| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjuan Zhao, Jiguo Zhang, Elizabeth G Davis, G William Rebec. Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Frontiers in aging neuroscience. vol 6. 2014-09-01. PMID:25177293. |
this system allowed us to examine aβ metabolism in vivo, and test the effects of both aging and apoe genotype, two of the strongest risk factors for alzheimer's disease. |
2014-09-01 |
2023-08-13 |
mouse |
| Anne-Sophie Carl. Sortilin, a novel APOE receptor implicated in Alzheimer disease. Prion. vol 7. issue 5. 2014-08-29. PMID:24121631. |
sortilin, a novel apoe receptor implicated in alzheimer disease. |
2014-08-29 |
2023-08-12 |
mouse |
| Anne-Sophie Carl. Sortilin, a novel APOE receptor implicated in Alzheimer disease. Prion. vol 7. issue 5. 2014-08-29. PMID:24121631. |
three apoe alleles exist in the human population with ε4 being an alzheimer disease (ad) risk gene and ε2 being protective relative to the common ε3 variant. |
2014-08-29 |
2023-08-12 |
mouse |
| Christian Montag, Lukas Kunz, Nikolai Axmacher, Rayna Sariyska, Bernd Lachmann, Martin Reute. Common genetic variation of the APOE gene and personality. BMC neuroscience. vol 15. 2014-08-27. PMID:24884737. |
a recent study yielded first evidence that personality plays an important role in explaining the influence of a prominent apoe polymorphism on cognitive decline and alzheimer's disease (ad) in elderly humans. |
2014-08-27 |
2023-08-13 |
human |
| Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PloS one. vol 8. issue 11. 2014-08-26. PMID:24260406. |
alzheimer's disease susceptibility genes apoe and tomm40, and hippocampal volumes in the lothian birth cohort 1936. |
2014-08-26 |
2023-08-12 |
human |
| Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PloS one. vol 8. issue 11. 2014-08-26. PMID:24260406. |
the apoe ε and tomm40 rs10524523 ('523') variable length poly-t repeat gene loci have been significantly and independently associated with alzheimer's disease (ad) related phenotypes such as age of clinical onset. |
2014-08-26 |
2023-08-12 |
human |
| Ruth F Itzhak. Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus. Frontiers in aging neuroscience. vol 6. 2014-08-26. PMID:25157230. |
herpes simplex virus type 1 (hsv1), when present in brain of carriers of the type 4 allele of the apolipoprotein e gene (apoe), has been implicated as a major factor in alzheimer's disease (ad). |
2014-08-26 |
2023-08-13 |
mouse |
| Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poo. Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain. PloS one. vol 8. issue 12. 2014-08-18. PMID:24312462. |
although the risk factor for apolipoprotein e (apoe) polymorphism in alzheimer's disease (ad) has been well described, the role that apoe plays in other neurodegenerative diseases, including pick's disease, is not well established. |
2014-08-18 |
2023-08-12 |
Not clear |
| Maire Percy, Martin J Somerville, Mark Hicks, Angeles Garcia, Teresa Colelli, Emily Wright, Julia Kitaygorodsky, Amy Jiang, Valerie Ho, Alyssa Parpia, Michael K Won. Risk factors for development of dementia in a unique six-year cohort study. I. An exploratory, pilot study of involvement of the E4 allele of apolipoprotein E, mutations of the hemochromatosis-HFE gene, type 2 diabetes, and stroke. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081379. |
factors included: apolipoprotein e (apoe) gene variants (the e4 allele is the strongest confirmed genetic predisposing factor for alzheimer's disease), the hemochromatosis-hfe gene mutations (h63d and c282y), diabetes, and stroke. |
2014-08-17 |
2023-08-12 |
human |
| Alexis Koutseff, Christophe Mittelhaeuser, Karim Essabri, Johan Auwerx, Hamid Mezian. Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease? Brain research. vol 1542. 2014-08-15. PMID:24140109. |
apolipoprotein e (apoe) is found in three different forms in humans (apoe2, apoe3 and apoe4), and apoe polymorphism is recognized as a major risk factor for alzheimer's disease (ad). |
2014-08-15 |
2023-08-12 |
mouse |
