| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PloS one. vol 8. issue 11. 2014-08-26. PMID:24260406. |
alzheimer's disease susceptibility genes apoe and tomm40, and hippocampal volumes in the lothian birth cohort 1936. |
2014-08-26 |
2023-08-12 |
human |
| Donald M Lyall, Natalie A Royle, Sarah E Harris, Mark E Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W Lutz, Ann M Saunders, Allen D Roses, Maria C del Valdés Hernández, John M Starr, David J Porteous, Joanna M Wardlaw, Ian J Dear. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. PloS one. vol 8. issue 11. 2014-08-26. PMID:24260406. |
the apoe ε and tomm40 rs10524523 ('523') variable length poly-t repeat gene loci have been significantly and independently associated with alzheimer's disease (ad) related phenotypes such as age of clinical onset. |
2014-08-26 |
2023-08-12 |
human |
| Ruth F Itzhak. Herpes simplex virus type 1 and Alzheimer's disease: increasing evidence for a major role of the virus. Frontiers in aging neuroscience. vol 6. 2014-08-26. PMID:25157230. |
herpes simplex virus type 1 (hsv1), when present in brain of carriers of the type 4 allele of the apolipoprotein e gene (apoe), has been implicated as a major factor in alzheimer's disease (ad). |
2014-08-26 |
2023-08-13 |
mouse |
| Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poo. Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain. PloS one. vol 8. issue 12. 2014-08-18. PMID:24312462. |
although the risk factor for apolipoprotein e (apoe) polymorphism in alzheimer's disease (ad) has been well described, the role that apoe plays in other neurodegenerative diseases, including pick's disease, is not well established. |
2014-08-18 |
2023-08-12 |
Not clear |
| Maire Percy, Martin J Somerville, Mark Hicks, Angeles Garcia, Teresa Colelli, Emily Wright, Julia Kitaygorodsky, Amy Jiang, Valerie Ho, Alyssa Parpia, Michael K Won. Risk factors for development of dementia in a unique six-year cohort study. I. An exploratory, pilot study of involvement of the E4 allele of apolipoprotein E, mutations of the hemochromatosis-HFE gene, type 2 diabetes, and stroke. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081379. |
factors included: apolipoprotein e (apoe) gene variants (the e4 allele is the strongest confirmed genetic predisposing factor for alzheimer's disease), the hemochromatosis-hfe gene mutations (h63d and c282y), diabetes, and stroke. |
2014-08-17 |
2023-08-12 |
human |
| Alexis Koutseff, Christophe Mittelhaeuser, Karim Essabri, Johan Auwerx, Hamid Mezian. Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease? Brain research. vol 1542. 2014-08-15. PMID:24140109. |
apolipoprotein e (apoe) is found in three different forms in humans (apoe2, apoe3 and apoe4), and apoe polymorphism is recognized as a major risk factor for alzheimer's disease (ad). |
2014-08-15 |
2023-08-12 |
mouse |
| Keith A Wesnes, Peter Annas, Hans Basun, Chris Edgar, Kaj Blenno. Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels. Alzheimer's research & therapy. vol 6. issue 2. 2014-08-12. PMID:24735568. |
this study involved the administration of a pattern separation paradigm to alzheimer's patients to investigate relationships between task performance and both apoe status and cerebrospinal fluid (csf) aβ42 levels. |
2014-08-12 |
2023-08-13 |
mouse |
| Miranka Wirth, Sylvia Villeneuve, Renaud La Joie, Shawn M Marks, William J Jagus. Gene-environment interactions: lifetime cognitive activity, APOE genotype, and β-amyloid burden. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948815. |
carriers of the apolipoprotein e (apoe) ε4 allele, the major genetic risk for alzheimer's disease (ad), harbor an increased load of β-amyloid (aβ) plaque burden that is felt to be a major instigator of ad development. |
2014-08-12 |
2023-08-13 |
human |
| Sana Suri, Verena Heise, Aaron J Trachtenberg, Clare E Macka. The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2. Neuroscience and biobehavioral reviews. vol 37. issue 10 Pt 2. 2014-08-06. PMID:24183852. |
the apoe ɛ4 allele is a well-established risk factor for alzheimer's disease (ad) and has thus dominated the apoe literature, with the putative protective role of ɛ2 receiving little attention. |
2014-08-06 |
2023-08-12 |
Not clear |
