |
2023-08-12 |
Not clear |
| Ane Korff, Changqin Liu, Carmen Ginghina, Min Shi, Jing Zhan. α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23603399. |
using an established, sensitive luminex assay, we measured α-synuclein levels in the csf of a cohort of close to 400 healthy control, mci, and ad subjects obtained from the alzheimer's disease neuroimaging initiative (adni) and factored in apoe genotype in data analysis. |
2014-03-24 |
2023-08-12 |
human |
| Corinne D Engelman, Rebecca L Koscik, Erin M Jonaitis, Ozioma C Okonkwo, Bruce P Hermann, Asenath La Rue, Mark A Sage. Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23669301. |
the strongest genetic factor for late-onset alzheimer's disease (ad) is apoe; nine additional susceptibility genes have recently been identified. |
2014-03-24 |
2023-08-12 |
human |
| Corinne D Engelman, Rebecca L Koscik, Erin M Jonaitis, Ozioma C Okonkwo, Bruce P Hermann, Asenath La Rue, Mark A Sage. Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23669301. |
we sought to examine the role of interactions between the nine recently identified ad susceptibility genes and apoe in cognitive function and decline in 1,153 participants from the wisconsin registry for alzheimer's prevention, a longitudinal study of middle-aged adults enriched for a parental history of ad. |
2014-03-24 |
2023-08-12 |
human |
| Afef Achouri Rassas, Sondess Hadj Fredj, Hela Mrabet Khiari, Safa Sahnoun, Amina Bibi, Hajer Siala, Amel Mrabet, Taieb Messaou. No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 9. 2014-03-18. PMID:23371443. |
we examined the potential involvement of the polymorphism in intron 8 of the presenilin-1 (psen1) gene as a risk factor for alzheimer disease (ad), both through independent effect and interaction with the apolipoprotein e (apoe) ε4 allele risk, in 85 patients and 90 controls. |
2014-03-18 |
2023-08-12 |
Not clear |
| Katie Kingwel. Alzheimer disease: Joining the dots between APOE ε4 and late-onset Alzheimer disease via integrative genomics. Nature reviews. Neurology. vol 9. issue 9. 2014-03-18. PMID:23938735. |
alzheimer disease: joining the dots between apoe ε4 and late-onset alzheimer disease via integrative genomics. |
2014-03-18 |
2023-08-12 |
Not clear |
| Perry G Ridge, Mark T W Ebbert, John S K Kauw. Genetics of Alzheimer's disease. BioMed research international. vol 2013. 2014-03-18. PMID:23984328. |
in contrast, while several common alleles associated with late-onset alzheimer's disease, including apoe, have been identified using association studies, the genetics of late-onset alzheimer's disease are not fully understood. |
2014-03-18 |
2023-08-12 |
Not clear |
| Jesse Mez, Stephanie Cosentino, Adam M Brickman, Edward D Huey, Jennifer J Manly, Richard Mayeu. Dysexecutive versus amnestic Alzheimer disease subgroups: analysis of demographic, genetic, and vascular factors. Alzheimer disease and associated disorders. vol 27. issue 3. 2014-03-17. PMID:23954887. |
the objective of this study was to compare the demographic and vascular characteristics and apoe genotypes of a dysexecutive subgroup of alzheimer disease (ad) with an amnestic subgroup of ad early in the disease course. |
2014-03-17 |
2023-08-12 |
human |
| Yue Yang, Eiron Cudaback, Nikolas L Jorstad, Jake F Hemingway, Catherine E Hagan, Erica J Melief, Xianwu Li, Tom Yoo, Shawn B Khademi, Kathleen S Montine, Thomas J Montine, C Dirk Keen. APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease. The American journal of pathology. vol 183. issue 3. 2014-03-12. PMID:23831297. |
here, we tested the hypothesis that bone marrow cell apoe genotype modulates pathological progression in experimental alzheimer disease. |
2014-03-12 |
2023-08-12 |
mouse |
| David P Salmon, Steven H Ferris, Ronald G Thomas, Mary Sano, Jeffery L Cummings, Reisa A Sperling, Ronald C Petersen, Paul S Aise. Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly. Neuropsychology. vol 27. issue 4. 2014-02-24. PMID:23876113. |
this study examined the impact of age and apolipoprotein e (apoe) genotype on the rate of cognitive decline in nondemented elderly participants in a simulated alzheimer's disease (ad) primary prevention treatment trial carried out by the alzheimer's disease cooperative study. |
2014-02-24 |
2023-08-12 |
human |
| Andrew S P Lim, Lei Yu, Matthew Kowgier, Julie A Schneider, Aron S Buchman, David A Bennet. Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep. JAMA neurology. vol 70. issue 12. 2014-02-20. PMID:24145819. |
the apolipoprotein e (apoe [genbank, 348; omim, 107741]) ε4 allele is a common and well-established genetic risk factor for alzheimer disease (ad). |
2014-02-20 |
2023-08-12 |
Not clear |
| Ling Li, Zegang Yin, Juan Liu, Gongbo Li, Yanjiang Wang, Jiachuan Yan, Huadong Zho. CYP46A1 T/C polymorphism associated with the APOE ε4 allele increases the risk of Alzheimer's disease. Journal of neurology. vol 260. issue 7. 2014-02-19. PMID:23070465. |
cyp46a1 t/c polymorphism associated with the apoe ε4 allele increases the risk of alzheimer's disease. |
2014-02-19 |
2023-08-12 |
Not clear |
| Flora H Duits, Maartje I Kester, Peter G Scheffer, Marinus A Blankenstein, Philip Scheltens, Charlotte E Teunissen, Wiesje M van der Flie. Increase in cerebrospinal fluid F2-isoprostanes is related to cognitive decline in APOE ε4 carriers. Journal of Alzheimer's disease : JAD. vol 36. issue 3. 2014-02-17. PMID:23629585. |
twenty non-demented subjects, 58 mild cognitive impairment (mci) patients, and 63 alzheimer's disease (ad) patients with measurements of csf f2-isoprostanes at two time points (with a mean interval of 2.0 ± 1.1 years) and known apoe genotype were included. |
2014-02-17 |
2023-08-12 |
human |