| Keith A Wesnes, Peter Annas, Hans Basun, Chris Edgar, Kaj Blenno. Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels. Alzheimer's research & therapy. vol 6. issue 2. 2014-08-12. PMID:24735568. |
this study involved the administration of a pattern separation paradigm to alzheimer's patients to investigate relationships between task performance and both apoe status and cerebrospinal fluid (csf) aβ42 levels. |
2014-08-12 |
2023-08-13 |
mouse |
| Miranka Wirth, Sylvia Villeneuve, Renaud La Joie, Shawn M Marks, William J Jagus. Gene-environment interactions: lifetime cognitive activity, APOE genotype, and β-amyloid burden. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948815. |
carriers of the apolipoprotein e (apoe) ε4 allele, the major genetic risk for alzheimer's disease (ad), harbor an increased load of β-amyloid (aβ) plaque burden that is felt to be a major instigator of ad development. |
2014-08-12 |
2023-08-13 |
human |
| Sana Suri, Verena Heise, Aaron J Trachtenberg, Clare E Macka. The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2. Neuroscience and biobehavioral reviews. vol 37. issue 10 Pt 2. 2014-08-06. PMID:24183852. |
the apoe ɛ4 allele is a well-established risk factor for alzheimer's disease (ad) and has thus dominated the apoe literature, with the putative protective role of ɛ2 receiving little attention. |
2014-08-06 |
2023-08-12 |
Not clear |
| Hemi Malkk. Alzheimer disease: Effects of the APOE ε4 allele on brain development. Nature reviews. Neurology. vol 10. issue 1. 2014-08-06. PMID:24323049. |
alzheimer disease: effects of the apoe ε4 allele on brain development. |
2014-08-06 |
2023-08-12 |
Not clear |
| Xin R Cheng, Ben Y H Hau, Tatsuro Endo, Kagan Kerma. Au nanoparticle-modified DNA sensor based on simultaneous electrochemical impedance spectroscopy and localized surface plasmon resonance. Biosensors & bioelectronics. vol 53. 2014-07-15. PMID:24220345. |
the dual-detection platform was applied to detect dna hybridization related to a specific point mutation in apolipoprotein e gene (apoe), which was related to the progression of alzheimer's disease. |
2014-07-15 |
2023-08-12 |
Not clear |
| R L Ashare, J H Karlawish, E P Wileyto, A Pinto, C Lerma. APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:23247396. |
apoe ɛ4, an alzheimer's disease susceptibility allele, and smoking cessation. |
2014-07-14 |
2023-08-12 |
Not clear |
| R L Ashare, J H Karlawish, E P Wileyto, A Pinto, C Lerma. APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:23247396. |
possessing an apolipoprotein e (apoe) ɛ4 allele, advanced age and smoking are risk factors for alzheimer's disease and cognitive decline. |
2014-07-14 |
2023-08-12 |
Not clear |
| Fan Liao, Yukiko Hori, Eloise Hudry, Adam Q Bauer, Hong Jiang, Thomas E Mahan, Katheryn B Lefton, Tony J Zhang, Joshua T Dearborn, Jungsu Kim, Joseph P Culver, Rebecca Betensky, David F Wozniak, Bradley T Hyman, David M Holtzma. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849360. |
apolipoprotein e (apoe) is the strongest known genetic risk factor for late onset alzheimer's disease (ad). |
2014-07-11 |
2023-08-13 |
mouse |
| Eloise Hudry, Jonathan Dashkoff, Alysson D Roe, Shuko Takeda, Robert M Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L Davidson, Bradley T Hyma. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science translational medicine. vol 5. issue 212. 2014-07-10. PMID:24259049. |
inheritance of the ε4 allele of apolipoprotein e (apoe) is the strongest genetic risk factor associated with the sporadic form of alzheimer's disease (ad), whereas the rare apoe ε2 allele has the opposite effect. |
2014-07-10 |
2023-08-12 |
mouse |
| Elizabeth C Mormino, Rebecca A Betensky, Trey Hedden, Aaron P Schultz, Andrew Ward, Willem Huijbers, Dorene M Rentz, Keith A Johnson, Reisa A Sperlin. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. vol 82. issue 20. 2014-07-10. PMID:24748674. |
amyloid and apoe ε4 interact to influence short-term decline in preclinical alzheimer disease. |
2014-07-10 |
2023-08-13 |
Not clear |