| Hemi Malkk. Alzheimer disease: Effects of the APOE ε4 allele on brain development. Nature reviews. Neurology. vol 10. issue 1. 2014-08-06. PMID:24323049. |
alzheimer disease: effects of the apoe ε4 allele on brain development. |
2014-08-06 |
2023-08-12 |
Not clear |
| Xin R Cheng, Ben Y H Hau, Tatsuro Endo, Kagan Kerma. Au nanoparticle-modified DNA sensor based on simultaneous electrochemical impedance spectroscopy and localized surface plasmon resonance. Biosensors & bioelectronics. vol 53. 2014-07-15. PMID:24220345. |
the dual-detection platform was applied to detect dna hybridization related to a specific point mutation in apolipoprotein e gene (apoe), which was related to the progression of alzheimer's disease. |
2014-07-15 |
2023-08-12 |
Not clear |
| R L Ashare, J H Karlawish, E P Wileyto, A Pinto, C Lerma. APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:23247396. |
apoe ɛ4, an alzheimer's disease susceptibility allele, and smoking cessation. |
2014-07-14 |
2023-08-12 |
Not clear |
| R L Ashare, J H Karlawish, E P Wileyto, A Pinto, C Lerma. APOE ɛ4, an Alzheimer's disease susceptibility allele, and smoking cessation. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:23247396. |
possessing an apolipoprotein e (apoe) ɛ4 allele, advanced age and smoking are risk factors for alzheimer's disease and cognitive decline. |
2014-07-14 |
2023-08-12 |
Not clear |
| Fan Liao, Yukiko Hori, Eloise Hudry, Adam Q Bauer, Hong Jiang, Thomas E Mahan, Katheryn B Lefton, Tony J Zhang, Joshua T Dearborn, Jungsu Kim, Joseph P Culver, Rebecca Betensky, David F Wozniak, Bradley T Hyman, David M Holtzma. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849360. |
apolipoprotein e (apoe) is the strongest known genetic risk factor for late onset alzheimer's disease (ad). |
2014-07-11 |
2023-08-13 |
mouse |
| Eloise Hudry, Jonathan Dashkoff, Alysson D Roe, Shuko Takeda, Robert M Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L Davidson, Bradley T Hyma. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science translational medicine. vol 5. issue 212. 2014-07-10. PMID:24259049. |
inheritance of the ε4 allele of apolipoprotein e (apoe) is the strongest genetic risk factor associated with the sporadic form of alzheimer's disease (ad), whereas the rare apoe ε2 allele has the opposite effect. |
2014-07-10 |
2023-08-12 |
mouse |
| Elizabeth C Mormino, Rebecca A Betensky, Trey Hedden, Aaron P Schultz, Andrew Ward, Willem Huijbers, Dorene M Rentz, Keith A Johnson, Reisa A Sperlin. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. vol 82. issue 20. 2014-07-10. PMID:24748674. |
amyloid and apoe ε4 interact to influence short-term decline in preclinical alzheimer disease. |
2014-07-10 |
2023-08-13 |
Not clear |
| Corinne Pettigrew, Anja Soldan, Shanshan Li, Yi Lu, Mei-Cheng Wang, Ola A Selnes, Abhay Moghekar, Richard O'Brien, Marilyn Albert, The Biocard Research Tea. Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease. Cognitive neuroscience. vol 4. issue 3-4. 2014-07-09. PMID:24168200. |
relationship of cognitive reserve and apoe status to the emergence of clinical symptoms in preclinical alzheimer's disease. |
2014-07-09 |
2023-08-12 |
Not clear |
| Corinne Pettigrew, Anja Soldan, Shanshan Li, Yi Lu, Mei-Cheng Wang, Ola A Selnes, Abhay Moghekar, Richard O'Brien, Marilyn Albert, The Biocard Research Tea. Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease. Cognitive neuroscience. vol 4. issue 3-4. 2014-07-09. PMID:24168200. |
the apoe ε4 allele increases the risk of developing alzheimer's disease, whereas the apoe ε2 allele reduces risk. |
2014-07-09 |
2023-08-12 |
Not clear |
| Andrew B Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo LaDu, Eric M Reiman, Richard J Casell. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 5. 2014-06-24. PMID:23998393. |
apoe, which encodes apolipoprotein e, is the most prevalent and best established genetic risk factor for late-onset alzheimer's disease. |
2014-06-24 |
2023-08-12 |
Not clear |
| Carl Frieden, Kanchan Gara. Concerning the structure of apoE. Protein science : a publication of the Protein Society. vol 22. issue 12. 2014-06-19. PMID:24115173. |
while studies initially focused on its role in cholesterol and lipid metabolism, one apoe isoform (apoe4) is a major risk factor for development of late onset alzheimer's disease. |
2014-06-19 |
2023-08-12 |
Not clear |